Гљstav experimentГЎlnej endokrinolГіgie SAV
SprГЎva o ДЌinnosti organizГЎcie SAV
za rok 2013
Bratislava
januГЎr 2014
Obsah osnovy SprГЎvy o ДЌinnosti organizГЎcie SAV za rok 2013
1.
ZГЎkladnГ© Гєdaje o organizГЎcii
2.
VedeckГЎ ДЌinnosЕҐ
3.
DoktorandskГ© ЕЎtГєdium, inГЎ pedagogickГЎ ДЌinnosЕҐ a budovanie ДѕudskГЅch zdrojov pre vedu a
techniku
4.
MedzinГЎrodnГЎ vedeckГЎ spoluprГЎca
5.
VednГЎ politika
6.
SpoluprГЎca s VЕ a inГЅmi subjektmi v oblasti vedy a techniky
7.
SpoluprГЎca s aplikaДЌnou a hospodГЎrskou sfГ©rou
8.
Aktivity pre NГЎrodnГє radu SR, vlГЎdu SR, ГєstrednГ© orgГЎny ЕЎtГЎtnej sprГЎvy SR a inГ©
organizГЎcie
9.
Vedecko-organizaДЌnГ© a popularizaДЌnГ© aktivity
10. ДЊinnosЕҐ kniЕѕniДЌno-informaДЌnГ©ho pracoviska
11. Aktivity v orgГЎnoch SAV
12. HospodГЎrenie organizГЎcie
13. NadГЎcie a fondy pri organizГЎcii SAV
14. InГ© vГЅznamnГ© ДЌinnosti organizГЎcie SAV
15. Vyznamenania, ocenenia a ceny udelenГ© pracovnГ­kom organizГЎcie SAV
16. Poskytovanie informГЎciГ­ v sГєlade so zГЎkonom o slobodnom prГ­stupe k informГЎciГЎm
17. ProblГ©my a podnety pre ДЌinnosЕҐ SAV
PRГЌLOHY
A
B
C
D
E
Zoznam zamestnancov a doktorandov organizГЎcie k 31.12.2013
Projekty rieЕЎenГ© v organizГЎcii
PublikaДЌnГЎ ДЌinnosЕҐ organizГЎcie
Гљdaje o pedagogickej ДЌinnosti organizГЎcie
MedzinГЎrodnГЎ mobilita organizГЎcie
SprГЎva o ДЌinnosti organizГЎcie SAV
1. ZГЎkladnГ© Гєdaje o organizГЎcii
1.1. KontaktnГ© Гєdaje
NГЎzov: Гљstav experimentГЎlnej endokrinolГіgie SAV
RiaditeДѕ: Ing. Е tefan Zorad, CSc.
ZГЎstupca riaditeДѕa: doc. MUDr. Boris Mravec, PhD.
VedeckГЅ tajomnГ­k: Ing. JГєlius Brtko, DrSc.
Predseda vedeckej rady: Mgr. Jozef Ukropec, PhD.
ДЊlen snemu SAV : Ing, Е tefan Zorad, CSc.
Adresa: VlГЎrska 3, 833 06 Bratislava
http://www.endo.sav.sk
Tel.: 02/54772800
Fax: neuvedenГЅ
E-mail: sekretariat.uee@savba.sk
NГЎzvy a adresy detaЕЎovanГЅch pracovГ­sk: nie sГє
VedГєci detaЕЎovanГЅch pracovГ­sk: nie sГє
Typ organizГЎcie: RozpoДЌtovГЎ od roku 1954
1.2. Гљdaje o zamestnancoch
TabuДѕka 1a PoДЌet a ЕЎtruktГєra zamestnancov
Е truktГєra zamestnancov
M
ЕЅ
K
do 35
rokov
M
ЕЅ
K
K
F
P
T
CelkovГЅ poДЌet zamestnancov
100
33
67
12
25
91
73,16
56,15
VedeckГ­ pracovnГ­ci
44
22
22
6
7
38
34,86
34,56
OdbornГ­ pracovnГ­ci VЕ 26
5
21
5
18
23
10,96
10,63
OdbornГ­ pracovnГ­ci ГљS
21
2
19
0
0
21
18,62
10,96
OstatnГ­ pracovnГ­ci
9
4
5
1
0
9
8,72
0
K – kmeňový stav zamestnancov v pracovnom pomere k 31.12.2013 (uvádzať zamestnancov v
pracovnom pomere, vrГЎtane riadnej materskej dovolenky, zamestnancov pГґsobiacich v zahraniДЌГ­, v
ЕЎtГЎtnych funkciГЎch, ДЌlenov PredsednГ­ctva SAV, zamestnancov pГґsobiacich v zastupiteДѕskГЅch
zboroch)
F – fyzický stav zamestnancov k 31.12.2013 (bez riadnej materskej dovolenky, zamestnancov
pГґsobiacich v zahraniДЌГ­ v ЕЎtГЎtnych funkciГЎch, ДЌlenov PredsednГ­ctva SAV, zamestnancov
pГґsobiacich v zastupiteДѕskГЅch zboroch)
P – celoročný priemerný prepočítaný počet zamestnancov
T – celoročný priemerný prepočítaný počet riešiteľov projektov
1
SprГЎva o ДЌinnosti organizГЎcie SAV
M, Ž – muži, ženy
TabuДѕka 1b Е truktГєra vedeckГЅch pracovnГ­kov (kmeЕ€ovГЅ stav k 31.12.2013)
RodovГЎ
PracovnГ­ci s hodnosЕҐou
VedeckГ­ pracovnГ­ci v stupЕ€och
skladba
DrSc.
CSc./PhD.
prof.
doc.
I.
IIa.
IIb.
MuЕѕi
6
16
2
2
6
12
4
ЕЅeny
1
21
1
1
1
14
7
TabuДѕka 1c Е truktГєra pracovnГ­kov podДѕa veku a rodu, ktorГ­ sГє rieЕЎiteДѕmi projektov
VekovГЎ ЕЎtruktГєra
(roky)
< 31
31-35
36-40
41-45
46-50
51-55
56-60
61-65
> 65
MuЕѕi
4
7
4
0
0
1
2
3
3
ЕЅeny
16
6
7
3
1
2
5
4
2
TabuДѕka 1d PriemernГЅ vek zamestnancov organizГЎcie k 31.12.2013
KmeЕ€ovГ­ zamestnanci
VedeckГ­ pracovnГ­ci
RieЕЎitelia projektov
MuЕѕi
46,5
49,0
45,2
ЕЅeny
42,0
39,5
40,3
Spolu
43,5
44,3
42,0
1.3. InГ© dГґleЕѕitГ© informГЎcie k zГЎkladnГЅm Гєdajom o organizГЎcii a zmeny za poslednГ© obdobie
(v zameranГ­, v organizaДЌnej ЕЎtruktГєre a pod.)
Zoznam laboratГіriГ­ ГљEE SAV k 31.12.2013 :
1. LABORATГ“RIUM BUNKOVEJ ENDOKRINOLГ“GIE - RNDr. MГЎria FickovГЎ, CSc.
2. LABORATГ“RIUM DIABETU A PORГљCH METABOLIZMU - prof. MUDr. Iwar KlimeЕЎ, DrSc.
• LDPM sekcia diabetu - Mgr. Daniela Gašperíková, CSc.
• LDPM sekcia obezity - Mgr. Jozef Ukropec, PhD.
3. LABORATГ“RIUM ENDOKRINOLГ“GIE ДЊLOVEKA - MUDr. Richard Imrich, PhD.
4. LABORATГ“RIUM FARMAKOLOGICKEJ NEUROENDOKRINOLГ“GIE - prof. PharmDr. Daniela
JeЕѕovГЎ, DrSc.
5. LABORATГ“RIUM FUNKДЊNEJ NEUROMORFOLГ“GIE - RNDr. Alexander Kiss, DrSc.
6. LABORATГ“RIUM MOLEKULOVEJ ENDOKRINOLГ“GIE - Ing. JГєlius Brtko, DrSc.
7. LABORATГ“RIUM NEUROBIOLГ“GIE - doc. MUDr. Boris Mravec, PhD.
8. LABORATГ“RIUM NEUROHUMORГЃLNYCH REGULГЃCIГЌ - MUDr. VladimГ­r Е trbГЎk, DrSc.
9. LABORATГ“RIUM PRE VГќSKUM STRESU - RNDr. Richard KvetЕ€anskГЅ, DrSc.
10. LABORATГ“RIUM REGULГЃCIE METABOLIZMU - Ing. Е tefan ZГіrad, CSc.
11. LABORATГ“RIUM VГќVOJOVEJ GENETIKY - RNDr. RГіbert FarkaЕЎ, CSc.
RiaditeДѕom ГљEE SAV je od 15.10.2013 Ing. Е tefan Zorad, CSc.
2
SprГЎva o ДЌinnosti organizГЎcie SAV
2. VedeckГЎ ДЌinnosЕҐ
2.1. DomГЎce projekty
A - organizГЎcia je nositeДѕom projektu
B - organizГЎcia sa zmluvne podieДѕa na rieЕЎenГ­ projektu
TabuДѕka 2a Zoznam domГЎcich projektov rieЕЎenГЅch v roku 2013
PoДЌet projektov
ДЊerpanГ© financie
za rok 2013 (v €)
A
Е TRUKTГљRA PROJEKTOV
pre
organizГЎciu
A
B
1. VedeckГ© projekty, ktorГ© boli
r. 2013 financovanГ© VEGA
17
-
102 168,00 102 168,00
2. Projekty, ktorГ© boli r. 2013
financovanГ© APVV
8
6
497 678,28 374 457,10 123 221,18
3. Projekty OP Е F
1
2
294 819,17 294 819,17
-
4. Projekty centier excelentnosti SAV
–
5
12 000,00 12 000,00
-
5. InГ© projekty (FM EHP, Е PVV,
Vedecko-technickГ© projekty, ESF,
na objednГЎvku rezortov a pod.)
4
-
31 333,00 31 333,00
-
3
spolu
B
-
SprГЎva o ДЌinnosti organizГЎcie SAV
2.2. MedzinГЎrodnГ© projekty
2.2.1. MedzinГЎrodnГ© projekty rieЕЎenГ© v roku 2013
A - organizГЎcia je nositeДѕom projektu
B - organizГЎcia sa zmluvne podieДѕa na rieЕЎenГ­ projektu
ДЊerpanГ© financie
za rok 2013 (v €)
PoДЌet projektov
A
Е TRUKTГљRA PROJEKTOV
1. Projekty 7. RГЎmcovГ©ho programu
EГљ
2. MultilaterГЎlne projekty v rГЎmci
vedeckГЅch programov COST,
ERANET , INTAS, EUREKA,
ESPIRIT, PHARE, NATO, UNESCO,
CERN, IAEA, ESF (European
Science Foundation), ERDF a inГ©
3. Projekty v rГЎmci medzivlГЎdnych
dohГґd o vedecko-technickej
spoluprГЎci
4. BilaterГЎlne projekty
5. Podpora medzinГЎrodnej
spoluprГЎce z nГЎrodnГЅch zdrojov
(MVTS, APVV,...)
6. InГ© projekty financovanГ© alebo
spolufinancovanГ© zo zahraniДЌnГЅch
zdrojov
spolu
pre
organizГЎciu
B
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
23 100,00 22 000,00 1 100,00
3
-
9 333,00
9 333,00
-
3
-
63 434,39 63 434,39
-
A
B
-
4
SprГЎva o ДЌinnosti organizГЎcie SAV
2.3. NajvГЅznamnejЕЎie vГЅsledky vedeckej prГЎce
2.3.1. ZГЎkladnГЅ vГЅskum
Laboratórium diabetu a porúch metabolizmu – sekcia obezity
Je expresia Fndc5 gГ©nu vo svale a v tukovom tkanive ДЌi uvoДѕЕ€ovanie irisГ­nu do cirkulГЎcie
ovplyvnenГЎ obezitou, diabetom a cviДЌenГ­m?
Toto bola kДѕГєДЌovГЎ doteraz nezodpovedanГЎ otГЎzka, na ktorГє sme hДѕadali v naЕЎej prГЎci odpoveДЏ.
Vedeli sme len to, Еѕe irisГ­n je pravdepodobne, cviДЌenГ­m indukovanГЅ sekretorickГЅ produkt
kostrového svalu, ktorý spôsobuje metabolickú aktiváciu „hnednutie“ bieleho tukového tkaniva, a
teda zvГЅЕЎenie celotelovГ©ho vГЅdaja energie.
NaЕЎa prГЎca ukГЎzala, Еѕe expresia Fndc5 a hladina irisГ­nu v cirkulГЎcii sГє pri diabete 2. typu rozdielne
regulovanГ© vo svale, v tukovom tkanive a v cirkulГЎcii. Expresia Fndc5 a cirkulujГєca hladina irisГ­nu
sa znГ­Еѕili u pacientov s diabetom 2. typu, priДЌom vo svalovГЅch bunkГЎch diabetickГЅch jedincov sa
expresia Fndc5 naopak zvГЅЕЎila. Tieto vГЅsledky naznaДЌili Еѕe existuje faktor, spojenГЅ s diabetom 2.
typu, ktorГЅ negatГ­vne ovplyvЕ€uje expresiu Fndc5. NГЎslednГЅ in vitro experiment ukГЎzal, Еѕe
regulaДЌnГЅmi faktormi expresie Fndc5 a uvoДѕЕ€ovania irisГ­nu vo svale by mohli byЕҐ zvГЅЕЎenГЎ
glykГ©mia a/alebo vyЕЎЕЎia hladina voДѕnГЅch mastnГЅch kyselГ­n. UkГЎzali sme tieЕѕ, Еѕe cviДЌenie vГґbec
neovplyvЕ€uje expresiu Fndc5 ДЌi sekrГ©ciu irisГ­nu vo svale. Napriek tomu bol vЕЎak irisГ­n pozitГ­vne
asociovanГЅ s objemom svalu, s maximГЎlnou silou svalovej kontrakcie ДЌi s parametrami
energetickГ©ho metabolizmu. IrisГ­n je teda ovplyvnenГЅ prГ­tomnosЕҐou diabetu 2. typu a mГЎ potenciГЎl
modulovaЕҐ metabolickГЅ fenotyp kostrovГ©ho svalu ДЌloveka.
KURDIOVA T, BALAZ M, VICIAN M, MADEROVA D, VLCEK M, VALKOVIC L,
SRBECKY M, IMRICH R, KYSELOVICOVA O, BELAN V, JELOK I, WOLFRUM C,
KLIMES I, KRSSAK M, ZEMKOVA E, GASPERIKOVA D, UKROPEC J, UKROPCOVA B
Are Skeletal Muscle & Adipose Tissue Fndc5 Gene Expression and Irisin Release Affected by
Obesity, Diabetes and Exercise? In vivo & in vitro studies. In The journal of physiology (London),
2013. (IF2012- 4.38)
BALГЃЕЅ M., KURDIOVA T., MADEROVA D., VICIAN M., GASPERIKOVA D., ZEMKOVA
E., UKROPEC J., UKROPCOVA B.: A Novel myokine irisin: in vivo & in vitro changes with
obesity & metabolic status. Keystone Symposia – Adipose Tissue Biology. Keystone, Colorado,
USA, 27.1-1.2.2013. J3041, p. 160
Are skeletal muscle & adipose tissue Fndc5 gene expression and irisin release affected
by obesity, diabetes and exercise?
This was a principal question we aimed to answer due to the fact that there is a large controversy
behind the proposed role of irisin, the putative exercise-induced muscle secretory product with
proposed beneficial impact on the adipose tissue and whole body energy metabolism.
The complex approach was undertaken to untangle some of the loose ends:
We could conclude that distinct patterns of Fndc5/irisin in muscle, adipose tissue & circulation
exist. However, concordant in vivo down-regulation in T2D was found. Fndc5 andirisin were
discordantly regulated in diabetic muscle ex vivo and in myotubes in vitro, suggesting that the
whole-body factors, such as glucose and fatty acids, might be important for irisin regulation. We
have also shown that exercise did not affect Fndc5/irisin. However, irisin was positively linked to
muscle mass, strength & metabolism, pointing to common regulatory factors and/or the potential for
irisin to modify muscle phenotype.
5
SprГЎva o ДЌinnosti organizГЎcie SAV
KURDIOVA T, BALAZ M, VICIAN M, MADEROVA D, VLCEK M, VALKOVIC L,
SRBECKY M, IMRICH R, KYSELOVICOVA O, BELAN V, JELOK I, WOLFRUM C,
KLIMES I, KRSSAK M, ZEMKOVA E, GASPERIKOVA D, UKROPEC J, UKROPCOVA B
Are Skeletal Muscle & Adipose Tissue Fndc5 Gene Expression and Irisin Release Affected by
Obesity, Diabetes and Exercise? In vivo & in vitro studies. In The journal of physiology (London),
2013. (IF2012-4.38)
BALГЃЕЅ M., KURDIOVA T., MADEROVA D., VICIAN M., GASPERIKOVA D., ZEMKOVA
E., UKROPEC J., UKROPCOVA B.: A Novel myokine irisin: in vivo & in vitro changes with
obesity & metabolic status. Keystone Symposia – Adipose Tissue Biology. Keystone, Colorado,
USA, 27.1-1.2.2013. J3041, p. 160
6
SprГЎva o ДЌinnosti organizГЎcie SAV
2.3.2. AplikaДЌnГЅ typ
Laboratórium diabetu a porúch metabolizmu – sekcia genetiky
DG9-glykГЎnovГЅ index je novГЅm klinickГЅm biomarkerom na odlГ­ЕЎenie HNF1A-MODY od inГЅch
typov diabetu.
EfektГ­vne vyhДѕadГЎvanie pacientov vhodnГЅch na DNA analГЅzu pomocou biomarkerov, ktorГ© sГє
lacnГ©, presnГ© a dostupnГ© je jednou z najdiskutovanejЕЎГ­ch Гєloh vedy v oblasti monogГ©novej
cukrovky v poslednГЅch rokoch. DoposiaДѕ jedinГЅm biomarkerom, ktorГЅ sa uplatЕ€uje v klinickej
praxi hsCRP, ktorГЅ uДѕahДЌuje vyhДѕadГЎvanie pacientov s diabetom HNF1A-MODY. Jeho vГЅhodou je
nГ­zka cena a veДѕkГЎ dostupnosЕҐ, nevГЅhodou senzitivita okolo 90 %. Okrem toho, hs-CRP je
markerom akГєtneho zГЎpalu, a teda diferenciГЎlna diagnostika mГґЕѕe byЕҐ naruЕЎenГЎ v dГґsledku
pridruЕѕenГЅch infekciГ­. Preto hДѕadanie doplnkovГ©ho biomarkera pokraДЌuje. VГЅsledky genГіmovГЅch
asociaДЌnГЅch ЕЎtГєdiГ­ ukГЎzali, Еѕe transkripДЌnГЅ faktor HNF1О± je kДѕГєДЌovГЅm regulГЎtorom
fukozylГЎcieglykanov v plazme. PilotnГЎ prГЎca ukГЎzala vplyv mutГЎciГ­ HNF1A na fukozylГЎciu.
Cieľom tejto štúdie bolo overiť hypotézu vplyvu mutácií HNF1A na glykánové spektrum (DG9glykánový index) vo väčšom súbore pacientov. Na štúdii participovalo niekoľko centier a zúčastnilo
sa jej 188 pacientov s HNF1A-MODY, 118 s GCK-MODY, 40 s HNF4A-MODY, 98 s 1. typom
diabetu, 167 pacientov s 2. typom diabetu a 98 kontrol bez diabetu. U vЕЎetkГЅch pacientov sa
stanovil
DG9-glykanovГЅ
index,
ktorГЅ
je
pomerom
fukozylovanГЅch
a nefukozylovanГЅchglykanov.DG9-glykanovГЅ index bol signifikantne niЕѕЕЎГ­ pri HNF1A-MODY ako
u kontrol, či iných podtypoch diabetu (ROC ≥ 0,90) a umožnil identifikovať troch pacientov
s HNF1A-MODY, ktorГ­ neboli predtГЅm diagnostikovanГ­. TГЎtoveДѕkГЎ multicentrickГЎ ЕЎtГєdia (na
pomery monogГ©novГ©ho diabetu) dokГЎzala, Еѕe DG9-glykanovГЅ index je dobrГЅm biomarkerom na
odlГ­ЕЎenie HNF1A-MODY od inГЅch typov diabetu. Jeho odliЕЎovacia schopnosЕҐ je dokonca vyЕЎЕЎia
ako v prГ­pade hsCRP (vyЕЎЕЎie priemernГ© ROC), preto sa do neho vkladajГє veДѕkГ© nГЎdeje. Hlavnou
nevГЅhodou vyЕЎetrovania DG9-glykanovГ©ho indexu je technickГЎ a finanДЌnГЎ nГЎroДЌnosЕҐ metodiky, ale
je perspektГ­va, Еѕe sa v budГєcnosti tieto nedostatky podarГ­ odstrГЎniЕҐ.
THANABALASINGHAM G, HUFFMAN JE, KATTLA, JJ, NOVOKMET M, RUDAN I,
GLOYN AL, HAYWARD C, ADAMCZYK B, REYNOLDS RM, MUZINIC A, HASSANALI N,
PUCIC M, BENNETT AJ, ESSAFI A, POLASEK O, MUGHAL SA, REDZIC I, PRIMORAC D,
ZGAGA L, KOLCIC I, HANSEN T, GASPERIKOVA D, TJORA E, STRACHAN MWJ,
NIELSEN T, STANIK J, KLIMES I, PEDERSEN O, NJ�LSTAD PR, WILD SH,
GYLLENSTEN U, GORNIK O, WILSON JF, HASTIE ND, CAMPBELL H, MCCARTHY MI,
RUDD MP, OWEN KR, LAUC G, WRIGHT AF: Mutations in HNF1A result in marked alterations
of plasma glycan profile. Diabetes, 62 (4): 1329-1337, 2012, (IF2012 = 7,895)
DG9-glycan index is the new clinical biomarker for distinguishing HNF1A-MODY from other
subtypes of diabetes.
Recent efforts to improve diagnostic performance by identifying biochemical markers specific for
MODY subtypes have met with varying success. We recently demonstrated that individuals with
HNF1A-MODY have low levels of C-reactive protein and that hs-CRP assays can discriminate well
between HNF1A-MODY and both type 2 diabetes and HNF4A-MODY. However, hs-CRP does not
provide good discrimination between HNF1A-MODY and type 1 diabetes. Furthermore, hs-CRP is
an acute inflammatory marker, and diagnostic discrimination can be disturbed by intercurrent
infection. Therefore searching for additional biomarker continues. A recent genome-wide
association study identified hepatocyte nuclear factor 1-a (HNF1A) as a key regulator of
7
SprГЎva o ДЌinnosti organizГЎcie SAV
fucosylation. The pilot study have shown that loss-of-function HNF1A mutations causal for
maturity-onset diabetes of the young (MODY) would display altered fucosylation of N-linked
glycans on plasma proteins and that glycan biomarkers could improve the efficiency of a diagnosis
of HNF1A-MODY. The aim of the study was to test the hypothesis if HNF1A mutations influence
the glycan spectrum (DG9-glycan index) in a larger set of patients. Five European centers
participated on this study, including HNF1A-MODY (n = 188), glucokinase (GCK)-MODY (n =
118), hepatocyte nuclear factor 4-alpha (HNF4A)-MODY (n = 40), type 1 diabetes (n = 98), type 2
diabetes (n = 167) patients and 98 nondiabetic controls. The DG9-glycan index was markedly lower
in HNF1A-induced MODY than in controls or other diabetes subtypes, offered good discrimination
between HNF1A-MODY and both type 1 and type 2 diabetes (C statistic >0.90), and enabled us to
detect three previously undetected HNF1A mutations in patients with diabetes. In conclusion,
glycan profiles are altered substantially in HNF1A-MODY, and the DG9- glycan index has
potential clinical value as a diagnostic biomarker of HNF1A dysfunction. The main disadvantages
of the assessment of DG9-glycan index are the technical and financial requirements, but there is the
perspective that these shortcomings will improve in the near future.
THANABALASINGHAM G, HUFFMAN JE, KATTLA, JJ, NOVOKMET M, RUDAN I,
GLOYN AL, HAYWARD C, ADAMCZYK B, REYNOLDS RM, MUZINIC A, HASSANALI N,
PUCIC M, BENNETT AJ, ESSAFI A, POLASEK O, MUGHAL SA, REDZIC I, PRIMORAC D,
ZGAGA L, KOLCIC I, HANSEN T, GASPERIKOVA D, TJORA E, STRACHAN MWJ,
NIELSEN T, STANIK J, KLIMES I, PEDERSEN O, NJ�LSTAD PR, WILD SH,
GYLLENSTEN U, GORNIK O, WILSON JF, HASTIE ND, CAMPBELL H, MCCARTHY MI,
RUDD MP, OWEN KR, LAUC G, WRIGHT AF: Mutations in HNF1A result in marked alterations
of plasma glycan profile. Diabetes, 62 (4): 1329-1337, 2012, (IF2012 = 7,895)
2.3.3. MedzinГЎrodnГ© vedeckГ© projekty
IntracelulГЎrna kooperГЎcia medzi oocytom a granulГіznymi bunkami: parakrinnГЎ regulГЎcia
ovariГЎlnych intrafolikulГЎrnych procesov. (PrioritnГЎ tГ©ma ДЌ.18 v rГЎmci MAD o spoluprГЎci SAV
a AV ДЊR 2012-2014)
V rГЎmci spoluprГЎce s MVDr. E. Nagyovou, CSc. (Гљstav ЕѕivoДЌГ­ЕЎnГ© fyziolГіgie a genetiky AVДЊR,
LibД›chov,
ДЊR)
ЕЎtudujeme
molekulГЎrne
mechanizmy
parakrinnej
regulГЎcie
ovariГЎlnychintrafolikulГЎrnych procesov (maturГЎciaoocytu, steroidogenГ©za) pГґsobenГ­m faktorov
lokГЎlne produkovanГЅch ovariГЎlnymi bunkami na modele primГЎrnej kultГєry oocyt-kumulГЎrnych
komplexov (OCC) a granulГіznych buniek izolovanГЅch z ovГЎriГ­ oЕЎГ­panГЅch. Zistili sme, Еѕe inhibГ­cia
tyrozГ­nkinГЎzy receptora pre EGF (EGFR) ГєДЌinkom jej inhibГ­torov, AG1478 a lapatinibu (klinicky
pouЕѕГ­vanГЅ pri lieДЌbe karcinГіmov prsnГ­ka), Гєplne zablokovala expanziu OCC a jadrovГ© zrenie
oocytov indukovanГ© pГґsobenГ­m EGF, ako aj gonadotropГ­nmi. ZГЎroveЕ€ sme ukГЎzali, Еѕe obidva
inhibГ­tory znГ­Еѕili syntГ©zu progesterГіnu stimulovanГє gonadotropГ­nmi v kumulГЎrnych, ako aj
granulГіznych bunkГЎch [1]. NaЕЎe predchГЎdzajГєce vГЅsledky ukazujГє, Еѕe proteozomГЎlnaproteolГЅza [2]
a aktivГЎcia SMAD2/3 signГЎlnej drГЎhy (aktivovanГЎ ГєДЌinkom faktorov TGF a BMP) [3] sГє zapojenГ©
do regulГЎcie maturГЎcieoocytov a procesu steroidogenГ©zy. Nami sledovanГ© procesy sГє nevyhnutnГ©
pre ГєspeЕЎnГє fertilizГЎciu, preto naЕЎe vГЅsledky mГґЕѕu byЕҐ prГ­nosom v ЕЎtГєdiu molekulГЎrnych
mechanizmov prГ­ДЌin infertility Еѕien.
NAGYOVA E, MLYNARCIKOVA A, NEMCOVA L, KALOUS J, SCSUKOVA S: Lapatinib
inhibits meiotic maturation of oocyte-cumulus complexes cultured in vitro in gonadotropinssupplemented medium. Fertility and Sterility, 99 (6): 1739-1748, 2013. (IF2012=4.174)
8
SprГЎva o ДЌinnosti organizГЎcie SAV
NAGYOVA E. - SCSUKOVA S. - NEMCOVA L. - MLYNARCIKOVA A. - YI Y.J. SUTOVSKY M. - SUTOVSKY P. Inhibition of proteasomal proteolysis affects expression of
extracellular matrix components and steroidogenesis in porcine oocyte-cumulus complexes.
Domestic Animal Endocrinology, 42 (1): 50-62, 2012. (A) (IF2012=2.377)
NAGYOVA E. - CAMAIONI A. - SCSUKOVA S. - MLYNARCIKOVA A. - PROCHAZKA R. NEMCOVA L. - SALUSTRI A. Activation of Cumulus Cell SMAD2/3 and Epidermal Growth
Factor Receptor Pathways Are Involved in Porcine Oocyte-Cumulus Cell Expansion and
Steroidogenesis. Molecular Reproduction and Development, 78 (6): 391-402, 2011. (A)
(IF2012=2.812)
Coordinationbetweenoocyte
and
granulosa
cells:
paracrineregulation
ovarianintrafollicularprocesses. (Priority ResearchCollaboration 2012-2014 No 18)
of
The aim of the project is to study molecular mechanisms of paracrine regulation of ovarian
intrafollicular processes (oocyte maturation, steroidogenesis) by the action of factors locally
produced by ovarian cells on the models of primary oocyte-cumulus complexes (OCC) and
granulosa cells isolated from porcine ovaries. We have found that inhibition of tyrosine kinase of
epidermal growth factor receptor (EGFR) by the action of its inhibitors, AG1478
and lapatinib(clinically used for mammary cancer therapy), blocked OCC expansion and oocyte
nuclear maturation induced by EGF and gonadotropins. We have shown that both inhibitors
significantly reduced gonadotropin-induced progesterone secretion by granulosa and cumulus cells
[1]. Moreover, our previous results demonstrate that proteosomal proteolysis [2] and activation of
SMAD2/3 signaling pathway (induced by TGF and MBP factors) [3] are involved in regulation of
oocyte maturation and steroidogenesis. These studied processes are indispensable for successful
fertilization and thereby our data might contribute to the study of molecular mechanisms of woman
infertility.
NAGYOVA E, MLYNARCIKOVA A, NEMCOVA L, KALOUS J, SCSUKOVA S:: Lapatinib
inhibits meiotic maturation of oocyte-cumulus complexes cultured in vitro in gonadotropinssupplemented medium. Fertility and Sterility, 99 (6): 1739-1748, 2013. (IF2012=4.174)
NAGYOVA E. - SCSUKOVA S. - NEMCOVA L. - MLYNARCIKOVA A. - YI Y.J. SUTOVSKY M. - SUTOVSKY P. Inhibition of proteasomalproteolysisaffectsexpression of
extracellularmatrixcomponents and steroidogenesis in porcineoocyte-cumuluscomplexes.
DomesticAnimalEndocrinology, 42 (1): 50-62, 2012. (IF2012=2.377)
NAGYOVA E. - CAMAIONI A. - SCSUKOVA S. - MLYNARCIKOVA A. - PROCHAZKA R. NEMCOVA L. - SALUSTRI A. Activation of CumulusCell SMAD2/3 and
EpidermalGrowthFactor
Receptor
Pathways
Are
Involved
in
PorcineOocyteCumulusCellExpansion and Steroidogenesis. MolecularReproduction and Development, 78 (6):
391-402, 2011. (IF2012=2.812)
9
SprГЎva o ДЌinnosti organizГЎcie SAV
2.4. PublikaДЌnГЎ ДЌinnosЕҐ (ГєplnГЅ zoznam je uvedenГЅ v PrГ­lohe C)
TabuДѕka 2c Е tatistika vybranГЅch kategГіriГ­ publikГЎciГ­
PUBLIKAČNÁ A EDIČNÁ ČINNOSŤ
A
B
C
PoДЌet v r. 2013/ PoДЌet v r. 2013/ PoДЌet v r. 2013/
doplnky z r.
doplnky z r.
doplnky z r.
2012
2012
2012
1. VedeckГ© monografie vydanГ© v domГЎcich
vydavateДѕstvГЎch
(AAB, ABB, CAB)
2. VedeckГ© monografie vydanГ© v
zahraniДЌnГЅch vydavateДѕstvГЎch
(AAA, ABA, CAA)
3. OdbornГ© monografie, vysokoЕЎkolskГ©
uДЌebnice a uДЌebnГ© texty vydanГ© v domГЎcich
vydavateДѕstvГЎch (BAB, ACB)
4. OdbornГ© monografie a vysokoЕЎkolskГ©
uДЌebnice a uДЌebnГ© texty vydanГ© v
zahraniДЌnГЅch vydavateДѕstvГЎch (BAA, ACA)
5. Kapitoly vo vedeckГЅch monografiГЎch
vydanГЅch v domГЎcich vydavateДѕstvГЎch
(ABD, ACD)
6. Kapitoly vo vedeckГЅch monografiГЎch
vydanГЅch v zahraniДЌnГЅch vydavateДѕstvГЎch
(ABC, ACC)
7. Kapitoly v odbornГЅch monografiГЎch,
vysokoЕЎkolskГЅch uДЌebniciach a uДЌebnГЅch
textoch vydanГЅch v domГЎcich
vydavateДѕstvГЎch (BBB, ACD)
8. Kapitoly v odbornГЅch monografiГЎch,
vysokoЕЎkolskГЅch uДЌebniciach a uДЌebnГЅch
textoch vydanГЅch v zahraniДЌnГЅch
vydavateДѕstvГЎch (BBA, ACC)
9. VedeckГ© a odbornГ© prГЎce v ДЌasopisoch
evidovanГЅch v Current Contents
(ADC, ADCA, ADCB, ADD, ADDA, ADDB,
CDC, CDCA, CDCB, CDD, CDDA, CDDB,
BDC, BDCA, BDCB, BDD, BDDA, BDDB)
10. VedeckГ© a odbornГ© prГЎce v
nekarentovanГЅch ДЌasopisoch
(ADE, ADEA, ADEB, ADF, ADFA, ADFB,
CDE, CDEA, CDEB, CDF, CDFA, CDFB,
BDE, BDEA, BDEB, BDF, BDFA, BDFB)
11. VedeckГ© a odbornГ© prГЎce v zbornГ­koch
(konferenДЌnГЅch aj nekonferenДЌnГЅch,
vydanГЅch tlaДЌou alebo na CD)
a/ recenzovanГЅch, editovanГ©
(AEC, AED, AFA, AFB, AFBA, AFBB,
BEC, BED, CEC, CED)
b/ nerecenzovanГЅch
(AEE, AEF, AFC, AFD, AFDA, AFDB, BEE,
BEF)
10
0/0
0/0
0/0
1/0
0/0
0/0
1/0
0/0
0/0
0/0
0/0
0/0
0/0
0/0
0/0
5/0
0/0
0/0
0/0
0/0
0/0
0/0
0/0
0/0
35/ 0
0/0
0/0
23 / 0
0/0
0/0
2/0
0/0
0/0
3/0
0/0
0/0
SprГЎva o ДЌinnosti organizГЎcie SAV
12. VydanГ© periodikГЎ evidovanГ© v Current
0
0
0
Contents
13. OstatnГ© vydanГ© periodikГЎ
1
0
0
14. VydanГ© alebo editovanГ© zbornГ­ky z
vedeckГЅch podujatГ­
0/0
0/0
0/0
(FAI)
15. VedeckГ© prГЎce uverejnenГ© na internete
0/0
0/0
0/0
(GHG)
16. Preklady vedeckГЅch a odbornГЅch textov
0/0
0/0
0/0
(EAJ)
17. HeslГЎ v odbornГЅch terminologickГЅch
slovnГ­koch a encyklopГ©diГЎch vydanГЅch *
0/0
0/0
0/0
(BDA, BDB)
A - pracovisko SAV je uvedenГ© ako pracovisko (adresa) autora, alebo je sГєДЌasЕҐou kolaborГЎcie
alebo inГ©ho zdruЕѕenia, ktorГ© je uvedenГ© ako pracovisko (adresa) autora
B - pracovisko SAV nie je na publikГЎcii uvedenГ©, pretoЕѕe prameЕ€ Гєdaj o pracovisku autora
neobsahuje, prГЎca ale vznikla na pracovisku SAV
C - pracovisko SAV je uvedenГ© ako materskГ© pracovisko autora odliЕЎnГ© od pracoviska, na ktorom
práca vznikla (napr. „on leave...“, „permanent address...“, „present address...“)
* - uvГЎdzajГє sa len heslГЎ, pri ktorГЅch je uvedenГЅ autor a ich rozsah je min. 1 autorskГЅ hГЎrok
11
SprГЎva o ДЌinnosti organizГЎcie SAV
TabuДѕka 2d Ohlasy
OHLASY
A
B
PoДЌet v r. 2012/ PoДЌet v r. 2012/
doplnky z r. 2011 doplnky z r. 2011
1001 / 1
0/0
CitГЎcie vo WOS (1.1, 2.1)
241 / 0
0/0
CitГЎcie v SCOPUS (1.2, 2.2)
0/0
0/0
CitГЎcie v inГЅch citaДЌnГЅch indexoch a databГЎzach (9, 10)
CitГЎcie v publikГЎciГЎch neregistrovanГЅch v citaДЌnГЅch
0/1
0/0
indexoch (3, 4)
0/0
0/0
Recenzie na prГЎce autorov z organizГЎcie (5, 6, 7, 8)
A - pracovisko SAV je uvedenГ© ako pracovisko (adresa) autora, alebo je sГєДЌasЕҐou kolaborГЎcie
alebo inГ©ho zdruЕѕenia, ktorГ© je uvedenГ© ako pracovisko (adresa) autora, alebo pracovisko SAV nie
je na publikГЎcii uvedenГ©, pretoЕѕe prameЕ€ Гєdaj o pracovisku autora neobsahuje, prГЎca ale vznikla
na pracovisku SAV
B - pracovisko SAV je uvedenГ© ako materskГ© pracovisko autora odliЕЎnГ© od pracoviska, na ktorom
práca vznikla (napr. „on leave...“, „permanent address...“, „present address...“)
Recenzie a posudky pracovnГ­kov
Mgr. Zuzana BaДЌovГЎ, PhD.
1 recenzia pre Physiological Research
RNDr. JГЎn BakoЕЎ, PhD.
1 recenzia pre General Physiology and Biophysics
Ing. J. Brtko, DrSc.
1 recenzia pre Journal of Biochemical and Molecular Toxicology
1 recenzia pre Toxicology Letters
1 recenzia pre Biomedical Papers
1 recenzia pre Endocrine Regulations
1 recenzia grantu VEGA
Mgr. Lucia GajdoЕЎechovГЎ
1 recenzia pre General Physiology and Biophysics
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
1 recenzia pre Neuroendocrinology
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
2 recenzie pre Behavioural Pharmacology
1 recenzie pre Psychiatry Research
2 recenzie pre Stress
1 recenzia pre Physiological Research
2 recenzie pre Endocrine Regulations
2 recenzie pre European Journal of Pharmacology
2 recenzie pre Brain Research
1 recenzia pre Journal of Neuroendocrinology
2 recenzie pre Journal of Cardiovascular Pharmacology
1 recenzia pre Brain Research Bulletin
1 recenzia pre Behavioural Processes
1 recenzia pre Progress in NeuroPsychopharmacology and Biological Psychiatry
1 recenzia pre Neurology Research International
1 recenzia pre Behavioral Brain Research
12
SprГЎva o ДЌinnosti organizГЎcie SAV
MUDr. Richard Imrich, PhD.
2 recenzie pre projekty VEGA
1 recenzia pre projekty APVV
2 recenzie pre General Physiology and Biophysics
doc. Ing. Jana JurДЌoviДЌovГЎ, CSc
2 recenzie pre Physiologial Research
RNDr. Alexander Kiss, DrSc.
2 recenzie pre Endocrine Regulations
2 recenzie pre BiolГіgiu
1 recenzia pre Neurochemistry International
2 recenzie pre Cell Molecular Neurobiology
2 recenzie pre Neuropsychopharmacology
1 recenzia pre Histol Histopatol
1 recenzia pre J Chem Neuroanat
3 recenzie VEGA projektov
2 recenzie APVV projektov
Ing. KatarГ­na KrЕЎkovГЎ, PhD.
1 recenzia pre Physiologial Research
1 recenzia pre Endocrine Regulations
doc. MUDr. Boris Mravec, PhD.
1 recenzia pre Acta Neurobiologiae Experimentalis
1 recenzia pre ДЊesko-slovenskГЎ pediatrie
1 recenzia pre projekt VEJA
RNDr. Jana OsackГЎ, PhD.
1 recenzia pre Endocrine Regulations
MUDr. Adela PenesovГЎ, PhD
2 recenzie pre Clinical Rheumatology
3 recenzie pre Endocrine Regulations
1 recenzia pre Physiological Research
1 recenzia pre projekt KEGA
PharmDr. Zdenko PirnГ­k, PhD
2 recenzie pre Endocrine Regulations
1 recenzia zbornГ­kovГЅch abstraktov pre MPaRV SR
MUDr. ЕЅofia RГЎdikovГЎ, PhD
1 recenzia pre Physiological Research
Prof. MUDr.Fedor Е imko, CSc.
1 Recenzia na ДЌlГЎnky v roku 2013 v casopisoch:
Lancet
Circulation
Journal of Hypertension
World Journal of Hypertension
Experimental Biology and Medicine
13
SprГЎva o ДЌinnosti organizГЎcie SAV
Chronobiology International
Archives of Internal Medicine
Cardiovascular Drugs and Therapy
Bratislava Medical Journal
BioMed Research Inerantional
11 recenzii na granty MZ
5 recenziГ­ na granty APVV
9 recenziГ­ na granty VEGA
9 recenziГ­ na granty SKS (Slov. kard. SpoloДЌnosti)
MUDr. VladimГ­r Е trbГЎk, DrSc.
1 recenzia pre Acta Histochemica
1 recenzia pre British Journal of Pharmacology
1 recenzia pre Canadian Journal of Physiology and Pharmacology
1 recenzia pre Human and Experimental Toxicology
1 recenzia pre Medicinal Chemistry
2 recenzie pre Physiological Research
1 recenzia pre Endocrine Regulations
Ing. Andrej Tillinger, PhD.
1 recenzia pre Physiological Research
Mgr. Jozef Ukropec, PhD
PLOS-One 2x
Journal of Clinical Endocrinology and Metabolism 5x
Physiological Research 1x
MUDr. Barbara UkropcovГЎ, PhD
Physiololgical Research 1x
MUDr. Miroslav VlДЌek, PhD.
1 recenzia pre General Physiology and Biophysics
1 recenzia pre Physiological Research
1 recenzia pre Endocrine Regulations
Ing. Е tefan Zorad, CSc.
1 recenzia pre Journal of Endocrinology
1 recenzia pre Translational Research
1 recenzia pre Hormone Metabolic Research
2 recenzie pre Physiological Research
9 recenziГ­ pre General Physiology and Biophysics
1 recenzia pre Endocrine Regulations
3 recenzie pre projekty APVV
2.5. AktГ­vna ГєДЌasЕҐ na vedeckГЅch podujatiach
TabuДѕka 2e VedeckГ© podujatia
PrednГЎЕЎky a vГЅvesky na medzinГЎrodnГЅch vedeckГЅch podujatiach
PrednГЎЕЎky a vГЅvesky na domГЎcich vedeckГЅch podujatiach
14
59+12+8 = 79
17+9+1 =27
SprГЎva o ДЌinnosti organizГЎcie SAV
2.5.1. PrednГЎЕЎky a vГЅvesky na medzinГЎrodnГЅch konferenciГЎch :
1. BABIC S.- DANEVOVA V.- POKUSA M.-JEZOVA D.: Stress-induced reduction of cell
proliferation in the hippocampus is not modified by treatment with oxytocin antagonist atosiban.7th
International Symposium on Experimental and Clinical Neurobiology, 23. – 27.6. 2013, Košice
2 BAČOVÁ Z. –LEŠŤANOVÁ Z. –ŠTRBÁK V.– BAKOŠJ . Vývinové zmeny cytoskeletových
proteГ­nov a rastovГЅch faktorov v hipokampe pod vplyvom oxytocГ­nu, 89. FyziologickГ© dni, 5.7.2.2013 Praha, ДЊeskГЎ republika, ZbornГ­k abstraktov s. 78
3. BAČOVÁ Z. –LEŠŤANOVÁ Z. –ŠTRBÁK V. –BAKOŠJ . Developmental effects of oxytocin
on gene expressin of cytoskeletal proteins and growth factors in the rat hippocampus, “New
frontiers in physiological research from scientific truth via friendship to the art “ 20.-22. 6.2013,
KovaДЌica, Srbsko, Abstract book p.31
4. BALГЃЕЅIOVГЃ D.- VOHNOUT B.- STANГЌKOVГЃ D.- HUДЊKOVГЃ M.- BALOGOVГЃ M.STANГЌK J.- KLIMEЕ I.- RAЕ LOVГЃ K.- GAЕ PERГЌKOVГЃ D.: MutaДЌnГЎ analГЅza gГ©nov LDLR,
ApoB-100 a PCSK9 u slovenskГЅch pacientov s familiГЎrnou hypercholesterolГ©miou. Abstrakt
z odbornej konferencie XXIV. IzakoviДЌov memoriГЎl s medzinГЎrodnou ГєДЌasЕҐou, Donovaly, 26.-27.
September 2013
5. BALГЃЕЅIOVГЃ D.- STANГЌKOVГЃ D.- HUДЊKOVГЃ M.- STANГЌK J.- VOHNOUT B.GAЕ PERГЌKOVГЃ D.- RAЕ LOVГЃ K.- KLIMEЕ I.: DNA diagnostika familiГЎrnej
hypercholesterolГ©mie na Slovensku. IL. DiabetologickГ© dnГ­, LuhaДЌovice, ДЊeskГЎ republika, 18.-20.
aprГ­la 2013
6. BAKOŠJ. –LEŠŤANOVÁ Z.–ŠTRBÁK V. –– BAČOVÁ Z. Ligandy oxytocínových
receptorov ovplyvЕ€ujГє gГ©novГє expresiu aj proteГ­novГ© hladiny neurofilamentov in vitro, 89.
FyziologickГ© dni, 5.-7.2.2013 Praha, ДЊeskГЎ republika, ZbornГ­k abstraktov s. 6
7. BAKOŠJ. –LEŠŤANOVÁ Z.–ŠTRBÁK V.–– BAČOVÁ Z. Oxytocin receptor ligands induce
changes in cytoskeleton in neuroblastoma cells, “New frontiers in physiological research from
scientific truth via friendship to the art “ 20.-22.
6.2013, KovaДЌica, Srbsko, Abstract book p.32
8. BAKOŠ, J. –LEŠŤANOVÁ, Z.–ŠTRBÁK, V. –– BAČOVÁ, Z. Oxytocin receptor ligands
modulate gene expression and protein levels of nestin and microtubule associated protein 2 in SKN-SH and U87-MG cells, 10th World Congress on Neurohypophysial hormones,. 15-19.7.2013,
Bristol, UK, Book of Abstracts p.26,
9. BARTEKOVГЃ M.- BARANДЊГЌK M.- BABIC S.- POKUSA M.- FRIMMEL K.OKRUHLICOVГЃ I.- JEЕЅOVГЃ D.: Selected molecular mechanisms involved in stress-induced
changes in the heart. International symposium, Advances in cardiovascular research : from bench to
bedside, 23. – 26. 5. 2013, Smolenice.
10. BIALEЕ OVГЃ L.- BRTKO J.- MACEJOVГЃ D.: The effect of isoflavone genistein on the
expression of selected nuclear receptors and their coregulators. Czech-Slovak Toxicology
Conference – TOXCON 2013, Hradec Králové, Česká republika, 19.-21.06.2013.
11. BIALEЕ OVГЃ L.- MACEJOVГЃ D., OndkovГЎ S., GalbavГЅ Е ., Brtko J.: Distribution pattern of
selected nuclear receptors expression in human breast carcinoma tissues. Bregenz Sommer School
15
SprГЎva o ДЌinnosti organizГЎcie SAV
on Endocrinology: Classical endocrine glands & mesenchymal tissues: Stem Cells, development,
function and regulatory principles, ESE Bregenz, Austria, 28.7.-1.8.2013.
12. BOHГЃДЊOVГЃ V., Е TETKA J., SULOVГЃ Z., MACEJOVГЃ D., BRTKO J., BREIER A.: May
ligands of nuclear receptors for retinoids all-trans- and 9-cis retinoic acid influence P-glyciprotein
mediated multidrug resistance? XXVII. XenobiotickГ© symposium, Pavlov u Mikulova, ДЊeskГЎ
republika, 27.-30.05.2013.
13. BRTKO J.- MACEJOVГЃ D.- Е ., BIALEЕ OVГЃ L.- FICKOVГЃ M.- HUNГЃKOVГЃ L.:
Toxicity of nuclear retinoid X receptors cognate ligands of organotin origin in breast cancer cell
lines: Effects on selected retinoid/retinoid X receptor subtypes expression. Czech-Slovak
Toxicology Conference – TOXCON 2013, Hradec Králové, Česká republika, 19.-21.06.2013.
14. BRTKO J.- MACEJOVГЃ D.- BIALEЕ OVГЃ L.- FICKOVГЃ M., BohГЎДЌovГЎ V., SulovГЎ Z., Breier
A., HunГЎkovГЎ L.: Selected organotin halides: Toxicity versus nuclear retinoic acid/retinoid X
receptors and their co-regulators expression in breast cancer and leukemia cell lines. 49th Congress
of the European Societes of Toxicology (EUROTOX), Interlaken, Е vjajДЌiarsko, 01.-04.09.2013.
15. BUETTNER M.- JEZOVA D.- MURCK H.: Salivary aldosterone, salt craving and depression
severity - a correlative analysis. 28th Symposium of the Association of Neuropsychopharmacology
and Pharmacopsychiatry (AGNP), 18. – 21.9. 2013, Munich, Germany.
16. DANEVOVГЃ V.- BABIC S.- HLAVГЃДЊOVГЃ N.- JEЕЅOVГЃ D.: ГљДЌinok blokГЎtora
oxytocГ­novГЅch receptorov na ГєzkostnГ© sprГЎvanie vyvolanГ© stresom. 55. ДЌesko-slovenskГЎ
psychofarmakologická konferencia, 4. – 8.1.2013, Lázně-Jeseník, Česká republika.
17. FICKOVГЃ M.- HAVRГЃNEK T.- BRTKO J.- MACEJOVГЃ D.: Reduced expression of genes
for nuclear receptors RXRalpha and RXRbeta by bisphenol A in human mammary cancer cells
(MCF7). 49th Congress of the European Societes of Toxicology (EUROTOX), Interlaken,
Е vjajДЌiarsko, 01.-04.09.2013.
18. FICKOVA M.- HAVRANEK T.- MLYNARCIKOVA A.: Bisphenol A modifies estradiol
effect on MCF7 cell proliferation. Modulation of apoptosis. 2nd Congress on Steroid Research,
Chicago, USA.
https://elsevier.conferenceOnline
services.net/secureProgrammeLogin.asp?conferenceID=3173
19. FICKOVГЃ M.- HAVRГЃNEK T.- MLYNARДЊГЌKOVГЃ A.: Alteration of cell cycle related genes
and their proteins by BPA and BPA-estradiol mixture in MCF7 human breast carcinoma cells. 18th
Interdisciplinary Czech-Slovak Toxicology Conference, TOXCON 2013, Hradec Králové 19.6. –
21.6. 2013, ДЊR
20. FRANKLIN M.- JEZOVA D.- HLAVACOVA N.- SINGEWALD N.- MURCK H.:
Aldosterone increases earlier than corticosterone in new animal models of depression: Is this an
early marker for depression onset? Summer Meeting of the British Association for
Psychopharmacology, 28. – 31.7. 2013, Harrogate, United Kingdom.
21. GAJDOSECHOVA L.- KRSKOVA K.- OLSZANECKI R.- ZORAD S. An integrative insight
into powerfull IRAP/AT4/OTASE in obesity: A glucose homeostasis, adipose tissue RAS and
oxytocin system. IRAP 2013, 9.9.-11.9. 2013, Monash University Prato, Italy
16
SprГЎva o ДЌinnosti organizГЎcie SAV
22. GAJDOSECHOVA L., SUSKI M., KRSKOVA K., OLSZANECKI R., ZORAD S. Metabolic
health in 12-week-old obese Zucker rats is associated with increase in 14-3-3ОІ and phosphorylation
of AS160 in epididymal adipose tissue. 20th European Congress on Obesity (ECO2013), poster ДЌ.
T1:P.109
23. GAŠPERÍKOVÁ D.- STANÍK J.- HUČKOVÁ M.- VALENTÍNOVÁ L.- MAŠINDOVÁ I.BALOGOVÁ M. SLOVENSKÁ SKUPINA PRE ŠTÚDIUM MONOGÉNOVÉHO DIABETU,
KLIMEЕ I.: VysokocitlivГЅ C-reaktГ­vny proteГ­n je potrebnГЅ klinickГЅ biomarker pre detekciu
monogГ©novГ©ho diabetu typu HNF1A-MODY (MODY3). IL. DiabetologickГ© dni, LuhaДЌovice,
ДЊeskГЎ republika, 18.-20. aprГ­la 2013
24. HAVRÁNEK T.– MACHO L. – FICKOVÁ M. Bisfnenol-A stimuluje proliferáciu buniek
ДѕudskГ©ho karcinГіmu prsnГ­ka (MCF-7) modulГЎciou apoptГіzy a cyklГ­nu-A; 89. FyziologickГ© dny,
05.-07.02.2013, Praha, ДЊeskГЎ republika, ZbornГ­k abstraktov, s. 96
25. HAVRÁNEK T.– MACHO L. – FICKOVÁ M.. Bisphenol-A modulates proliferation of
human breast adenocarcinoma cells (MCF-7) by modulating apoptosis and cyclin-A; 15th European
Congress of Endocrinology (ECE2013) 27.04.-01.05.2013, Copehagen, Denmark, Endocrine
Abstracts P502, April 2013 Volume 32, ISSN 1479-6848 (online)
26. HLAVГЃДЊOVГЃ N.- MAKATSORI A.- HINGHOFER-SZALKAY H.- JEЕЅOVГЃ D.:
HormonГЎlna a kardiovaskulГЎrna odpoveДЏ na kombinovanГЅ stresovГЅ podnet pri zvГЅЕЎenej Гєzkosti
vyvolanej počúvaním hudby. 55. česko-slovenská psychofarmakologická konferencia, 4. – 8.1.
2013, LГЎznД›-JesenГ­k, ДЊeskГЎ republika.
27. HLAVACOVA N.- WAWRUCH M.- TISONOVA J.- JEZOVA D.: Neuroendocrine activation
during stress in women depends on trait anxiety. 11th World Congress of Biological Psychiatry, 23.
– 27.6. 2013, Kyoto, Japan.
28. CHOVANOVГЃ L.- VLДЊEK M.-, KRЕ KOVГЃ K.- SPOUSTIL F.- PENESOVГЃ A. - RAЕ LOVГЃ
K.- VOHNOUT B.- KILLINGER Z.- JOCHMANOVГЃ I.-, LAZUROVГЃ I. RADNER H.STEINER G.- SMOLEN J.- IMRICH R. : Discrimination analysis of multiple genetic risk
markers associated with rheumatoid arthritis in Slovakia eular 2013, 12-15 JГєn 2013, Madrid,
Е panielsko
poster
29. CHOVANOVA L.- VLCEK M.- KRSKOVA K.- SPOUTIL F.- ROVENSKY J.- BROWNLIE
R.- ZAMOYSKA R. – IMRICH R. : Effect of multiple genetic risk factors associated with
rheumatoid arthritis on immune cell phenotypes.
15th ICI (International Congress of Immunology) 22-27 Aug. 2013, Milano, Taliansko
prednГЎЕЎka
30. CHOVANOVA L.- VLCEK M.- KRSKOVA K.- SPOUTIL F.- J. ROVENSKY R. –
BROWNLIE R. - ZAMOYSKA R.- IMRICH R. : Effect of genetic risk factors on immune cell
phenotypes in patients with rheumatoid arthritis.
V4 International Conference Analytical Cytometry VII, 21-24 Sept. 2013, Mikulov, ДЊesko
prednГЎЕЎka
31. JURДЊOVIДЊOVГЃ J.- JAKUBГЌKOVГЃ L.- Е TOFKOVГЃ A. DvojfГЎzovГ© vychytГЎvanie 2-[18F]
fluoro-2-deoxy-d-glukГіzy v limbickom systГ©me potkanov poДЌas adjuvantnej artritГ­dy. 89.
FyziologickГ© dni, 2013, 5.2. -7. 2. 2013. Praha, prednГЎЕЎka a predsedanie sekcie.
17
SprГЎva o ДЌinnosti organizГЎcie SAV
32. KRSKOVA K.- PENESOVA A.- VLCEK M.- IMRICH R.- GAJDOSECHOVA L.- OKSA A.POGLITSCH M.- ZORAD S. Replacement of ACEi by AT1 receptor blocker candesartan changes
pattern of serum angiotensin peptides without effect on glucose metabolism and subcutaneous
adipose tissue. IRAP 2013, 9.9.-11.9. 2013, Monash University Prato, Italy
33. KRSKOVA K.- ZORAD S.- GAJDOSECHOVA L.- IMRICH R.- PENESOVA A.- VLCEK
M.- CHOVANOVA L.- OKSA A. Renin-angiotensin system blockade with AT1 receptor blocker
versus ACE inhibitors - impact on glucose metabolism in hypertensive patients. 20th European
Congress on Obesity (ECO2013), poster ДЌ. T1:P.090
34. KRSKOVA K.- ZORAD S.- GAJDOSECHOVA L.- PENESOVA A.- VLCEK M.- IMRICH
R.- CHOVANOVA L.- OKSA A. Selected metabolic effects of ace inhibitor replacement by at1
receptor blocker candesartan in hypertensive patients. 5th International Congress on Prediabetes and
the Metabolic Syndrome, April 18-20, 2013, Vienna, Austria, poster ДЌ. 24
35. KVETŇANSKÝ, R.: Our experience with Palkovits´ microdisection technique of the brain.
PrednesenГ© na Scientific Symposium in Honor of the 80th Birthday of Prof. Palkovits, BudapeЕЎt,
Hungary, 20. novembra 2013.
36. LACKOVIДЊOVГЃ ДЅ.- BГЃNOVSKГЃ L.- KISS A.- SIVГЃKOVГЃ I.- BГЌZIK J.- MRAVEC B.
SympatikovГЅ nervovГЅ systГ©m potencuje rast fibrosarkГіmu a melanГіmu, ale neovplyvЕ€uje progresiu
ascitickГ©ho nГЎdoru u laboratГіrnych zvierat. 89. FyziologickГ© dny 5.-7.2.2013, Praha, poster ДЌ. 113.
37. LEŠŤANOVÁ Z. – BAČOVÁ Z. –ŠTRBÁK V. –BAKOŠ, J . Vplyv podania oxytocínu a
lipopolysacharidu neonatГЎlnym samiДЌkГЎm potkana na zmenu hladГ­n cytoskeletovГЅch proteГ­nov a
rastovГЅch faktorov v hipokampe, FyziologickГ© dni, 5.-7.2.2013 Praha, ДЊeskГЎ republika, ZbornГ­k
abstraktov s. 116
38. LEŠŤANOVÁ Z. – BAČOVÁ Z. –ŠTRBÁK V. –BAKOŠ, J. . Time effect of oxytocin on
mRNA and protein levels of nestin and microtubule associated protein 2 in glioblastoma cells, 10th
World Congress on Neurohypophysial hormones,. 15-19.7.2013, Bristol, UK, Book of Abstracts
p.118
39. MACEJOVГЃ D.- BIALEЕ OVГЃ L.- BRTKO J.: Effects of two isomers of retinoic acid and
genistein on the expression of selected nuclear receptors, their coregulators and genes involved in
apoptosis in ACHN human kidney cancer cell line. Czech-Slovak Toxicology Conference –
TOXCON 2013, Hradec KrГЎlovГ©, ДЊeskГЎ republika, 19.-21.06.2013.
40. MACEJOVГЃ D.- BIALEЕ OVГЃ L.- HAVRГЃNEK T.- BRTKO J.- FICKOVГЃ M.: Effects of
di(2-ethylhexyl)-phtalate alone or in combination with 17ОІ-estradiol on expression of RXRalpha
and RXRbeta retinoid X receptor subtypes in the MCF-7 breast cancer cell line. 49th Congress of
the European Societes of Toxicology (EUROTOX), Interlaken, Е vjajДЌiarsko, 01.-04.09.2013.
41. HUNГЃKOVГЃ L. - MACEJOVГЃ D.- BIALEЕ OVГЃ L. - BRTKO J.: Effects of selected
organotin halides on human breast cancer cell line growth and nuclear all-trans retinoic acid
receptor (RAR) and retinoid X receptor (RXR) subtypes expression. UAE Cancer Congress, Dubai,
03.-05.10.2013.
18
SprГЎva o ДЌinnosti organizГЎcie SAV
42. MAJERДЊГЌKOVГЃ Z. - UKROPEC J. - UKROPCOVA B. - BALAЕЅ M. TkaДЌova R., Kiss A.
Distribucia zink-2-glykoproteinu a tyrozin hydroxylazy v tukovom tkanive pacientov s obezitou a
pДѕucnou kachexiou. 89. FyziologickГ© dny 5.-7.2.2013, Praha, poster ДЌ. 118.
43. MAЕ INDOVГЃ I.- VARGA L.- HUДЊKOVГЃ M.- BALOGOVГЃ M.- Е UCHOVГЃ ДЅ.- PROFANT
M.- KLIMEЕ I.- GAЕ PERГЌKOVГЃ D.: CeloslovenskГЅ genetickГЅ skrГ­ning pacientov s bilaterГЎlnou
nesyndrГіmovou senzorineurГЎlnou poruchou sluchu. XXIV. IzakoviДЌov memoriГЎl s medzinГЎrodnou
ГєДЌasЕҐou, Donovaly, 26.-27. September 2013
44. MLYNARCIKOVA A. - HAVRANEK T. - FICKOVA M: Effects of endocrine disruptors
Di(2-ethylhexyl) phthalate and Bisphenol A in a combination with 17ОІ-estradiol on apoptosisrelated genes expression in the MCF-7 breast cancer cells. 18th Interdisciplinary Czech-Slovak
Toxicology Conference TOXCON 2013, Hradec KrГЎlovГ©, ДЊeskГЎ republika, 19.-21.06.2013.
45. MLYNARCIKOVA A. - HAVRANEK T. - FICKOVA M: Effects of the endocrine disruptor
di(2-ethylhexyl) phthalate in a combination with 17ОІ-estradiol on expression of apoptosis- and cell
cycle progression-related genes in the MCF-7 breast cancer cell line. Joint meeting of national
physiological societies, “New frontiers in physiological research – from scientific truth via
friendship to the art”, Kovačica, Srbsko, 20-22.06.2013.
46. MLYNARCIKOVA A. - HAVRANEK T. - FICKOVA M: Effects of endocrine disruptors
Bisphenol A and di(2-ethylhexyl) phthalate in a combination with 17ОІ-estradiol on apoptosisrelated genes in the MCF-7 breast cancer cell line. 49th Congress of the European Societies of
Toxicology (EUROTOX), Interlaken, Е vajДЌiarsko, 01.-04.09.2013.
47. MURCK H. - BUETTNER M. - JEZOVA D.: Role of mineralcorticoid receptors in major
depression. 11th World Congress of Biological Psychiatry, 23. – 27.6. 2013, Kyoto, Japan.
48. PENESOVA A.- KRSKOVA K.- ZORAD S.- HOLUBKOVA A.- GARAFOVA A.- VLCEK
M.- IMRICH R.- JEZOVA D.: Metabolic abnormalities in young subjects with hypertension in
comparison to obese and lean healthy individuals – a pilote study
5th International Congress of Prediabetes and Metabolic Syndrome, 18-20 Apr. 2013, ViedeЕ€,
RakГєsko
Poster
49. POKUSA M.- GAJDOЕ ECHOVГЃ L.- KRЕ KOVГЃ K.- CSГЃNOVГЃ A.- ZORAD Е .FRANKLIN M.- JEЕЅOVГЃ D.: VybranГ© metabolickГ© parameter v tukovom tkanive a animГЎlnom
modeli depresie. 55. česko-slovenská psychofarmakologická konferencia, 4. – 8.1. 2013, LázněJeseník, Česká republika.
50. PROKOPOVГЃ B.- KRГЌЕЅOVГЃ L. - VLДЊEK M.- PENESOVГЃ A.- HLAVГЃДЊOVГЃ N.KOLLГЃR B.- TURДЊГЃNI P.- JEЕЅOVГЃ D.: VybranГ© psychologickГ© charakteristiky u pacientov so
sklerózou multiplex. 55. česko-slovenská psychofarmakologická konferencia, 4. – 8.1. 2013, LázněJeseník, Česká republika.
51. SCSUKOVA S. –MLYNARCIKOVA A. - SMOLIKOVA K.- ROLLEROVA E.: Effects of
titanium dioxide and silver nanoparticles on in vitro steroid hormone secretion by porcine ovarian
granulosa cells. 18th Interdisciplinary Czech-Slovak Toxicology Conference TOXCON 2013,
Hradec KrГЎlovГ©, ДЊeskГЎ republika. 19.-21.6.2013.
19
SprГЎva o ДЌinnosti organizГЎcie SAV
52. SCSUKOVA S.- MLYNARCIKOVA A. – SMOLIKOVA K .- ROLLEROVA E.: Effects of
selected nanoparticles on in vitro steroid hormone secretion by porcine ovarian granulosa cells. 41st
Annual Conference of the European Teratology Society, Stresa, Taliansko, 8.-11.9.2013.
53. STANГЌK J.- GAЕ PERГЌKOVГЃ D.- HUДЊKOVГЃ M.- VALENTГЌNOVГЃ L.- STANГЌKOVГЃ D.MAЕ INDOVГЃ I.- BALOGOVГЃ M.- SLOVENSKГЃ SKUPINA PRE Е TГљDIUM
MONOGÉNOVÉHO DIABETU- KLIMEŠI.: Klinická diagnostika pacientov s MODY. Abstrakt
z XXIII. DiabetologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna 2013
54. STANГЌKOVГЃ D.- BALOGOVГЃ M.- STANГЌK J.- HUДЊKOVГЃ M.,-TICHГЃ ДЅ- VIRGOVГЃ D.PETRГЃЕ OVГЃ M.- LOBOTKOVГЃ D.- KLIMEЕ I.- GAЕ PERГЌKOVГЃ D: Monogenic obesity
caused by mutations in the MC4R gene in Slovak obese children. 19th Middle European Worshop
of Paediatric Endocrinology. Endocr Regul. 2013 October;47(3):229.
55. STANГЌK J.- ROSOДЅANKOVГЃ M.- HUДЊKOVГЃ M.- VALENTГЌNOVГЃ L.- MAЕ INDOVГЃ I.MIKULAJOVГЃ S.- STANГЌKOVГЃ D.- KYЕ KOVГЃ S.- Slovak Congenital Hyperinsilinism Study
Group, ДЅ. TichГЎ, D. GaЕЎperГ­kovГЎ a I. KlimeЕЎ: Pharmacogenetics in channelopathies causing
congenital hyperinsulinism. 19th Middle European Worshop of Paediatric Endocrinology. Endocr
Regul. 2013 October;47(3):228
56. Е TOFKOVГЃ A. JURДЊOVIДЊOVГЃ J. Hormonal and Adipokine Profile in Relation to
Metabolic Impairment in Rat Model of Rheumatoid Arthritis. 2nd World Congress on
Controversies, Debates and Consensus on Bone Muscles and Joint Diseases 20. 11. – 24. 11. 2013,
Brusel, Belgicko, e-poster.
57. VALENTГЌNOVГЃ L.- BEER L.- OSBAK K.- VAN DE BUNT M.- TRIBBLE N.D.- STEELE
A. M.- WENSLEY K. J.- EDGHILL E. L.- COLCOUGH J.- BARRETT A.- RUNDLE J. K.RAIMONDO A.- GRIMSBY J.- ELLARD S.- GLOYN A. L.: RaritnГ© dvojitГ© mutГЎcie
v glukokinГЎze s prejavmi GCK-MODY a ich funkДЌnГЎ charakterizГЎcia. XXIII. DiabetologickГ© dnГ­
s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna 2013
58. VALENTГЌNOVГЃ L.- HUДЊKOVГЃ M.- MAЕ INDOVГЃ I.- BALOGOVГЃ M.- STANГЌK J.KLIMEЕ I.- GAЕ PERГЌKOVГЃ D.: Testovanie moЕѕnosti vyuЕѕГ­vania DHPLC metГіdy na DNA
diagnostiku monogГ©novej cukrovky - IzakoviДЌov memoriГЎl s medzinГЎrodnou ГєДЌasЕҐou, Donovaly,
26.-27. September 2013
59. VARGA L.- MASINDOVA I.- KABATOVA Z.- HUCKOVA M.-KLIMES I.GASPERIKOVA D.- PROFANT M.: Screening for hereditary causes of SNHL in Slovak deaf
population and it’s practical consequences. Konferencie 20th IFOS World Congress Seoul Korea,
1.-5. June 2013
2.5.2. PrednГЎЕЎky a vГЅvesky na domГЎcich konferenciГЎch :
1. BABIC S. - JEЕЅOVГЃ D.: Brain plasticity and stress. The Miniconference of the PhD Students,
Institute of Experimental Pharmacology & Toxicology, 10.6. 2013, Bratislava.
20
SprГЎva o ДЌinnosti organizГЎcie SAV
2. BARTEKOVГЃ M. - BARANДЊГЌK M. - BABIC S. - POKUSA M. - FRIMMEL K. OKRUHLICOVГЃ L. - RADOЕ INSKГЃ J.- JEЕЅOVГЃ D.: MolekulГЎrne mechanizmy zahrnutГ© v
odpovediach srdca na chronickГЅ imobilizaДЌnГЅ stres. 41. konferencia Komisie experimentГЎlnej
kardiológie, 16. –18.10. 2013, Martin.
3. BALГЃЕЅIOVГЃ D.- STANГЌKOVГЃ D.- HUДЊKOVГЃ M.- STANГЌK J.- VOHNOUT B.- RAЕ LOVГЃ
K.- KLIMEЕ I.- GAЕ PERГЌKOVГЃ D.: DNA analГЅza gГ©nov zodpovednГЅch za familiГЎrnu
hypercholesterolГ©miu (LDLR, ApoB-100 a PCSK9) u SlovenskГЅch pacientov. Е tudentskГЎ vedeckГЎ
konferencie Prif UK v Bratislave, 24. AprГ­l 2013
4. BALГЃЕЅIOVГЃ D.- VOHNOUT B.- STANГЌKOVГЃ D.- HUДЊKOVГЃ M.- BALOGOVГЃ M.STANГЌK J.- KLIMEЕ I.- RAЕ LOVГЃ K.- GAЕ PERГЌKOVГЃ D.: DNA analГЅza monogГ©novej
familiГЎrnej hypercholesterolГ©mie u slovenskГЅch pacientov. Kongrese Slovenskej kardiologickej
spoloДЌnosti, Bratislava, 10.-12. OktГіber 2013
5. BIALEЕ OVГЃ L.- BRTKO J.- ONDKOVГЃ S.- GALBAVГќ Е .- MACEJOVГЃ D.: Selected
nuclear receptors expression in human breast carcinoma tissues. Genetic Toxicology and Cancer
Prevention Conference, Smolenice, SlovenskГЎ republika, 13.-16.10.2013.
6. FICKOVГЃ M. - KOVГЃДЊIKOVГЃ Z. - MACEJOVГЃ D.- BRTKO J.: The effect of of Bisphenol
A in combination with estradiol on the activity of antioxidant enzymes in human breast carcinoma
cells. Genetic Toxicology and Cancer Prevention, Smolenice 13. – 16. októbra 2013.
7. GAJDOЕ ECHOVГЃ L., KRЕ KOVГЃ K., ZORAD S. Гљloha tukovГ©ho tkaniva pri rozvoji
inzulГ­novej rezistencie. XXIII. DiabetologickГ© dni Bratislava, 12.-14. jГєna 2013
8. SOLГЃRIKOVГЃ P.- BREZINA I.- HLAVГЃДЊOVГЃ N.: Reakcia salivГЎrneho kortizolu pri
psychosociГЎlnom stresovom podnete vo vzЕҐahu k pohlaviu. OsobnosЕҐ v kontexte kognГ­ciГ­,
emocionality a motivácií IV, 27. – 28.11. 2013, Bratislava.
9. CHOVANOVA L.- VLCEK M.- KRSKOVA K.- PENESOVA A.- RADIKOVA Z.-,
ROVENSKY J.-, CHOLUJOVA D.- SEDLAK J.- IMRICH R.. PBMC from patients with
rheumatoid arthritis are mopre sensitive to LPS stimulation and effect of cortisol. 5th International
Student Medical Congress KoЕЎice 2013, 26-28 JГєn 2013, KoЕЎice
prednГЎЕЎka
10. CHOVANOVГЃ L.- VLДЊEK M.- ROVENSKГќ J.- IMRICH R.. Effects of Multiple (Genetic)
Risk Factors Associated with Rheumatoid Arthritis on Immune Cell Phenotypes VII. SiЕҐajovo
predvianoДЌnГ© sympГіzium, 6-7. Dec. 2013, PieЕЎЕҐany
prednГЎЕЎka
11. KRЕ KOVГЃ K.- GAJDOЕ ECHOVГЃ L.- OLSZANECKI R.- POGLITSCH M. - ZORAD S.
FunkДЌnГЅ lokГЎlny renГ­n-angiotenzГ­novГЅ systГ©m v tukovom tkanive - fakt alebo hypotГ©za? XXIII.
DiabetologickГ© dni Bratislava, 12.-14. jГєna 2013
LENKO V.- OBЕ ITNГЌK M.- ONDRIЕ M.: VГЅznam TRUS riadenej punkcie a aspirГЎcie v lieДЌbe
abscesu prostaty – naše skúsenosti. 20. výročná konferencia Slovenskej urologickej spoločnosti
SLS, Trnava, 12.-14.6.2013.
12. LENKO V., OBЕ ITNГЌK M., ONDRIЕ M.: VГЅznam TRUS riadenej punkcie a aspirГЎcie v lieДЌbe
abscesu prostaty – naše skúsenosti. 20. výročná konferencia Slovenskej urologickej spoločnosti SLS,
Trnava, 12.-14.6.201
21
SprГЎva o ДЌinnosti organizГЎcie SAV
13. LEŠŤANOVÁ Z. – BAČOVÁ Z. –ŠTRBÁK . –BAKOŠJ.. Vývinový vplyv neonatálneho
podania oxytocГ­nu na lipopolysachridom indukovanГє stimulГЎciu imunitnГ©ho system, NovГ© trendy
vo vГЅvinovej toxikolГіgii a teratolГіgii, Bratislava, 27.11.2013
14. MACEJOVГЃ D.- BIALEЕ OVГЃ L.- HAVRГЃNEK T.- BRTKO J.- FICKOVГЃ M.: Di(2ethylhexyl)-phtalate: Effects on expression of RXRalpha and RXRbeta retinoid X receptor
subtypes in the MCF-7 breast cancer cell line. Genetic Toxicology and Cancer Prevention
Conference, Smolenice, SlovenskГЎ republika, 13.-16.10.2013.
15. PENESOVГЃ A.- KRЕ KOVГЃ K.- ZГ“RAD Е .- HOLГљBKOVГЃ A.- GARAFOVГЃ A.- VLДЊEK
M.- IMRICH R.- JEЕЅOVГЃ D. MetabolickГ© abnormality u mladГЅch pacientov s hypertenziouPilotnГЎ ЕЎtГєdia XXIII. DiabetologickГ© dni, 12-14 jГєn 2013, Bratislava
Poster
16. VARGOVIČ, P. – UKROPEC, J. – KVETŇANSKÝ, R.: Opakovaný stres zvyšuje produkciu
endogГ©nnych katecholamГ­nov v adipocytoch mezenterickГ©ho tukovГ©ho tkaniva potkana. PrednesenГ©
na VII. RoДЌnГ­ku Drobnicovho memoriГЎlu, BojnГЎ, 16.-18. sept. 2013, strana 54-55.
17. VLДЊEK M.- CHOVANOVГЃ L.- KRЕ KOVГЃ K.- Е POUTIL F.- PENESOVГЃ A.- RAЕ LOVГЃ
K.- VOHNOUT B.-, ROVENSKГќ J.- KILLINGER Z.- JOCHMANOVГЃ I.- LAZГљROVГЃ I.RADNER H.- STEINER G. - SMOLEN J.-, IMRICH R. GenetickГ© rizikovГ© fatory reumatoidnej
artritГ­dy v slovenskej populГЎcii
57. zjazd slovenskГЅch a ДЌeskГЅch reumatolГіgov, 26-28 Sept. 2013, ЕЅilina, Slovensko
poster
2.6. VyЕѕiadanГ© prednГЎЕЎky
2.6.1. VyЕѕiadanГ© prednГЎЕЎky na medzinГЎrodnГЅch vedeckГЅch podujatiach
1. BRTKO J.- MACEJOVГЃ D.- GALBAVГќ Е .- BIALEЕ OVГЃ L.- PODOBA J.: Expression
mRNA pattern of retinoic acid and retinoid X nuclear receptor subtypes in thyroid carcinomas. The
4th Congress of the Polish Thyroid Association, Lodz, Poland, 11.-13.03.2013.
2. BRTKO J.- MACEJOVГЃ D.- BIALEЕ OVГЃ L.- GALBAVГќ Е .: Expresia podtypov retinoidnГЅch
a rexinoidnГЅch jadrovГЅch receptorov a ich koregulГЎtorov v karcinГіmoch ЕЎtГ­tnej ЕѕДѕazy. XXXVI.
EndokrinologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou, PlzeЕ€, ДЊeskГЎ republika, 10.-12.10.2013.
3. GAЕ PERГЌKOVГЃ D.: Od DNA analГЅzy ku klinickГЅm biomarkerom: NovГ© moЕѕnosti diagnostiky
monogГ©novГ©ho diabetu. XXI. NovГ© trendy v prevencie aterosklerГіzy, 13-14.2.2013, City Hotel
Bratislava, sympГіzium s medzinГЎrodnou ГєДЌasЕҐou
4. JEŽOVÁ D.- HLAVÁČOVÁ N.: Ovplyvnenie hormónu aldosterónu – nový smer vo vývoji
anxiolytík. 55. česko-slovenská psychofarmakologická konferencia, 4. – 8.1. 2013, Lázně-Jeseník,
ДЊeskГЎ republika.
5. JEZOVA D.- HLAVACOVA N.: Hyperaldosteronism in an animal model - changes in
depression-like behavior and gene expression relevant to major depressive disorder. 11th World
Congress of Biological Psychiatry, 23. – 27.6. 2013, Kyoto, Japan.
22
SprГЎva o ДЌinnosti organizГЎcie SAV
6. JEZOVA D.- HLAVACOVA N.: Aldosterone - A Bridge Between Cardiovascular and Mood
Disorders? 18th World Congress on Heart Disease, 26. – 29.7. 2013, Vancouver, Canada.
7. KVETŇANSKÝ, R.: „Activity of the adrenomedullary and other catecholaminergic systems in
stress“.Pozvaná prednáška na 17th International Symposium on Chromaffin Cell Biology,
Rouen, FrancГєzsko, 13.-17. jГєla 2013
8. KVETŇANSKÝ R.: „Stress-induced regulation of molecular genetic mechanisms in neuroendocrine-immune systems“.Pozvaná prednáška na Európskom kongrese pre neurovedy „FENS
Featured Regional Meeting“ v Prahe, 11.-15. September 2013.
9. MRAVEC B. Neuro-endocrine-immune interactions in etiopathogenesis of somatic diseases.
FENS 11. - 14. 9. 2013; Praha
10. ŠTRBÁK V. – BAČOVÁ Z. Cell swelling, novel regulatory signal affecting various functions.
Ligandy oxytocГ­novГЅch receptorov ovplyvЕ€ujГє gГ©novГє expresiu aj proteГ­novГ© hladiny
neurofilamentov in vitro. “New frontiers in physiological research from scientific truth via
friendship to the art “ 20.-22. 6.2013, Kovačica, Srbsko, Abstract book p.19. Invited lecture.
11. ŠTRBÁK V.– BAČOVÁ Z.– RAVINGEROVÁ T.. Cell swelling-induced hormone secretion
– pathophysiological implications. The 10th International Congress Cell volume regulation – novel
therapeutic targets & pharamcological approaches. Bulletin of Siberian Medicine. 2013, vol. 12, no
4, p. 64. ISSN 1682-0363. Invited lecture
12. UKROPCOVГЃ B.: Metabolic health and muscle secretory profile in aerobic and resistance
trained overweight/obese individuals. EFSD/Lilly Symposium, Bad Homburg, Germany
2.6.2. VyЕѕiadanГ© prednГЎЕЎky na domГЎcich vedeckГЅch podujatiach
1. BRTKO J.- BIALEЕ OVГЃ L.-LENKO V.- MACEJOVГЃ D.: The road to nuclear receptors and
their cognate ligands: Insight into physiology and therapy of malignant diseases. Genetic
Toxicology and Cancer Prevention Conference, Smolenice, SlovenskГЎ republika, 13.-16.10.2013.
2. FICKOVГЃ M.- KOVГЃДЊIKOVГЃ Z.- MACEJOVГЃ D.- BRTKO J.: The effect of of Bisphenol
A in combination with estradiol on the activity of antioxidant enzymes in human breast carcinoma
cells. Genetic Toxicology and Cancer Prevention, Smolenice 13. – 16. októbra 2013.
3. JEЕЅOVГЃ D.: ГљzkosЕҐ ako zloЕѕka ДЌi nГЎsledok stresovej reakcie. OsobnosЕҐ v kontexte kognГ­ciГ­,
emocionality a motivácií IV, 27. – 28.11. 2013, Bratislava.
4. JURДЊOVIДЊOVГЃ J. : Je naruЕЎenГЅ transport glukГіzy do mozgu v experimentГЎlnom
autoimunitnom zГЎpale ? Гљstav experimentГЎlnej garmakolГіgie SAV, Bratislava, 11.3.2013
5. KVETŇANSKÝ R.: „Does chronic or repeated stress produce pathological changes in the
organism: Effect of catecholaminergic systems“.
PozvanГЎ prednГЎЕЎka na 7th International Symposium on Experimental and Clinical Neurobiology,
23.-27. jГєna 2013 v KoЕЎiciach
23
SprГЎva o ДЌinnosti organizГЎcie SAV
6. Е TRBГЃK, V. ГљДЌasЕҐ zmien bunkovГ©ho objemu v patogenГ©ze ochorenГ­. 6. roДЌnГ­k MemoriГЎl
DionГЅza Oravca, 12.decembra 2013, Bratislava. PozvanГЎ prednГЎЕЎka.
7. UKROPCOVГЃ B.: ГљДЌinky fyzickej (in)aktivity: DialГіg svalu s telom. LekГЎrska Fakulta UK
v Bratislave. 12. FebruГЎr 2013
8. UKROPCOVГЃ B.: KostrovГЅ sval ako mediГЎtor benefiДЌnГ©ho ГєДЌinku pravidelnГ©ho cviДЌenia.
XVIII. Kongres Slovenskej kardiologickej spoloДЌnosti, Bratislava, 10.-12. OktГіber 2013
9. UKROPCOVГЃ B. - MADEROVГЃ D.- KURDIOVГЃ T.- BALГЃЕЅ M.- KLIMEЕ I.GAЕ PERГЌKOVГЃ D.- VICIAN M.- ZEMKOVГЃ E.- UKROPEC J.: KostrovГЅ sval v patogenГ©ze
chorôb z nedostatku pohybu. Národný kongres telovýchovného lekárstva: „Aktuálne problémy
telovýchovného lekárstva“, 22 – 23.11.2013, Bratislava.
2.6.3. VyЕѕiadanГ© prednГЎЕЎky na vГЅznamnГЅch vedeckГЅch inЕЎtitГєciГЎch
Ak boli prГ­spevky publikovanГ©, sГє sГєДЌasЕҐou PrГ­lohy C, kategГіria (AFC, AFD, AFE, AFF, AFG,
AFH)
1. BRTKO J.: Nuclear receptors. Department of Medical Chemistry and Biochemistry. Medical
Faculty, Palacky University, Olomouc, ДЊeskГЎ republika, 26.03.2013.
2. BRTKO J.: Гљloha selГ©nu, selenoenzГЅmov a selenoproteГ­nov na Гєrovni bunky a v integrovanom
organizme. Faculty of Natural Sciences, Department of Cell Biology and Genetics, Olomouc, ДЊeskГЎ
republika, 23.04.2013.
3. BRTKO J.: NukleГЎrne receptory a ich biologicky aktГ­vne ligandy vo vzЕҐahu k regulaДЌnГЅm
procesom na Гєrovni bunky a v terapii niektorГЅch nГЎdorovГЅch ochorenГ­. Faculty of Natural Sciences,
Department of Cell Biology and Genetics, Olomouc, ДЊeskГЎ republika, 24.04.2013.
4. BRTKO J.- MACEJOVГЃ D.- BIALEЕ OVГЃ L.- BOBГЃLOVГЃ J.: Nuclear receptors and their
cognate ligands: Insight into physiology and therapy of malignant diseases. Technische Universität,
Dresden, Nemecko, 22.10.2013.
5. BRTKO J.: NukleГЎrne receptory a ich biologickГ© aktГ­vne ligandy vo vzЕҐahu k regulaДЌnГЅm
procesom na Гєrovni bunky a v terapii niektorГЅch nГЎdorovГЅch ochorenГ­. Гљstav analytickГ© chemie
AV ДЊR, v. v. i., Brno, ДЊeskГЎ republika, 20.11.2013.
6. HLAVACOVA N.: Aldosterone and Mood Disorders: Anxiogenic and depressogenic actions.
Instituto de Investigaciones BiotechnolГіgicas, USAM-CONICET de Buenos Aires, 11.11. 2013,
Argentina.
7. JEZOVA D.: Aldosterone and Mood Disorders: therapeutic and clinical implications. Instituto
de Investigaciones BiotechnolГіgicas, USAM-CONICET de Buenos Aires, 11.11. 2013, Argentina.
8. JURДЊOVIДЊOVГЃ J.: Je naruЕЎenГЅ transport glukГіzy do mozgu v experimentГЎlnom
autoimunitnom zГЎpale? Гљstav experimentГЎlnej farmakolГіgie SAV, Bratislava 11. 3. 2013.
24
SprГЎva o ДЌinnosti organizГЎcie SAV
9. Е TRBГЃK V. visting professor Faculty of Medical Sciences, University of Kragujevac, Serbia:
May 31st: for undergraduate students of Pharmacy. Cell volume regulation – specific features of
osmotically – induced secretion. And June 1st: for PhD students Cell volume regulation –
pathophysiological implications.
2.7. PatentovГЎ a licenДЌnГЎ ДЌinnosЕҐ na Slovensku a v zahraniДЌГ­ v roku 2013
2.7.1. VynГЎlezy, na ktorГ© bol udelenГЅ patent 0
2.7.2. PrihlГЎsenГ© vynГЎlezy 0
2.7.3. PredanГ© licencie 0
2.7.4. RealizovanГ© patenty 0
FinanДЌnГЅ prГ­nos pre organizГЎciu SAV v roku 2013 a sГєДЌet za predoЕЎlГ© roky sa neuvГЎdzajГє, ak je
zverejnenie v rozpore so zmluvou sГєvisiacou s realizГЎciou patentu.
2.8. ГљДЌasЕҐ expertov na hodnotenГ­ nГЎrodnГЅch projektov (APVV, VEGA a inГЅch)
TabuДѕka 2h Experti hodnotiaci nГЎrodnГ© projekty
Typ programu/projektu/vГЅzvy
PoДЌet
hodnotenГЅch
projektov
KEGA
1
Ing. JГєlius Brtko, DrSc.
VEGA
1
RNDr. Alexander Kiss, DrSc.
VEGA
2
RNDr. Alexander Kiss, DrsC.
APVV
3
Doc. MUDr. Boris Mravec, PhD.
VEGA
1
MUDr. Adela PenesovГЎ, PhD.
KEGA
1
MUDr. Richard Imrich, PhD.
VEGA
2
MUDr. Richard Imrich, PhD.
APVV
1
Ing. Е tefan Zorad, CSc.
APVV
3
Prof. MUDr. Fedor Е imko, CSc.
MZ
11
Prof. MUDr. Fedor Е imko, CSc.
APVV
5
Prof. MUDr. Fedor Е imko, CSc.
VEGA
9
Prof. MUDr. Fedor Е imko, CSc.
SKS
9
Meno pracovnГ­ka
PharmDr. Zdenko PirnГ­k, PhD
2.9. InГ© informГЎcie k vedeckej ДЌinnosti.
25
SprГЎva o ДЌinnosti organizГЎcie SAV
3. DoktorandskГ© ЕЎtГєdium, inГЎ pedagogickГЎ ДЌinnosЕҐ a budovanie ДѕudskГЅch
zdrojov pre vedu a techniku
3.1. Гљdaje o doktorandskom ЕЎtГєdiu
Doktorandi dennej formy
Mgr. Stanislav Babic – prijatý 1.9.2009
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
ukonДЌil ГєspeЕЎnou obhajobou 8/2013
Mgr. Miroslav Baláž – prijatý 1.9.2010
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. Jozef Ukropec, PhD.
Vykonal dizertaДЌnГє skГєЕЎku
Mgr. Dominka Balážiová – prijatá 1.9.2012
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. Daniela GaЕЎperГ­kovГЎ, CSc.
Ing. Lucia Bialešová – prijatá 1.9.2010
ЕЎtudijnГЅ odbor: 4.1.22. ЕЎtudijnГЅ program: BiochГ©mia
ЕЎkoliteДѕ: Mgr. Dana MacejovГЎ, PhD
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Agneša Csánová – prijatá 1.9.2013
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
Mgr. Lucia GajdoЕЎechovГЎ - prijatГЎ 1.9.2011
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Ing. Е tefan Zorad, CSc.
Vykonal dizertaДЌnГє skГєЕЎku
Mgr. Tomáš Havránek – prijatý 1.9.2011
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. Zuzana BaДЌovГЎ, PhD.
Vykonal dizertaДЌnГє skГєЕЎku
Mgr. Lucia Chovanová – od 1.9.2009
ЕЎtudijnГЅ odbor: 4.2.10. FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: MUDr. Richard Imrich, PhD.
ukonДЌila ГєspeЕЎnou obhajobou 8/2013
Mgr. Timea Kurdiová – prijatá 1.9.2009 (štúdium predĺžené)
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. Jozef Ukropec, PhD.
Vykonala dizertaДЌnГє skГєЕЎku
26
SprГЎva o ДЌinnosti organizГЎcie SAV
Mgr. Patrik Krumpolec – prijatý 1.9.2013
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. Jozef Ukropec, PhD.
Mgr. Zuzana Lešťanová – prijatá 1.9.2012
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: RNDr. JГЎn BakoЕЎ, PhD.
Mgr. Zuzana Majerčíková – prijatá 1.9.2011
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: RNDr. Alexander Kiss, DrSc.
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Ivica Mašindová – prijatá 1.9.2010
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. Daniela GaЕЎperГ­kovГЎ, CSc.
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Lívia Mikuška (rod. Pallová) – prijatá 1.9.2009 štúdium prerušené
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Doc. MUDr. Boris Mravec, PhD.
V sГєДЌasnosti na materskej dovolenke
MUDr. Martina Mravcová – od 1.9.2013
ЕЎtudijnГЅ odbor: 7.1.3 NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: MUDr. Richard Imrich, PhD.
Mgr. Michal Pokusa – prijatý 1.9.2011
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
Vykonal dizertaДЌnГє skГєЕЎku
Mgr. Kvetoslava Smolíková – prijatá 1.9.2010
ЕЎtudijnГЅ odbor: 4.2.10. ЕЎtudijnГЅ program: FyziolГіgia ЕѕivoДЌГ­chov
ЕЎkoliteДѕ: Mgr. SoЕ€a ScsukovГЎ, CSc.
Vykonala dizertaДЌnГє skГєЕЎku
Ing. Lucia Toporová – prijatá 1.9.2013
ЕЎtudijnГЅ odbor: 4.1.22. ЕЎtudijnГЅ program: BiochГ©mia
ЕЎkoliteДѕ: Ing. JГєlius Brtko, DrSc.
Doktorandské štúdium – externá forma
MUDr. Andrea GГЎlusovГЎ
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: MUDr. Adela PenesovГЎ, PhD.
vykonala dizertaДЌnГє skГєЕЎku
MUDr. Alexandra GarafovГЎ
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: MUDr. Adela PenesovГЎ, PhD.
vykonala dizertaДЌnГє skГєЕЎku
27
SprГЎva o ДЌinnosti organizГЎcie SAV
MUDr. Daniela StanГ­kovГЎ, rod LesayovГЎ - prijatГЎ od 1. 9. 2009
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: prof. MUDr. I. KlimeЕЎ, DrSc.
Doktorandi ЕЎkolenГ­ pre inГ© vzdelГЎvacie inЕЎtitГєcie
Doktorandi, ЕЎkolenГ­ pre inГ© inЕЎtitГєcie, ktorГ­ na ГљEE SAV vykonГЎvajГє vedeckГє ДЌasЕҐ ЕЎtГєdia
v plnom rozsahu
Mgr. Veronika DanevovГЎ - prijatГЎ od 1. 9. 2011 /FaF UK/
ЕЎtudijnГЅ odbor: 7.3.2. ЕЎtudijnГЅ program: farmakolГіgia
ЕЎkoliteДѕ: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
vykonala dizertaДЌnГє skГєЕЎku
Mgr. Lucia FiaДЌanovГЎ - prijatГЎ od 1. 9. 2013 /FaF UK/
ЕЎtudijnГЅ odbor: 7.3.2. ЕЎtudijnГЅ program: farmakolГіgia
ЕЎkoliteДѕ: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
MUDr. Michaela Jakubová – prijatá 1.9.2013 (LF UK)
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patlogickГЎ fyziolГіgia
ЕЎkoliteДѕ: MUDr. Barbara UkropcovГЎ, PhD.
Mgr. KatarГ­na LejavovГЎ - prijatГЎ od 1. 9. 2011 /LF UK/
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: Doc. MUDr. Boris Mravec, PhD.
ЕЎkoliteДѕ ЕЎpecialista: RNDr. R. KvetЕ€anskГЅ, DrSc.
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Ludmila PeДЌeЕ€ovГЎ - prijatГЎ od 1. 9. 2011 /PriF UK/
ЕЎtudijnГЅ odbor: 4.2.1. ЕЎtudijnГЅ program: Genetika
ЕЎkoliteДѕ: RNDr. R. FarkaЕЎ, CSc.
Mgr. Barbora ProkopovГЎ - prijatГЎ od 1. 9. 2011 /FaF UK/
ЕЎtudijnГЅ odbor: 7.3.2. ЕЎtudijnГЅ program: farmakolГіgia
ЕЎkoliteДѕ: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Silvia Vallová – prijatá 1.9.2013 (LF UK
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: MUDr. Barbara UkropcovГЎ, PhD.
Doktorandi ЕЎkolenГ­ s ГєДЌasЕҐou ЕЎkoliteДѕa ЕЎpecialistu (nezapoДЌГ­tanГ­ v tabuДѕke):
MUDr. Lucia Krížová – prijatá od 1.9.2010 pre LF UK
Е tudijnГЅ odbor: 7.1.11. ЕЎtudijnГЅ program: NeurolГіgia
Е koliteДѕ-ЕЎpecialista: prof. PharmDr. D. JeЕѕovГЎ, DrSc.
Vykonala dizertaДЌnГє skГєЕЎku
MUDr. RNDr. Lukáš Varga – prijatý od 1.9.2009 pre LF UK
Е tudijnГЅ odbor: 5119 OtorinolaryngolГіgia
Е koliteДѕ-ЕЎpecialista: Mgr. Daniela GaЕЎperГ­kovГЎ, CSc.
ГљspeЕЎne obhГЎjil
28
SprГЎva o ДЌinnosti organizГЎcie SAV
Doktorandi ЕЎkolenГ­ pracovnГ­kmi ГљEE SAV, ktorГ­ sГє zГЎroveЕ€ pracovnГ­kmi fakulty
(nezapoДЌГ­tanГ­ v tabuДѕke):
Mgr. NoГ©mi HegedЕ±sovГЎ - prijatГЎ od 1. 9. 2011 /LF UK/
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: Doc. MUDr. Boris Mravec, PhD.
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Lucia MikovГЎ (rod. BГЎnovskГЎ) - prijatГЎ od 1. 9. 2011 /LF UK/
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: Doc. MUDr. Boris Mravec, PhD.
Vykonala dizertaДЌnГє skГєЕЎku
Mgr. Michaela VrabcovГЎ - prijatГЎ od 1. 9. 2008 /LF UK/
ЕЎtudijnГЅ odbor: 7.1.3. ЕЎtudijnГЅ program: NormГЎlna a patologickГЎ fyziolГіgia
ЕЎkoliteДѕ: Doc. MUDr. Boris Mravec, PhD.
TabuДѕka 3a PoДЌet doktorandov v roku 2013
Forma
PoДЌet k 31.12.2013
Doktorandi
celkovГЅ poДЌet
PoДЌet ukonДЌenГЅch doktorandГєr
v r. 2013
UkonДЌenie z dГґvodov
z toho
novoprijatГ­
ukonДЌenie
ГєspeЕЎnou
obhajobou
predДЌasnГ©
ukonДЌenie
neГєspeЕЎnГ©
ukonДЌenie
M
ЕЅ
M
ЕЅ
M
ЕЅ
M
ЕЅ
M
ЕЅ
InternГЎ zo zdrojov SAV
4
11
1
3
1
1
-
-
-
-
InternГЎ z inГЅch zdrojov
-
7
-
3
-
-
-
-
-
-
ExternГЎ
-
3
-
-
-
-
-
-
-
-
Spolu
4
21
1
6
1
1
-
-
-
-
SГєhrn
25
7
2
-
-
3.2. Zmena formy doktorandskГ©ho ЕЎtГєdia
TabuДѕka 3b PoДЌty preradenГ­
InternГЎ z
InternГЎ z
InternГЎ z
InternГЎ z
Z formy prostriedkov prostriedkov
inГЅch
inГЅch
ExternГЎ
ExternГЎ
SAV
SAV
zdrojov
zdrojov
InternГЎ z
InternГЎ z
InternГЎ z
InternГЎ z
Do formy
inГЅch
ExternГЎ prostriedkov ExternГЎ prostriedkov
inГЅch
zdrojov
SAV
SAV
zdrojov
0
0
0
0
0
0
PoДЌet
3.3. Zoznam doktorandov, ktorГ­ ukonДЌili doktorandskГ© ЕЎtГєdium ГєspeЕЎnou obhajobou
29
SprГЎva o ДЌinnosti organizГЎcie SAV
TabuДѕka 3c MennГЅ zoznam ukonДЌenГЅch doktorandov v roku 2013 ГєspeЕЎnou obhajobou
Mesiac,
Fakulta
Mesiac, ДЊГ­slo a nГЎzov
Meno a
Meno
Forma
rok
udeДѕujГєca
rok
ЕЎtudijnГ©ho
organizГЎcia
doktoranda
DЕ nГЎstupu
vedeckГє
obhajoby
odboru
ЕЎkoliteДѕa
na DЕ hodnosЕҐ
internГ©
prof. PharmDr.
ЕЎtГєdium
Daniela JeЕѕovГЎ
hradenГ©
Mgr. Stanislav
4.2.10 fyziolГіgia DrSc., Гљstav PrГ­rodovedeckГЎ
z
9 / 2009 8 / 2013
Babic
ЕѕivoДЌГ­chov
experimentГЎlnej
fakulta UK
prostrie
endokrinolГіgie
dkov
SAV
SAV
internГ©
MUDr. Richard
ЕЎtГєdium
Imrich PhD.,
hradenГ©
Mgr. Lucia
4.2.10 fyziolГіgia
Гљstav
PrГ­rodovedeckГЎ
z
9 / 2009 8 / 2013
ChovanovГЎ
ЕѕivoДЌГ­chov
experimentГЎlnej
fakulta UK
prostrie
endokrinolГіgie
dkov
SAV
SAV
Zoznam internГЅch a externГЅch doktorandov je uvedenГЅ v PrГ­lohe A.
3.4. Zoznam akreditovanГЅch ЕЎtudijnГЅch programov s uvedenГ­m VЕ TabuДѕka 3d Zoznam akreditovanГЅch ЕЎtudijnГЅch programov s uvedenГ­m univerzity/vysokej ЕЎkoly a
fakulty
Univerzita/vysokГЎ ЕЎkola a fakulta
NГЎzov ЕЎtudijnГ©ho
NГЎzov ЕЎtudijnГ©ho
ДЊГ­slo Е O
odboru (Е O)
programu (Е P)
Fakulta chemickej a
potravinГЎrskej technolГіgie STU
biochГ©mia
biochГ©mia
4.1.22
fyziolГіgia
ЕѕivoДЌГ­chov
normГЎlna a
patologickГЎ
fyziolГіgia
fyziolГіgia ЕѕivoДЌГ­chov
4.2.10
normГЎlna a patologickГЎ
7.1.3
fyziolГіgia
PrГ­rodovedeckГЎ fakulta UK
LekГЎrska fakulta UK
TabuДѕka 3e ГљДЌasЕҐ na pedagogickom procese
MennГЅ prehДѕad pracovnГ­kov,
ktorГ­ boli menovanГ­
do spoloДЌnГЅch odborovГЅch
komisiГ­ pre doktorandskГ©
ЕЎtГєdium
MennГЅ prehДѕad pracovnГ­kov,
ktorГ­ pГґsobili ako ДЌlenovia
vedeckГЅch rГЎd univerzГ­t,
sprГЎvnych rГЎd univerzГ­t a fakГєlt
MennГЅ prehДѕad pracovnГ­kov,
ktorГ­ zГ­skali vyЕЎЕЎiu vedeckГє,
pedagogickГє hodnosЕҐ
alebo vyЕЎЕЎГ­ kvalifikaДЌnГЅ stupeЕ€
Ing. JГєlius Brtko, DrSc.
prof. PharmDr. Daniela JeЕѕovГЎ,
prof. PharmDr. Daniela JeЕѕovГЎ,
DrSc.
DrSc.
(4.2.10. fyziolГіgia ЕѕivoДЌГ­chov
(FarmaceutickГЎ fakulta UK)
PrifUK)
prof. PharmDr. Daniela JeЕѕovГЎ, prof. PharmDr. Daniela JeЕѕovГЎ,
Mgr. Stanislav Babic , PhD.
(PhD., PrГ­rodovedeckГЎ fakulta
UK)
30
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
SprГЎva o ДЌinnosti organizГЎcie SAV
DrSc.
DrSc.
(7.3.2. farmakolГіgia FaFUK) (LekГЎrska fakulta UK)
prof. PharmDr. Daniela JeЕѕovГЎ,
DrSc.
(7.3.3. farmaceutickГЎ chГ©mia
FaFUK)
prof. PharmDr. Daniela JeЕѕovГЎ,
DrSc.
(4.1.22. biochГ©mia JLF UK)
prof. PharmDr. Daniela JeЕѕovГЎ,
DrSc.
(7.1.26. klinickГЎ farmakolГіgia
LFUK)
Mgr. Daniela GaЕЎperГ­kovГЎ,
prof. MUDr. Iwar KlimeЕЎ,
CSc. (fyziolГіgia ЕѕivoДЌГ­chov)
DrSc. (LekГЎrska fakulta UK)
prof. MUDr. Iwar KlimeЕЎ,
DrSc. (normГЎlna a patologickГЎ
prof. MUDr. Iwar KlimeЕЎ,
fyziolГіgia)
DrSc. (FarmaceutickГЎ fakulta
UK) - do 1. 3. 2013
prof. MUDr. Iwar KlimeЕЎ,
DrSc. (vnГєtornГ© choroby)
(SVP IIa)
Mgr. Lucia ChovanovГЎ, PhD.
(PhD., PrГ­rodovedeckГЎ fakulta
UK)
MUDr. Miroslav VlДЌek, PhD.
(SVP IIa)
Ing. Marcela LaukovГЎ, PhD.
(SVP IIa )
3.5. Гљdaje o pedagogickej ДЌinnosti
TabuДѕka 3f PrednГЎЕЎky a cviДЌenia vedenГ© v roku 2013
PrednГЎЕЎky
PEDAGOGICKÁ ČINNOSŤ
PoДЌet prednГЎЕЎateДѕov alebo vedГєcich cviДЌenГ­
CviДЌenia a seminГЎre
doma
v zahraniДЌГ­
doma
v zahraniДЌГ­
12
0
9
0
287
0
672
0
CelkovГЅ poДЌet hodГ­n v r. 2013
Prehľad prednášateľov predmetov a vedúcich cvičení, s uvedením názvu predmetu, úväzku, katedry,
fakulty, univerzity/vysokej ЕЎkoly je uvedenГЅ v PrГ­lohe D.
TabuДѕka 3g Aktivity pracovnГ­kov na VЕ 1.
PoДЌet pracovnГ­kov, ktorГ­ pГґsobili ako vedГєci alebo konzultanti diplomovГЅch a
bakalГЎrskych prГЎc
16
2.
PoДЌet vedenГЅch alebo konzultovanГЅch diplomovГЅch a bakalГЎrskych prГЎc
36
3.
PoДЌet pracovnГ­kov, ktorГ­ pГґsobili ako ЕЎkolitelia doktorandov (PhD.)
16
NaformГЎtovГЎno: zarovnГЎnГ­
na stЕ™ed
4.
PoДЌet ЕЎkolenГЅch doktorandov (aj pre inГ© inЕЎtitГєcie)
25
NaformГЎtovГЎno: zarovnГЎnГ­
na stЕ™ed
PoДЌet oponovanГЅch dizertaДЌnГЅch a habilitaДЌnГЅch prГЎc
12
5.
31
SprГЎva o ДЌinnosti organizГЎcie SAV
6.
7.
8.
9.
PoДЌet pracovnГ­kov, ktorГ­ oponovali dizertaДЌnГ© a habilitaДЌnГ© prГЎce
8
PoДЌet pracovnГ­kov, ktorГ­ pГґsobili ako ДЌlenovia komisiГ­ pre obhajoby DrSc. prГЎc
11
PoДЌet pracovnГ­kov, ktorГ­ pГґsobili ako ДЌlenovia komisiГ­ pre obhajoby PhD. prГЎc
15
PoДЌet pracovnГ­kov, ktorГ­ pГґsobili ako ДЌlenovia komisiГ­, resp. oponenti
v inauguraДЌnom alebo habilitaДЌnom konanГ­ na vysokГЅch ЕЎkolГЎch
4
3.6. InГ© dГґleЕѕitГ© informГЎcie k pedagogickej ДЌinnosti
MennГЅ prehДѕad pracovnГ­kov, ktorГ­ boli menovanГ­ do odborovГЅch komisiГ­ vysokГЅch ЕЎkГґl
pre doktorandskГ© ЕЎtГєdium (podДѕa novГ©ho postupu).
Ing. JГєlius Brtko, DrSc.
- ДЌlen odborovej komisie ЕЎtudijnГ©ho programu BiochГ©mia ЕЎtudijnГ©ho odboru 4.1.22 na LF
UK, Bratislava
- ДЌlen odborovej komisie ЕЎtudijnГ©ho programu BiochГ©mia ЕЎtudijnГ©ho odboru 4.1.22 na
FCHPT STU, Bratislava
- ДЌlen odborovej rady doktorskГ©ho ЕЎtudijnГ©ho programu VЕЎeobecnГ© lekГЎrstvo ЕЎtudijnГ©ho
odboru LekГЎrska farmakolГіgia na LF v Plzni Karlovej univerzity v Prahe - ЕЎtudijnГЅ odbor v
zahraniДЌГ­
RNDr. Robert FarkaЕЎ, CSc.
- ДЌlen odborovej komisie ЕЎtudijnГ©ho programu Genetika ЕЎtudijnГ©ho odboru 4.2.4 na PriF UK,
Bratislava
MUDr. Richard Imrich, PhD.
- ДЌlen Vedeckej rady LekГЎrskej fakulty UK v Bratislave
RNDr. Alexander Kiss, DrSc.
- ДЌlen odborovej komisie ЕЎtudijnГ©ho programu FyziolГіgia ЕѕivoДЌГ­chov ЕЎtudijnГ©ho odboru
4.2.10 na PriF UK, Bratislava
Prof.MUDr.Fedor Е imko,CSc.
Predseda odborovej komisie NormГЎlna a patologickГЎ fyziolГіgia a hlavnГЅ garant odboru
MennГЅ prehДѕad pracovnГ­kov, ktorГ­ pГґsobili ako ДЌlenovia vedeckГЅch rГЎd fakГєlt
a univerzГ­t a sprГЎvnych rГЎd univerzГ­t :
32
SprГЎva o ДЌinnosti organizГЎcie SAV
Prof.MUDr.Fedor Е imko,CSc.
ДЊlen VR LFUK
ДЊlen VR SLK
ДЊlen VR MZ
ДЊlen VR ГљNPF SAV
MennГЅ prehДѕad pracovnГ­kov, ktorГ­ zГ­skali vyЕЎЕЎiu vedeckГє, pedagogickГє hodnosЕҐ alebo
vyЕЎЕЎГ­ kvalifikaДЌnГЅ stupeЕ€ (s uvedenГ­m hodnosti/stupЕ€a)
Mgr. Stanislav Babic, PhD.
ZГ­skal hodnosЕҐ PhD. z odboru fyziolГіgia ЕѕivoДЌГ­chov na PrГ­rodovedeckej fakulte UK
v Bratislave 26.8.2013
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
ZГ­skal vyЕЎЕЎГ­ kvalifikaДЌnГЅ stupeЕ€ samostatnГЅ vedeckГЅ pracovnГ­k IIa dЕ€a 3.12.2013
Mgr. Lucia ChovanovГЎ
ZГ­skala hodnosЕҐ PhD. z odboru fyziolГіgia ЕѕivoДЌГ­chov na PrГ­rodovedeckej fakulte UK
v Bratislave 27.8.2013
Ing. Marcela LaukovГЎ, PhD.
ZГ­skal vyЕЎЕЎГ­ kvalifikaДЌnГЅ stupeЕ€ samostatnГЅ vedeckГЅ pracovnГ­k IIa dЕ€a 3.12.2013
MUDr. Miroslav VlДЌek, PhD.
ZГ­skal vyЕЎЕЎГ­ kvalifikaДЌnГЅ stupeЕ€ samostatnГЅ vedeckГЅ pracovnГ­k IIa dЕ€a 23.5.2013
33
SprГЎva o ДЌinnosti organizГЎcie SAV
4. MedzinГЎrodnГЎ vedeckГЎ spoluprГЎca
RNDr. Alexander Kiss, DrSc.
1.
Pracovisko v zahraniДЌГ­: NeurobiologickГЎ vГЅskumnГЎ jednotka Univerzitnej nemocnice, KodaЕ€ a
Гљstav translaДЌnej neurobiolГіgie, Ballerup, DГЎnsko (Neurobiology Research Unit, University
Hospital Copenhagen, Denmark; Department of Translational Neurobiology, NeuroSearch A/S,
Ballerup, Denmark, (Dr. J.D. Mikkelsen).
2.
Pracovisko v zahraniДЌГ­: Гљstav organickej chГ©mie a biochГ©mie (Institute of Organic Chemistry and
Biochemistry), Flemingovo nГЎm. 2, 166 10 Prague 6, Czech Republic, (RNDr. Lenka MaletinskГЎ,
CSc. A Ing. Blanka ЕЅeleznГЎ, CSc)
PharmDr. Zdenko PirnГ­k, PhD
Pracovisko v zahraniДЌГ­: Гљstav organickej chГ©mie a biochГ©mie (Institute of Organic Chemistry and
Biochemistry), Flemingovo nГЎm. 2, 166 10 Prague 6, Czech Republic, (RNDr.
Lenka MaletinskГЎ, CSc., Ing. Blanka ЕЅeleznГЎ, CSc
4.1. MedzinГЎrodnГ© vedeckГ© podujatia
4.1.1. MedzinГЎrodnГ© vedeckГ© podujatia, ktorГ© organizГЎcia SAV organizovala v roku 2013
alebo sa na ich organizГЎcii podieДѕala, s vyhodnotenГ­m vedeckГ©ho a spoloДЌenskГ©ho prГ­nosu
podujatia
XXIII. DiabetologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, Slovensko, 12.06.-14.06.2013
SlovenskГЎ
lekГЎrska
spoloДЌnosЕҐ,
SlovenskГЎ
diabetologickГЎ
spoloДЌnosЕҐ
v
spoluprГЎci
s
Гљstavom
experimentГЎlnej
endokrinolГіgie
VГЎs
pozГЅvajГє
na
XXIII.
DiabetologickГ©
dni
s
medzinГЎrodnou
ГєДЌasЕҐou
12.
–
14.
jГєn
2013,
Hotel
DoubleTree
by
Hilton,
Bratislava
4.1.2. MedzinГЎrodnГ© vedeckГ© podujatia, ktorГ© usporiada organizГЎcia SAV v roku 2014
(anglickГЅ a slovenskГЅ nГЎzov podujatia, miesto a termГ­n konania, meno, telefГіnne ДЌГ­slo a e-mail
zodpovednГ©ho pracovnГ­ka)
4.1.3. PoДЌet pracovnГ­kov v programovГЅch a organizaДЌnГЅch vГЅboroch medzinГЎrodnГЅch
konferenciГ­
TabuДѕka 4a ProgramovГ© a organizaДЌnГ© vГЅbory medzinГЎrodnГЅch konferenciГ­
Typ vГЅboru
ProgramovГЅ
OrganizaДЌnГЅ
ProgramovГЅ i organizaДЌnГЅ
3
4
3
PoДЌet ДЌlenstiev
4.2. ДЊlenstvo a funkcie v medzinГЎrodnГЅch orgГЎnoch
4.2.1. ДЊlenstvo a funkcie v medzinГЎrodnГЅch vedeckГЅch spoloДЌnostiach, ГєniГЎch a nГЎrodnГЅch
komitГ©toch SR
34
SprГЎva o ДЌinnosti organizГЎcie SAV
Mgr. Stanislav Babic, PhD.
ДЊeskГЎ neuropsychofarmakologicГЎ spoloДЌnosЕҐ (funkcia: ДЌlen - volenГ© ДЌlenstvo)
Mgr. Zuzana BaДЌovГЎ, PhD.
European Peptide Society (funkcia: ДЌlen)
RNDr. JГЎn BakoЕЎ, PhD.
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
European Peptide Society (funkcia: ДЌlen)
Federation of European Neuroscience Societies (funkcia: ДЌlen
Ing. JГєlius Brtko, DrSc.
ДЊeskГЎ a SlovenskГЎ neurochemickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
European Peptide Society (funkcia: ДЌlen)
European Thyroid Association ETA (funkcia: člen – volené členstvo)
Mgr. Veronika DanevovГЎ
ДЊeskГЎ neuropsychofarmakologicГЎ spoloДЌnosЕҐ (funkcia: ДЌlen - volenГ© ДЌlenstvo)
RNDr. Robert FarkaЕЎ, CSc.
Genetics Society of America (funkcia: ДЌlen)
Mgr. Lucia GajdoЕЎechovГЎ
European Peptide Society (funkcia: ДЌlen)
Mgr. Daniela GaЕЎperГ­kovГЎ, CSc.
EurГіpska asociГЎcia pre ЕЎtГєdium diabetu EASD (funkcia: ДЌlen)
MedzinГЎrodnГЎ diabetologickГЎ federГЎcia IDF (funkcia: ДЌlen)
EurГіpska spoloДЌnosЕҐ pre humГЎnnu genetiku ASHG (funkcia ДЌlen)
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen - volenГ© ДЌlenstvo)
The Physiological Society (funkcia: ДЌlen)
RNDr. Miroslava HuДЌkovГЎ
EurГіpska spoloДЌnosЕҐ pre humГЎnnu genetiku ASHG (funkcia ДЌlen)
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
Academia Europaea (funkcia: ДЌlen)
Collegium Internationale Neuro-Psychopharmacologicum CINP (funkcia: ДЌlen)
ДЊeskГЎ a SlovenskГЎ NeurochemickГЎ spoloДЌnosЕҐ (funkcia: podpredseda)
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: vedeckГЅ tajomnГ­k vГЅboru)
European Neurochemical Society (funkcia: ДЌlen)
European Peptide Society (funkcia: ДЌlen)
Regional Central/Eastern Europe CINP (funkcia: ДЌlen vГЅboru)
doc. Ing. Jana JurДЌoviДЌovГЎ, CSc
European Peptide Society (funkcia: ДЌlen)
International Society for Neuroimmunomodulation (funkcia: ДЌlen)
RNDr. Alexander Kiss, DrSc.
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
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SprГЎva o ДЌinnosti organizГЎcie SAV
prof. MUDr. Iwar KlimeЕЎ, DrSc
AmerickГЎ diabetologickГЎ spoloДЌnosЕҐ ADA (funkcia: ДЌlen)
EurГіpska asociГЎcia pre ЕЎtГєdium diabetu EASD (funkcia: ДЌlen)
EurГіpska federГЎcia nГЎrodnГЅch endokrinologickГЅch spoloДЌnostГ­ EFES (funkcia: ДЌlen)
FederГЎcia dunajskГЅch sympГіziГ­ o diabetes mellitus FID (funkcia: ДЌlen medzinГЎrodnГ©ho
organizaДЌnГ©ho vГЅboru)
MedzinГЎrodnГЎ diabetologickГЎ federГЎcia IDF (funkcia: ДЌlen)
MedzinГЎrodnГЎ endokrinologickГЎ spoloДЌnosЕҐ ISE (funkcia: ДЌlen)
EurГіpska spoloДЌnosЕҐ pre humГЎnnu genetiku ASHG (funkcia ДЌlen)
Ing. KatarГ­na KrЕЎkovГЎ, PhD.
European Peptide Society (funkcia: ДЌlen)
Mgr. Ivica MaЕЎindovГЎ
EurГіpska spoloДЌnosЕҐ pre humГЎnnu genetiku ASHG (funkcia ДЌlen)
doc. MUDr. Boris Mravec, PhD.
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
European Association for Cancer Research (funkcia: ДЌlen)
MVDr. KatarГ­na OndiДЌovГЎ, PhD.
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
MUDr. Adela PenesovГЎ, PhD
European Society of Hypertension (funkcia: ДЌlen)
Mgr. Michal Pokusa
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen - volenГ© ДЌlenstvo)
Mgr. Barbora ProkopovГЎ
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen - volenГ© ДЌlenstvo)
PharmDr. Zdenko PirnГ­k, PhD.
ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
MUDr. VladimГ­r Е trbГЎk, DrSc.,
Internationa Society for Pathophysiology – Council member
European Peptide Society (funkcia: ДЌlen)
MUDr. Barbara UkropcovГЎ, PhD.
ДЌlenka EurГіpskej AsociГЎcie pre Е tГєdium Obezity (EASO) zastupovala ObezitologickГє sekciu
Slovenskej Diabetologickej SpoloДЌnosti, zasadnutГ­ riadiaДЌeho vГЅboru EASO, Liverpool, UK
Mgr. Lucia ValentГ­novГЎ
EurГіpska asociГЎcia pre ЕЎtГєdium diabetu EASD (funkcia: ДЌlen)
EurГіpska spoloДЌnosЕҐ pre humГЎnnu genetiku ASHG (funkcia ДЌlen)
Ing. Е tefan Zorad, CSc.
European Peptide Society (funkcia: ДЌlen)
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SprГЎva o ДЌinnosti organizГЎcie SAV
4.3. ГљДЌasЕҐ expertov na hodnotenГ­ medzinГЎrodnГЅch projektov (EГљ RP, ESF a inГЅch)
TabuДѕka 4b Experti hodnotiaci medzinГЎrodnГ© projekty
Meno pracovnГ­ka
Imrich Richard
Miroslav VlДЌek
JeЕѕovГЎ Daniela
Typ programu/projektu/vГЅzvy
ESF CSP-Naples
SAV - NSC (Taiwan)
ERC - Starting Grants
FP7-PEOPLE-2013-Fellowships
PoДЌet
hodnotenГЅch
projektov
10
10
30
21
4.4. NajvГЅznamnejЕЎie prГ­nosy MVTS Гєstavu vyplГЅvajГєce z mobility a
medzinГЎrodnГЅch projektov a inГ© informГЎcie k medzinГЎrodnej vedeckej spoluprГЎci
rieЕЎenia
V roku 2013 Гљstav experimentГЎlnej endokrinolГіgie SAV participoval na rieЕЎenГ­ mnohГЅch
vГЅznamnГЅch multilaterГЎlnych ako aj bilaterГЎlnych projektoch v rГЎmci medzinГЎrodnej vedeckotechnickej spoluprГЎce (MVTS).
V rГЎmci spoluprГЎce s MVDr. E. Nagyovou, CSc. (Гљstav ЕѕivoДЌГ­ЕЎnГ© fyziolГіgie a genetiky
AVДЊR, LibД›chov, ДЊR) Mgr. SoЕ€a ScsukovГЎ, CSc. so svojimi spolupracovnГ­kmi ЕЎtudujГє
molekulГЎrne mechanizmy parakrinnej regulГЎcie ovariГЎlnych intrafolikulГЎrnych procesov (maturГЎcia
oocytu, steroidogenГ©za) pГґsobenГ­m faktorov lokГЎlne produkovanГЅch ovariГЎlnymi bunkami na
modeli primГЎrnej kultГєry oocyt-kumulГЎrnych komplexov (OCC) a granulГіznych buniek
izolovanГЅch z ovГЎriГ­ oЕЎГ­panГЅch. SledovanГ© procesy sГє nevyhnutnГ© pre ГєspeЕЎnГє fertilizГЎciu, preto
naЕЎe vГЅsledky mГґЕѕu byЕҐ prГ­nosom v ЕЎtГєdiu molekulГЎrnych mechanizmov prГ­ДЌin infertility Еѕien.
RieЕЎenie bilaterГЎlneho projektu s nГЎzvom: Interakcia vГЅЕѕivy a oxytocГ­nu vo vzЕҐahu k
neuroendokrinnГЅm, metabolickГЅm a kardiovaskulГЎrnym funkciГЎm (zodpovednГЅ rieЕЎiteДѕ: prof.
PharmDr. D. JeЕѕovГЎ, DrSc.) s vedeckГЅmi ustanovizЕ€ami na Taiwane prinieslo vГЅsledky
tГЅkajГєcich sa chronickГ©ho stresu na tkanivГЎ podieДѕajГєce sa na syntГ©ze a odbГєravanГ­
lipoproteГ­novГЅch molekГєl. Vystavenie stresu malo za nГЎsledok pokles aktivity lipoproteГ­novej
lipГЎzy (LPL) v tukovom tkanive, ktorГЎ sa podieДѕa na uskladnenГ­ mastnГЅch kyselГ­n. ZaujГ­mavГ©
pГґvodnГ© nГЎlezy sa zГ­skali pri skГєmanГ­ vplyvu stresu a atosibanu a antagonistu oxytocГ­nu na Гєrovni
nadobliДЌky, pri ktorom sa vyuЕѕili metodickГ© prГ­stupy taiwanskГЅch partnerov.
PokraДЌovalo sa v spoluprГЎci s Neurobiologickou vГЅskumnou jednotkou Univerzitnej nemocnice,
KodaЕ€ a Гљstav translaДЌnej neurobiolГіgie, Ballerup, DГЎnsko (Neurobiology Research Unit,
University Hospital Copenhagen, Denmark; Department of Translational Neurobiology,
NeuroSearch A/S, Ballerup, Denmark, (Dr. A.Kiss, DrSc./Dr. J.D. Mikkelsen).
V spolupráci s „Pediatric and Reproductive Endocrinology Branch, National Institute of
Child and Human Development“, NIH, Bethesda, USA sa ďalej úspešne pokračovalo v riešení
projektu: Biomarkery pre skorГє detekciu a terapiu nГЎdorov nadobliДЌky: MolekulГЎrna
patogenГ©za a klinickГ© korelГЎty. ZvieracГ­ model metastatickГ©ho feochromocytГіmu dГЎva tak
jedineДЌnГє prГ­leЕѕitosЕҐ pre predklinickГ© hodnotenie lieДЌby rakoviny rГґznymi liekmi, radiofarmakami,
a rГґznymi zobrazovacГ­mi technikami. Tento model je obzvlГЎЕЎЕҐ uЕѕitoДЌnГЅ pre ЕЎtГєdium fyziolГіgie
metastatickГ©ho feochromocytГіmu Doc. MUDr. B. Mravec, PhD./Prof. K. PacГЎk)
V rГЎmci rieЕЎenia ДЏalЕЎieho bilaterГЎlneho projektu s vedeckГЅmi ustanovizЕ€ami na Taiwane sa
sledoval vplyv podГЎvania agonistu PPARgama pioglitazГіnu na vГЅvoj hypertenzie a metabolickГ©
parametre SHR potkanov (Dr. Е . Zorad, CSc.).
Pokračovalo sa v spolupráci s „European Foundation for the Study of Diabetes“ v rámci
ktorej sa raelizovala pilotnГЎ ЕЎtГєdia, zameranГЎ na zmeny profilu svalovo ЕЎpecifickГЅch mikroRNA
v cerebrospinГЎlnom likvore ГєДЌinkom akГєtnej fyzickej zГЎЕҐaЕѕe u trГ©novanГЅch zdravГЅch jedincov (Dr.
B. UkropcovГЎ, PhD.).
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SprГЎva o ДЌinnosti organizГЎcie SAV
Е irokГЅ tematickГЅ zГЎber rieЕЎenia vedeckГЅch problГ©mov ako aj adekvГЎtny metodickГЅ potenciГЎl
pracoviska tvorili i v roku 2013 seriГіzny zГЎklad pre ГєДЌasЕҐ viacerГЅch vedecko-vГЅskumnГЅch tГ­mov
pracoviska v spoluprГЎci s renomovanГЅmi vedeckГЅmi pracoviskami v krajinГЎch EurГіpskej Гљnie, v
USA a v ГЃzii.
PrehДѕad Гєdajov o medzinГЎrodnej mobilite pracovnГ­kov organizГЎcie je uvedenГЅ v PrГ­lohe E.
PrehДѕad a Гєdaje o medzinГЎrodnГЅch projektoch sГє uvedenГ© v kapitole 2 a PrГ­lohe B.
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SprГЎva o ДЌinnosti organizГЎcie SAV
5. VednГЎ politika
ГљEE SAV ako jedno z najlepЕЎГ­ch pracovГ­sk SAV si konЕЎtantne udrЕѕuje vysokГє ГєroveЕ€ v poДЌte
a v kvalite publikГЎciГ­ ako aj v citovanosti. V roku 2013 bolo publikovanГЅch 35 impaktovanГЅch
publikácií (v roku 2013 – 34) s priemerným IF 2,96 (v roku 2012 – 3,59), pričom priemerný IF
prvých desiatich najlepších publikácií bol 4,61 (v roku 2012 – 5,50). Je však potrebné spomenúť
nerovnomernГЅ prГ­spevok jednotlivГЅch laboratГіriГ­ k celkovej publikaДЌnej aktivite Гєstavu.
Po nГЎstupe novГ©ho vedenia ГљEE SAV sa sГєДЌasne ДЌrtГЎ aj nГЎstup novej generГЎcie vedГєcich
jednotlivГЅch laboratГіriГ­. PovaЕѕujeme za pozitГ­vne spojenie ambicioznej mladej generГЎcie vedcov
s generГЎciou skГєsenГЅch a vo svete uznГЎvanГЅch vedeckГЅch pracovnГ­kov a verГ­me, Еѕe prinesie ДЏalЕЎie
zvГЅЕЎenie kvality vedeckГ©ho bГЎdania a publikaДЌnej aktivity.
V blГ­zkej budГєcnosti ДЌakajГє ГљEE SAV nasledovnГ© vГЅzvy:
-transformГЎcia inЕЎtitГєcie na VVI
-sЕҐahovanie sa do novГЅch priestorov v budove PavilГіnu lekГЎrskych vied, SAV
-spájanie sa laboratórií v rámci ÚEE ako aj v rámci príbuzných ústavov do väčších celkov
-čo najväčšia účasť vo výzvach rámci Horizon 2020
Vedenie Гєstavu spolu s Vedeckou radou ГљEE SAV vyvinГє maximГЎlne Гєsilie, aby sme
v spomenutГЅch vГЅzvach ГєspeЕЎne obstГЎli t.j. aby sme sa do novej budovi sЕҐahovali ako organizГЎcia
organizaДЌne, vedecky a finaДЌne plne konsolidovanГЎ a schopnГЎ obstГЎЕҐ v ЕЎirЕЎej konkurencii. JednГЅm
z nГЎstrojov zvyЕЎovania kvality vedeckej prГЎce bude rozЕЎГ­renie vysielania ukonДЌenГЅch doktorandov
na dlhodobГ© ЕЎtudijnГ© pobyty na kvalitnГ© zahraniДЌnГ© pracoviskГЎ a prirodzenГ© spГЎjanie jednotlivГЅch
laboratórií na základe príbuznosti riešenej problematiky s cielom uspieť s väčšími spoločnými
projektami vo vГЅzvach domacich a zahraniДЌnГЅch grantovГЅch agentГєr.
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SprГЎva o ДЌinnosti organizГЎcie SAV
6. SpoluprГЎca s univerzitami/vysokГЅmi ЕЎkolami, ЕЎtГЎtnymi a neziskovГЅmi
inЕЎtitГєciami okrem aktivГ­t uvedenГЅch v kap. 2, 3, 4
6.1. SpoluprГЎca s univerzitami/VЕ (fakultami)
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: Fakulta chemickej a potravinГЎrskej technolГіgie,
STU Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): nezmluvnГЎ spoluprГЎca
RNDr. JГЎn BakoЕЎ, PhD. (LaboratГіrium neurohumorГЎlnych regulГЎciГ­)
ZaДЌiatok spoluprГЎce: januГЎr 2012
Zameranie: FluorescenДЌnГЎ mikroskopia fixovanГЅch neuronГЎlnych buniek
Zhodnotenie: V roku 2013 sme pokraДЌovali v spoluprГЎci s doc. PaulГ­kovou z FCHPT, STU
zameranГє na hodnotenie morfolГіgie neuroblastГіmovГЅch a glioblastГіmovГЅch
buniek pod vplyvom ligandov oxytocГ­novГЅch receptorov. TГЎto spoluprГЎca sa rozЕЎГ­rila na vedenie
bakalГЎrskej prГЎce A. Reichovej, ktorГЎ vykonГЎva experimenty na oboch spolupracujГєcich
inЕЎtitГєciГЎch.
PublikГЎcia:
BAKOS, Jan – STRBAK, Vladimir – PAULIKOVA, Helena – KRAJNAKOVA, Lucia –
LESTANOVA, Zuzana – BACOVA, Zuzana. Oxytocin receptor ligands induce changes in
cytoskeleton in neuroblastoma cells. In Journal of Mollecular Neuroscience. 2013; vol. 50, n. 3, pp.
462-468
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: LekГЎrska fakulta, UK, Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): spoluprГЎca na projekte APVV
RNDr. JГЎn BakoЕЎ, PhD. (LaboratГіrium neurohumorГЎlnych regulГЎciГ­)
ZaДЌiatok spoluprГЎce: mГЎj 2010
Zameranie: Projekt sa zaoberГЎ autistickГЅmi pacientami.
Zhodnotenie: V roku 2013 sme pokraДЌovali v spoluprГЎci s FyziologickГЅm Гєstavom pod vedenГ­m
Prof. MUDr.OstatnГ­kovej, PhD.
PublikГЎcia:
HUSÁROVÁ, Veronika–– LAKATOŠOVÁ Silvia–– PIVOVARČIOVÁ, Anna–– BAKOŠ, Ján––
DURDIAKOVÁ, Jaroslava–– KUBRANSKÁ, Aneta–– OSTATNÍKOVÁ, Daniela. Brief report:
Plasma oxytocin is lower in children with Asperger syndrome and associated with autistic trait
attention to detail Open Journal of Psychiatry, 3, 399-402 (B)
NГЎzov univerzity/vysokej ЕЎkoly a fakulty:
Technische Universität, Dresden, Nemecko
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): nezmluvnГЎ spoluprГЎca
Ing. JГєlius Brtko, DrSc., Mgr. Dana MacejovГЎ, PhD
LaboratГіrium molekulovej endokrinolГіgie
ZaДЌiatok spoluprГЎce: 2013
Zameranie: MNU-aktivovanГЎ karcinogenГ©za mlieДЌnej ЕѕДѕazy u potkana
Zhodnotenie: Mgr. Dana MacejovГЎ, PhD. aktГ­vne participovala pri organizovanГ­ a uskutoДЌnenГ­
experimentov na potkanoch kmeЕ€a Sprague-Dawley.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty:
PrГ­rodovedeckГЎ fakulta Univerzity PalackГ©ho v Olomouci, ДЊeskГЎ republika
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): nezmluvnГЎ spoluprГЎca
Ing. JГєlius Brtko, DrSc., Ing. Lucia BialeЕЎovГЎ
LaboratГіrium molekulovej endokrinolГіgie
40
SprГЎva o ДЌinnosti organizГЎcie SAV
ZaДЌiatok spoluprГЎce: 2013
Zameranie: Experimenty na transfekovanГЅch stabilnГЅch lГ­niГЎch buniek
Zhodnotenie: Ing. Lucia BialeЕЎovГЎ aktГ­vne participovala pri uskutoДЌnenГ­ in vitro experimentov s
cieДѕom sledovania ГєДЌinkov izoflavГіnov a organocГ­novГЅch zlГєДЌenГ­n
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: FarmaceutickГЎ fakulta UK
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): VEGA grant
RNDr. MГЎria FickovГЎ, PhD.
ZaДЌiatok spoluprГЎce: 2011
Zameranie: SkrГ­ning biologickГЅch aktivГ­t vybranГЅch druhov lieДЌivГЅch rastlГ­n a identifikГЎcia ich
aktГ­vnych zloЕѕiek
Zhodnotenie: Hodnotila sa biologickГЎ aktivita, t.j. antiproliferaДЌnГЅ ГєДЌinok/toxicita lyofilizГЎtov
vodnГЅch extraktov listov Cornus pendula a, Cornus kousa (Cornaceae) na ДѕudskГЅch nГЎdorovГЅch
bunkГЎch prsnГ­ka (lГ­nia MCF7). Rast inhibiДЌnГЅ ГєДЌinok sa menГ­ v zГЎvislosti od ДЌasu expozГ­cie
a dГЎvky, priДЌom aktivity jednotlivГЅch extraktov sa vГЅrazne medzi sebou lГ­ЕЎia.
AntiproliferaДЌnГє/cytotoxickГє ГєДЌinnosЕҐ vyjadruje hodnota ED50, jej niЕѕЕЎia hodnota znamenГЎ vyЕЎЕЎiu
aktivitu. V naЕЎich podmienkach bol v kaЕѕdom ДЌasovom intervale: 24h, 48h a 72h, bol z oboch
testovanГЅch ГєДЌinnejЕЎГ­ extrakt Cornus kousa(vs. C. pendula).
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: Katedra ЕѕivoДЌГ­ЕЎnej fyziolГіgie a etolГіgie,
PrГ­rodovedeckГЎ fakulta UK, Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
RNDr. Alexander Kiss, DrSc. (LaboratГіrium funkДЌnej neuromorfolГіgie)
ZaДЌiatok spoluprГЎce: 2012
Zameranie: PokraДЌovali sme v sledovanГ­ distribГєcie melatonГ­novГЅch (MT1) receptorov a
katecholamГ­nov (TH imunoreaktivity) v cievach normГЎlnych a hypertenznГЅch potkanov (Mgr. ДЅ.
MolДЌan z Katedry ЕѕivoДЌГ­ЕЎnej fyziolГіgie a etolГіgie, PriF UK v Bratislave, vedГєci katedry prof.
RNDr. Michal Zeman, DrSc.). CieДѕom ЕЎtГєdia je objasnenie skutoДЌnosti ДЌi dochГЎdza ku kolokalizГЎcii
MT1 a TH v mezenteriГЎlnej artГ©rii a hrudnej aorte u normГЎlnych a hypertenznГЅch potkanov.
Zhodnotenie: V roku 2012 sme zaДЌali spoluprГЎcu na horeuvedenГє tГ©mu a v rГЎmci tohto vГЅskumu
sme vyЕЎetrovali vГЅskyt MT1 a TH v mezenteriГЎlnej artГ©rii a hrudnej aorte u normГЎlnych a
hypertenznГЅch potkanov. PredbeЕѕnГ© vГЅsledky naЕЎich spoloДЌnГЅch vГЅsledkov naznaДЌujГє moЕѕnosЕҐ
kolokalizГЎcie MT1 s TH ДЌo by znamenal novГЅ pohДѕad na regulГЎciu tГЅchto ciev.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: Гљstav histolГіgie a embryolГіgie, LekГЎrska fakulta UK,
Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
ZaДЌiatok spoluprГЎce: 2007
RNDr. Alexander Kiss, DrSc. (LaboratГіrium funkДЌnej neuromorfolГіgie)
Zameranie: PokraДЌovanie v ЕЎtГєdiu o priestorovom rozmiestnenГ­ a vzЕҐahov ciev v slezine ДЌloveka.
Zhodnotenie: V roku 2007 zaДЌala spoluprГЎca s MUDr. PaulГ­nou GГЎlfiovou z Гљstavu histolГіgie a
embryolГіgie LF UK (doc. MUDr. Е tefan POLГЃK, CSc.) Bratislava v problematike vГЅskumu
mikroЕЎtruktГєry Дѕudskej sleziny a jej zmien vo vybranГЅch ochoreniach. V roku 2013 pokraДЌovala
spolupráca opäť zameraná hlavne na získavanie ľudského materiálu pre ďalšie spoločné štúdie na
Гєrovni konfokГЎlneho mikroskopu a prГ­prava podkladov pre publikГЎcie.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: PsychiatrickГЎ klinika LF UK a UN, Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
ZaДЌiatok spoluprГЎce: 2013
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SprГЎva o ДЌinnosti organizГЎcie SAV
RNDr. Alexander Kiss, DrSc. (LaboratГіrium funkДЌnej neuromorfolГіgie)
Zameranie: V roku 2013 sme otvorili ЕЎtГєdium o ГєДЌinku antipsychotГ­k vo vzЕҐahu k jemnГ©mu
chronickГ©ho stresu. Zamerali na azenapГ­n (AZE), pomerne mГЎlo ЕЎtudovanГє lГЎtku v
experimentГЎlnych modeloch. NaЕЎim cieДѕom bolo a je zistiЕҐ do akej miery mГґЕѕe mierny opakovanГЅ
stres po dobu 21 dnГ­ interferovaЕҐ s centrГЎlnym ГєДЌinkom AZE.
Zhodnotenie: NovГЎ spoluprГЎca s Doc. MUDr. JГЎnom PeДЌeЕ€ГЎkom, CSc., prednostom Psychiatrickej
kliniky LF UK a UN, priniesla prvГ© predbeЕѕnГ© vГЅsledky o centrГЎlnom ГєДЌinku AZE. V roku 2013
sme vyЕЎetrovali expresiu Fos proteГ­nu v neurГіnoch prednГ©ho mozgu v oblastiach septa, striata,
prefrontГЎlneho kortexu a nucleus accumbens po jeho jednorazovom podanГ­. Tieto predbeЕѕnГ©
vГЅsledky ukГЎzali na veДѕmi nerovnomernГє distribГєciu efektu AZE v ЕЎtudovanГЅch oblastiach. Na
zГЎklade tГЅchto predbeЕѕnГЅch vГЅsledkov sa ukazuje, Еѕe tГЎto tГ©ma mГґЕѕe priniesЕҐ originГЎlne vГЅsledky a
preto budeme pokraДЌovaЕҐ v ДЏalЕЎom obdobГ­.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: LekГЎrska fakulta UK
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): rieЕЎenie grantu APVV
Doc. MUDr. Boris Mravec, PhD. (LaboratГіrium neurobiolГіgie)
ZaДЌiatok spoluprГЎce: mГЎj 2011
Zameranie: rieЕЎenie grantu APVV
Zhodnotenie: V roku 2013 sme s pracovnГ­kmi Гљstavu patologickej fyziolГіgie pokraДЌovali v rieЕЎenГ­
problematiky neurobiolГіgie nГЎdorovГЅch chorГґb.
SkГєmala sa Гєloha hypotalamickГ©ho zГЎpalu pri vzniku nГЎdorovej kachexie. Pri zvolenom nГЎdorovom
modeli sme nepozorovali vГЅraznejЕЎie zГЎpalovГ© zmeny na Гєrovni hypotalamu, ДЌo naznaДЌuje, Еѕe
rozdielne nГЎdory mГґЕѕu podmieЕ€ovaЕҐ nГЎdorovГє kachexiu rozliДЌnГЅmi mechanizmami.
PublikГЎcie:
Lackovicova L, Gaykema RP, Banovska L, Kiss A, Goehler LE, Mravec B. The time-course of
hindbrain neuronal activity varies according to location during either intraperitoneal or
subcutaneous tumor growth in rats: single Fos and dual Fos/dopamine ОІ-hydroxylase
immunohistochemistry. J Neuroimmunol 2013; 260: 37-46.
Banovska L, Lackovicova L, Mravec B. NГЎdorovГЎ kachexia z neurobiologickГ©ho hДѕadiska: vplyv
hypotalamickГ©ho zГЎpalu. Monitor mediciny 2013; 1-2: 9-13.
Mravec B. NervovГЅ systГ©m: patofyziolГіgia. SAP, Bratislava 2013;132 s.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: StrojnГ­cka fakulta, STU Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): nezmluvnГЎ spoluprГЎca
MUDr. Adela PenesovГЎ, PhD. (LaboratГіrium endokrinolГіgie ДЌloveka)
ZaДЌiatok spoluprГЎce: september 2010
Zameranie: Hodnotenie pulzovej frekvencie po stresovom podnete (ortostГЎze) a hodnotenie
dynamiky ГєДЌinku inzulГ­nu po rozliДЌnГЅch podnetoch napr. poДЌas orГЎlneho toleranДЌnГ©ho testu ДЌi
poДЌas hyperinzulinemickГ©ho euglykemickГ©ho zГЎmku.
Zhodnotenie: V roku 2013 sme s kolektГ­vom prof. Ladislava DedГ­ka z STU hodnotili dynamiku
odpovede inzulГ­nu poДЌas orГЎlneho glukГіzovГ©ho toleranДЌnГ©ho testu ДЌi poДЌas hyperinzulinemickГ©ho
euglykemickГ©ho zГЎmku ako aj matematickГ© modelovanie stresovej odpovede na ortostГЎzu. KolektГ­v
prof. DedГ­ka vyvinul novГ© modely na ich hodnotenie.
PublikГЎcie:
HlavГЎДЌovГЎ E, ChrenovГЎ J, RausovГЎ Z, VlДЌek M, PenesovГЎ A, DedГ­k L. Identification of regulatory
mechanism of orthostatic response. World Academy of Science, Engineering and Technology
2013;77:715-721. ISSN 2010-376X.
HlavГЎДЌovГЎ E, ChrenovГЎ J, RausovГЎ Z, VlДЌek M, PenesovГЎ A, DedГ­k L, MatematickГЅ nГЎstroj
v modelovanГ­ biologickГ©ho procesu nameranГЅch veliДЌГ­n ortostatickГ©ho testu. AutomatizГЎcia
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SprГЎva o ДЌinnosti organizГЎcie SAV
a riadenie v teГіrii a praxi, ARTEP 2013, Workshop, StarГЎ LesnГЎ. PublikГЎcia v zbornГ­ku 09-1- 09-7
ISBN 978-80-553-1330-6
NГЎzov univerzity/vysokej ЕЎkoly a fakulty:
Fakulta telesnej vГЅchovy a ЕЎportu Univerzity KomenskГ©ho v Bratislave
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
MUDr. Barbara UkropcovГЎ, PhD., Mgr. Jozef Ukropec, PhD. (Sekcia obezity, LaboratГіrium diabetu
a porГєch metabolizmu)
ZaДЌiatok spoluprГЎce: 2011
Zameranie: Šport a zdravie – Vplyv pohybovej aktivity na metabolické zdravie človeka.
Zhodnotenie: PokraДЌovanie veДѕmi aktГ­vnej spoluprГЎce s Katedrou kinantropolГіgie FTVЕ v Bratislave (prof. Mgr. Erika ZemkovГЎ, PhD, Mgr. Milan Sedliak, PhD; Prof. DuЕЎan Hamar, PhD,
Doc OДѕga KyseloviДЌovГЎ, PhD), spojenГ© s ГєspeЕЎnГЅm ukonДЌenГ­m ЕЎtГєdie EurГіpskej federГЎcie na
vГЅskum diabetu, zameranej na ГєДЌinky trojmesaДЌnГ©ho trГ©ningovГ©ho programu na metabolickГ©
zdravie jedincov so sedavГЅm spГґsobom Еѕivota. V spoluprГЎci s FTVЕ sa eЕЎte na rozhranГ­ rokov
2012/2013 realizoval trГ©ningovГЅ program ako aj komplexnГЎ kinantropologickГЎ a silovГЎ
fenotypizГЎcia jedincov pred a po uskutoДЌnenГ­ trГ©ningovГ©ho programu. NГЎslednГ© aktivity v roku
2013 boli okrem publikovania zГ­skanГЅch vГЅsledkov spojenГ© so ЕЎtГєdiom odpovede ЕЎpecificky
trГ©novanГЅch jedincov (triatlon vs. cross fit) na akГєtnu proprioceptГ­vne stimulujГєcu zГЎЕҐaЕѕ.
VyЕЎetrenia boli spojenГ© aj s biologickГ©ho materiГЎlu a budГє v plnej miere vyhodnotenГ© na zaДЌiatku
roka 2014. SpoluprГЎca bola do roku 2013 podporovanГЎ vГЅhradne grantom EFSD & Lilly
(zodpovednГЎ rieЕЎiteДѕka MUDr. Barbara UkropcovГЎ, PhD) a nepriamo v rГЎmci projektu VEGA
“Účinok vytrvalostného a silového tréningu na sekrečný profil a charakteristiky kostrového svalu a
primárnych bunkových kultúr kostrového svalu u obéznych prediabetikov.” (zodpovedná riešiteľka
MUDr. Barbara UkropcovГЎ, PhD). ZГЎujem o ДЏalЕЎiu aktГ­vnu spoluprГЎce s FTVЕ pri uskutoДЌЕ€ovanГ­
trГ©ningovГЅch ЕЎtГєdiГ­ podnietil vznik ДЏalЕЎГ­ch grantovГЅch podanГ­ v roku 2013 (APVV a Taiwan NSCSAV).
NГЎzov univerzity/vysokej ЕЎkoly a fakulty:
Eidgenössische Technische Hochschule Zürich - ETH, Zurich, Švajčiarsko
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
Mgr. Jozef Ukropec, PhD., MUDr. Barbara UkropcovГЎ, PhD.
(Sekcia obezity, LaboratГіrium diabetu a porГєch metabolizmu)
ZaДЌiatok spoluprГЎce: 2010
Zameranie: EndokrinnГЎ aktivita a mikroRNA profil kostrovГ©ho svalu vo vzЕҐahu
k metabolickГ©mu zdraviu a patogenГ©ze diabetu 2. typu
Zhodnotenie: NaЕЎa spoluprГЎca s profesorom Christianom Wolfrumom podporovanГЎ spoloДЌnГЅmi
zГЎujmami v oblasti vГЅskumu a energetickГ©ho metabolizmu uЕѕ v minulosti viedla k veДѕmi
zaujГ­mavГЅm zisteniam, ktorГ© boli publikovanГ© v renomovanГЅch zahraniДЌnГЅch ДЌasopisoch (EMBO
Mol Med, Journal of Physiology, Molecular Metabolism). V sГєДЌasnosti spolupracujeme na projekte
zameranom na endokrinnГє aktivitu kostrovГ©ho svalu, ktorГє skГєmame in vitro na modeli primГЎrnych
buniek ДѕudskГ©ho kostrovГ©ho svalu od donorov s rГґznym metabolickГЅm fenotypom. SpoluprГЎca s
ETH nГЎm umoЕѕЕ€uje vyuЕѕiЕҐ prГ­strojovГ© vybavenie a metodiky na in vitro fenotypizГЎciu buniek,
ktorГ© sГє na naЕЎom pracovisku prakticky nedostupnГ© (zobrazovacГ­ systГ©m Opereta od PerkinElmer ДЌi
XF-Extracellular Flux Analyzer od Seahorse Biosciences). V spojenГ­ so skvelГЅm tГ­mom na
pracovisku v ZГјrichu je vГЅznamnГЅm prГ­nosom pre rieЕЎenie naЕЎich vГЅskumnГЅch zГЎmerov. V roku
2013 sme v rГЎmci ЕЎtudijnГ©ho pobytu Mgr Miroslava BalГЎЕѕa (financovanГ©ho NЕ P-SR) ЕЎtudovali
jednak Гєlohu adipokГ­nov (biologicky aktГ­vnych produktov tukovГ©ho tkaniva) pri regulГЎcii
metabolizmu v tukovom tkanive ДЌloveka (publikГЎcie v prГ­prave) a nГЎsledne sme sa zamerali na
ЕЎtГєdium potenciГЎlnej Гєlohy svalovo ЕЎpecifickГЅch miRNA hДѕadiska rozvoja metabolickГЅch ochorenГ­
ako aj ich vzЕҐahu k zmenГЎm spГґsobenГЅm pravidelnГЅm cviДЌenГ­m.
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SprГЎva o ДЌinnosti organizГЎcie SAV
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: ChirurgickГЎ klinika Slovenskej ZU.
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
MUDr. Barbara UkropcovГЎ, PhD., Mgr. Jozef Ukropec, PhD. (Sekcia obezity, LaboratГіrium diabetu
a porГєch metabolizmu)
ZaДЌiatok spoluprГЎce: 2007
Zameranie: VГЅznam tukovГ©ho tkaniva a kostrovГ©ho svalu v patogenГ©ze obezity a inzulГ­novej
rezistencie.
Zhodnotenie: Aj v roku 2013 pokraДЌovala mimoriadne ГєspeЕЎnГЎ spoluprГЎca s MUDr. Marekom
Vicianom, PhD a prof. MUDr. Jurajom OlejnГ­kom, CSc zameranГЎ na ЕЎtГєdium Гєlohy lipidov
v patogenГ©ze diabetu 2. typu ako aj na ЕЎpecifickГ© ГєДЌinky pravidelnej pohybovej aktivity u aerГіbne a
silovo trГ©novanГЅch jedincov na metabolickГ© a funkДЌnГ© charakteristiky kostrovГ©ho svalu. SpoluprГЎca
s Chirurgickou klinikou nГЎm v minulosti umoЕѕnila zavedenie biopsie ДѕudskГ©ho kostrovГ©ho svalu
(m. vastus lateralis) pomocou Bergstromovej ihly (2007), ktorГЎ sa v sГєДЌasnosti vyuЕѕГ­va aj na odber
vzoriek svalu od pacientov za ГєДЌelom diagnostiky neuromuskulГЎrnych a muskulГЎrnych ochorenГ­.
TГєto techniku samozrejme hojne vyuЕѕГ­vame v rГЎmci naЕЎich klinickГЅch ЕЎtГєdiГ­, na zГ­skavanie vzoriek
kostrovГ©ho svalu. Okrem toho nГЎm spoluprГЎca s chirurgickou klinikou umoЕѕnila odber vzoriek
subkutГЎnneho a viscerГЎlneho tuku ako aj kostrovГ©ho svalu od morbГ­dne obГ©znych jedincov, ktorГ­
absolvovali chirurgickГЅ laparoskopickГЅ vГЅkon adjustabilnГЎ bandГЎЕѕ ЕѕalГєdka. VГЅsledky tejto
spoluprГЎce boli prezentovanГ© na mnohГЅch domГЎcich aj medzinГЎrodnГЅch odbornГЅch podujatiach.
V sГєДЌasnosti pracujeme na viacerГЅch spoloДЌnГЅch publikГЎciГЎch ako aj na prГ­prave ДЏalЕЎieho
spoloДЌnГ©ho projektu.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: Division of Endocrinology and Metabolism
Department of Medicine III Medical University of Vienna & Centre of Excellence High Field MR,
Dpt. of Radiology AKH, Austria
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): projektovГЎ spoluprГЎca
Mgr. Jozef Ukropec, PhD., MUDr. Barbara UkropcovГЎ, PhD. (Sekcia obezity, LaboratГіrium diabetu
a porГєch metabolizmu)
ZaДЌiatok spoluprГЎce: 2011
Zameranie: ГљДЌinok pravidelnГ©ho cviДЌenia na in vivo metabolizmus kostrovГ©ho svalu vo
vzЕҐahu k metabolickГ©mu zdraviu a patogenГ©ze diabetu 2. typu
Zhodnotenie: V roku 2011 sa zaДЌala mimoriadne zaujГ­mavГЎ spoluprГЎca s dr. Martinom KrЕЎЕЎГЎkom z
LekГЎrskej fakulty univerzity vo Viedni, umoЕѕЕ€ujГєca vyuЕѕitie unikГЎtnej metodiky magnetickej
rezonanДЌnej spektroskopie na sledovanie in vivo metabolickГ©ho obratu v Дѕudskom kostrovom svale.
PilotnГЎ publikГЎcia, v ktorej sa porovnГЎvajГє dva rГґzne metodickГ© prГ­stupy na stanovenie dynamiky
energetického metabolizmu v mitochondriách svalu in vivo s názvom „Interrelation of 31P-MRS
Metabolism Measurements in Resting and Exercised Quadriceps Muscle of Overweight-to-Obese
Sedentary Individuals“ vyšla v časopise NMR in Biomedicine 2013. Výsledky našej spolupráce sa
premietli aj pri vzniku publikГЎcie KurdiovГЎ a spol Journal of Physiology 2013. V roku 2013 sa nГЎm
podarilo zГ­skaЕҐ podporu na projekt cezhraniДЌnej spoluprГЎce s RakГєskom, ktorГЅ vГЅznamne podporГ­
naЕЎe snahy pri ДЏalЕЎom ЕЎtГєdiu energetickГ©ho metabolizmu a fyziologickГЅch mechanizmov spojenГЅch
a metabolickou aktiváciou “hnednutím” tukového tkaniva u človeka.
NГЎzov univerzity/vysokej ЕЎkoly a fakulty: Fakulta chemickej a potravinГЎrskej technolГіgie,
STU Bratislava
Druh spoluprГЎce (spoloДЌnГ© pracovisko alebo inГ©): nezmluvnГЎ spoluprГЎca
MUDr. Miroslav VlДЌek, PhD., MUDr. Adela PenesovГЎ, PhD. (LaboratГіrium endokrinolГіgie
ДЌloveka)
ZaДЌiatok spoluprГЎce: januГЎr 2011
Zameranie: Testovanie glykemickГ©ho indexu zdraviu prospeЕЎnГЅch lГЎtok v Дѕudskom organizme
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SprГЎva o ДЌinnosti organizГЎcie SAV
Zhodnotenie: V roku 2013 sme s kolektГ­vom doc. Е turdГ­ka z FCHPT, STU testovali vplyv zdraviu
prospeЕЎnГЅch lГЎtok na ДѕudskГЅ organizmus a to konkrГ©tne beta glukГЎnu na hladinu glykГ©mie
u ДЌloveka.
PublikГЎcie:
MikuЕЎovГЎ L, PenesovГЎ A, BobrГ­k M, Е turdГ­k E. The role of diet and exercise in obesity prevention.
Slovak Journal of Health Sciences 2013;4(1):33-46
6.2. VГЅznamnГ© aplikГЎcie vГЅsledkov vГЅskumu v spoloДЌenskej praxi alebo vyrieЕЎenie problГ©mu
pre ЕЎtГЎtnu alebo neziskovГє inЕЎtitГєciu
ZadГЎvateДѕ, odberateДѕ, zmluvnГЅ partner: OnkologickГЅ Гєstav sv. AlЕѕbety v Bratislave.
NГЎzov aplikГЎcie/objekt vГЅskumu: Nahradenie sГєpravy ELISA na stanovenie diaminooxidГЎzy
(DAO) rГЎdioenzymatickГЅm stanovenГ­m aktivity DAO pre ГєДЌely diagnostiky histamГ­novej
intolerancie (HIT).
ZaДЌiatok spoluprГЎce: 1.1 2013
StruДЌnГЅ opis aplikГЎcie/vГЅsledku: Z dГґvodu ukonДЌenia vГЅroby ELISA sГєpravy na stanovenie
aktivity DAO sme sa spolupodielali na vypracovanГ­ rГЎdioenzymatickej metodiky stanovenia.
Posledný krok v stanovení aktivity DAO – stanovenie uvoľnenej rádioktivity 3H-pyrrolínu sa
rutinne vykonГЎva v ГљEE SAV s pouЕѕitГ­m meraДЌa beta Еѕiarenia Perkin Elmer TriCarb 2910.
Zhodnotenie : V obdobГ­ od 7.5. 2013 do konca roka 2013 bolo vykonanГЅch 3 282 meranГ­ aktivity
DAO na meraДЌi TriCarb 2910 ДЌo znamenГЎ, Еѕe rovnakГЅ poДЌet pacientov bol vyЕЎetrenГЅ na HIT.
PorovnanГ­m aktivity DAO u pacientov s rГґznym vekom (do 20 rokov, od 20 rokov do 50 rokov
a nad 50 rokov) sa zistilo, Еѕe v slovenskej populГЎcii je najrizikovejЕЎou skupinou pre HIT skupina
pacientov s vekom pod 20 rokov.
Maschkanova E1., DenskГЎ P1., JakubДЌovГЎ E1., ZuzulovГЎ M1., Zorad S2.: Meranie aktivity DAO
v sГ©rach pacientov pri podozrenГ­ na histamГ­novГє intoleranciu. 1OnkologickГЅ Гєstav sv. AlЕѕbety,
Bratislava, 2Гљstav experimentГЎlnej endokrinolГіgie, SAV, Bratislava.
6.3. InГЎ ДЌinnosЕҐ vyuЕѕiteДѕnГЎ pre potreby spoloДЌenskej praxe
45
SprГЎva o ДЌinnosti organizГЎcie SAV
7. SpoluprГЎca s aplikaДЌnou a hospodГЎrskou sfГ©rou okrem aktivГ­t uvedenГЅch v
kap. 2, 3, 4
7.1. SpoloДЌnГ© pracoviskГЎ s aplikaДЌnou sfГ©rou
7.2. Kontraktový – zmluvný výskum (vrátane zahraničných kontraktov)
NГЎzov kontraktu: COLLABORATION CONTRACT
Partner(i): ГљEE SAV a Attoquant Diagnostics GmbH, Vienna, Austria
ZaДЌiatok spoluprГЎce: 24.1. 2013
Ukončenie spolupráce: Objem získaných prostriedkov v bežnom roku (€): 0 ( bezplatný prístup k patentovanej
technolГіgii RAS FINGERPRINTING
StruДЌnГЅ opis vГЅstupu/vГЅsledku: TechnolГіgia RAS FINGERPRINTING je stanovenie mnoЕѕstva
peptidových hormónov (najmä angiotenzíny a oxytocín) najmodernejšiou hmotnostnou
spektrometriou. SpoloДЌne sme vyvinuli technolГіgiu stanovenia endogГ©nnych angiotenzГ­novГЅch
peptidov v tukovom tkanive.
Zhodnotenie: Tento kontrakt nГЎm umoЕѕЕ€uje prГ­stup k ЕЎpiДЌkovej analytickej technolГіgii, ДЌo
bolo vyuЕѕitГ© na analГЅzu angiotenzГ­novГЅch peptidov v sГ©rach pacientov s hypertenziou
sledovanГЅch v ГљEE SAV. Pripravuje sa spoloДЌnГ© podanie projektu v rГЎmci Horizon 2020.
7.3. InГЎ ДЌinnosЕҐ vyuЕѕiteДѕnГЎ pre potreby hospodГЎrskej praxe
46
SprГЎva o ДЌinnosti organizГЎcie SAV
8. Aktivity pre NГЎrodnГє radu SR, vlГЎdu SR, ГєstrednГ© orgГЎny ЕЎtГЎtnej sprГЎvy SR
a inГ© organizГЎcie
8.1. ДЊlenstvo v poradnГЅch zboroch vlГЎdy SR, NГЎrodnej rady SR, ministerstiev SR, orgГЎnoch
EГљ, EP, NATO a pod.
TabuДѕka 8a ДЊlenstvo v poradnГЅch zboroch NГЎrodnej rady SR, vlГЎdy SR, ministerstiev SR, orgГЎnoch
EГљ, EP, NATO a pod.
Meno pracovnГ­ka
NГЎzov orgГЎnu
Funkcia
Mgr. SoЕ€a ScsukovГЎ, CSc NГЎrodnГЅ ЕЎtipendijnГЅ program SR na
ДЌlen vГЅberovej komisie
podporu mobility uchГЎdzaДЌov zo
(menovanГЎ ministrom
zahraniДЌia
ЕЎkolstva SR)
prof. PharmDr. Daniela
JeЕѕovГЎ, DrSc.
SlovenskГЎ komisia pre vedeckГ© hodnosti ДЌlen
prof. PharmDr. Daniela
JeЕѕovГЎ, DrSc.
Akreditačná komisia – poradný orgán
vlГЎdy SR
ДЌlen
prof. PharmDr. Daniela
JeЕѕovГЎ, DrSc.
ALLEA – organizácia Európskych
akadГ©miГ­
viceprezident
Mgr. Jozef Ukropec, PhD.
NГЎrodnГЅ ЕЎtipendijnГЅ program Slovenskej ДЌlen vГЅberovej komisie
republiky pre ЕЎtipendijnГ© pobyty
(menovanГЅ ministrom
uchГЎdzaДЌov zo Slovenska
ЕЎkolstva)
8.2. ExpertГ­zna ДЌinnosЕҐ a inГ© sluЕѕby pre ЕЎtГЎtnu sprГЎvu a samosprГЎvy
8.3. ДЊlenstvo v radГЎch ЕЎtГЎtnych programov a podprogramov Е PVV a Е O
8.4. PrehДѕad aktuГЎlnych spoloДЌenskГЅch problГ©mov, ktorГ© rieЕЎilo pracovisko v spoluprГЎci s
KancelГЎriou prezidenta SR, s vlГЎdnymi a parlamentnГЅmi orgГЎnmi alebo pre ich potrebu
47
SprГЎva o ДЌinnosti organizГЎcie SAV
9. Vedecko-organizaДЌnГ© a popularizaДЌnГ© aktivity
9.1.Vedecko-popularizaДЌnГЎ ДЌinnosЕҐ
9.1.1. NajvГЅznamnejЕЎia vedecko-popularizaДЌnГЎ ДЌinnosЕҐ pracovnГ­kov organizГЎcie SAV
TabuДѕka 9a Vedecko-popularizaДЌnГЎ ДЌinnosЕҐ pracovnГ­kov organizГЎcie SAV
Miesto
DГЎtum alebo
Meno
Spoluautori
Typ
NГЎzov
zverejnenia
poДЌet za rok
Daniela JeЕѕovГЎ
Daniela JeЕѕovГЎ
RNDr. JГЎn BakoЕЎ,
PhD
MUDr. Adela
PenesovГЎ, PhD.
MUDr. Barbara
UkropcovГЎ, PhD.
MUDr. Barbara
UkropcovГЎ, PhD.
Mgr. Jozef
Ukropec, PhD.
Гљstredie
Depresia a
slovenskej
PB
stres – vieme
kresЕҐanskej
sa brГЎniЕҐ?
inteligencie, Quo
vadis, Bratislava
NominovanГЎ
v ДЌitateДѕsko STV1, STV2,
PB, TL, TV, divГЎckej
ankete
Slovenka, Internet
IN
Slovenka roka
2013
HormГіny
1. SГєkromnГ©
IN
v naЕЎom tele
GymnГЎzium,
Bratislava
TV MarkГ­za,
IN ,TV
UmelГ© sladidlГЎ
Reflex
MetamorfГіza
tukovГ©ho
tkaniva : ДЏalЕЎГ­ http://www.medipo
IN
prГ­sДѕub
rtal.sk,
rieЕЎenia
obezity
20. EurГіpsky
obezitologickГЅ
Diabetes a obezita
kongres v
TL
RoДЌnГ­k 13, 26, s.
meste Beatles,
105-108, 2013.
Liverpool,
Anglicko
5.3.2013
02-03/2013
15.11.2013
26.06.2013
26.11.2013
Е arm.
http://www.plus
ka.sk/zena/zdra
Cukrovku
vie/cukrovkumГґЕѕete dostaЕҐ mozete-dostat27.11.2013
aj z chГ©mie
aj-z-chemiev potravinГЎch
potravinach.htm
l
IN
1
PB - prednГЎЕЎka/beseda, TL - tlaДЌ, TV - televГ­zia, RO - rozhlas, IN - internet, EX - exkurzia, PU publikГЎcia, MM - multimГ©diГЎ, DO - dokumentГЎrny film
48
SprГЎva o ДЌinnosti organizГЎcie SAV
9.1.2. SГєhrnnГ© poДЌty vedecko-popularizaДЌnГЅch ДЌinnostГ­ organizГЎcie SAV
TabuДѕka 9b SГєhrnnГ© poДЌty vedecko-popularizaДЌnГЅch ДЌinnostГ­ organizГЎcie SAV
Typ
PoДЌet Typ
PoДЌet Typ
prednГЎЕЎky/besedy
2
tlaДЌ
2
TV
rozhlas
0
internet
5
exkurzie
publikГЎcie
multimediГЎlne nosiДЌe
dokumentГЎrne filmy
PoДЌet
3
0
9.2. Vedecko-organizaДЌnГЎ ДЌinnosЕҐ
TabuДѕka 9c Vedecko-organizaДЌnГЎ ДЌinnosЕҐ
DomГЎca/
NГЎzov podujatia
medzinГЎrodnГЎ
XXIII. DiabetologickГ© dni
medzinГЎrodnГЎ
s medzinГЎrodnou ГєДЌasЕҐou
Miesto
DГЎtum konania
PoДЌet
ГєДЌastnГ­kov
Bratislava,
Slovensko
12.06.-14.06.2013
-
9.3. ГљДЌasЕҐ na vГЅstavГЎch
9.4. ГљДЌasЕҐ v programovГЅch a organizaДЌnГЅch vГЅboroch nГЎrodnГЅch konferenciГ­
TabuДѕka 9d ProgramovГ© a organizaДЌnГ© vГЅbory nГЎrodnГЅch konferenciГ­
Typ vГЅboru
ProgramovГЅ
OrganizaДЌnГЅ
ProgramovГЅ i organizaДЌnГЅ
0
0
0
PoДЌet ДЌlenstiev
9.5. ДЊlenstvo v redakДЌnГЅch radГЎch ДЌasopisov
Ing. JГєlius Brtko, DrSc.
Biomarkers and Environment (ДЊeskГЎ republika) (funkcia: ДЌlen)
Biomedical Papers (ДЊeskГЎ republika) (funkcia: ДЌlen)
Thyroid Research (PoДѕsko) (funkcia: deputy editor)
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
Endocrine Regulations (funkcia: ДЌlen)
MUDr. Richard Imrich, PhD.
General Physiology and Biophysic (funkcia: editor)
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
Neuroendocrinology (UK, USA) (funkcia: editor)
Psychoneuroendocrinology (funkcia: ДЌlen)
International Journal of Endocrinology (USA) (funkcia: editor)
Endocrine Regulations (funkcia: ДЌlen redakДЌnej rady)
Acta Facultatis Pharmaceuticae Universitatis Comenianae (funkcia: editor)
49
SprГЎva o ДЌinnosti organizГЎcie SAV
RNDr. Alexander Kiss, DrSc.
BiolГіgia, sekcia ZoolГіgia (funkcia: ДЌlen redakДЌnej rady medzinГЎrodnГ©ho ДЌasopisu )
Endocrine Regulations (funkcia: hlavnГЅ redaktor )
RNDr. Richard KvetЕ€anskГЅ, DrSc.
Cellular and Molecular Neurobiology (funkcia: ДЌlen)
Endocrine Regulations (funkcia: ДЌlen redakДЌnej rady)
Journal of Gravitation Physiology (USA) (funkcia: ДЌlen)
Neuroendocrinology Letters (Е vГ©dsko) (funkcia: ДЌlen)
Neuroscience News (USA) (funkcia: ДЌlen)
Stress (GB,USA) (funkcia: ДЌlen
Mgr. AlЕѕbeta MlynarДЌГ­kovГЎ, PhD.
Endocrine Regulations (funkcia: editor)
MUDr. Adela PenesovГЎ, PhD.
Endocrine Regulations (funkcia: ДЌlen redakДЌnej rady medzinГЎrodnГ©ho ДЌasopisu)
MUDr. ЕЅofia RГЎdikovГЎ, PhD.
Endocrine Regulations (funkcia: ДЌlen redakДЌnej rady medzinГЎrodnГ©ho ДЌasopisu )
Mgr. SoЕ€a ScsukovГЎ, CSc.
Endocrine Regulations (funkcia: assistent/managing editor)
Prof.MUDr.Fedor Е imko,CSc.
ДЌlen redakДЌnej rady:
Journal of Hypertension
Frontiers in Bioscience
World Journal of Hypertension
Bratislava Medical Journal
Cardiology Letters
MUDr. VladimГ­r Е trbГЎk, DrSc.
- General Physiology and Biophysics (funkcia: ДЌlen )
Iugoslavica Physiologica et Pharmacologica Acta (Member of the International Advisory Board)
- Physiological Research (Prague) (funkcia: ДЌlen)
MUDr. Miroslav VlДЌek, PhD.
Endocrine Regulations (funkcia: ДЌlen redakДЌnej rady medzinГЎrodnГ©ho ДЌasopisu)
50
SprГЎva o ДЌinnosti organizГЎcie SAV
9.6. ДЊinnosЕҐ v domГЎcich vedeckГЅch spoloДЌnostiach
Mgr. Stanislav Babic, PhD.
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
Mgr. Zuzana BaДЌovГЎ, PhD.
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐSLS (funkcia: ДЌlen)
RNDr. JГЎn BakoЕЎ, PhD.
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ pediatrickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
Mgr. Miroslav BalГЎЕѕ
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
Sekcia obezity – Slovenskej diabetologickej spoločnosti (funkcia :člen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
Ing. Lucia BialeЕЎovГЎ
SlovenskГЎ biochemickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ lekГЎrska spoloДЌnosЕҐ (funkcia: ДЌlen)
Ing. JГєlius Brtko, DrSc.
SlovenskГЎ biochemickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen )
SETOX (funkcia: ДЌlen )
SlovenskГЎ lekГЎrska spoloДЌnosЕҐ (funkcia: ДЌlen)
RNDr. Robert FarkaЕЎ, CSc.
SlovenskГЎ biochemickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
RNDr. MГЎria FickovГЎ, CSc.
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SETOX (funkcia: ДЌlen )
Mgr. Lucia GajdoЕЎechovГЎ
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
SlovenskГЎ farmaceutickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
Mgr. ДЅubica HorvГЎthovГЎ, PhD.
SlovenskГЎ spoloДЌnosЕҐ pre neurovedy pri SAV (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
51
SprГЎva o ДЌinnosti organizГЎcie SAV
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
SlovenskГЎ farmaceutickГЎ spoloДЌnosЕҐ (funkcia: ДЌestnГЅ ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen vГЅboru)
RNDr. Alexander Kiss, DrSc.
SlovenkГЎ spoloДЌnosЕҐ pre neurovedy pri SAV (funkcia: ДЌlen)
Ing. KatarГ­na KrЕЎkovГЎ, PhD.
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
Mgr. TГ­mea KurdiovГЎ
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
Sekcia obezity – Slovenskej diabetologickej spoločnosti (funkcia :člen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
RNDr. R. KvetЕ€anskГЅ, DrSc.
podpredseda vГЅboru Slovenskej spoloДЌnosti pre neurovedy pri SAV
emeritnГЅ ДЌlen UДЌenej spoloДЌnosti pri SAV
Mgr. Dana MacejovГЎ, PhD.
SlovenskГЎ biochemickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen )
SlovenskГЎ lekГЎrska spoloДЌnosЕҐ (funkcia: ДЌlen)
Mgr. Lucia MikovГЎ
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
Slovenska spoloДЌnosЕҐ pre neurovedy (funkcia: ДЌlen)
SlovenskГЎ onkologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ spoloДЌnosЕҐ patologickej a klinickej fyziolГіgie (funkcia: ДЌlen)
doc. MUDr. Boris Mravec, PhD.
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ neuropsychiatrickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
Slovenska spoloДЌnosЕҐ pre neurovedy (funkcia: ДЌlen)
MVDr. KatarГ­na OndiДЌovГЎ, PhD.
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
MUDr. Adela PenesovГЎ, PhD.
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ SLS
ObezitologickГЎ sekcia, SDS (funkcia: ДЌlen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ hypertenziologickГЎ spoloДЌnosЕҐ SLD (funkcia: ДЌlen)
Prof.MUDr.Fedor Е imko,CSc.
SlovenskГЎ kardiologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ hypertenziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
SlovenskГЎ patofyziologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
52
SprГЎva o ДЌinnosti organizГЎcie SAV
SlovenskГЎ lekГЎrska spoloДЌnosЕҐ (funkcia: ДЌlen)
MUDr. VladimГ­r Е trbГЎk, DrSc.
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌestnГЅ ДЌlen vГЅboru)
SlovenskГЎ pediatrickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
MUDr. Barbara UkropcovГЎ, PhD.
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
Sekcia obezity – Slovenskej diabetologickej spoločnosti (funkcia :člen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
Mgr. Jozef Ukropec, PhD.
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
Sekcia obezity – Slovenskej diabetologickej spoločnosti (funkcia :člen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ (funkcia :ДЌlen)
MUDr. Miroslav VlДЌek, PhD.
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ reumatologickГЎ spoloДЌnosЕҐ (funkcia: ДЌlen)
Ing. Е tefan Zorad, CSc.
SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
SlovenskГЎ fyziologickГЎ spoloДЌnosЕҐ SLS (funkcia : ДЌlen )
SlovenskГЎ diabetologickГЎ spoloДЌnosЕҐ SLS (funkcia: ДЌlen)
9.7. InГ© dГґleЕѕitГ© informГЎcie o vedecko-organizaДЌnГЅch a popularizaДЌnГЅch aktivitГЎch
Laboratórium diabetu a porúch metabolizmu – sekcia obezity :
PodДѕa veДѕkГЅch klinickГЅch ЕЎtГєdiГ­ sГє jednГЅm z najГєДЌinnejЕЎГ­ch faktorov prevencie chronickГЅch
ochorenГ­ informГЎcie. EdukГЎcia mГЎ ЕЎancu motivovaЕҐ ДѕudГ­ k dlhodobej zmene ЕѕivotnГ©ho ЕЎtГЅlu, a je
ДЌasto ГєДЌinnejЕЎia ako farmakoterapia. O edukГЎciu sa snaЕѕГ­me vo vЕЎetkГЅch klinickГЅch ЕЎtГєdiГЎch,
v rГЎmci ktorГЅch dobrovoДѕnГ­kov zrozumiteДѕnou formou informujeme o cieДѕoch vГЅskumu ako aj
o prГ­ДЌinГЎch, dГґsledkoch a prevencii obezity a diabetu.
UverejЕ€ujeme on-line populГЎrne ДЌlГЎnky zameranГ© na benefity pravidelnej fyzickej aktivity.
CieДѕom je tieЕѕ zvГЅЕЎiЕҐ informovanosЕҐ slovenskej odbornej lekГЎrskej verejnosti prostrednГ­ctvom
ДЌlГЎnkov v slovenskГЅch odbornГЅch lekГЎrskych ДЌasopisoch ДЌi webovГЅch portГЎloch (Diabetes
a obezita, Via practica, http://www.mediportal.sk,http://www.diaslovakia.sk).
V spoluprГЎci s Obezitologickou sekciou Slovenskej diabetologickej spoloДЌnosti sme uЕѕ tretГ­ rok za
sebou (201-2013) pripravili sekciu prednГЎЕЎok v rГЎmci SlovenskГЅch obezitologickГЅch dnГ­
venovanú najmä prezentácii výsledkov našej výskumnej práce.
AktГ­vne sa zГєДЌastЕ€ujeme projektu Noc vГЅskumnГ­ka, v rГЎmci ktorej verejnosti pribliЕѕujeme
metodickГ© i myЕЎlienkovГ© pozadie naЕЎej vГЅskumnej prГЎce ako aj aplikГЎciu jej vГЅsledkov
v kaЕѕdodennom Еѕivote.
53
SprГЎva o ДЌinnosti organizГЎcie SAV
ДЊinnosЕҐ
10.
kniЕѕniДЌno-informaДЌnГ©ho
10.1. KniЕѕniДЌnГЅ fond
TabuДѕka 10a KniЕѕniДЌnГЅ fond
KniЕѕniДЌnГ© jednotky spolu
z toho
knihy a zviazanГ© periodikГЎ
1113
audiovizuГЎlne dokumenty
0
elektronickГ© dokumenty (vrГЎtane digitГЎlnych)
0
mikroformy
0
inГ© ЕЎpeciГЎlne dokumenty - dizertГЎcie, vГЅskumnГ© sprГЎvy
118
PoДЌet titulov dochГЎdzajГєcich periodГ­k
12
z toho zahraniДЌnГ© periodikГЎ
7
RoДЌnГЅ prГ­rastok kniЕѕniДЌnГЅch jednotiek
v tom
0
kГєpou
0
darom
0
vГЅmenou
0
bezodplatnГЅm prevodom
0
Гљbytky kniЕѕniДЌnГЅch jednotiek
0
KniЕѕniДЌnГ© jednotky spracovanГ© automatizovane
0
10.2. VГЅpoЕѕiДЌky a sluЕѕby
TabuДѕka 10b VГЅpoЕѕiДЌky a sluЕѕby
VГЅpoЕѕiДЌky spolu
z toho
378
odbornГЎ literatГєra pre dospelГЅch
1
vГЅpoЕѕiДЌky periodГ­k
0
prezenДЌnГ© vГЅpoЕѕiДЌky
0
MVS inГЅm kniЕѕniciam
0
MVS z inГЅch kniЕѕnГ­c
0
MMVS inГЅm kniЕѕniciam
0
MMVS z inГЅch kniЕѕnГ­c
0
PoДЌet vypracovanГЅch bibliografiГ­
0
PoДЌet vypracovanГЅch reЕЎerЕЎГ­
0
10.3. PouЕѕГ­vatelia
TabuДѕka 10c UЕѕГ­vatelia
RegistrovanГ­ pouЕѕГ­vatelia
65
NГЎvЕЎtevnГ­ci kniЕѕnice spolu (bez nГЎvЕЎtevnГ­kov podujatГ­)
65
54
pracoviska
SprГЎva o ДЌinnosti organizГЎcie SAV
10.4. InГ© Гєdaje
TabuДѕka 10d InГ© Гєdaje
On-line katalГіg kniЕѕnice na internete ( 1=ГЎno, 0=nie)
0
Náklady na nákup knižničného fondu v €
0
10.5. InГ© informГЎcie o kniЕѕniДЌnej ДЌinnosti
Knižnica je v zmysle Štatistického úradu SR stagnujúca, nemá pracovníka na plný úväzok
(nehospodárne ), neposkytuje širokej verejnosti základné knižnično – informačné služby a jej
kniЕѕniДЌnГЅ fond nie je obnovovanГЅ. Vedie sa prehДѕad a zakladajГє sa dochГЎdzajГєce periodikГЎ,
vГЅskumnГ© sprГЎvy a starГЎ sa o archivГЎciu ostatnГЅch kniЕѕniДЌnГЅch jednotiek. (1113) .
55
SprГЎva o ДЌinnosti organizГЎcie SAV
11. Aktivity v orgГЎnoch SAV
RNDr. R. KvetЕ€anskГЅ, DrSc.
- ДЌlen VedeckГ©ho kolГ©gia SAV pre molekulovГє a bunkovГє biolГіgiu
- je jednГЅm z 20 zakladajГєcich ДЌlenov UДЌenej spoloДЌnosti SAV
- ДЌlen Komisie SAV pre vesmГ­rne aktivity
11.1. ДЊlenstvo vo VГЅbore Snemu SAV
11.2. ДЊlenstvo v PredsednГ­ctve SAV a vo Vedeckej rade SAV
MUDr. Richard Imrich, PhD.
- podpredseda SAV pre II. oddelenie vied
- ДЌlen vedeckej rady SAV
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
- podpredsednГ­ДЌka (do jГєna 2013), ДЌlen (od jГєla 2013) SAV pre vzdelГЎvanie a doktorandskГ©
ЕЎtГєdium - doteraz
11.3. ДЊlenstvo vo vedeckГЅch kolГ©giГЎch SAV
Ing. JГєlius Brtko, DrSc.
- VK SAV pre chemickГ© vedy (ДЌlen)
MUDr. Richard Imrich, PhD.
- VK SAV pre lekГЎrske vedy (ДЌlen)
RNDr. R. KvetЕ€anskГЅ, DrSc.
- VK SAV pre molekulovГє a bunkovГє biolГіgiu (ДЌlen)
MUDr. VladimГ­r Е trbГЎk, DrSc.
- VK SAV pre lekГЎrske vedy (predseda)
11.4. ДЊlenstvo v komisiГЎch SAV
Ing. JГєlius Brtko, DrSc.
- Komisia SAV pre duЕЎevnГ© vlastnГ­ctvo (ДЌlen)
- Komisia SAV pre posudzovanie vedeckej kvalifikГЎcie zamestnancov (ДЌlen)
MUDr. Richard Imrich, PhD.
- Komisia pre transformГЎciu SAV (ДЌlen)
- Komisia SAV pre duЕЎevnГ© vlastnГ­ctvo, inovГЎcie a technologickГЅ transfer (ДЌlen)
- Komisia SAV pre ekonomickГ© otГЎzky (ДЌlen)
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
- Rada SAV pre vzdelГЎvanie a doktorandskГ© ЕЎtГєdium (predseda)
- Komisia SAV pre rovnosЕҐ prГ­leЕѕitostГ­ (predseda)
56
SprГЎva o ДЌinnosti organizГЎcie SAV
MUDr. Miroslav VlДЌek, PhD.
Komisia SAV pre vyhodnocovanie medzinГЎrodnГЅch projektov (ДЌlen)
11.5. ДЊlenstvo v orgГЎnoch VEGA
Prof.MUDr.Fedor Е imko,CSc.
Komisia VEGA ДЌ. 9 pre lekГЎrske a farmaceutickГ© vedy (ДЌlen)
57
SprГЎva o ДЌinnosti organizГЎcie SAV
12. HospodГЎrenie organizГЎcie
12.1. VГЅdavky RO SAV
Tabuľka 12a Výdavky RO SAV (v €)
VГЅdavky
SkutoДЌnosЕҐ k v tom:
31.12.2013
zo Е R
spolu
z toho:
Е F EГљ vr.
spolufinan.zo
Е R
z mimorozp. z toho:
zdrojov
Е F EГљ vr.
spolufinan.zo
Е R
VГЅdavky spolu
2 070 690,22
1 453 976,07
281 570,15
616 714,15
0,00
BeЕѕnГ© vГЅdavky
v tom:
mzdy (610)
2 052 752,77
1 436 038,62
281 570,15
616 714,15
0,00
702 262,51
636 052,41
35 049,41
66 210,10
0,00
252 272,60
225 606,86
11 437,86
26 665,74
906 268,16
464 031,35
235 082,88
442 236,81
5 076,00
5 076,00
0,00
0,00
102 168,00
102 168,00
0,00
0,00
31 333,00
31 333,00
0,00
0,00
12 000,00
12 000,00
0,00
0,00
6 400,00
6 400,00
0,00
0,00
191 949,50
110 348,00
0,00
81 601,50
100 680,00
100 680,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
81 601,50
0,00
0,00
81 601,50
17 937,45
17 937,45
0,00
0,00
0,00
0,00
0,00
0,00
17 937,45
17 937,45
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
0,00
poistnГ© a prГ­spevok do
poisЕҐovnГ­ (620)
tovary a sluЕѕby (630)
z toho: ДЌasopisy
VEGA projekty
MVTS projekty
CE
vedeckГЎ vГЅchova
beЕѕnГ© transfery (640)
z toho: ЕЎtipendiГЎ
transfery partnerom
projektov
KapitГЎlovГ© vГЅdavky
v tom:
obstarГЎvanie kapitГЎlovГЅch
aktГ­v
kapitГЎlovГ© transfery
z toho: transfery partnerom
projektov
12.2. PrГ­jmy RO SAV
Tabuľka 12b Príjmy RO SAV (v €)
PrГ­jmy
PrГ­jmy spolu
NedaЕ€ovГ© prГ­jmy
SkutoДЌnosЕҐ v tom:
k
rozpoДЌtovГ© z mimorozp.
31.12.2013
zdrojov
spolu
684 114,83
67 400,68
616 714,15
67 400,68
67 400,68
14 300,68
14 300,68
0,00
v tom:
prГ­jmy z prenГЎjmu
58
0,00
0,00
0,00
0,00
SprГЎva o ДЌinnosti organizГЎcie SAV
prГ­jmy z predaja vГЅrobkov a
sluЕѕieb
inГ©
Granty a transfery (mimo
zdroja 111)
v tom:
tuzemskГ©
z toho: APVV
inГ©
zahraniДЌnГ©
z toho: projekty rГЎmcovГ©ho
programu EГљ
inГ©
53 100,00
53 100,00
0,00
0,00
0,00
0,00
616 714,15
0,00
616 714,15
504 161,88
0,00
504 161,88
504 161,88
0,00
504 161,88
0,00
0,00
0,00
112 552,27
0,00
112 552,27
0,00
0,00
0,00
0,00
0,00
0,00
59
SprГЎva o ДЌinnosti organizГЎcie SAV
13. NadГЎcie a fondy pri organizГЎcii SAV
14.
InГ©
ДЌinnosti
vГЅznamnГ©
organizГЎcie
SAV
MГЎme povolenie Гљradu verejnГ©ho zdravotnГ­ctva SR /ako jeden z mГЎla Гєstavov SAV/ pre prГЎcu
s nasledujГєcimi rГЎdionuklidmi: 3H, 14C, 32P, 35S, 45Ca, 51Cr, 125I (beta a gama ЕѕiariДЌe), ktorГЎ sa
uskutoДЌЕ€uje v sledovanom pГЎsme zahЕ•Е€ajГєcom sedem miestnostГ­.
V sГєДЌasnosti je toto naЕЎe pracovisko vybavenГ© beta meraДЌom PerkinElmer Tri-Carb 2910TR a
meraДЌom gama Еѕiarenia PerkinElmer 2470 Automatic Gamma Counter WIZARD. V
roku 2013 bolo na meraДЌi beta Еѕiarenia Tri-Carb zmeranГЅch 3 282 vzoriek pre potreby
OnkologickГ©ho Гєstavu sv. AlЕѕbety v Bratislave, 1425 vzoriek pre potreby pracovnГ­kov nГЎЕЎho
Гєstavu, 20 vzoriek pre potreby Гљstavu experimentГЎlnej onkolГіgie SAV a 455 vzoriek pre potreby
PrГ­rodovedeckej fakulty UK v Bratislave. Na meraДЌi gama Еѕiarenia bolo zmeranГЅch 2 927 vzoriek
pre potreby ГљEE SAV a 2 927 vzoriek pre potreby PrГ­rodovedeckej fakulty UK v Bratislave.
V roku 2013 sme s pomocou finanДЌnГЅch prostriedkov zГ­skanГЅch zo ЕЎtrukturГЎlnych fondov doplnili
a uviedli do prevГЎdzky sadu prГ­strojov: kryostat, rotaДЌnГЅ sГЎnkovГЅ mikrotГіm, inverznГЅ mikroskop,
pipetovaciu stanicu, laminГЎrny box, bioanalyzГЎtor pre DNA, RNA a proteГ­ny, multifunkДЌnГЅ
mikroplatniДЌkovГЅ spektrofotomer s kontinuГЎlne voliteДѕnou vlnovou dДєЕѕkou, systГ©m na masГ­vne
paralelnГ© sekvenovanie nukleovГЅch kyselГ­n vrГЎtane automatizovanej prГ­pravy templГЎtu pre masГ­vne
paralelnГ© sekvenovanie, ergometrickГЅ bicykel, ruДЌnГЅ obojsmernГЅ doppler pre vyЕЎetrenie ciev a
systГ©m na zГЎznam EEG
PracovnГ­k ГљEE SAV Richard Imrich bol menovanГЅ za
rГЎmcovГ©ho programu EГљ pre vГЅskum a inovГЎcie na roky
Horizont 2020 pre prioritu "Zdravie, demografickГ© zmeny a blahobyt".
nГЎrodnГ©ho
2014 aЕѕ
delegГЎta
2020 -
PracovnГ­ДЌka ГљEE SAV Daniela JeЕѕovГЎ bola nominovanГЎ za ДЌlenku evaluaДЌnГ©ho panelu European
Research Council (ERC) pre "Starting Grants", konkrГ©tne panelu LS4 "Physiology,
Pathophysiology and Endocrinology".
PracovnГ­k ГљEE SAV Stefan Zorad bol menovanГЅ za predsedu komisie pre obhajoby eurГіpskych
PhD v University of JaГ©n, JaГ©n, Е panielsko.
Pracovníci ústavu /prof. Klimeš, dr.Gašperíková, dr.Staník/ sú zakladateľmi „Národného registra
monogénových foriem cukrovky na Slovensku“ a po rozhodnutí MZ SR o jeho začlenení do NCZI
sa
aj
v roku
2013
podieДѕali
na
aktualizГЎcii
Гєdajov
registra.
60
SprГЎva o ДЌinnosti organizГЎcie SAV
15. Vyznamenania, ocenenia a ceny udelenГ© pracovnГ­kom organizГЎcie v roku
2013
15.1. DomГЎce ocenenia
15.1.1. Ocenenia SAV
Е trbГЎk VladimГ­r
Medaila SAV za podporu vedy
15.1.2. InГ© domГЎce ocenenia
Ing. JГєlius Brtko, DrSc.
Pozdravný list Slovenskej Endokrinologickej spoločnosti k životnému jubileu – za významný
prГ­nos v odbore molekulГЎrnej endokrinolГіgie.
OceЕ€ovateДѕ: SlovenskГЎ lekГЎrska spoloДЌnosЕҐ a SlovenskГЎ endokrinologickГЎ spoloДЌnosЕҐ
Mgr. Lucia ChovanovГЎ
NajlepЕЎia prezentГЎcia International Student Medical Congress in Kosice ISMCK 2013
OceЕ€ovateДѕ: organizaДЌnГЅ vГЅbor ISMCK
Opis: 2. miesto v súťaži o najlepšiu prezentáciu v sekcii “PhD Student’s Works – Clinical part” na
International Student Medical Congress in Kosice ISMCK 2013
NataЕЎa HlavГЎДЌovГЎ
Cena Slovenskej farmakologickej spoloДЌnosti SLS pre mladГ©ho slovenskГ©ho farmakolГіga za
najlepЕЎiu publikГЎciu v roku 2012
OceЕ€ovateДѕ: SlovenskГЎ farmakologickГЎ spoloДЌnosЕҐ SLS
Opis: cena za najlepšiu publikáciu v roku 2012: „Hlavacova N, Wes PD, Ondrejcakova M, Flynn
ME, Poundstone PK, Babic S, Murck H, Jezova D. Subchronic treatment with aldosterone induces
depression-like behaviours and gene expression changes relevant to major depressive disorder. Int
J Neuropsychopharmacol. 15(2):247-65, 2012.
Mgr. Barbora ProkopovГЎ
Grant Farmaceutickej fakulty UK
OceЕ€ovateДѕ: FaF UK Bratislava
Opis: ZГ­skanie grantu Farmaceutickej fakulty UK ДЌ. FaFUK/64/2013 na podporu rieЕЎenia
vedeckГ©ho projektu.
15.2. MedzinГЎrodnГ© ocenenia
Mgr. Stanislav Babic, PhD.
Cena ДЊeskej neuropsychofarmakologickej spoloДЌnosti za najlepЕЎiu originГЎlnu odbornГє prГЎcu
z oblasti psychofarmakolГіgie a psychofarmakoterapie publikovanГє v roku 2012.
OceЕ€ovateДѕ: ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (ДЊNPS)
Opis: cena ДЊNPS za najlepЕЎiu originГЎlnu odbornГє prГЎcu z preklinickej oblasti publikovanГє v roku
2012: „Babic S., Ondrejcakova M., Bakos J., Racekova E., Jezova D.: Cell proliferation in the
hippocampus and the heart is modified by exposure to repeated stress and with memantine. Journal
of Psychiatric Research, 46: 526-532, 2012.
61
SprГЎva o ДЌinnosti organizГЎcie SAV
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
CestovnГЅ/pobytovГЅ grant
OceЕ€ovateДѕ: ДЊeskГЎ neuropsychofarmakologickГЎ spoloДЌnosЕҐ (ДЊNPS)
Opis: cestovnГЅ grant ДЊeskej neuropsychofarmakologickej spoloДЌnosti vДЏaka ktorГ©mu sa mohla
aktГ­vne zГєДЌastniЕҐ na 11th World Congress of Biological Psychiatry v Kyote, Japonsku.
RNDr. Richard KvetЕ€anskГЅ, DrSc.
Predlžená funkcia „Visiting Professor“ v Center of Alcohol Studies, Rutgers University,
Piscataway, N.J. USA od 1. jГєla 2013
62
SprГЎva o ДЌinnosti organizГЎcie SAV
16. Poskytovanie informГЎciГ­ v sГєlade so zГЎkonom ДЌ. 211/2000 Z. z. o slobodnom
prГ­stupe k informГЎciГЎm v znenГ­ neskorЕЎГ­ch predpisov (ZГЎkon o slobode
informГЎciГ­)
17. ProblГ©my a podnety pre ДЌinnosЕҐ SAV
63
SprГЎva o ДЌinnosti organizГЎcie SAV
SprГЎvu o ДЌinnosti organizГЎcie SAV spracoval(i):
RiaditeДѕ organizГЎcie SAV:
..............................................
Ing. Е tefan ZГіrad, CSc.
64
SprГЎva o ДЌinnosti organizГЎcie SAV
PrГ­lohy
PrГ­loha A
Zoznam zamestnancov a doktorandov organizГЎcie k 31.12.2013
Zoznam zamestnancov podľa štruktúry (nadväzne na údaje v Tabuľke 1a)
Úväzok
RoДЌnГЅ prepoДЌГ­tanГЅ
Meno s titulmi
(v %)
úväzok
VedГєci vedeckГ­ pracovnГ­ci DrSc.
1.
Ing. JГєlius Brtko, DrSc.
100
1.00
2.
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
50
0.58
3.
RNDr. Alexander Kiss, DrSc.
100
1.00
4.
prof. MUDr. Iwar KlimeЕЎ, DrSc.
100
1.00
5.
RNDr. Richard KvetЕ€anskГЅ, DrSc.
100
1.00
6.
akad. MUDr. Ladislav Macho, DrSc.
20
0.20
7.
MUDr. VladimГ­r Е trbГЎk, DrSc.
51
0.51
SamostatnГ­ vedeckГ­ pracovnГ­ci
1.
Mgr. Zuzana BaДЌovГЎ, PhD.
100
1.00
2.
RNDr. JГЎn BakoЕЎ, PhD.
100
1.00
3.
RNDr. Robert FarkaЕЎ, CSc.
100
1.00
4.
RNDr. MГЎria FickovГЎ, CSc.
100
1.00
5.
Mgr. Daniela GaЕЎperГ­kovГЎ, CSc.
100
1.00
6.
RNDr. NataЕЎa HlavГЎДЌovГЎ, PhD.
100
1.00
7.
MUDr. Richard Imrich, PhD.
48
0.35
8.
doc. Ing. Jana JurДЌoviДЌovГЎ, CSc.
50
0.50
9.
doc. MUDr. Boris Krahulec, PhD.
20
0.20
10. Ing. KatarГ­na KrЕЎkovГЎ, PhD.
100
1.00
11. Ing. Marcela LaukovГЎ, PhD.
100
1.00
12. MVDr. JГЎn LГ­ЕЎka, CSc.
10
0.10
13. Mgr. Dana MacejovГЎ, PhD.
100
1.00
14. Mgr. AlЕѕbeta MlynarДЌГ­kovГЎ, PhD.
100
1.00
15. doc. MUDr. Boris Mravec, PhD.
51
0.51
16. RNDr. Jana OsackГЎ, PhD.
100
1.00
17. MUDr. Adela PenesovГЎ, PhD.
50
0.50
18. PharmDr. Zdenko PirnГ­k, PhD.
10
0.10
19. MUDr. ЕЅofia RГЎdikovГЎ, PhD.
100
1.00
20. Mgr. SoЕ€a ScsukovГЎ, CSc.
120
1.20
21. prof. MUDr. Fedor Е imko, CSc.
50
0.50
65
SprГЎva o ДЌinnosti organizГЎcie SAV
22. Ing. Andrej Tillinger, PhD.
100
1.00
23. MUDr. Barbara UkropcovГЎ, PhD.
100
1.00
24. Mgr. Jozef Ukropec, PhD.
100
1.00
25. MUDr. Miroslav VlДЌek, PhD.
100
1.00
26. Ing. Е tefan ZГіrad, CSc.
100
1.00
VedeckГ­ pracovnГ­ci
1.
Mgr. Stanislav Babic, PhD.
100
0.51
2.
Mgr. Milan BeЕ€o, PhD.
100
1.00
3.
Mgr. Denisa BeЕ€ovГЎ, PhD.
51
0.51
4.
Mgr. ДЅubica HorvГЎthovГЎ, PhD.
100
1.00
5.
Mgr. Lucia ChovanovГЎ, PhD.
100
0.51
6.
MVDr. KatarГ­na OndiДЌovГЎ, PhD.
10
0.10
7.
Mgr. Martina OreДЌnГЎ, PhD.
100
1.00
8.
MUDr. Juraj StanГ­k, PhD.
30
0.30
9.
RNDr. Martina Е kopkovГЎ, PhD.
100
0.95
10. Mgr. Lucia ValentГ­novГЎ, PhD.
100
1.00
11. Ing. Peter VargoviДЌ, PhD.
100
1.00
OdbornГ­ pracovnГ­ci s VЕ vzdelanГ­m
1.
Mgr. Miroslav BalГЎЕѕ
16
0.16
2.
Mgr. Dominika BalГЎЕѕiovГЎ
10
0.10
3.
MUDr. Lucia BГЎnovskГЎ
10
0.10
4.
Ing. Lucia BialeЕЎovГЎ
16
0.16
5.
Ing. Jana BlaЕЎkovГЎ
100
1.00
6.
Mgr. Veronika DanevovГЎ
10
0.10
7.
Mgr. Renáta Dörnhöferová
50
0.50
8.
Mgr. Lucia GajdoЕЎechovГЎ
10
0.10
9.
Mgr. TomГЎЕЎ HavrГЎnek
10
0.10
10. RNDr. Miroslava HuДЌkovГЎ
100
1.00
11. Mgr. Timea KurdiovГЎ
100
0.51
12. Mgr. KatarГ­na LejavovГЎ
10
0.10
13. MUDr. VladimГ­r Lenko
10
0.10
14. Mgr. Zuzana LeЕЎЕҐanovГЎ
10
0.10
15. Bc. Tatiana LipovskГЎ
100
1.00
16. Mgr. Zuzana MajerДЌГ­kovГЎ
10
0.10
17. Mgr. Ivica MaЕЎindovГЎ
16
0.16
66
SprГЎva o ДЌinnosti organizГЎcie SAV
18. Mgr. Michal Pokusa
10
0.10
19. Mgr. Barbora ProkopovГЎ
10
0.10
20. Ing. Milada RakickГЎ
50
0.50
21. Ing. Nina RatulovskГЎ
100
1.00
22. Mgr. Kvetoslava SmolГ­kovГЎ
16
0.16
23. MUDr. Daniela StanГ­kovГЎ
30
0.30
24. Mgr. Zuzana StrapatГЎ
100
1.00
25. Mgr. Martina SЕЇrovГЎ
100
1.00
26. MUDr. RNDr. LukГЎЕЎ Varga
30
0.30
OdbornГ­ pracovnГ­ci ГљSV
1.
MagdalГ©na BardГЎДЌovГЎ
100
1.00
2.
Alena BlechovГЎ
100
1.00
3.
MГЎria DanihelovГЎ
80
0.80
4.
Gizela GajdoЕЎГ­kovГЎ
30
0.30
5.
SlГЎvka GorДЌГ­kovГЎ
100
1.00
6.
Martin Hudec
100
0.83
7.
SoЕ€a HudecovГЎ
100
0.75
8.
Daniela ChalupkovГЎ
100
1.00
9.
KatarГ­na JanatovГЎ
100
1.00
10. Dagmar JanovovГЎ
100
1.00
11. Marta LГЎniovГЎ
100
1.00
12. MГЎria MackoviДЌovГЎ
100
1.00
13. ДЅubica MГЎlekovГЎ
26
0.26
14. Lucia MarkovГЎ
50
0.55
15. KaterГ­na Mihaleje
100
0.64
16. Alica MitkovГЎ
100
1.00
17. Milan Е ajГЎnek
100
1.00
18. Marta Е iЕЎolГЎkovГЎ
100
1.00
19. KatarГ­na VrzalovГЎ
100
1.00
20. Dana ZemekovГЎ
150
1.16
21. ДЅudmila ЕЅilavГЎ
100
1.00
OstatnГ­ pracovnГ­ci
1.
Peter Bitto
100
1.00
2.
Anna BuzekovГЎ
100
1.00
3.
Е tefan ДЊechoviДЌ
100
1.00
67
SprГЎva o ДЌinnosti organizГЎcie SAV
4.
Ing. VladimГ­r KukliЕЎ
100
1.00
5.
Darina MackoviДЌovГЎ
100
1.00
6.
MГЎria OndriskovГЎ
100
1.00
7.
Helena PГ­ЕЎovГЎ
100
1.00
8.
Filip Ruppert
100
0.17
9.
Regina ЕЅuЕѕiДЌovГЎ
80
0.80
DГЎtum odchodu
RoДЌnГЅ prepoДЌГ­tanГЅ
úväzok
Zoznam zamestnancov, ktorГ­ odiЕЎli v priebehu roka
Meno s titulmi
SamostatnГ­ vedeckГ­ pracovnГ­ci
1.
MUDr. Roman DunДЌko, PhD.
30.4.2013
0.33
2.
doc. MUDr. KatarГ­na RaЕЎlovГЎ, CSc.
31.8.2013
0.19
VedeckГ­ pracovnГ­ci
1.
Mgr. Roman Hafko, PhD.
20.6.2013
0.00
2.
MUDr. Branislav Vohnout, PhD.
31.8.2013
0.21
OdbornГ­ pracovnГ­ci s VЕ vzdelanГ­m
1.
Ing. Silvia HoreckГЎ
30.9.2013
0.33
2.
Ing. Inge IvaЕЎkovГЎ
30.11.2013
0.67
3.
Mgr. LГ­via MikuЕЎka
31.8.2013
0.11
OdbornГ­ pracovnГ­ci ГљSV
1.
MГЎria DanihelovГЎ
31.12.2013
0.80
2.
Martin Hudec
30.4.2013
0.33
3.
SoЕ€a HudecovГЎ
31.3.2013
0.25
4.
Marta LГЎniovГЎ
31.12.2013
1.00
5.
KaterГ­na Mihaleje
31.12.2013
0.64
6.
Adela SlovГЎДЌkovГЎ
30.4.2013
0.33
8.10.2013
0.75
OstatnГ­ pracovnГ­ci
1.
Silvester Osvald
Zoznam doktorandov
Meno s titulmi
Е kola/fakulta
Е tudijnГЅ odbor
InternГ­ doktorandi hradenГ­ z prostriedkov SAV
1.
Mgr. Miroslav BalГЎЕѕ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
2.
Mgr. Dominika BalГЎЕѕiovГЎ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
Ing. Lucia BialeЕЎovГЎ
Fakulta chemickej a
potravinГЎrskej technolГіgie
4.1.22 biochГ©mia
3.
68
SprГЎva o ДЌinnosti organizГЎcie SAV
STU
4.
Mgr. AgneЕЎa CsГЎnovГЎ
Univerzita KomenskГ©ho v
Bratislave
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
5.
Mgr. Lucia GajdoЕЎechovГЎ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
6.
Mgr. TomГЎЕЎ HavrГЎnek
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
7.
Mgr. Zuzana LeЕЎЕҐanovГЎ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
8.
Mgr. Zuzana MajerДЌГ­kovГЎ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
9.
Mgr. Ivica MaЕЎindovГЎ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
10. Mgr. LГ­via MikuЕЎka
12. Mgr. Michal Pokusa
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
Univerzita KomenskГ©ho v 7.1.3 normГЎlna a patologickГЎ
Bratislave
fyziolГіgia
PrГ­rodovedeckГЎ fakulta UK 4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
13. Mgr. Kvetoslava SmolГ­kovГЎ
PrГ­rodovedeckГЎ fakulta UK
4.2.10 fyziolГіgia ЕѕivoДЌГ­chov
14. Ing. Lucia ToporovГЎ
SlovenskГЎ technickГЎ
univerzita v Bratislave
4.1.22 biochГ©mia
11. MUDr. Martina MravcovГЎ
PrГ­rodovedeckГЎ fakulta UK
InternГ­ doktorandi hradenГ­ z inГЅch zdrojov
1.
Mgr. Veronika DanevovГЎ
FarmaceutickГЎ fakulta UK
2.
Mgr. Lucia FiaДЌanovГЎ
3.
MUDr. Michaela JakubovГЎ
Univerzita KomenskГ©ho v
Bratislave
Univerzita KomenskГ©ho v
Bratislave
4.
Mgr. KatarГ­na LejavovГЎ
LekГЎrska fakulta UK
5.
MUDr. Lucia MikovГЎ
LekГЎrska fakulta UK
6.
Mgr. Barbora ProkopovГЎ
FarmaceutickГЎ fakulta UK
7.
Mgr. Silvia VallovГЎ
Univerzita KomenskГ©ho v
Bratislave
8.
RNDr. MUDr. LukГЎЕЎ Varga
LekГЎrska fakulta UK
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
ExternГ­ doktorandi
1.
MUDr. Andrea GГЎlusovГЎ
LekГЎrska fakulta UK
2.
MUDr. Alexandra GarafovГЎ
LekГЎrska fakulta UK
3.
MUDr. Daniela StanГ­kovГЎ
LekГЎrska fakulta UK
69
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
7.1.3 normГЎlna a patologickГЎ
fyziolГіgia
SprГЎva o ДЌinnosti organizГЎcie SAV
PrГ­loha B
Projekty rieЕЎenГ© v organizГЎcii
MedzinГЎrodnГ© projekty
Programy: 7RP
1.) IntegrovanГЎ infraЕЎtruktГєra pre ЕЎtrukturГЎlnu biolГіgiu (Integrated Structural Biology
Infrastructure)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Robert FarkaЕЎ
1.1.2013 / 31.12.2015
FP7 211252
nie
University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
15
Podpora medzinárodnej spolupráce z národných zdrojov: 4000 €
DosiahnutГ© vГЅsledky :
ParticipГЎciou na projekte INSTRUCT (Integrated Structural Biology Infrastructure, 7FP), ktorГЅ sa
sГєstreДЏuje na rieЕЎenie kДѕГєДЌovГЅch biomedicГ­nskych problГ©mov a na budovanie a integrГЎciu
potrebnej infraЕЎtruktГєry, sme realizovali viacГєДЌelovГ© subklonovanie gГ©nu Met, kГіdujГєceho bHLHPAS proteГ­n Drosophila zapojenГЅ do signalizГЎcie juvenilnГ©ho hormГіnu (JH). V rГЎmci tohto zГЎmeru
sme celГє dДєЕѕku cDNA Met ako aj jednotlivГ© ЕЎtruktГєrne a funkДЌnГ© domГ©ny, resp. ich kombinГЎcie,
klonovali do transformaДЌnГЅch pUAST-NTAP, pUAST-CTAP a attB-pNE3 vektorov a do
bakteriГЎlneho expresnГ©ho vektoru pET46-Ek/LIC. PrvГЎ polovica zГЎmeru sa sГєstreДЏuje na zГ­skanie
elementГЎrnych funkДЌnГЅch informГЎciГ­ o jednotlivГЅch domГ©nach MET proteГ­nu ich ektopickou
expresiou na divom resp. mutantnom Met- pozadГ­ jako aj analГЅzu proteГ­n-proteГ­novГЅch interakciГ­
izolГЎciou interakДЌnГЅch partnerov MET tandГ©movou afinitnou purifikГЎciou pre ГєДЌely ich identifikГЎcie
hmotnostnou spektrometriou. NГЎplЕ€ou druhej polovice zГЎmeru je expresia jednotlivГЅch domГ©n MET
proteГ­nu v BL21(DE3)-pLys, BL21(DE3)-RIL alebo BL21(DE3)-RP baktГ©riach za ГєДЌelom ich
afinitnej purifikГЎcie pre potreby ЕЎtrukturГЎlnej RTG-analГЅzy, ktorГє plГЎnujeme uskutoДЌniЕҐ so
zahraniДЌnГЅm partnerom. DosiaДѕ sme zГ­skali 15 klonov MET v pET46-Ek/LIC vektore, ktorГ© v
súčasnosti podrobujeme sekvenčnej verifikácii. Všetky za uplynulý rok získané klony v pUASTNTAP aj pUAST-CTAP vektoroch a väčšinu v attB-pNE3 vektore sme už sekvenačne verifikovali
a potvrdili ich úspešné klonovanie „in frame“.
Programy: bilaterГЎlne - inГ©
1.) MetabolickГ© zdravie a sekreДЌnГЅ profil svalu v aerГіbnych a rezistentnГЅch trГ©novanГЅch
obГ©znych pre-diabetickГЅch jedincov. (Metabolic health and muscle secretory profile in aerobic
and resistance trained obese pre-diabetic individuals)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
Barbara UkropcovГЎ
1.5.2010 / 31.5.2013
EvidenДЌnГ© ДЌГ­slo projektu:
70
SprГЎva o ДЌinnosti organizГЎcie SAV
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
European Foundation for the Study of Diabetes (EFSD): 22341,36 €
Podpora medzinárodnej spolupráce z národných zdrojov: 2333 €
DosiahnutГ© vГЅsledky:
CieДѕom tejto klinickej intervenДЌnej ЕЎtГєdie je komplexne zhodnotiЕҐ a porovnaЕҐ ГєДЌinok silovГ©ho a
aerГіbneho trГ©ningu na metabolickГ© zdravie, fyzickГє zdatnosЕҐ a sekreДЌnГЅ profil kostrovГ©ho svalu
sedavГЅch jedincov s rizikom metabolickГ©ho ochorenia. V rokoch 2011-2012 sa zrealizovala
klinickГЎ ДЌasЕҐ ЕЎtГєdie, v spoluprГЎci s FTVЕ , ktorГЎ zastreЕЎovala trГ©ningovГє ДЌasЕҐ ako aj funkДЌnГє
kinantropologickГє diagnostiku. KomplexnГЅ ЕЎtГєdiovГЅ protokol vrГЎtane 3-mesaДЌnГ©ho silovГ©ho (n=15)
alebo vytrvalostnГ©ho (n=11) trГ©ningovГ©ho programu absolvovalo 26 dobrovoДѕnГ­kov v troch
etapГЎch. Vzorky svalu, zГ­skanГ© svalovou biopsiou z musculus vastus lateralis, sa pouЕѕili na
zaloЕѕenie primГЎrnych bunkovГЅch kultГєr a imunohistochГ©miu. V tomto roku sme realizovali
proteГ­novГ© ereje, s cieДѕom stanoviЕҐ profil cytokГ­nov/myokГ­nov vo svale a jeho zmeny ГєДЌinkom
trГ©ningu. Relizovali sme pilotnГє ЕЎtГєdiu, zameranГє na zmeny profilu svalovo ЕЎpecifickГЅch
mikroRNA v cerebrospinГЎlnom likvore ГєДЌinkom akГєtnej fyzickej zГЎЕҐaЕѕe u trГ©novanГЅch zdravГЅch
jedincov.
DokonДЌili sme a ГєspeЕЎne opublikovali prГЎcu zameranГє na myokГ­n irisГ­n, v ktorej sa venujeme aj
jeho regulГЎcii akГєtnym cviДЌenГ­m a trГ©ningom. V ДЏalЕЎej etape sa klinickГ© vГЅsledky budГє dopДєЕ€aЕҐ s
vГЅsledkami molekulГЎrne genetickГЅch a biochemickГЅch stanovenГ­ vo vzorkГЎch plazmy, sГ©ra a v
kostrovom svale, odobratГЅch pred a po ukonДЌenГ­ trГ©ningovГ©ho programu, resp. v sГ©re
a v cerebrospinГЎlnom likvore, odobratГЅch pred a po akГєtnej fyzickej zГЎЕҐaЕѕi.Na ЕЎtГєdium
metabolizmu svalu in vivo sme vyuЕѕili metodiku 31P MRS v spoluprГЎci s Centrom-Excelentnosti
Viedenskej unicverzity.
In extenso publikГЎcie :
KURDIOVA T., BALAZ M., VICIAN M., MADEROVA D., VLCEK M., VALKOVIC L.,
SRBECKY M., IMRICH R., KYSELOVICOVA O., BELAN V., JELOK I., WOLFRUM C.,
KLIMES I., KRSSAK M., ZEMKOVA E., GASPERIKOVA D., UKROPEC J., UKROPCOVA B.
Are Skeletal Muscle & Adipose Tissue Fndc5 Gene Expression and Irisin Release Affected by
Obesity, Diabetes and Exercise? In vivo & in vitro studies. In The journal of physiology (London),
2013. (4.38 - IF2012)
VALKOVIДЊ L., UKROPCOVГЃ B., CHMELГЌK M., BALГЃЕЅ M., BOGNER W., SCHMID AI.,
FROLLO I., ZEMKOVГЃ E., KLIMEЕ I., UKROPEC J., TRATTNIG S., KRЕ Е ГЃK M. Interrelation
of (31) P-MRS metabolism measurements in resting and exercised quadriceps muscle of
overweight-to-obese sedentary individuals. NMR Biomed. 2013 Dec;26(12):1714-22. doi:
10.1002/nbm.3008. (IF - 3,446)
- OstatnГ© krГЎtke prГЎce, krГЎtke prГЎce v zbornГ­koch zo sympГіziГ­, krГЎtke prГЎce uverejЕ€ovanГ© ako
sГєbor prГ­spevkov zo sympГіziГ­ aj keДЏ sГє uverejnenГ© v CC ДЌasopisoch:
KURDIOVA T., UKROPCOVA B., BALAZ M., LIEBISH G., VICIAN M., VLCEK, M.,
SRBECKY
M., OLEJNIK J., IMRICH R., BELAN V., KLIMES I., SCHMITZ G.,
71
SprГЎva o ДЌinnosti organizГЎcie SAV
GASPERIKOVA D., UKROPEC J. Specific changes in plasma lipidome in obesity and type 2
diabetes are associated with physical inactivity and muscle mitochondrial function. In Treatment
Strategies – Diabetes, 2013, vol. 5 issue 1, p.42-43.
PozvanГ© prednГЎЕЎky v zahraniДЌГ­ :
UKROPCOVГЃ B.: Metabolic health and muscle secretory profile in aerobic and resistance trained
overweight/obese individuals. EFSD/Lilly Symposium, Bad Homburg, Germany, May 2013.
PozvanГ© prednГЎЕЎky na Slovensku :
UKROPCOVГЃ B.: ГљДЌinky fyzickej (in)aktivity: DialГіg svalu s telom. LekГЎrska Fakulta UK
v Bratislave. 12. FebruГЎr 2013
UKROPCOVГЃ B.: KostrovГЅ sval ako mediГЎtor benefiДЌnГ©ho ГєДЌinku pravidelnГ©ho cviДЌenia. XVIII.
Kongres Slovenskej kardiologickej spoloДЌnosti, Bratislava, 10.-12. OktГіber 2013
UKROPCOVГЃ B., MADEROVГЃ D., KURDIOVГЃ T., BALГЃЕЅ M., KLIMEЕ I., GAЕ PERГЌKOVГЃ
D., VICIAN M., ZEMKOVГЃ E., UKROPEC J.: KostrovГЅ sval v patogenГ©ze chorГґb z nedostatku
pohybu. Národný kongres telovýchovného lekárstva: „Aktuálne problémy telovýchovného
lekárstva“, 22 – 23.11.2013, Bratislava.
AktГ­vna ГєДЌasЕҐ na zahraniДЌnГЅch konferenciГЎch:
BALГЃЕЅ M., KURDIOVA T., MADEROVA D., VICIAN M., GASPERIKOVA D., ZEMKOVA
E., UKROPEC J., UKROPCOVA B.: A Novel myokine irisin: in vivo & in vitro changes with
obesity & metabolic status. Keystone Symposia – Adipose Tissue Biology. Keystone, Colorado,
USA, 27.1-1.2.2013. J3041, p. 160 (poster)
KURDIOVA T., UKROPCOVA B., BALAZ M., VICIAN M., VLCEK M., SRBECKY M.,
OLEJNIK J., IMRICH R., BELAN V., KLIMES I., SCHMITZ G., GASPERIKOVA D.,
UKROPEC J.: Physical inactivity and muscle mitochondrial function in diabetes are associated with
specific changes in plasma lipidome. 20th European Congress on Obesity, Liverpool, UK, 12-14.mГЎj
2013, In Obes Facts, vol. 6, Suppl.1, 2013, p166, ISBN 978-3-318-02450-0, (poster).
BALГЃЕЅ M., KURDIOVГЃ T., MADEROVГЃ D., VICIAN M., JELOK I., GAЕ PERГЌKOVГЃ D.,
ZEMKOVГЃ E., KRЕ Е AK M., WOLFRUM CH., UKROPEC J., UKROPCOVГЃ B.: A novel
myokine irisin: in vivo and in vitro changes with obesity and metabolic status“. 20 th. European
Congress on Obesity, ECO 2013, Liverpool, 12.-15. mГЎj 2013, abstrakt publikovanГЅ v Obesity
facts, ISSN 1662-4025, aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka).
UKROPCOVГЃ B., KURDIOVГЃ T., BALГЃЕЅ M., ZEMKOVГЃ E., JELOK I., KYSELOVIДЊOVГЃ
O., UKROPEC, J, KRЕ Е AK, M.: The effects of three months exercise training on physical fitness,
adiposity and muscle energy metabolism in obese individuals. 5th International Congress on
Prediabetes and the Metabolic Syndrome, April 2013, Vienna, Austria (poster).
AktГ­vna ГєДЌasЕҐ na domГЎcich konferenciГЎch:
UKROPCOVГЃ B., KURDIOVГЃ T., BALГЃЕЅ M., MADEROVГЃ D., VICIAN M., ZEMKOVГЃ E.,
UKROPEC J.: Zmeny v spektre myokГ­nov, bioaktГ­vnych sekreДЌnГЅch produktov kostrovГ©ho svalu,
vo vzЕҐahu k obezite a diabetu 2. typu. XI. SlovenskГ© obezitologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou,
14.-16. november 2013, Dudince, aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka).
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BALГЃЕЅ M., KURDIOVГЃ T., MADEROVГЃ D., KLIMEЕ I., GAЕ PERГЌKOVГЃ D., VICIAN M.,
ZEMKOVГЃ E., HAMAR D., UKROPEC J., UKROPCOVГЃ B.: Je hnedГЅ tuk a energetickГЅ
metabolizmus ДЌloveka regulovanГЅ irisГ­nom? Diabetes, cviДЌenie a irisГ­n vo svale. XXIII.
DiabetologickГ© dni v Bratislave, 12.-14. jГєn 2013, aktГ­vna ГєДЌasЕҐ (poster). Program/abstrakty str. 112
2.) Plasticita tukovГ©ho tkaniva a kostrovГ©ho svalu v metabolickom zdravГ­ a v inzulГ­novej
rezistencii. (Adipose tissue and skeletal muscle plasticity in metabolic health and in insulin
resistance)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Jozef Ukropec
1.7 2010 - 31.7.2013
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
EFSD: 40184,12 €
Podpora medzinárodnej spolupráce z národných zdrojov: 2666 €
DosiahnutГ© vГЅsledky:
Kostrový sval je najväčším a zatiaľ najmenej preskúmaným endokrinne aktívnym orgánom.
Sekrečné produkty svalu – myokíny – sa zo svalu uvoľňujú najmä pri kontrakcii a ovplyvňujú
mnoЕѕstvo fyziologickГЅch procesov v celom organizme. PredpokladГЎ sa, Еѕe zmena spektra
myokГ­nov je jednГЅm z mediГЎtorov pozitГ­vneho ГєДЌinku cviДЌenia na zdravie ako aj sГєДЌasЕҐou
patogenГ©zy chronickГЅch ochorenГ­, ako je diabetes 2. typu ДЌi kardiovaskulГЎrne ochorenia. CieДѕom
ЕЎtГєdie je (i) identifikovaЕҐ rozdiely v sekreДЌnom (endokrinnom) profile kostrovГ©ho
svalu a primГЎrnych buniek kostrovГ©ho svalu od chudГЅch, obГ©znych, prediabetikov diabetikov 2.
typu; (ii) ЕЎtudovaЕҐ ГєДЌinok vybranГЅch lГЎtok na sekrГ©ciu myokГ­nov (sekreДЌnГ© produkty kostrovГ©ho
svalu) in vitro; (iii) sledovaЕҐ ГєДЌinok myokГ­nov na metabolizmus lipidov, diferenciГЎciu adipocytov a
na expresiu markerov zГЎpalu v primГЎrnych ДѕudskГЅch adipocytoch. Skompletizovali sme sГєbor
primГЎrnych buniek m. vastus lateralis od jedincov (chudГЅch, obГ©znych, prediabetikov a diabetikov
2. typu) s komplexnГЅm klinickГЅm fenotypom inzulГ­novГЎ senzitivita, nepriama kalorimetria,
magnetickГЎ rezonancia a magnetickГЎ rezonanДЌnГЎ spektroskopia, oGTT, profil pohybovej aktivity
pomocou akcelerometra...), ДЌo nГЎm umoЕѕnilo analyzovaЕҐ sГєvislosti medzi in vivo a in vitro
fenotypmi. V roku 2013 sme uskutoДЌnili molekulГЎrno-biologickГ© analГЅzy vzoriek zГ­skanГЅch v
rГЎmci bunkovГ©ho experimentu na primГЎrnych diferencovanГЅch svalovГЅch bunkГЎch, s cieДѕom
sledovaЕҐ ГєДЌinok rГґznych mastnГЅch kyselГ­n na sekreДЌnГє aktivitu a mitochondriГЎlnu biogenГ©zu
myotГєb chudГЅch, obГ©znych, prediabetickГЅch a diabetickГЅch jedincov. Pomocou RT PCR sme
stanovili gГ©novГ© expresie vybranГЅch sekreДЌnГЅch produktov kostrovГ©ho svalu. A protilГЎtkovГ© array
sa pouЕѕili na stanovenie spektra ЕЎpecifickГЅch myokГ­nov, ktorГ© diferencovanГ© svalovГ© bunky
produkujГє mГ©diГ­. V spoluprГЎci s ETH v Zurichu (prof. Wolfrum) sme tohto roku realizovali
bunkovГЅ experiment na primГЎrnych sortovanГЅch svalovГЅch bunkГЎch ako aj na primГЎrnych myЕЎГ­ch
adipocytoch, s cieДѕom sledovaЕҐ profil myokГ­nov ako aj regulГЎciu akumulГЎcie lipidov vo forme
kvapГґДЌiek neutrГЎlnych lipidov v bunkГЎch kostrovГ©ho svalu ДЌloveka ako aj lipolГЅzy in vitro. CieДѕom
73
SprГЎva o ДЌinnosti organizГЎcie SAV
bolo definovaЕҐ ЕЎpecifickГ© myokГ­ny a mikroRNA, ktorГ© by mohli maЕҐ potenciГЎl ovplyvniЕҐ jednak
metabolickГЅ fenotyp svalu, ale aj metabolizmus na celotelovej Гєrovni.
In extenso publikГЎcie:
KURDIOVA T., BALAZ M., VICIAN M., MADEROVA D., VLCEK M., VALKOVIC L.,
SRBECKY M., IMRICH R., KYSELOVICOVA O., BELAN V., JELOK I., WOLFRUM C.,
KLIMES I., KRSSAK M., ZEMKOVA E., GASPERIKOVA D., UKROPEC J., UKROPCOVA B.
Are Skeletal Muscle & Adipose Tissue Fndc5 Gene Expression and Irisin Release Affected by
Obesity, Diabetes and Exercise? In vivo & in vitro studies. In The journal of physiology (London),
2013. (4.38 - IF2012)
MROSEK N., MEISSBURGER B., MATAKI C., ROEDER E., UKROPEC J., KLIMES I.,
GASPERIKOVA D., NAWROTH PP., RUDOFSKY G., AUWERX J., SCHOONJANS K.,
WOLFRUM C. Transcriptional regulation of adipocyte formation by the liver receptor homologue
1 (Lrh1)-Small hetero-dimerization partner (Shp) network. Mol Metab. 2013 Mar 16;2(3):314-23.
doi: 10.1016/j.molmet.2013.03.003. (IF-N.A. - 2 years history)
VALKOVIДЊ L., UKROPCOVГЃ B., CHMELГЌK M., BALГЃЕЅ M., BOGNER W., SCHMID AI.,
FROLLO I., ZEMKOVГЃ E., KLIMEЕ I., UKROPEC J., TRATTNIG S., KRЕ Е ГЃK M. Interrelation
of (31) P-MRS metabolism measurements in resting and exercised quadriceps muscle of
overweight-to-obese sedentary individuals. NMR Biomed. 2013 Dec;26(12):1714-22. doi:
10.1002/nbm.3008. (IF - 3,446)
OstatnГ© krГЎtke prГЎce, krГЎtke prГЎce v zbornГ­koch zo sympГіziГ­, krГЎtke prГЎce uverejЕ€ovanГ© ako
sГєbor prГ­spevkov zo sympГіziГ­ aj keДЏ sГє uverejnenГ© v CC ДЌasopisoch:
KURDIOVA T., UKROPCOVA B., BALAZ M., LIEBISH G., VICIAN M., VLCEK, M.,
SRBECKY M., OLEJNIK J., IMRICH R., BELAN V., KLIMES I., SCHMITZ G.,
GASPERIKOVA D., UKROPEC J. Specific changes in plasma lipidome in obesity and type 2
diabetes are associated with physical inactivity and muscle mitochondrial function. In Treatment
Strategies – Diabetes, 2013, vol. 5 issue 1, p.42-43.
AktГ­vna ГєДЌasЕҐ na zahraniДЌnГЅch konferenciГЎch:
KURDIOVA T., BALГЃЕЅ M., VICIAN M., CHALLA T.D., GASPERIKOVA D., WOLRUM, C.,
UKROPCOVA B., UKROPEC J.: The accumulation of lipid droplets but not mitochondrial cotent
is decreased in cultured myotubes from patients with type 2 diabetes. Keystone Symposia –
Adipose Tissue Biology. Keystone, Colorado, USA, 27.1-1.2.2013. J3042, p. 160 (poster)
KURDIOVA T., UKROPCOVA B., BALAZ M., VICIAN M., VLCEK M., SRBECKY M.,
OLEJNIK J., IMRICH R., BELAN V., KLIMES I., SCHMITZ G., GASPERIKOVA D.,
UKROPEC J.: Physical inactivity and muscle mitochondrial function in diabetes are associated with
specific changes in plasma lipidome. 20th European Congress on Obesity, Liverpool, UK, 12-14.mГЎj
2013, In Obes Facts, vol. 6, Suppl.1, 2013, p166, ISBN 978-3-318-02450-0, (poster).
KURDIOVA T., UKROPCOVA B., BALAZ M., LIEBISH G., VICIAN M., VLCEK M.,
SRBECKY M., OLEJNIK J., IMRICH R., BELAN V., KLIMES I., SCHMITZ G.,
GASPERIKOVA D., UKROPEC J. Specific changes in plasma lipidome in obesity and type 2
diabetes are associated with physical inactivity and muscle mitochondrial function. 49th annual
meeting of EASD, Barcelona, Spain, 23-27. september, 2013, In: Diabetologia, vol.56, Suppl.1,
2013, p.S307, ISSN:0012-186X, (poster).
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SprГЎva o ДЌinnosti organizГЎcie SAV
AktГ­vna ГєДЌasЕҐ na domГЎcich konferenciГЎch:
UKROPEC J., KURDIOVГЃ T., BALГЃЕЅ M., VALENTГЌNOVГЃ L., VLДЊEK M., VICIAN M.,
OLEJNГЌK J., KLIMEЕ I., SCHMITZ G., GASPERГЌKOVA D., UKROPCOVГЃ B.: VГЅsledky
komplexnej lipidomickej analГЅzy plazmy a tukovГ©ho tkaniva pri obezite a diabete 2 typu, vzЕҐah s
pohybovou aktivitou. XI. SlovenskГ© obezitologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou, 14.-16. november
2013, XXIII. DiabetologickГ© dni v Bratislave, 12.-14. jГєn 2013, aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka).
KURDIOVГЃ T., UKROPCOVГЃ B., LIEBISCH G., BALГЃЕЅ M., VICIAN M., VLДЊEK M.,
SRBECKГќ M., OLEJNГЌK J., IMRICH R., BELAN V., KLIMEЕ I., SCHMITZ G.,
GAЕ PERГЌKOVГЃ D., UKROPEC J.: KomplexnГЎ lipidomickГЎ analГЅza plazmy ukazuje na znГ­Еѕenie
LPC u obГ©znych a diabetikov 2. Typu. XXIII. DiabetologickГ© dni v Bratislave, 12.-14. jГєn 2013,
aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka). Program/abstrakty str. 68
3. ГљДЌinok dlhodobej suplementaДЌnej terapie rastovГЅm hormГіnom na celotelovГЅ metabolizmus
a fenotyp tukovГ©ho tkaniva u dospelГЅch s deficitom rastovГ©ho hormГіnu: 5-roДЌnГ© sledovanie.
(The Effect of a Long-Term Growth Hormone Supplementation on the Whole-Body Metabolic
Characteristics and Adipose Tissue Phenotype in Growth Hormone Deficient Adults: the 5-yr
follow-up. )
ZodpovednГЅ rieЕЎiteДѕ:
Jozef Ukropec
Trvanie projektu:
1.1.2011 / 1.6.2013
EvidenДЌnГ© ДЌГ­slo projektu: WS689054
OrganizГЎcia
je ГЎno
koordinГЎtorom projektu:
Гљstav experimentГЎlnej endokrinolГіgie SAV
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
0
inЕЎtitГєciГ­:
Pfizer: 0 €
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky:
V roku sme v spoluprГЎci s LaboratГіriom endokrinolГіgie ДЌloveka (dr. Richard Imrich, dr. Miroslav
VlДЌek) ukonДЌili klinickГє ДЌasЕҐ ЕЎtГєdie, spojenГє s nГЎborom a komplexnou metabolickou
fenotypizГЎciou dospelГЅch pacientov s deficitom rastovГ©ho hormГіnu, ktorГ­ boli v priebehu
poslednГЅch piatich rokov substituovanГ­ hRH (n=18) ako aj fenotypizГЎcu zdravГЅch jedincov s
rovnakГЅm pohlavГ­m, vekom a BMI (n=18). Podskupina pacientov s deficitom rastovГ©ho hormГіnu
pred substitГєciou hRH sa u nГЎs zГєДЌastnila klinickej ЕЎtГєdie v rokoch 2005-2006, ДЌo nГЎm poskytlo
jedineДЌnГє moЕѕnosЕҐ sledovaЕҐ zmeny metabolickГ©ho fenotypu aj fenotypu tukovГ©ho tkaniva u tГЅchto
ЕЎpecifickГЅch pacientov. Pripravili sme dve publikГЎcie, dve z nich ktorГ© sГє v tomto okamihu
v rezencnom konanГ­. Vzorky tukovГ©ho tkaniva sa v sГєДЌasnosti ДЏalej spracovГЎvajГє za ГєДЌelom
imunohistochemickГЅch stanovenГ­ a charaktrizГЎcie proteГ­novГ©h zloЕѕenia (protilГЎtkovГЎ erej), s cieДѕom
sledovaЕҐ efekt substitГєcie hRH na metabolickГЅ a zГЎpalovГЅ fenotyp tukovГ©ho tkaniva.
PublikГЎcie zaslanГ© do tlaДЌe:
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SprГЎva o ДЌinnosti organizГЎcie SAV
BALAZ M., UKROPCOVA B., KURDIOVA T., GAJDOSECHOVA L., VLCEK M.;
JANAKOVA Z., PURA M., GASPERIKOVA D., TKACOVA R., KLIMES I., PAYER J.,
WOLFRUM C., UKROPEC J.: Zinc-О±2-glycoprotein, a key factor in growth hormone-induced
changes in adipose tissue lipid metabolism. Submitted for publication in The Journal of Clinical
Endocrinology & Metabolism (JCEM).
AktГ­vna ГєДЌasЕҐ na zahraniДЌnГЅch konferenciГЎch:
BALГЃЕЅ M., UKROPCOVГЃ B., KURDIOVГЃ T., PENESOVГЃ A., VLДЊEK M., BELAN V.,
KLIMEЕ I., PAYER J., IMRICH R., GAЕ PERГЌKOVГЃ D., UKROPEC J.: Adult growth hormone
deficiency and metabolic disease are associated with a substantial reduction in adipose tissue
expression levels of zinc-О±2-glycoprotein: Effect of GH supplementation. European Congress on
Obesity, ECO 2013, Liverpool, 12.-15. mГЎj 2013, abstrakt publikovanГЅ v Obesity facts, ISSN 16624025, aktГ­vna ГєДЌasЕҐ (poster)
AktГ­vna ГєДЌasЕҐ na domГЎcich konferenciГЎch:
BALГЃЕЅ M., JANГЃKOVГЃ Z., UKROPCOVГЃ B., KURDIOVГЃ T., BALOGOVГЃ M., PENESOVГЃ P.,
VLДЊEK M., MГЃDEROVГЃ D., BELAN V., KISS A., KLIMEЕ I., IMRICH R., GAЕ PERГЌKOVГЃ D.,
UKROPEC J.: Obezita a diabetes 2. typu sa spГЎjajГє s vГЅraznГЅm poklesom produkcie zink-О±2glykoproteГ­nu v podkoЕѕnom tukovom tkanive. XXIII. DiabetologickГ© dni v Bratislave, 12.-14. jГєn 2013,
aktГ­vna ГєДЌasЕҐ (poster). Program/abstrakty str. 30
BALГЃЕЅ M., UKROPCOVГЃ B., KURDIOVГЃ T., BELAN V., STRAUB L., VLДЊEK M.,
MГЃDEROVГЃ D., PAYER J., KLIMEЕ I., IMRICH R., GAЕ PERГЌKOVГЃ D., WOLFRUM C.,
UKROPEC J.: PozitГ­vny vplyv rastovГ©ho hormГіnu na metabolickГЅ fenotyp tukovГ©ho tkaniva je
sprostredkovanГЅ zink-О±2-glykoproteГ­nom. XI. SlovenskГ© obezitologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou,
14.-16. november 2013, Dudince, aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka).
UKROPEC J., BALГЃЕЅ M., KURDIOVГЃ T., BELAN V., VLДЊEK M., PAYER J., KLIMEЕ I.,
GAЕ PERГЌKOVГЃ D., UKROPCOVГЃ B.: ГљДЌinok suplementГЎcie rastovГЅm hormГіnom na metabolickГЅ
profil a charakteristiky tukovГ©ho tkaniva pacientov s deficitom rastovГ©ho hormГіnu. XI. SlovenskГ©
obezitologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou, 14.-16. november 2013, Dudince, aktГ­vna ГєДЌasЕҐ
(prednГЎЕЎka).
4.) Interakcia vГЅЕѕivy a oxytocГ­nu vo vzЕҐahu k neuroendokrinnГЅm, metabolickГЅm a
kardiovaskulГЎrnym funkciГЎm. (Interaction of nutrients and oxytocin in modulating
neuroendocrine, metabolic and cardiovascular functions.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Daniela JeЕѕovГЎ
1.5.2011 / 1.5.2013
SAS-NSC JRP 2010/07
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
22.000,- Eur
76
SprГЎva o ДЌinnosti organizГЎcie SAV
DosiahnutГ© vГЅsledky:
SkГєmali sa dГґsledky chronickГ©ho stresu na tkanivГЎ podieДѕajГєce sa na syntГ©ze a odbГєravanГ­
lipoproteГ­novГЅch molekГєl. Vystavenie stresu malo za nГЎsledok pokles aktivity lipoproteГ­novej
lipГЎzy (LPL) v tukovom tkanive, ktorГЎ sa podieДѕa na uskladnenГ­ mastnГЅch kyselГ­n. Signifikantne
zvГЅЕЎenГЎ bola gГ©novГЎ ako aj proteГ­novГЎ expresia apolipopoproteГ­nu C3 (ApoC3), ktorГЅ je
inhibГ­torom LPL. ApoC3 je zloЕѕkou lipoproteГ­novГЅch ДЌastГ­c malej hustoty a je spГЎjanГЅ s nГЎrastom
krvnej koncentrГЎcie triacylglycerolov (Pokusa a spol. 2014a). Tieto, ako aj ДЏalЕЎie nedГЎvno zГ­skanГ©
vГЅsledky na naЕЎom, aj Tajvanskom pracovisku odkГЅvajГє novГ©, dosiaДѕ nepoznanГ© mechanizmy,
a preto vyЕѕadujГє potvrdenie viacerГЅmi metodickГЅmi prГ­stupmi. Rozhodli sme sa preto publikovaЕҐ
len niektorГ© ДЌiastkovГ© vГЅsledky vo forme abstraktov a plnohodnotnГЅ rukopis zaslaЕҐ do tlaДЌe aЕѕ po
inkorporovanГ­ vГЅsledkov intenzГ­vnej experimentГЎlnej ДЌinnosti vykonГЎvanej na oboch pracoviskГЎch
v ostatnГЅch troch mesiacoch.
Pri chronickom strese sa mГґЕѕe oslabovaЕҐ reakcia stresovГЅch hormГіnov. PopГ­sali sme, Еѕe zvГЅЕЎenie
sekrГ©cie hormГіnu oxytocГ­nu vyvolanГ© akГєtnym stresovГЅm podnetom mГґЕѕe pretrvaЕҐ aj po
niekoДѕkonГЎsobnom opakovanГ­ podnetu, ak je tento podnet dostatoДЌne intenzГ­vny (Danevova a spol.
2013). Sledovali sme preto vplyv chronickГ©ho podГЎvania antagonistu oxytocГ­novГЅch
a vazopresГ­novГЅch receptorov na dГґsledky opakovanГ©ho stresu. VГЅsledky ukГЎzali, Еѕe podГЎvanie
atosibanu ovplyvЕ€uje gГ©novГє expresiu oxytocГ­novГЅch receptorov v hypotalame, ale nemГЎ vplyv na
proliferГЎciu buniek v mozgu (zaslanГ© do tlaДЌe).
ZaujГ­mavГ© pГґvodnГ© nГЎlezy sa zГ­skali pri skГєmanГ­ vplyvu stresu a atosibanu na Гєrovni nadobliДЌky,
pri ktorom sa vyuЕѕili metodickГ© prГ­stupy TajvanskГЅch partnerov (Pokusa a spol 2014b). Vystavenie
opakovanГ©mu stresu ako aj subchronickГ© podГЎvanie atosibanu viedli k znГ­Еѕeniu gГ©novej expresie
soДѕou indukovateДѕnej kinГЎzy (SIK), ktorГЎ negatГ­vne ovplyvЕ€uje expresiu gГ©nov pre enzГЅmy
zГєДЌastЕ€ujГєce sa syntГ©zy steroidnГЅch hormГіnov. Pozorovali sa zmeny expresie viacerГЅch
steroidogГ©nnych faktorov. ZГ­skanГ© vГЅsledky predstavujГє prvГ© informГЎcie o moЕѕnom vplyve
oxytocГ­novГЅch ako aj vazopresГ­novГЅch receptorov na steroidogenГ©zu v nadobliДЌke v stresovГЅch
podmienkach. Pri poslednej pracovnej nГЎvЕЎteve partnerskГ©ho pracoviska sa vykonali doplЕ€ujГєce
analГЅzy k tГЅmto dГґleЕѕitГЅm nГЎlezom rak, aby bolo moЕѕnГ© zhrnГєЕҐ novГ© poznatky do kvalitnej
publikГЎcie.
PublikГЎcie:
DANEVOVA V., KVETNANSKY R., JEZOVA D. Kinetics of oxytocin response to repeated
restraint stress and/or chronic cold exposure. In Hormone and Metabolic Research, 2013, vol. 45,
no. 12, p. 845-848. (IF=2,146)
BABIC S., POKUSA M., DANEVOVA V., DING SHIH-TORNG, JEZOVA D. Treatment with
atosiban results in reduction of stress-induced anxiety, hypothalamic oxytocin receptor gene
expression and increased release of copeptin without altering stress-induced decrease in
hippocampal cell proliferation (zaslanГ© do tlaДЌe)
VybranГ© abstrakty:
BABIC S., DANEVOVA V., POKUSA M., JEZOVA D. Stress-induced reduction of cell
proliferation in the hippocampus is not modified by treatment with oxytocin antagonist atosiban. 7th
International Symposium on Experimental and Clinical Neurobiology, Abstract book, 2013, p. 18.
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BARTEKOVГЃ M., BARANДЊГЌK M., BABIC S., POKUSA M., FRIMMEL K., OKRUHLICOVГЃ
ДЅ., RADOЕ INSKГЃ J., JEЕЅOVГЃ D. Selected molecular mechanisms involved in stress-induced
changes in the heart. Advances in Cardiovascular Research: from bench to bedside, Program and
Book of Abstracts, 2013, p. 54.
DANEVOVГЃ V., BABIC S., HLAVГЃДЊOVГЃ N., JEЕЅOVГЃ D: ГљДЌinok blokГЎtora oxytocГ­novГЅch
receptorov na ГєzkostnГ© sprГЎvanie vyvolanГ© stresom. In Psychiatrie, 2013, vol. 17, suppl. 1, p. 52.
POKUSA M., GAJDOЕ ECHOVГЃ L., KRЕ KOVГЃ K., CSГЃNOVГЃ A., ZORAD Е ., FRANKLIN
M., JEЕЅOVГЃ D. VybranГ© metabolickГ© parametre v tukovom tkanive v animГЎlnom modeli depresie.
In Psychiatrie, 2013, vol. 17, suppl. 1, p. 51.
POKUSA M., LIN H.J., GAJDOЕ ECHOVГЃ L., BABIC S., DANEVOVГЃ V., DING S.T., ZГ“RAD
Е ., JEЕЅOVГЃ D. Vplyv chronickГ©ho stresu na ГєzkostnГ© sprГЎvanie a expresiu gГ©nov regulujГєcich
metabolizmus lipoproteГ­nov. 56. ДЊesko-slovenskГЎ psycho-farmakologickГЎ konference, LГЎznД›
Jeseník, 8. – 12. 1. 2014a (v tlači)
POKUSA M., CHOU H.Y.E., DING S.T., BABIC S., JEЕЅOVГЃ D. Vplyv blokГЎdy oxytocГ­novГЅch a
vazopresГ­novГЅch receptorov na steroidogenГ©zu v nadobliДЌkГЎch poДЌas stresu. 90. FyziologickГ© dni,
Bratislava, 4. – 6. 2. 2014b (v tlači)
5. Zavedenie animГЎlneho modelu depresie zaloЕѕenom na tryptofГЎnovej deplГ©cii (Developing a
rat model of depression based on tryptophan deficiency)
ZodpovednГЅ rieЕЎiteДѕ:.Daniela JeЕѕovГЎ
Trvanie projektu: 1.5.2011 / 31.12.2013
EvidenДЌnГ© ДЌГ­slo projektu: Proof of Concept Funding, Oxford Brookes University
OrganizГЎcia je koordinГЎtorom projektu: ГЎno
KoordinГЎtor: Гљstav experimentГЎlnej endokrinolГіgie SAV
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­: 0
Čerpané financie: 1100 €
DosiahnutГ© vГЅsledky:
ZГ­skali sme doplЕ€ujГєce Гєdaje k mechanizmom, ktorГЅmi deplГ©cia aminokyseliny tryptofГЎnu
vyvolГЎva depresii podobnГЅ stav u samГ­c potkanov. UkГЎzali sme, Еѕe konzumГЎcia diГ©ty s nГ­zkym
obsahom tryptofГЎnu navodГ­ znГ­Еѕenie koncentrГЎciГ­ horДЌГ­ka s dopadom na glutamГЎtovГє
neurotransmisiu a tГЎto zmena je rezistentnГЎ na podГЎvanie antidepresГ­va paroxetГ­nu. Pripravuje sa
rukopis publikГЎcie. O testovanie ГєДЌinkov novГЅch lieДЌiv v naЕЎom novozavedenom animГЎlnom
modeli rezistentnej depresie u samiДЌiek uЕѕ prejavila zГЎujem zahraniДЌnГЎ farmaceutickГЎ firma.
Abstrakty:
FRANKLIN M., JEZOVA D., HLAVACOVA N., SINGEWALKD N., MURCK H. Aldosterone
increases earlier than corticosterone in new animal models of depression: Is this an early marker for
depression onset? In Journal of Psychopharmacology, 2013, vol. 27, no. 8, suppl., p. 19.
6. Е tГєdium interakciГ­ reaktГ­vnych foriem kyslГ­ka a oxidu dusnatГ©ho pri hДѕadanГ­ novГЅch
mechanizmov ovplyvЕ€ujГєcich. (Study of interactions between reactive oxygen species and nitric
oxide in search for novel mechanisms of hypertension)
78
SprГЎva o ДЌinnosti organizГЎcie SAV
Ima DovinovГЎ
ZodpovednГЅ rieЕЎiteДѕ:
Е tefan Zorad
ZodpovednГЅ rieЕЎiteДѕ v ГљEE SAV
1.1.2011 / 31.12.2013
Trvanie projektu:
SAS-NSC JRP 2010/01
EvidenДЌnГ© ДЌГ­slo projektu:
nie
OrganizГЎcia je koordinГЎtorom projektu:
UNPF SAV
KoordinГЎtor:
3
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­:
3000 €
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky:
Sledoval sa vplyv podГЎvania agonistu PPARgama pioglitazГіnu na vГЅvoj hypertenzie a metabolickГ©
parametre SHR potkanov. MladГ© pre-hypertenzГ­vne potkany vo veku 5 tГЅЕѕdЕ€ov dostГЎvali dГЎvku 10
mg/kg/deЕ€ pioglitazГіnu poДЌas 2 tГЅЕѕdЕ€ov a ich kontroly fyziologickГЅ roztok. PioglitazГіn
signifikantne zniЕѕoval priebeh zvyЕЎovania krvnГ©ho tlaku a hladiny sГ©rovГ©ho cholesterolu. Na druhej
strane pioglitazГіn signifikantne zvyЕЎoval expresiu angiotenzГ­novГ©ho AT1 receptora v tukovom
tkanive bez vplyvu na expresiu PPARgama, aP2, UCP1, AGT a ACE.
PublikГЎcie :
DOVINOVГЃ I., BARANCIK M., MAJZUNOVA M., ZORAD S., GAJDOSECHOVA L.,
GRESOVA L., CACANYIOVA S., KRISTEK F., BALIS P., CHAN J.Y.H. : Effects of PPARОі
Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Sponaneously Hypertensive
Rats. PPAR Research, vol. 2013, Article ID 541871, 11 pages, 2013.
MedziГєstavnГЎ bilaterГЎlna spoluprГЎca nefinancovanГЎ
1. LaboratГіrium farmakologickej neuroendokrinolГіgie (prof. D. JeЕѕovГЎ) rieЕЎi spoloДЌnГЅ projekt
s Instituto de Investigaciones BiotecnolГіgicas, CONICET, Buinos Aires, ArgentГ­na (Dr. B.
Fuchsová) na tému „Chronic stress impact on neuronal membrane glycoprotein M6a: pathway and
regulation analysis“. Absolvovali sa vzájomné výmenné pobyty a na ÚEE sa vykonal spoločný
experiment. VГЅsledky sГє v ЕЎtГЎdiu analГЅzy.
LaboratГіrium farmakologickej neuroendokrinolГіgie (prof. D. JeЕѕovГЎ) rieЕЎi spoloДЌnГЅ projekt
s Гљstavom experimentГЎlnej medicГ­ny MaДЏarskej akadГ©mie vied, BudapeЕЎЕҐ (Dr. D. Zelena) na tГ©mu
„Specific features of stress regulation during the perinatal period“. Absolvovali sa vzájomné
vГЅmennГ© pobyty a na oboch pracoviskГЎch sa vykonali spoloДЌnГ© experimenty. VГЅsledky sГє v ЕЎtГЎdiu
analГЅzy.
2. Mapovanie aktivovanГЅch neurГіnov (Fos imunohistochГ©mia) v hypotalamickej oblasti
mozgu po akГєtnom podanГ­ "VareniklГ­nu" (Mapping of activated neurons in the hypothalamus of
rat after acute treatment with Varenicline)
SpolurieЕЎiteДѕskГЎ inЕЎtitГєcia: Neurobiology Research Unit, University Hospital Copenhagen,
Denmark; Department of Translational Neurobiology, NeuroSearch A/S, Ballerup, Denmark
ZodpovednГ­ rieЕЎitelia: Alexander Kiss
Jens D. Mikkelsen
Dátum začiatku a ukončenia projektu: 1.1.2011 – 31.12.2015
Pracovisko v zahraniДЌГ­: NeurobiologickГЎ vГЅskumnГЎ jednotka Univerzitnej nemocnice, KodaЕ€ a
Гљstav translaДЌnej neurobiolГіgie, Ballerup, DГЎnsko (Neurobiology Research Unit, University
Hospital Copenhagen, Denmark; Department of Translational Neurobiology, NeuroSearch A/S,
Ballerup, Denmark, (Dr. J.D. Mikkelsen).
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SprГЎva o ДЌinnosti organizГЎcie SAV
Predmet spoluprГЎce: PokraДЌovanie v spoluprГЎci na tГ©mu "Mapovanie aktivovanГЅch neurГіnov (Fos
imunohistochГ©mia) v hypotalamickej oblasti mozgu po akГєtnom podanГ­ "VareniklГ­nu"
(Varenicline, obchodnГ© meno - Champix). (Mapping of activated neurons in the hypothalamus of
rat after acute treatment with Varenicline). TГЎto lГЎtka bola vyvinutГЎ ako nГЎpomocnГЎ lГЎtka fajДЌiarom
na zastavenie nГЎvyku na fajДЌenie. VareniklГ­n mimikuje efekt nikotГ­nu v organizme. Redukuje
potrebu fajДЌenia ako aj symptГіmy zГЎvislosti na nikotГ­n tak, Еѕe obsadzuje receptory v mozgu, ktorГ©
nikotГ­n stimuluje a ДЌiastoДЌne ich udrЕѕuje stimulovanГ© ДЌГ­m zabraЕ€uje zГЎvislosti na cigaretovГЅ
nikotГ­n. NaЕЎou Гєlohou bolo zistiЕҐ ДЌi akГєtne podanie VareniklГ­nu ovplyvЕ€uje aktivitu
hypokretГ­novГЅch (HCRT) a melanГ­n koncentrujГєcich (MCH) neurГіnov, ktorГ© sa spoloДЌne vyskytujГє
v zona incerta, perifornikГЎlnom jadre a laterГЎlnom hypotalame a sГє zapojenГ© do regulГЎcie prГ­jmu
potravy a metabolizmu lГЎtok. Aktivitu neurГіnov sme vyhodnocovali na zГЎklade expresie Fos
peptidu v spomГ­nanГЅch fenotypoch neurГіnov.
StruДЌnГЎ charakteristika dosiahnutГЅch vГЅsledkov: VГЅsledky poukГЎzali na vГЅraznГє expresiu Fos
len v HCRT neurГіnoch. Fos aktivujГєci efekt VareniklГ­nu bol totГЎlne neГєДЌinnГЅ v MCH neurГіnoch.
JednoznaДЌnГЎ reakcia len HCRT neurГіnov poukazuje na vГЅluДЌnГЅ ГєДЌinok VareniklГ­nu na
jednosmernГє HCRT regulГЎciu bez kompenzaДЌnГ©ho regulaДЌnГ©ho mechanizmu MCH neurГіnov.
PublikГЎcie:
MAJERДЊГЌKOVГЃ Z., Van WEERING H., SCSUKOVГЃ S., MIKKELSEN J.D., KISS A. A new
approach of light microscopic immunohistochemical triple-staining: combination of Fos labeling
with diaminobenzidine-nickel and neuropeptides labeled with Alexa488 and Alexa555 fluorescent
dyes. Endocr Regul 46, 217-223, 2012.
3. Vplyv novГЅch analГіgov grelГ­nu s agonistickou aktivitou na regulГЎciu prГ­jmu potravy a
aktivitu hypotalamickГЅch neurГіnov zapojenГЅch do jej regulГЎcie u myЕЎГ­ C57Bl/6. (Effect of new
ghrelin analogs, with agonistic and antagonistic activities on the food intake regulation and the
activity of hypothalamic neurons involved in the food intake regulation in C57Bl/6 male mice )
SpolurieЕЎiteДѕskГЎ inЕЎtitГєcia: Institute of Organic Chemistry and Biochemistry), Flemingovo nГЎm.
2, 166 10 Prague 6, Czech Republic
ZodpovednГ­ rieЕЎitelia:RNDr. Alexander Kiss, Zdenko PirnГ­k
Lenka MaletinskГЎ, Blanka ЕЅeleznГЎ
Dátum začiatku a ukončenia projektu: 1.1.2012 – 31.12.2015
Pracovisko v zahraniДЌГ­: Гљstav organickej chГ©mie a biochГ©mie (Institute of Organic Chemistry and
Biochemistry), Flemingovo nГЎm. 2, 166 10 Prague 6, Czech Republic, (RNDr. Lenka MaletinskГЎ,
CSc. A Ing. Blanka ЕЅeleznГЎ, CSc)
Predmet spoluprГЎce: Vplyv novГЅch analГіgov ghrelГ­nu s agonistickГЅm (DprGhr) ako aj
antagonistickГЅm (DLysGHRP) ГєДЌinkom na regulГЎciu prГ­jmu potravy a aktivitu hypotalamickГЅch
neurГіnov zapojenГЅch do jej regulГЎcie u myЕЎГ­ C57Bl/6. (Effect of new ghrelin analogs, with
agonistic and antagonistic activities on the food intake regulation and the activity of hypothalamic
neurons involved in the food intake regulation in C57Bl/6 male mice).
StruДЌnГЎ charakteristika dosiahnutГЅch vГЅsledkov: Hypotalamus hrГЎ dГґleЕѕitГє Гєlohu v regulГЎcii
prГ­jmu potravy, priДЌom jeho jednotlivГ© jadrГЎ a oblasti sГє pod kontrolou niekoДѕkГЅch
orexigГ©nnych a anorexigГ©nnych peptidov. CieДѕom vzГЎjomnej spoluprГЎce bolo charakterizovanie
ГєДЌinku novГЅch perifГ©rne aplikovanГЅch agonistov a antagonistov grelГ­nu (orexigГ©nneho
neuropeptidu tvorenГ©ho v ЕѕalГєdku) na prГ­jem potravy a aktivitu katecholaminergickГЅch (KA)
neurГіnov nucleus hypothalamicus arcuatus (ARC). VГЅsledky ukГЎzali mimoriadne rozsiahlu
aktivГЎciu KA neurГіnov s prГ­tomnosЕҐou Fos proteГ­nu, t.j. markera reflektujГєceho stimulГЎciu
neurГіnov. Reakcia prГ­jmu potravy u myЕЎГ­ bola adekvГЎtnak charakteru podГЎvanГЅch syntetickГЅch
analГіgov ghrelГ­nu. VГЅsledky s vyЕЎe 50% stimulГЎciou TH neurГіnov v ARC sГє v literatГєre takmer
neopГ­sanГ© a ojedinelГ©. V rroku 2013 sme skompletizovali vГЅsledky a zaslali publiokГЎciu do tlaДЌe.
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SprГЎva o ДЌinnosti organizГЎcie SAV
PublikГЎcie:
PIRNIK Z., MAJERДЊГЌKOVГЃ Z., HOLUBOVГЃ M., PYCHOVГЃ M., ZELEZNГЃ, B.,
MALETГЌNSKA L., KISS A. Effect of ghrelin receptor agonist and antagonist on the activity of
arcuate nucleus tyrosine hydroxylase containing neurons in C57BL/6 male mice exposed to normal
or high fat diet. Neurochem Int 2013. (zaslanГЎ)
4. Pracovisko v zahraniДЌГ­: : Oxford NIHR Biomedical Research Centre, Churchill Hospital,
Oxford, U.K. (prof. Katahrine R. Owen) a Oxford Centre for Diabetes, Endocrinology and
Metabolism, University of Oxford, UK /Prof. A. Gloyn/
ZodpovednГЅ rieЕЎiteДѕ : Iwar KlimeЕЎ
Predmet spoluprГЎce: IdentifikГЎcia novГЅch biomarkerov v oblasti monogГ©novГ©ho diabetu
V rГЎmci medzinГЎrodnej spoluprГЎce v celoeurГіpskej multicentrickej ЕЎtГєdii participovalo 457
pacientov s HNF1A-MODY (46 z SK), 404 s GCK-MODY (88 Z SK), 54 a HNF4A-MODY (2
z SK), 98 s 1. typom diabetu, 167 pacientov s 2. typom diabetu a 98 kontrol bez diabetu. Zistili sme,
Еѕe DG9-glykanovГЅ index bol signifikantne niЕѕЕЎГ­ pri HNF1A-MODY ako u kontrol, ДЌi inГЅch
podtypoch diabetu (ROC ≥ 0.90) a umožnil identifikovať troch pacientov s HNF1A-MODY, ktorí
neboli predtГЅm diagnostikovanГ­. DG9 glykГЎnovГЅ index sa po javГ­ ako potencionГЎlny uЕѕitoДЌnГЅ
klinickГЅ biomarker vhodnГЅ na identifikГЎciou pacientov s HNF1A dysfunkciou.
Okrem toho sa rozvinula spolurГЎca v oblasti identifikГЎcie novГЅch genetickГЅch prГ­ДЌin
monogГ©novГ©ho diabetu metГіdou sekvenovania novej generГЎcie, v rГЎmci ktorej bolo zaslanГЅch na
Univerzitu v Oxforde DNA 7 rodГ­n s klinickГЅm podozrenГ­m na MODY diabetes, ale bez nГЎlezu
mutГЎcie v doteraz znГЎmych gГ©noch.
PublikГЎcie:
THANABALASINGHAM G, HUFFMAN JE, KATTLA JJ, NOVOKMET M, RUDAN I, GLOYN
AL, HAYWARD C, ADAMCZYK B, REYNOLDS RM, MUZINIC A, HASSANALI N, PUCIC
M, BENNETT AJ, ESSAFI A, POLASEK O, MUGHAL SA, REDZIC I, PRIMORAC D, ZGAGA
L, KOLCIC I, HANSEN T, GASPERIKOVA D, TJORA E, STRACHAN MW, NIELSEN T,
STANIK J, KLIMES I, PEDERSEN OB, NJ�LSTAD PR, WILD SH, GYLLENSTEN U,
GORNIK O, WILSON JF, HASTIE ND, CAMPBELL H, MCCARTHY MI, RUDD PM, OWEN
KR, LAUC G, WRIGHT AF.: Mutations in HNF1A result in marked alterations of plasma glycan
profile. DIABETES 62 (4), pp. 1329-37, 2013 Apr. IF 2012 = 7.895
5. RegulГЎcia expresie gГ©nov enzГЅmov syntetizujГєcich katecholamГ­ny je zГЎvislГЎ na ЕЎpecificite
stresora (Stressor-specific regulation of catecholamine biosynthetic enzyme gene expression)
SpolurieЕЎiteДѕskГЎ inЕЎtitГєcia: New York Medical College, Valhalla, USA
ZodpovednГ­ rieЕЎitelia: RNDr. Richard KvetЕ€anskГЅ
Esther L. Sabban
DГЎtum zaДЌiatku a ukonДЌenia projektu: 2010-2015
Treba uviesЕҐ, Еѕe v predchГЎdzajГєcich rokoch bol projekt financovanГЅ zo zahraniДЌnГЅch
zdrojov. Aj v roku 2013 sa pokraДЌovalo v rieЕЎenГ­ tohto, pre obe strany vГЅhodnГ©ho projektu, avЕЎak
nГЎklady neboli oficiГЎlne financovanГ© ЕЎpecifickГЅm grantom.
V naЕЎom laboratГіriu na ГљEE SAV v Bratislave sa realizovali nГЎroДЌnГ© experimenty na
myЕЎiach, ktorГ© mali vyradenГЅ gГ©n kortikoliberГ­nu (CRH). TakГ©to CRH-KO a WT myЕЎi sme
vystavili akГєtnemu a opakovanГ©mu imobilizaДЌnГ©mu stresu na rГґzne ДЌasovГ© intervaly a extirpovali
drene nadobliДЌiek, ktorГ© sme v zamrazenom stave zaslali na spolupracujГєce pracovisko do USA. Na
81
SprГЎva o ДЌinnosti organizГЎcie SAV
americkom pracovisku sa realizovala analГЅza vzoriek zameranГЎ predovЕЎetkГЅm na sledovanie
expresie a translГЎcie enzГЅmov syntГ©zy katecholamГ­nov a ich transportГ©rov, ako aj urokortГ­nu-2
a angiotenzГ­novГЅch a bradykinГ­novГЅch receptorov.
ZГ­skali sa unikГЎtne vГЅsledky, ktorГ© ukГЎzali, Еѕe expresia urokortГ­nu-2 sa v dreni nadobliДЌiek
zvГЅЕЎila po akГєtnej imobilizГЎcii viac ako 30-nГЎsobne. IMO tieЕѕ indukovala 6-nГЎsobne expresiu CRH
a dvojnГЎsobne expresiu CRH receptorov typu 1. SГєhrnne, tieto vГЅsledky naznaДЌujГє, Еѕe stresom
vyvolanГЅ vzostup hladГ­n kortikosterГіnu je zodpovednГЅ za vГЅraznГЅ vzostup hladГ­n urokortГ­nu-2 po
IMO strese. TakЕѕe urokortГ­n-2 pГґsobГ­ ako vГЅznamnГЅ modulГЎtor adrenomedulГЎrnej funkcie
(Tillinger et al., 2013).
BradykinГ­n, ktorГЅ pГґsobГ­ cez bradykinГ­n B2 receptory, je silnГЅm stimulГЎtorom biosyntГ©zy
a uvoДѕЕ€ovania katecholamГ­nov v dreni nadobliДЌiek a hrГЎ vГЅznamnГє Гєlohu pri odpovedi drene na
stresovГЅ podnet. Zistili sme, Еѕe po imobilizГЎcii dochГЎdza k 9-nГЎsobnГ©mu vzostupu mRNA
bradykinГ­novГ©ho B2 receptora. Tento vzostup bol zablokovanГЅ u CRH-KO myЕЎГ­, ДЌo indikuje
potrebu glukokortikoidov pri upregulГЎcii B2 receptora za stresu (Nostramo et al. 2013).
PublikГЎcie:
TILLINGER A., NOSTRAMO R., KVETŇANSKÝ R., SEROVA L., SABBAN E. L.: Stressinduced changes in gene expression of urocortin 2 and other CRH peptids in rat adrenal medulla:
involvement of glucocorticoids.
Journal of
Neurochemistry, 2013, 125: pp. 185-192. DOI: 10.1111/jnc.12152.
(3,973 – IF2013)
Typ: ADCA
NOSTRAMO R., TILLINGER A. SEROVA L., KVETŇANSKÝ R., SABBAN, E. L.:
Bradykinin B2 reeptor in the adrenal medulla of male rats and mice: Glucocorticoid-dependent
increase with immobilization stress.
Endocrinology,
2013, 154 (10): pp. 3729-3738. (4,717 – IF2013)
Typ: ADCA
6. BiomГЎrkery pre skorГє detekciu a terapiu nГЎdorov nadobliДЌky: MolekulГЎrna patogenГ©za
a klinickГ© korelГЎty. (Biomarkers for Early Detection and Therapy of Adrenal Gland Tumors:
Molecular Pathogenesis and Clinical Correlates)
ZodpovednГ­ rieЕЎitelia: Boris Mravec
Richard KvetЕ€anskГЅ
Karel PacГЎk
SpolurieЕЎiteДѕskГЎ inЕЎtitГєcia:
Pediatric and Reproductive Endocrinology Branch, National Institute of Child and Human
Development, NIH, Bethesda, USA
JednГЎ sa o projekt, ktorГЅ sa realizuje v rГЎmci dohody o spoluprГЎci medzi SAV a National
Institute of Child and Human Development, NIH, Bethesda, USA. Ide o veДѕmi vГЅhodnГє
spoluprГЎcu, ktorГЎ bola oficiГЎlne podpГ­sanГЎ v roku 2010.
DosiahnutГ© vГЅsledky:
Projekt sa realizuje na myЕЎiach aj u ДѕudГ­, u ktorГЅch sa analyzujГє nГЎdory drene nadobliДЌiekfeochromocytГіmy, ktorГ© produkujГє enormnГ© mnoЕѕstvГЎ katecholamГ­nov. ZvieracГ­ model
metastatickГ©ho feochromocytГіmu dГЎva jedineДЌnГє prГ­leЕѕitosЕҐ pre predklinickГ© hodnotenie lieДЌby
rakoviny rГґznymi liekmi, radio-farmakami, a rГґznymi zobrazovacГ­mi technikami. Tento model je
obzvlГЎЕЎЕҐ uЕѕitoДЌnГЅ pre ЕЎtГєdium fyziolГіgie metastatickГ©ho feochromocytГіmu.
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SprГЎva o ДЌinnosti organizГЎcie SAV
V ostatnom obdobГ­ sa projekt zameriava na sledovanie vzniku a vГЅvoja feochromocytГіmu
u zvierat vystavenГЅch akГєtnemu a opakovanГ©mu stresu. DosiahnutГ© vГЅsledky sa kompletizujГє a
neboli dosiaДѕ publikovanГ©.
7. RegulГЎcia enzГЅmu PNMT syntetizujГєceho adrenalГ­n za stresu
(Regulation of PNMT, the enzyme regulating adrenaline biosynthesis in stress)
ZodpovednГ­ rieЕЎitelia: Richard KvetЕ€anskГЅ
Dona L. Wong
SpolurieЕЎiteДѕskГЎ inЕЎtitГєcia: Department of Molecular and Developmental
Neurobiology, Harvard Medical School, Belmont, MA, USA
DosiahnutГ© vГЅsledky:
CieДѕom spoluprГЎce bolo vyvinГєЕҐ model na sledovanie potenciГЎlnej Гєlohy adrenalГ­nu
pri ochoreniach spojenГЅch so stresovГЅmi situГЎciami. Ak chronickГЎ nadprodukcia adrenalГ­nu
spГґsobuje ochorenie, potom mГЎme moЕѕnosЕҐ terapeutickГ©ho zГЎsahu do regulГЎcie stresomindukovanej expresie syntГ©zy adrenalГ­nu, funkcie adrenergickГЅch receptorov a ГєДЌinku
kortikosteroidov na syntГ©zu adrenalГ­nu. TerapeutickГ© zГЎsahy je potrebnГ© naДЏalej ЕЎtudovaЕҐ.
8. Vplyv novГЅch analГіgov grelГ­nu s agonistickou aktivitou na regulГЎciu prГ­jmu potravy a
aktivitu hypotalamickГЅch neurГіnov zapojenГЅch do jej regulГЎcie u myЕЎГ­ C57Bl/6. (Effect of new
ghrelin analogs with agonist activity on food intake regulation and on
the activity of neurons in hypothalamic structures of C57Bl/6 male mice involved in the food intake
regulation )
SpolurieЕЎiteДѕskГЎ inЕЎtitГєcia: Institute of Organic Chemistry and Biochemistry), Flemingovo nГЎm.
2, 166 10 Prague 6, Czech Republic
ZodpovednГ­ rieЕЎitelia:Zdenko PirnГ­k, Alexander Kiss
Lenka MaletinskГЎ, Blanka ЕЅeleznГЎ
Dátum začiatku a ukončenia projektu: 2013 – 2016
Pracovisko v zahraniДЌГ­: Гљstav organickej chГ©mie a biochГ©mie (Institute of Organic Chemistry and
Biochemistry), Flemingovo nГЎm. 2, 166 10 Prague 6, Czech Republic, (RNDr.
Lenka MaletinskГЎ, CSc., Ing. Blanka ЕЅeleznГЎ, CSc)
Predmet spoluprГЎce: Vplyv novГЅch analГіgov grelГ­nu s agonistickou aktivitou na regulГЎciu prГ­jmu
potravy a aktivitu hypotalamickГЅch neurГіnov zapojenГЅch do jej regulГЎcie u myЕЎГ­ C57Bl/6. (Effect
of new ghrelin analogs with agonist activity on food intake regulation and on
the activity of neurons in hypothalamic structures of C57Bl/6 male mice involved in the food intake
regulation).
StruДЌnГЎ charakteristika dosiahnutГЅch vГЅsledkov: Hypotalamus hrГЎ dГґleЕѕitГє Гєlohu v regulГЎcii
prГ­jmu potravy, priДЌom jeho jednotlivГ© jadrГЎ a oblasti sГє pod kontrolou niekoДѕkГЅch orexigГ©nnych a
anorexigГ©nnych peptidov. CieДѕom vzГЎjomnej spoluprГЎce bolo charakterizovanie ГєДЌinku CART
(cocaine- and amphetamine-regulated transcript) peptidu na vnГєtrobunkovГє signalizГЎciu resp. na
aktivitu mozgovГЅch jadier zapojenГЅch do regulГЎcie prГ­jmu potravy ako aj perifГ©rne aplikovanГ©ho
analГіgu grelГ­nu (orexigГ©nneho neuropeptidu tvorenГ©ho v ЕѕalГєdku) a jeho antagonistu na prГ­jem
potravy a ich vplyv na aktivitu TH neurГіnov u myЕЎГ­ dlhodobo chovanГЅch na ЕЎtandardnej resp.
vysokotukovej diГ©te.
SprГЎva o ДЌinnosti organizГЎcie SAV
VГЅsledky prГЎce boli spracovanГ© vo forme publikГЎcii, ktorГ© sГє aktuГЎlne v recenznom konanГ­ resp.
boli aktuГЎlne akceptovanГ© v zahraniДЌnom IF ДЌasopise
PublikГЎcie:
83
SprГЎva o ДЌinnosti organizГЎcie SAV
NAGELOVГЃ V., PIRNIK Z., ZELEZNГЃ B., MALETГЌNSKA L. CART (cocaine- and
amphetamine-regulated transcript) peptide specific binding sites in PC12 cells have characteristics
of CART peptide receptors. Brain Res. 2013 Dec 27
Projekty nГЎrodnГЅch agentГєr
Programy: VEGA
1.) ProtektГ­vne ГєДЌinky neuropeptidov (Protective effects of neuropeptides)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Zuzana BaДЌovГЎ
1.1.2012 / 31.12.2014
VEGA 2/0132/12
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
5.906,- Eur
DosiahnutГ© vГЅsledky:
V rГЎmci projektu sa uskutoДЌnili experimenty, v ktorГЅch sa testovali ГєДЌinky prolaktГ­nu na
neuroblastГіmovГ© bunkovГ© lГ­nie (SK-N-SH, SH-SY5Y) a glioblastГіmovГє bunkovГє lГ­niu U-87MG.
ProlaktГ­n zvyЕЎuje expresiu cytoskeletГЎrnych proteГ­nov nestГ­nu a MAP-2 a oxytocГ­novГ©ho receptoru
u neuroblastГіmovГЅch ale nie u glioblastГіmovГЅch buniek. ZvГЅЕЎenie mnoЕѕstva sledovanГЅch
proteГ­nov u neuronГЎlneho typu buniek bolo pozorovanГ© vДЏaka in-cell-westernblotu.
PublikГЎcie :
BAKOS J., STRBAK V., PAULIKOVA H., KRAJNAKOVA L., LESTANOVA Z., BACOVA Z.
Oxytocin receptor ligands induce changes in cytoskeleton in neuroblastoma cells. In Journal of
Mollecular Neuroscience. 2013; vol. 50, n. 3, pp. 462-468.
LEŠŤANOVÁ Z., BAČOVÁ Z., HAVRÁNEK T.,BAKOŠJ. Neuropeptidy vo vývine mozgu –
potenciГЎl na protekciu proti zГЎpalovГЅm zmenГЎm. In DubovickГЅ M: Trendy vo vГЅvinovej toxikolГіgii
a teratolГіgii. 2013, pp. 59-73; ISBN 978-80-971042-2-1
ŠTRBÁK, V. Cell volume –role in obesity and its maintenance. Minireview. Invited review. In
Serbian Journal of Experimental and Clinical Research. 2013, vol. 14, no 2, p. 45-48. ISSN 18208665.
Е TRBГЃK, V. Cell volume conferences. In Bulletin of Siberian Medicine. 2013, vol. 12, no 4, p. 812. ISSN 1682-0363.
BAДЊOVГЃ Z., LEЕ Е¤ANOVГЃ Z., Е TRBГЃK V., BAKOЕ J . VГЅvinovГ© zmeny cytoskeletovГЅch
proteГ­nov a rastovГЅch faktorov v hipokampe pod vplyvom oxytocГ­nu, ZbornГ­k abstraktov z 89.
FyziologickГЅch dnГ­ v Prahe, ISBN 978-80-87432-06-8, s. 78, 2013
84
SprГЎva o ДЌinnosti organizГЎcie SAV
BAДЊOVГЃ Z., LEЕ Е¤ANOVГЃ Z., Е TRBГЃK V., BAKOЕ J . Developmental effects of oxytocin on
gene expressin of cytoskeletal proteins and growth factors in the rat hippocampus, Abstract book
p.31. “New frontiers in physiological research from scientific truth via friendship to the art “20.-22.
6.2013, KovaДЌica, Srbsko, ISBN 978-86-904799-6-2
Е TRBГЃK V., BAДЊOVГЃ Z. Cell swelling, novel regulatory signal affecting various functions.
Abstract book p.19. “New frontiers in physiological research from scientific truth via friendship to
the art “20.-22. 6.2013, Kovačica, Srbsko, ISBN 978-86-904799-6-2. Invited lecture.
ŠTRBÁK V., BAČOVÁ Z., RAVINGEROVÁ T. Cell swelling-induced hormone secretion –
pathophysiological implications. The 10th International Congress Cell volume regulation – novel
therapeutic targets & pharamcological approaches. Bulletin of Siberian Medicine. 2013, vol. 12, no
4, p. 64. ISSN 1682-0363. Invited lecture
2.) SkrГ­ning biologickГЅch aktivГ­t vybranГЅch druhov rastlГ­n a identifikГЎcia ich aktГ­vnych
konЕЎtituentov (Biological activities of selected plants and identification of their active contituents.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
MГЎria FickovГЎ
1.1.2011 / 31.12.2014
1/0059/11
nie
FaF UK
1
918,- Eur
DosiahnutГ© vГЅsledky :
Hodnotila sa biologickГЎ aktivita, t.j. antiproliferaДЌnГЅ ГєДЌinok/toxicita lyofilizГЎtov vodnГЅch extraktov
listov Cornus pendula a, Cornus kousa (Cornaceae) na ДѕudskГЅch nГЎdorovГЅch bunkГЎch prsnГ­ka
(lГ­nia MCF7). Rast inhibiДЌnГЅ ГєДЌinok sa menГ­ v zГЎvislosti od ДЌasu expozГ­cie a dГЎvky, priДЌom aktivity
jednotlivГЅch extraktov sa vГЅrazne medzi sebou lГ­ЕЎia. AntiproliferaДЌnГє/cytotoxickГє ГєДЌinnosЕҐ
vyjadruje hodnota ED50, jej niЕѕЕЎia hodnota znamenГЎ vyЕЎЕЎiu aktivitu. V naЕЎich podmienkach bol v
kaЕѕdom ДЌasovom intervale: 24h, 48h a 72h, bol z oboch testovanГЅch ГєДЌinnejЕЎГ­ extrakt Cornus
kousa(vs. C. pendula).
3. Molekularno-geneticka a proteomicka analyza vyvinovo-spriahnutej
metabolickej funkcie rodiny (komplexu) hormonalne responzivnych a
obligatnych malat dehydrogenaz u Drosophila melanogaster.
(Molecular-genetic and proteomic analysis of developmentally-linked
metabolic function of hormonally responsive and obligatory malate
dehydrogenases complex in Drosophila melanogaster.)
Robert FarkaЕЎ
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ
v organizГЎcii SAV
1.1.2013 / 31.12.2016
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu: 2/0109/13
ГЃno
OrganizГЎcia je
koordinГЎtorom projektu:
85
SprГЎva o ДЌinnosti organizГЎcie SAV
Гљstav experimentГЎlnej endokrinolГіgie SAV
KoordinГЎtor:
1
PriF UK, Katedra genetiky
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
VEGA: 6076 €
ДЊerpanГ© financie:
StruДЌnГЎ charakterisitika dosiahnutГЅch vГЅsledkov
DosiahnutГ© vГЅsledky:
S cieДѕom pokraДЌovaЕҐ v podrobnej alelickej identifikГЎcii MDH lokusov sme v uplynulom roku
pokraДЌovali v zahГЎjenej analГЅze fenotypov jwednotlivcГЅh aliel a transgГ©nov dvoch kДѕГєДЌovГЅch
gГ©nov hormonГЎlne regulovanГЅch malГЎt dehydrogenГЎz, MDH87C a MDH97E, za vyuЕѕitia novГЅch
aliel, deficienciГ­ ako aj na bГЎze derivГЎtov P-elementov generovanГЅch transgГ©nnych inzerciГ­. Oba
tieto gГ©ny kГіdujГє pre postembryonГЎlny vГЅvoj kДѕГєДЌovГ© hormonГЎlne regulovanГ© malГЎt
dehydrogenГЎzy, ktorГЅch odstrГЎnenie vedie k stagnГЎcii vГЅvinovГ©ho progresu v 1. resp. 2. instare na
obdobie aЕѕ 2 tГЅЕѕdЕ€ov prГ­p. k letalite. PouЕѕitГ­m uЕѕ osvedДЌenГЅch aliel Men4, Men6, a delГ©ciГ­
Df(3R)kar3l, Df(3R)kar-lG27 a Df(3R)kar-Sz31 v kombinГЎcii s MennNC1, Men nNC2, Men nNC3, Men
nNC4
, Men nNC5, Men nNC6 a Men nGB1 sme nielen potvrdili vГЅznam MDH87C pre tranzГ­ciu medzi 1. a
2. instarom, ale aj expresivitu tohto fenotypu pri kaЕѕdej zo zvolenГЅch kombinГЎciГ­ aliel a deficienciГ­.
Fenotyp uvedených heteroalelických kombinácií bolo možné “zachrániť” exogénne riadenou
ektopickou expresiou P{EP}MenEP377, P{EP}MenEP507 alebo P{EP}MenEP1250, alebo tieЕѕ nutriДЌnou
suplementГЎciou oxalacetГЎtu, ДЌГ­m sa potvrdil fenotyp s jednotnГЅm metabolickГЅm zГЎkladom
charakterizovanГЅm deficienciou oxalacetГЎtu. AvЕЎak, ako sme tentokrГЎt zistili podrobnou
manipulГЎciou teplotnГЅch podmienok pri pouЕѕitГ­ hs-Gal4 driveru, kaЕѕdГЎ z troch trnasgГ©nnych lГ­niГ­,
P{EP}MenEP377, P{EP}MenEP507 a P{EP}MenEP1250, prispieva k ektopickej zГЎchrane fenotypu
rГґznou mierou. NutriДЌnГЎ manipulГЎcia s pyruvГЎtom zatiaДѕ nevyvolala Еѕiadne detekovateДѕnГ© ГєДЌinky.
Je pozoruhodnГ©, Еѕe novГ© RNA interferenДЌnГ© transgГ©nne lГ­nie MenGD6873 a MenGD16565 (pod
kontrolou hs-Gal4 alebo Act5C-Gal4 driverov) neboli tak efektГ­vne v induckii stagnaДЌnГ©ho
fenotypu pre 1. resp. 2. instar ako pГґvodnГЎ injikГЎcia dsRNA do preblastodermovГЅch embryГ­. Tento
vГЅsledok bude v najbliЕѕЕЎom obdobГ­ prehodnotenГЅ analГЅzou hladiny prГ­sluЕЎnГЅch mRNA MDH87C,
obzvlГЎЕЎЕҐ so zreteДѕom na izoformy MDH87C proteГ­nov, ako aj doplnenГЅ screeningom na
potenciГЎlne efektГ­vnejЕЎie -Gal4 drivery. DoterajЕЎie ЕЎtГєdie s robustnou ektopickou expresiou
P{EP}MenEP377, P{EP}MenEP507 ani P{EP}MenEP1250 na ЕЎtandardnom pozadГ­ nenaznaДЌili vyvolanie
pozorovateДѕnГ©ho antimorfnГ©ho resp. dominantne negatГ­vneho fenotypu.
Potvrdili sme, Еѕe u gГ©nu MDH97E bola situГЎcia na rozdiel od MDH87C odliЕЎnГЎ pretoЕѕe
spomedzi troch novo testovanГЅch aliel (Men-bYB0142, Men-b03094, Men-bd11068) len Men-bd11068 v
kombinГЎcii s delГ©ciou Df(3R)Exel6207 vyvolala jednoznaДЌnГЅ predpokladanГЅ a pre RNAi
charakteristickГЅ stagnaДЌnГЅ fenotyp postihujГєci 1. a 2. larvГЎlny instar. Spolu s predoЕЎlГЅmi v
minulosti zГ­skanГЅmi vГЅsledkami mГЎme takto okrem Df(3R)Exel6207 k dispozГ­cii 3 fenotypicky
ГєДЌinnГ© alely MDH97E (Men-bEY01197, Men-bKG02266 a Men-bd11068). Podobne ako u MDH87C aj u
gГ©nu MDH97E robustnГЎ ektopickГЎ expresia transgГ©nov P{EP}Men-bEP470, P{EP}Men-bEP3349 a
Men-be03094 na ЕЎtandardnom pozadГ­ nenaznaДЌili vyvolanie pozorovateДѕnГ©ho antimorfnГ©ho resp.
dominantne negatГ­vneho fenotypu.
SГ©ria reciprokГЅch krГ­ЕѕenГ­, nazatiaДѕ s alelami Men4, Men6, MenG02709 a Men5-SZ-3451 pre gГ©n
MDH87C a Men-bKG02266, Men-bd11379, Men-bGS8066 a Men-bEP3349 pre gГ©n MDH97E nepotvrdila
moЕѕnosЕҐ prГ­tomnosti sekundГЎrnych mutГЎciГ­, ktorГ© by mohli prispievaЕҐ na pozadГ­ ЕЎtudovanГЅch
mutГЎciГ­ k znГЎmemu stagnaДЌnГ©mu fenotypu v 1. alebo 2. larvГЎlnom instare.
4.) UrДЌenie frekvencie vГЅskytu jednotlivГЅch podtypov cukrovky typu MODY na Slovensku
(Epidemiology and genetics of MODY subtypes in Slovakia)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
Daniela GaЕЎperГ­kovГЎ
1.1.2011 / 31.12.2013
2/0151/11
86
SprГЎva o ДЌinnosti organizГЎcie SAV
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
10.565,- Eur
DosiahnutГ© vГЅsledky :
V roku 2013 sme sa v rГЎmci projektu zamerali na vГЅskyt de novo mutГЎcii v registri pacientov
s diabetu typu MODY a to nielen v rГЎmci Slovenska, ale ja v rГЎmci ДЊeskej republiky v spoluprГЎci
s tГ­mom Prof. MUDr. Jana Lebla, CSc. z PediatrickГ© kliniky 2. lГ©kaЕ™skГ© fakulty UK a FN
v Motole, Praha. V naЕЎej ЕЎtГєdii spomedzi 922 pacientov z dvoch nГЎrodnГЅch MODY centier sa
identifikovalo 150 probandov bez rodinnej anamnГ©zy diabetu (napriek tomu, Еѕe viacgeneraДЌnГЅ
vГЅskyt diabetu je pre diabetes MODY typickГЅ), ale spДєЕ€ajГєcich zostГЎvajГєce diagnostikГ© kritГ©riГЎ.
DNA analГЅzou gГ©nov GCK , HNF1A a HNF4A sa identifikovala mutГЎcia u 58 osГґb. Spomedzi nich
u 11 probandov vznikli mutГЎcie de novo. V naЕЎom sГєbore pacientov MODY z dvoch nГЎrodnГЅch
centier podiel de novo mutГЎciГ­ v GCK , HNF1A a HNF4A gГ©noch predstavoval 7,3 % z 150 rodГ­n
bez rodinnej anamnГ©zy diabetu a 1,2 % zo vЕЎetkГЅch pacientov odoslanГЅch na DNA analГЅzu
MODY. Toto je doposiaľ najväčší súbor MODY pacientov s de novo mutáciami. Výsledky ukazujú
oveДѕa vyЕЎЕЎiu frekvenciu de novo mutГЎciГ­, neЕѕ sa predtГЅm predpokladalo. Z tohto dГґvodu, DNA
analГЅza najДЌastejЕЎГ­ch MODY gГ©nov mГЎ vГЅznam aj u starostlivo vybranГЅch osГґb bez rodinnej
anamnГ©zy diabetu (ale spДєЕ€ajГєcich ostatnГ© kritГ©riГЎ pre MODY).
DruhГЅm dГґleЕѕitГЅm vГЅsledkov v roku 2013 je rieЕЎenie Гєlohy DG9 glykГЎnovГ©h profilu v plazme
pacientov s mutГЎciou v gГ©ne HNF1A. V rГЎmci medzinГЎrodnej spoluprГЎce v celoeurГіpskej
multicentrickej ЕЎtГєdii participovalo 457 pacientov s HNF1A-MODY (46 z SK), 404 s GCK-MODY
(88 Z SK), 54 a HNF4A-MODY (2 z SK), 98 s 1. typom diabetu, 167 pacientov s 2. typom diabetu
a 98 kontrol bez diabetu. Zistili sme, že DG9-glykanový index bol signifikantne nižší pri HNF1AMODY ako u kontrol, či iných podtypoch diabetu (ROC ≥ 0.90) a umožnil identifikovať troch
pacientov s HNF1A-MODY, ktorГ­ neboli predtГЅm diagnostikovanГ­. DG9 glykГЎnovГЅ index sa po
javГ­ ako potencionГЎlny uЕѕitoДЌnГЅ klinickГЅ biomarker vhodnГЅ na identifikГЎciou pacientov s HNF1A
dysfunkciou
PublikГЎcie :
STANIK J., DUSATKOVA P., CINEK O., VALENTINOVA L., HUCKOVA M., SKOPKOVA
M., DUSATKOVA L., STANIKOVA D., PURA M., KLIMES I., LEBL J., GASPERIKOVA D.,
PRUHOVA S.: De novo mutations of GCK, HNF1A and HNF4A may be more frequent in MODY
than previously assumed. DIABETOLOGIA, 2013 Dec 10. IF 2012 = 6.487
THANABALASINGHAM G., HUFFMAN JE., KATTLA JJ., NOVOKMET M., RUDAN I.,
GLOYN AL., HAYWARD C., ADAMCZYK B., REYNOLDS RM., MUZINIC A., HASSANALI
N., PUCIC M., BENNETT AJ., ESSAFI A., POLASEK O., MUGHAL SA., REDZIC I.,
PRIMORAC D., ZGAGA L., KOLCIC I., HANSEN T., GASPERIKOVA D., TJORA E.,
STRACHAN MW., NIELSEN T., STANIK J., KLIMES I., PEDERSEN OB., NJ�LSTAD PR.,
WILD SH., GYLLENSTEN U., GORNIK O., WILSON JF., HASTIE ND., CAMPBELL H.,
MCCARTHY MI., RUDD PM., OWEN KR., LAUC G., WRIGHT AF..: Mutations in HNF1A
result in marked alterations of plasma glycan profile. DIABETES 62 (4), pp. 1329-37, 2013 Apr. IF
2012 = 7.895
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SprГЎva o ДЌinnosti organizГЎcie SAV
Abstrakty :
STANIK J., GASPERIKOVA D., HUCKOVA M., VALENTINOVA L., STANIKOVA D.,
MICHALEK J., BARAK L., SLOVAK MODY COLLABORATIVE STUDY GROUP, KLIMES
I.: Clinical homogeneity and genetic heterogeneity of patients with familial young-onset diabetes:
the Slovak national data. Poster v rГЎmci odbornГ©ho podujatia IDF world diabetes congres
Melbourne 2013, 2.-6. December 2013
GASPERIKOVA D., STANIK J., VALENTINOVA L., HUCKOVA M., BALOGOVA M.,
SLOVAK MODY COLLABORATIVE STUDY GROUP, KLIMES I.: Spectrum of glucokinase
(GCK) gene mutations and prevalence of monogenic diabetes type GCK-MODY in Slovakia.
Poster v rГЎmci odbornГ©ho podujatia IDF world diabetes congres Melbourne 2013, 2.-6. December
2013
VALENTГЌNOVГЃ L., HUДЊKOVГЃ M., MAЕ INDOVГЃ I., BALOGOVГЃ M., STANГЌK J., KLIMEЕ I., GAЕ PERГЌKOVГЃ D.: Testovanie moЕѕnosti vyuЕѕГ­vania DHPLC metГіdy na DNA diagnostiku
monogГ©novej cukrovky. Abstrakt z odbornej konferencie XXIV. IzakoviДЌov memoriГЎl
s medzinГЎrodnou ГєДЌasЕҐou, Donovaly, 26.-27. September 2013
STANГЌK J., GAЕ PERГЌKOVГЃ D., HUДЊKOVГЃ M., VALENTГЌNOVГЃ L., STANГЌKOVГЃ D.,
MAЕ INDOVГЃ I., BALOGOVГЃ M., SLOVENSKГЃ SKUPINA PRE Е TГљDIUM
MONOGÉNOVÉHO DIABETU, KLIMEŠI.: Klinická diagnostika pacientov s MODY. Abstrakt
z XXIII. DiabetologickГЅch dnГ­ s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna 2013
VALENTГЌNOVГЃ L., BEER L., OSBAK K., VAN DE BUNT M., TRIBBLE N.D., STEELE A. M.,
WENSLEY K. J., EDGHILL E. L., COLCOUGH J., BARRETT A., RUNDLE J. K., RAIMONDO
A., GRIMSBY J., ELLARD S., GLOYN A. L.: RaritnГ© dvojitГ© mutГЎcie v glukokinГЎze s prejavmi
GCK-MODY a ich funkДЌnГЎ charakterizГЎcia. Abstrakt z XXIII. DiabetologickГЅch dnГ­
s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna 2013
GAЕ PERГЌKOVГЃ D., STANГЌK J., HUДЊKOVГЃ M., VALENTГЌNOVГЃ L., MAЕ INDOVГЃ I.,
STANГЌKOVГЃ D., MICHГЃLEK J.: Genetic heterogeneity of patients with Familial Young-Onset
Diabetes: data from the Slovak nation-wide survey in years 2003-2012. Abstrakt z odbornej
konferencie European Journal of Human Genetics, ParГ­Еѕ, FrancГєzsko, 8.- 11.june 2013
5. VГЅskum inervГЎcie vybranГЅch modelov nГЎdorov: morfologicko-funkДЌnГЎ charakterizГЎcia
(Investigation of innervations in selected experimental tumor models: morphological-functional
characterization)
ZodpovednГЅ rieЕЎiteДѕ:
ДЅubica HorvГЎthovГЎ
Trvanie projektu:
1.1.2013-31.12.2015
EvidenДЌnГ© ДЌГ­slo projektu: VEGA ДЌ. 2/0016/13
OrganizГЎcia
jeГЎno
koordinГЎtorom projektu:
Гљstav experimentГЎlnej endokrinolГіgie SAV
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch1
0
inЕЎtitГєciГ­:
5844 EUR
ДЊerpanГ© financie:
88
SprГЎva o ДЌinnosti organizГЎcie SAV
DosiahnutГЅch vГЅsledky:
V tkanive fibrosarkГіmu indukovanГ©ho u laboratГіrnych potkanov intraperitoneГЎlnou alebo
subkutГЎnnou aplikГЎciou BP6-TU2 fibrosarkГіmovГЅch buniek sme preukГЎzali prГ­tomnosЕҐ
nervovГЅch ЕЎtruktГєr prostrednГ­ctvom detekcie viacerГЅch neuronГЎlnych markerov. Okrem toho
sme sa v experimentoch zamerali aj na ЕЎtГєdium inervГЎcie nГЎdorovГ©ho tkaniva v ДЏalЕЎГ­ch
nГЎdorovГЅch modeloch, konkrГ©tne v tkanive melanГіmu indukovanГ©ho u laboratГіrnych myЕЎГ­
subkutГЎnnou aplikГЎciou B16F10 melanГіmovГЅch buniek a v tkanive feochromocytГіmu
indukovanГ©ho u laboratГіrnych myЕЎГ­ intraperitoneГЎlnou aplikГЎciou feochromocytГіmovГЅch
buniek MPC 4/30PRR. Po extirpГЎcii nГЎdorov boli tieto histologicky spracovanГ©. Okrem
základného farbenia hematoxylínom – eozínom bolo tkanivo nádorov vyšetrené na
prГ­tomnosЕҐ nervovГЅch ЕЎtruktГєr vyuЕѕitГ­m viacerГЅch vЕЎeobecnГЅch neuronГЎlnych markerov
zahЕ•Е€ajГєcich neurГіn ЕЎpecifickГє enolГЎzu (NSE), proteГ­n S100, chromogranГ­n A(ChrA) a
neurofilamentovГЅ proteГ­n (NF). U jednotlivГЅch typov nГЎdorov sme detegovali pozitivitu na
rГґzne neuronГЎlne markery, priДЌom denzita signГЎlu sa medzi jednotlivГЅmi markermi a nГЎdormi
lГ­ЕЎila. ZatiaДѕ ДЌo u intraperitoneГЎlnych fibrosarkГіmov sme preukГЎzali pozitivitu na NF, ChrA a
NSE, v prГ­pade subkutГЎnnych fibrosarkГіmov bola zistenГЎ len pozitivita na NF. U melanГіmu a
feochromocytГіmu sme zistili pozitivitu na NF, ChrA, ako aj S100 proteГ­n. NaЕЎe vГЅsledky
naznaДЌujГє, Еѕe inervГЎcia nГЎdorovГ©ho tkaniva vykazuje ЕЎpecifickosЕҐ v zГЎvislosti od typu
nГЎdoru.
PodДѕa nedГЎvno publikovanej prГЎce sympatikovГЎ inervГЎcia potencuje nГЎdorovГЅ rast v jeho
poДЌiatoДЌnГЅch ЕЎtГЎdiГЎch, zatiaДѕ ДЌo parasympatikovГЎ inervГЎcia podporuje tvorbu metastГЎz. Preto
sme sa zamerali aj na urДЌenie fenotypu prГ­tomnej inervГЎcie nГЎdorovГ©ho tkaniva. Tkanivo
intraperitoneГЎlneho a subkutГЎnneho fibrosarkГіmu sme vyЕЎetrili imunohistochemicky, ako aj
pouЕѕitГ­m imunofluorescencie na prГ­tomnosЕҐ enzГЅmu tyrozГ­nhydroxylГЎzy (marker
sympatikovej inervГЎcie) a enzГЅmu cholГ­n acetyltransferГЎzy (marker parasympatikovej
inervГЎcie). AvЕЎak ani v prГ­pade intraperitoneГЎlneho ani subkutГЎnneho fibrosarkГіmu sa nГЎm
nepodarilo jednoznaДЌne preukГЎzaЕҐ prГ­tomnosЕҐ sledovanГЅch fenotypov inervГЎcie.
6.) Interakcie neuroendokrinnГЅch a metabolickГЅch faktorov u kriticky chorГЅch pacientov
(Interactions of neuroendocrine and metabolic factors in critically ill patients)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Richard Imrich
1.1.2012 / 31.12.2014
VEGA 2/0084/12
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
5.843,- Eur
DosiahnutГ© vГЅsledky:
V druhom roku rieЕЎenia projektu sme v spoluprГЎci s Klinikou intenzГ­vnej medicГ­ny
a anestГ©ziolГіgie (Dr. GГЎlusovГЎ) odobrali vzorky krvi od 44 kriticky chorГЅch pacientov, ktorГ©
89
SprГЎva o ДЌinnosti organizГЎcie SAV
sme priebežne spracovávali. Jednalo sa najmä o polytraumatizovaných pacientov, pacientov
s kardiorespiraДЌnГЅm zlyhanГ­m, alebo s kraniocerebrГЎlnym poranenГ­m. Postupne sa vo vzorkГЎch
zaДЌali analyzovaЕҐ neuroendokrinnГ© parametre ako je koncentrГЎcia rastovГ©ho hormГіnu, prolaktГ­nu,
TSH, tyroidГЎlnych hormГіnov a kortizolu.
7.) AtypickГ© ГєДЌinky hormГіnov (Atypical effects of hormones)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Daniela JeЕѕovГЎ
1.1.2011 / 31.12.2013
2/0118/11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
11.107,- Eur
DosiahnutГ© vГЅsledky:
NaЕЎe nedГЎvne nГЎlezy (Varga et al. 2013) odkryli vГЅznam aldosterГіnu v obdobГ­ ontogenГ©zy. SkorГ©
obdobie po narodenГ­ (2-14 deЕ€) sa u hlodavcov nazГЅva obdobГ­m znГ­Еѕenej stresovej odpovede (stress
hyporesponsive period), kedy je veДѕmi nГ­zka sekrГ©cia glukokortikoidov v stresovГЅch situГЎciГЎch.
MГґЕѕe to predstavovaЕҐ fyziologickГє ochranu vyvГ­jajГєcich sa systГ©mov pred neЕѕiaducimi ГєДЌinkami
nadmernГ©ho zvГЅЕЎenia hladГ­n glukokortikoidov. NaЕЎe vГЅskumy ukГЎzali, Еѕe prГЎve v tomto obdobГ­
nastГЎva poДЌas stresu vГЅraznГ© zvГЅЕЎenie sekrГ©cie mineralokortikoidu aldosterГіnuv porovnanГ­ so
sekrГ©ciou aldosterГіnu u dospelГЅch zvierat. V ranom postnatГЎlnom obdobГ­ sa zvyЕЎovala aj gГ©novГЎ
expresia enzГЅmu, ktorГЅ premieЕ€a glukokortikoidy na neaktГ­vne metabolity a umoЕѕЕ€uje ГєДЌinky
aldosterГіnu, a to nielen v perifГ©rnych tkanivГЎch, ale aj v mozgu (Varga a spol. 2013).
DokГЎzali sme, Еѕe sekrГ©cia hormГіnov u zdravГЅch ДѕudГ­ poДЌas stresu, vrГЎtane hormГіnu aldosterГіnu,
zГЎvisГ­ od miery pociЕҐovanej akГєtnej Гєzkosti. Vyslovenie tohto zГЎveru nГЎm umoЕѕnili vГЅsledky ЕЎtГєdie
s pouЕѕitГ­m originГЎlneho prГ­stupu, a to vystavenie ДѕudГ­ stresovГЅm podnetom pri sГєДЌasnom poДЌГєvanГ­
neprГ­jemnГЅch alebo prГ­jemnГЅch zvukov (Jezova a spol. 2013).
PublikГЎcie:
JEZOVA D., HLAVACOVA N., MAKATSORI A., DUNCKO R., LODER I., HINGHOFERSZALKAY H. Increased anxiety induced by listening to unpleasant music during stress exposure is
associated with reduced blood pressure and ACTH responses in healthy men. In
Neuroendocrinology, 2013, vol. 98, no. 2, p. 144-150. (IF=3,537)
VARGA J., FERENCZI S., KOVГЃCS KJ., GARAFOVA A., JEZOVA D., ZELENA D.
Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main
Adrenocortical Stress Hormone during the Perinatal Period in Rats? In PLoS One, 2013, vol. 8, no.
9, p. e72313. (IF=3,730)
HLAVACOVA N., KERLIK J., RADIKOVA Z., IZAKOVA L., JEZOVA D. Measurement of
salivary aldosterone: validation by low-dose ACTH test and gender differences. In Endocrine
Regulations. 2013, vol. 47, no. 4, p. 201-204.
90
SprГЎva o ДЌinnosti organizГЎcie SAV
IZAKOVA L., JEZOVA D. Aldosterón – nový biologický marker alebo ďalšia možnosť v liečbe
depresie? In Psychiatrie, 2013, vol. 17, no. 1, p. 13-18.
Abstrakty
DANEVOVA V., BABIC S., HLAVACOVA N., JEZOVA D. ГљДЌinok blokГЎtora oxytocГ­novГЅch
receptorov na ГєzkostnГ© sprГЎvanie vyvolanГ© stresom. In Psychiatrie, 2013, vol. 17, suppl. 1, p. 52.
JEZOVA D., HLAVACOVA. Ovplyvnenie hormónu aldosterónu – nový smer vo vývoji anxiolytík.
In Psychiatrie, 2013, vol. 17, suppl 1, p. 25.
JEZOVA D., HLAVACOVA N. Hyperaldosteronism in an animal model - changes in depressionlike behavior and gene expression relevant to major depressive disorder. Abstracts of the 11th
World Congress of Biological Psychiatry, Abstract CD-ROM, 2013.
JEZOVA D., HLAVACOVA N. Aldosterone - A Bridge Between Cardiovascular and Mood
Disorders? Abstracts of The International Academy of Cardiology, 18th World Congress on Heart
Disease Annual Scientific Sessions 2013, In The Journal of Heart Disease, 2013, vol.10, no. 1, p.
21.
8. Je naruЕЎnГЅ transport glukГіzy do kritickГЅch tkanГ­v v experimentГЎlnom autoimunitnom
zГЎpale? (What is the glucose transport in critical tissues in experimental autoimmune inflammation
?)
Jana JurДЌoviДЌovГЎ
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ
rieЕЎiteДѕ
v organizГЎcii SAV
1.1.2013 – 31.12.2015
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu: VEGA2/0033/13
ГЎno
OrganizГЎcia
koordinГЎtorom projektu:
doc. Ing. Jana JurДЌoviДЌovГЎ, CSc
KoordinГЎtor:
PoДЌet
spolurieЕЎiteДѕskГЅch
0
inЕЎtitГєciГ­:
3077,00 Euro
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky :
V tomto roku sme sa zamerali na sledovanie expresie vybranГЅch glukГіzovГЅch transportГ©rov
v hipokampe potkana v ЕЎtГЎdiu rozvГ­jajГєceho sa experimentГЎlneho autoimunitnГ©ho zГЎpalu. Na 10,
deЕ€ adjuvantnej artritГ­dy (eЕЎte pred manifestovanГ­m prГ­znakov artritickГЅch opuchov) sme zistli
znГ­Еѕenie expresie inzulГ­n dependentnГ©ho glukГіzovГ©ho transportГ©ra GLUT4. Zmeny v expresiach
GLUT1, -3, -5 a -8 sme nezaznamenali. Tento predbeЕѕnГЅ vГЅsledok je v sГєhlase s predoЕЎlГЅm
pozorovanГ­m, kedy sme u artirtickГЅch potkanov zistili kognitГ­vne poruchy, znГ­Еѕenie vychytГЎvania
fluorovanej glukГіzy v hipokampe a naznaДЌuje poruchu inzulГ­nom regulovanГ©ho transportu glukГіzy
do neurГіnov hipokampu.
9.) PilotnГЅ skrГ­ning vybranГЅch hereditГЎrnych porГєch sluchu na Slovensku . (Pilot screening of
selected hereditary hearing loss in Slovakia.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
Iwar KlimeЕЎ
1.1.2011 / 31.12.2013
91
SprГЎva o ДЌinnosti organizГЎcie SAV
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
1/0465/11
nie
LF UK
1
1.369,- Eur
DosiahnutГ© vГЅsledky
V rГЎmci rieЕЎenia projektu VEGA boli zГ­skanГ© klinickГ© dГЎta a materiГЎl od vyЕЎe 500 vyЕЎetrenГЅch
pacientov. ZavedenГ­m prГ­sluЕЎnГЅch metodГ­k DNA analГЅzy bol realizovanГЅ skrГ­ning mutГЎciГ­ gГ©nov
GJB2, GJB6, SLC26A4 a mitochondriГЎlnych mutГЎciГ­. Nad rГЎmec stanovenГЅch cieДѕov sme vyЕЎetrili
gГ©ny GJB3, POU3F4, WS1 a MARVELD2. Bol zistenГЅ vГЅskyt jednotlivГЅch mutГЎciГ­ v populГЎcii
pacientov so SNHL a v prГ­pade najДЌastejЕЎie identifikovanej prГ­ДЌiny dediДЌnej hluchoty na Slovensku
(mutГЎcie gГ©nu pre konexГ­n 26) bol stanovenГЅ odhad prevalencie aj vo vzЕҐahu k celkovej populГЎcii.
ZaloЕѕenГЎ DNA banka v budГєcnosti zaistГ­ okamЕѕitГє dostupnosЕҐ vzoriek pre ДЏalЕЎГ­ vГЅskum. U
pacientov so suspektnou alebo potvrdenou syndrГіmovou poruchou sluchu boli realizovanГ©
doplЕ€ujГєce laboratГіrne a klinickГ© vyЕЎetrenia (biochemickГ©, diabetologickГ©, kardiologickГ©, atДЏ.).
Získané výsledky boli využité na doplnenie odporúčaní diagnostiky porúch sluchu, najmä u detí a
boli doteraz prezentovanГ© na viacerГЅch klinickГЅch a vedeckГЅch podujatiach.
PUBLIKГЃCIE:
VARGA L., MAЕ INDOVГЃ I., HUДЊKOVГЃ M., KABГЃTOVГЃ Z., GAЕ PERГЌKOVГЃ D., KLIMEЕ I., PROFANT M.
Prevalence of DFNB1 mutations among cochlear implant users in Slovakia and its clinical
implications. Eur Arch Otorhinolaryngol. 2013, DOI 10.1007/s00405-013-2559-0
ABSTRAKTY
MAЕ INDOVГЃ I., VARGA L., HUДЊKOVГЃ M., BALOGOVГЃ M., Е UCHOVГЃ ДЅ., PROFANT M., KLIMEЕ I.,
GASPERIKOVA D. 2013. Nation-wide genetic screening for patients with bilateral nonsyndromic
sensorineural hearing loss (SNHL) in Slovakia. European Journal of Human Genetics, 21 (supp. 2): p.124125
VARGA L., MAЕ INDOVГЃ I., KABГЃTOVГЃ Z., HUДЊKOVA M., KLIMEЕ I., GAЕ PERГЌKOVГЃ D., PROFANT M.
Screening for hereditary causes of SNHL in Slovak deaf population and its practical consequences.
IFOS 20th World Congress, June 1-5 2013, Seoul, Korea, Book of abstracts (on CD), FA-00237.
VARGA L., MAЕ INDOVГЃ I., KABГЃTOVГЃ Z., GAЕ PERГЌKOVГЃ D., KLIMEЕ I., PROFANT M. 2013.
Prevalence of mutations in the DFNB1 locus among cochlear implant users in Slovakia and their
impact on postoperative hearing outcomes in prelingually deaf children. 9th Molecular Biology of
Hearing and Deafness Conference, 22-25 June, 2013, Stanford, USA. Book of abstracts, p.176
MAЕ INDOVГЃ I., VARGA L., HUДЊKOVГЃ M., PROFANT M., KLIMEЕ I., GAЕ PERГЌKOVГЃ D. 2013. Mutation
in MARVELD2 gene detected in Slovak roma patients with nonsyndromic hearing loss. 9th
Molecular Biology of Hearing and Deafness Conference, 22-25 June, 2013, Stanford, USA. Book
of abstracts, p.106
VARGA L., KABГЃTOVГЃ Z., MAЕ INDOVГЃ I., GAЕ PERГЌKOVГЃ D., KLIMEЕ I., PROFANT M. 2013 Hearing
outcomes after cochlear implantation in three etiology groups of prelingually deaf children. 29th
Politzer Society Meeting, 14-17 November, Antalya, Turkey, The International Journal of
Advanced Otology, 9 (3, suppl. 1): p. 131-132.
MAЕ INDOVГЃ I., VARGA L., HUДЊKOVГЃ M., BALOGOVГЃ M., Е UCHOVГЃ ДЅ., PROFANT M., KLIMEЕ I.,
GAЕ PERГЌKOVГЃ D. CeloslovenskГЅ genetickГЅ skrГ­ning pacientov s bilaterГЎlnou nesyndrГіmovou
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SprГЎva o ДЌinnosti organizГЎcie SAV
senzorineurГЎlnou poruchou sluchu. XXIV. IzakoviДЌov MemoriГЎl, 26. - 27. 9. 2013, Donovaly,
Hotel Residence, Program a zbornГ­k abstraktov, p. 52-53.
10.) RegulГЎcia imunitnГ©ho systГ©mu aktivitou sympatikoadrenГЎlneho a adrenokortikГЎlneho
systГ©mu u cicavcov vystavenГЅch akГєtnemu a chronickГ©mu stresu. (Regulation of the immune
system by activity of sympathoadrenal and adrenocortical systems in mammals exposed to acute
and chronic stress)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
Richard KvetЕ€anskГЅ
1.1.2011 / 31.12.2014
2/0036/11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
1
Department of Biochemistry and Molecular Biology, New York
Medical College, Valhalla, NY, USA
ДЊerpanГ© financie:
7.749,- Eur
DosiahnutГ© vГЅsledky:
Je jednoznaДЌne dokГЎzanГ©, Еѕe stres vГЅznamne ovplyvЕ€uje aktivitu imunitnГ©ho systГ©mu.
Mechanizmy pГґsobenia stresu na imunitnГЅ systГ©m nie sГє vЕЎak objasnenГ©. KatecholamГ­ny (CA) sГє
vГЅznamnГЅmi regulГЎtormi uvedenГ©ho systГ©mu. Popri CA produkovanГЅch sympatikovГЅmi nervami aj
imunitnГ© orgГЎny sГє schopnГ© produkovaЕҐ CA de novo. FyziologickГЅ vГЅznam CA produkovanГЅch
priamo v imunitnГЅch orgГЎnoch nie je jasnГЅ.
A prГЎve cieДѕom naЕЎich sledovanГ­ v roku 2013, bolo prispieЕҐ k objasneniu funkcie lokГЎlneho
katecholaminergnГ©ho systГ©mu v slezine, predovЕЎetkГЅm v jej T- a B-bunkГЎch. Stresom-indukovanГє
modulГЎciu produkcie endogГ©nnych katecholamГ­nov v T- a B-bunkГЎch sleziny sme publikovali ako
prvГ­ vГґbec (LaukovГЎ et al., 2013). DokГЎzali sme prГ­tomnosЕҐ noradrenalГ­nu (NE), adrenalГ­nu (ADR)
a dopamГ­nu (DA) a tieЕѕ expresiu CA-syntetizujГєcich enzГЅmov tyrozГ­n-hydroxylГЎzy a PNMT, ako aj
beta-adrenergnГЅch receptorov CA a zvГЅЕЎenie tГЅchto parametrov po vystavenГ­ organizmu
imobilizaДЌnГ©mu stresu.
NaЕЎe vГЅsledky ukГЎzali Еѕe:
- T- a B-bunky sleziny odpovedajГє rozdielne na akГєtne a opakovanГ© vystavenie stresu.
- B-bunky sГє hlavnГЅm zdrojom PNMT mRNA v slezine, zatiaДѕ ДЌo TH mRNA je vyЕЎЕЎia v TbunkГЎch.
- AkГєtny imobilizaДЌnГЅ stres indukuje expresiu TH aj PNMT v T-bunkГЎch
najpravdepodobnejЕЎie mechanizmom zvГЅЕЎenГ©ho uvoДѕЕ€ovania CA z T-buniek. Na druhej
strane, po opakovanej imobilizГЎcii sa biosyntГ©za CA zvyЕЎuje v B-bunkГЎch.
- JednorazovГЎ IMO indukuje expresiu vЕЎetkГЅch troch beta-adrenergnГЅch receptorov v TbunkГЎch, zatiaДѕ ДЌo Еѕiadne signifikantnГ© zmeny sa nepozorovali v B-bunkГЎch.
- Prepokladali sme, Еѕe adrergickГ© receptory mГґЕѕu ovplyvЕ€ovaЕҐ cytokГ­ny, a preto sme merali
gГ©novГє expresiu pro-zГЎpalovГЅch cytokГ­nov TNF-alfa, IL-1beta, IL-6 a IL-18, ako aj protizГЎpalovГЅch cytokГ­nov IL-10, TGF-beta1 u potkanov vystavenГЅch stresu. Zistili sme zmeny
iba v expresii IL-6 a IL-10 mRNA. Hladiny IL-6 mRNA sa v slezine vГЅznamne zvyЕЎovali,
hladiny IL-10 mRNA zasa vГЅznamne poklesli po opakovanej IMO.
Tieto vГЅsledky nГЎm umoЕѕЕ€uju konЕЎtatovaЕҐ, Еѕe zmeny beta-2 a alfa-2C adrenergnГЅch
93
SprГЎva o ДЌinnosti organizГЎcie SAV
receptorov sa podielajГє na posune mechanizmu pГґsobiaceho cez IL-6 v slezine,
predovЕЎetkГЅm poДЌas chronickГЅch stresovГЅch situГЎciГ­.
- SГєhrnne teda mГґЕѕeme konЕЎtatovaЕҐ, Еѕe opakovanГЅ stres zniЕѕuje expresiu beta-2 a alfa-2C
adrenergnГЅch receptorov a vГЅrazne zvyЕЎuje expresiu IL-6. ZmenenГЎ signalizГЎcia cez tieto
receptory mГґЕѕe ovplyvniЕҐ funkciu iminitnГ©ho systГ©mu v stresovГЅch situГЎciГЎch.
NaЕЎe vГЅsledky teda ukГЎzali, Еѕe rozdielna aktivГЎcia katecholaminergnГ©ho systГ©mu v T- a BbunkГЎch sleziny poДЌas stresu je vГЅznamnГЅm faktorom pri modulГЎcii funkcie imunitnГ©ho systГ©mu
v organizme vystavenom stresu.
Pochopenie mechanizmu interakcie medzi nervovГЅm, endokrinnГЅm a imunitnГЅm systГ©mom
poДЌas stresu posГєva sГєДЌasnГЅ stav poznania tГЅchto regulГЎciГ­ a v budГєcnosti urДЌite povedie k
priamym terapeutickГЅm aplikГЎciГЎm.
PublikГЎcie :
LAUKOVГЃ M., VARGOVIДЊ P., VLДЊEK M., LEJAVOVГЃ K., HUDECOVГЃ S.,
KRIŽANOVÁ O., KVETŇANSKÝ R.: Catecholamine production is differently regulated in
splenic
Tand
B-cells
following
stress
exposure.
Immunobiology,2013,218(5):pp.780-789.
http://dx.doi.org
/10.1016/j.imbio.2012.08.279. (3.321 - IF2011).
Typ: ADCA
VARGOVIДЊ P., UKROPEC J., LAUKOVГЃ M., KURDIOVГЃ T., BALГЃЕЅ M., MANZ
B.,UKROPCOVÁ B., KVETŇANSKÝ R.:
Repeated
immobilization stress induces catecholamine production in rat mesenteric adipocytes.
Stress : The international journal on the biologie of stress, 2013, 16 (3): pp. 340-352.
(2.476
– IF 2011). DOI:10.3109/10253890.736046.
Typ: ADCA
Abstrakty z konferenciГ­ :
KVETŇANSKÝ, R.: „Stress-induced regulation of molecular genetic mechanisms in neuroendocrine-immune systems“.
Pozvaná prednáška na Európskom kongrese pre neurovedy „FENS Featured Regional Meeting“
v Prahe, 11.-15. September 2013.
KVETŇANSKÝ R.: „Does chronic or repeated stress produce pathological changes in the
organism: Effect of catecholaminergic systems“.
PozvanГЎ prednГЎЕЎka na 7th International Symposium on Experimental and Clinical Neurobiology,
23.-27. jГєna 2013 v KoЕЎiciach.
KVETŇANSKÝ R.: „Activity of the adrenomedullary and other catecholaminergic systems in
stress“.
PozvanГЎ prednГЎЕЎka na 17th International Symposium on Chromaffin Cell Biology, Rouen,
FrancГєzsko, 13.-17. jГєla 2013.
94
SprГЎva o ДЌinnosti organizГЎcie SAV
VARGOVIČ P., UKROPEC J., KVETŇANSKÝ R.: Opakovaný stres zvyšuje produkciu
endogГ©nnych katecholamГ­nov v adipocytoch mezenterickГ©ho tukovГ©ho tkaniva potkana.
PrednesenГ© na VII. RoДЌnГ­ku Drobnicovho memoriГЎlu, BojnГЎ, 16.-18. Sept. 2013, str .54-55.
11.) KomunikГЎcia medzi transaktivaДЌnГЅmi procesmi sprostredkovanГЅch biologicky aktГ­vnymi
ligandami indukovateДѕnГЅch transkripДЌnГЅch faktorov a regulaДЌnГЅmi drГЎhami vybranГЅch
izoflavГіnov v nГЎdorovГЅch bunkГЎch. (Cross-talk between transctivation processes mediated by
ligand inducible transcription factors and isoflavone regulatory pathways in tumour cells.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Dana MacejovГЎ
1.1.2011 / 31.12.2013
2/0008/11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
7.184,- Eur
DosiahnutГ© vГЅsledky:
Retinoidy/rexinoidy/vitamГ­n D a ich analГіgy sa pouЕѕГ­vajГє v lieДЌbe rГґznych malГ­gnych ochorenГ­. Ich
pГґsobenГ­m mГґЕѕe dГґjsЕҐ k indukcii bunkovej diferenciГЎcie alebo apoptГіzy, ДЌo je veДѕmi dГґleЕѕitГЅ
proces v lieДЌbe nГЎdorovГЅch ochorenГ­. Ich jadrovГ© receptory sГє transkripДЌnГ© faktory s
nezastupiteДѕnou Гєlohou v Дѕudskom organizme. GenisteГ­n patrГ­ do triedy izoflavГіnov a je tieЕѕ
klasifikovanГЅ ako fytoestrogГ©n s mnohГЅmi pozitГ­vnymi ГєДЌinkami na nГЎdorovГ© bunky. Sledovali
sme vplyv genisteГ­nu (GEN) (1 mikro M), kyseliny all-trans retinovej (AtRA) (1 mikro M), 9-cis
retinovej (9cRA) (1 mikro M), vitamГ­nu D (VD) (100 nM) a Seokalcitolu (Seo) (100 nM)
a vzГЎjomnej kombinГЎcie jednotlivГЅch ret. kyselГ­n/vitamГ­nu D resp. Seo s GEN na expresiu
jadrovГЅch receptorov a vybranГЅch gГ©nov zahrnutГЅch v procese apoptГіzy v Дѕudskej obliДЌkovej
nГЎdorovej lГ­nii ACHN. AtRA samotnГЎ alebo kombinГЎcia AtRA+GEN, 9cRA+GEN
a AtRA+9cRA+GEN signifikantne zvГЅЕЎila expresiu RARgama, RXRalfa a RARalfa. AtRA, 9cRA,
GEN a ich kombinГЎcie zvГЅЕЎili expresiu korepresorov NCoR, SMRT a koaktivГЎtora SRC-1.
Kyseliny retinovГ© a ich kombinГЎcie s GEN nemali vplyv na expresiu mRNA tohto proliferaДЌnГ©ho
markera. GEN samotnГЅ vЕЎak tГєto expresiu redukoval. RetinovГ© kyseliny samotnГ© alebo vo
vzГЎjomnej kombinГЎcii zvГЅЕЎili expresiu BAX. GEN v kombinГЎcii s AtRA alebo s 9cRA
signifikantne zvГЅЕЎil expresiu BAX. ZvГЅЕЎenГ© hladiny p53 mRNA boli pozorovanГ© po pridanГ­ GEN,
ATRA+9cRA a kombinГЎcie retinovГЅch kyselГ­n s GEN. Napriek znГЎmym pozitГ­vnym ГєДЌinkom
retinovГЅch kyselГ­n na redukciu expresie Bcl2 mRNA v prsnГ­kovГЅch bunkovГЅch lГ­niГЎch (MCF-7),
48h inkubГЎcia ACHN buniek s AtRA, 9cRA alebo ich kombinГЎciГ­ s GEN signifikantne zvГЅЕЎili
expresiu tohto anti-apoptotickГ©ho gГ©nu. PodobnГ© zvГЅЕЎenie expresie Bcl2 sme pozorovali aj
v prГ­pade vitamГ­nu D, Seo a ich kombinГЎcie s GEN, samotnГЅ GEN expresiu mierne znГ­Еѕil.
V prГ­pade BAX bola hladina mRNA vo vЕЎetkГЅch sledovanГЅch skupinГЎch zvГЅЕЎenГЎ. VD, Seo a GEN
signifikantne znГ­Еѕili expresiu RARalfa, RARgama, RXRbeta. KombinГЎcia VD+GEN a Seo+GEN
vЕЎak v prГ­pade RARalfa a RARgama tГєto expresiu zvГЅЕЎila. Takisto kombinГЎcie VD a Seo s GEN
mierne zvГЅЕЎili expresiu p53 mRNA. VD a Seo samotnГЅ.
PublikГЎcie:
95
SprГЎva o ДЌinnosti organizГЎcie SAV
MACEJOVГЃ D., GALBAVГќ S., PODOBA J., BIALEЕ OVГЃ L., BRTKO J.: mRNA expression
pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary
carcinoma, Oncology Reports, 30: 2371-2378, 2013.
LENKO V., BIALESOVA L., MACEJOVA D., BUJDAK P., BREZA J., BRTKO J.: The
relationship between renal cell carcinoma and nuclear retinoid/rexinoid receptors. Biomed Pap Med
Fac Univ Palacky Olomouc Czech Repub. 157: 316-324, 2013.
BIALEЕ OVГЃ L., BRTKO J., LENKO V., MACEJOVГЃ D.: Nuclear receptors - target molecules
for isoflavones in cancer chemoprevention. Gen. Physiol. Biophys., 32: 467–478, 2013.
FLODROVA D., BENKOVSKA D., MACEJOVA D., BIALESOVA L., BOBALOVA L., BRTKO
J.: Effects of retinoic acid isomers on proteomic pattern in human breast cancer MCF-7 cell line.
Endocr. Regul., 47: 205-2209, 2013.
Abstrakty:
BRTKO J., MACEJOVГЃ D., GALBAVГќ Е ., BIALEЕ OVГЃ L., PODOBA J.: Expression mRNA
pattern of retinoic acid and retinoid X nuclear receptor subtypes in thyroid carcinomas. Thyroid
Research, 6: (Suppl. 2): 4-5, 2013.
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., GALBAVГќ Е .: Expresia podtypov retinoidnГЅch a
rexinoidnГЅch jadrovГЅch receptorov a ich koregulГЎtorov v karcinГіmoch ЕЎtГ­tnej ЕѕДѕazy. Diabetologie,
Metabolizmus, Endokrinologie, VГЅЕѕiva, 16: (Suppl.), 2-3, 2013.
BIALEЕ OVГЃ L., BRTKO J., MACEJOVГЃ D.: The effect of isoflavone genistein on the expression
of selected nuclear receptors and their coregulators. Military Medical Science Letters, 82: (Suppl.),
2-3, 2013.
MACEJOVГЃ D., BIALEЕ OVГЃ L., BRTKO J.: Effects of two isomers of retinoic acid and genistein
on the expression of selected nuclear receptors, their coregulators and genes involved in apoptosis
in ACHN human kidney cancer cell line. Military Medical Science Letters, 82: (Suppl.), 18, 2013.
MACEJOVГЃ D., BIALEЕ OVГЃ L., HAVRГЃNEK T., BRTKO J., FICKOVГЃ M.: Effects of di(2ethylhexyl)-phtalate alone or in combination with 17пЃў-estradiol on expression of RXRalpha and
RXRbeta retinoid X receptor subtypes in the MCF-7 breast cancer cell line. Toxicology Letters,
221S: S105, P08-23, 2013.
BRTKO J., BIALEЕ OVГЃ L., LENKO V., MACEJOVГЃ D.: The road to nuclear receptors and their
cognate ligands: Insight into physiology and therapy of malignant diseases. Abstracts from the
Genetic Toxicology and Cancer Prevention Conference, Smolenice, L5, 6, 2013.
MACEJOVГЃ D., BIALEЕ OVГЃ L., HAVRГЃNEK T., BRTKO J., FICKOVГЃ M.: Di(2-ethylhexyl)phtalate: Effects on expression of RXRalpha and RXRbeta retinoid X receptor subtypes in the
MCF-7 breast cancer cell line. Abstracts from the Genetic Toxicology and Cancer Prevention
Conference, Smolenice, P1, 39, 2013.
BIALEЕ OVГЃ L., BRTKO J., ONDKOVГЃ S., GALBAVГќ Е ., MACEJOVГЃ D.: Selected nuclear
receptors expression in human breast carcinoma tissues. Abstracts from the Genetic Toxicology and
Cancer Prevention Conference, Smolenice, P6, 44, 2013.
96
SprГЎva o ДЌinnosti organizГЎcie SAV
LENKO V., OBЕ ITNГЌK M., ONDRIЕ M.: VГЅznam TRUS riadenej punkcie a aspirГЎcie v lieДЌbe
abscesu prostaty – naše skúsenosti. Klin. urol. 2013; 9(S): s. 34. ISSN 1336-7579.
12.) FunkДЌnГЅ vzЕҐah medzi aktivitou hypotalamo-hypofГЅzo-adrenokortikГЎlnej osi a ГєДЌinkom
vybranГЅch antipsychotГ­k. (Functional relationship between activity of the hypothalamichypophyseal- adrenocortical axis and the effect of selected antipsychotic)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Jana OsackГЎ
1.1.2012 / 31.12.2014
VEGA 2/0069/12
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
9.836,- Eur
DosiahnutГ© vГЅsledky:
SerotonergickГ© 5HT-2A/C receptory zohrГЎvajГє vГЅznamnГє Гєlohu v patogenГ©ze schizofrГ©nie a
ДЏalЕЎГ­ch podobnГЅch psychiatrickГЅch ochorenГ­. Zistili sme, Еѕe akГєtne podanie agonistu 5HT-2A/C
serotonergickГЅch receptorov 2,5-dimetoxy-4-iodoamfetamГ­nu (DOI) zvyЕЎuje expresiu Fos proteinu
v paraventrikulГЎrnom jadre hypotalamu, nucleus tractus solitarii a locus coeruleus za bazГЎlnych
podmienok a takisto po vystavenГ­ zvierat stresu znehybnenГ­m na 30 min. Podanie DOI stimulovalo
vyluДЌovanie kortikosterГіnu za bazГЎlnych podmienok a pri vystavenГ­ zvierat stresu trvala stresovГЎ
odpoveДЏ dlhЕЎie. Sledovali sme ДЌi chronickГ© vystavenie zvierat miernemu stresu (2 tГЅЕѕdne) ovplyvnГ­
efekt subchronicky podГЎvanГ©ho atypickГ©ho antipsychotika klozapГ­nu (7 dnГ­). Vystavenie stresu u
kontrolných zvierat spôsobilo zväčšenie nadobličiek, čo sme nepozorovali u zvierat, ktorým bol
podГЎvanГЅ klozapГ­n. AvЕЎak zvieratГЎ, ktorГЅm bol podГЎvanГЅ klozapГ­n mali za bazГЎlnych podmienok
väčšie nadobličky a menší týmus v porovnaní s kontrolnými. Sledovali sme aj mieru anxiety u
týchto zvierat pomocou ”open fieldu” a anhedónie pomocou testu preferencie sacharózy. U
klozapínových zvierat sme pozorovali tendenciu pohybovať sa viac po okrajoch “open field-u” a
menej vstupovaЕҐ do stredu. V teste preferencie sacharГіzy sme pozorovali tendenciu menej piЕҐ
sacharГіzu u stresovanГЅch zvierat, ale nenaЕЎli sme rozdiely medzi kontrolnГЅmi zvieratami a tГЅmi,
ktorГЅm bol podГЎvanГЅ klozapГ­n.
13. Е tГєdium a hodnotenie reprodukДЌnej toxicity nanoДЌastГ­c na in vitro modeloch (Testing and
assessment of reproductive toxicity of nanoparticles in in vitro models).
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v organizГЎcii SAV:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­:
ДЊerpanГ© financie:
SoЕ€a ScsukovГЎ
SoЕ€a ScsukovГЎ
1.1.2011-31.12.2013
VEGA 2/0165/11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
5 721,00 eur
97
SprГЎva o ДЌinnosti organizГЎcie SAV
DosiahnutГ© vГЅsledky:
CieДѕom projektu je ЕЎtГєdium moЕѕnГ©ho toxickГ©ho ГєДЌinku vybranГЅch nanoДЌastГ­c s odliЕЎnГЅmi
fyzikГЎlno-chemickГЅmi vlastnosЕҐami (PEG-b-PLA, oxid titaniДЌitГЅ, fulerГ©n) na funkcie
reprodukДЌnГ©ho systГ©mu na Гєrovni ovГЎria (steroidogenГ©za folikulГЎrnych buniek, ovulГЎcia, maturГЎcia
oocytov) i na Гєrovni nadriadenej jednotky, hypofГЅzy. Z naЕЎich vГЅsledkov vyplГЅva, Еѕe testovanГ©
nanoДЌastice mГґЕѕu negatГ­vne ovplyvniЕҐ proces syntГ©zy steroidnГЅch hormГіnov granulГіznymi
bunkami, ako aj sekrГ©ciu gonadotropГ­nov hypofyzГЎrnymi bunkami. V treЕҐom roku rieЕЎenia projektu
sme ЕЎtudovali moЕѕnГ© mechanizmy pГґsobenia (proliferГЎcia, apoptГіza, ГєДЌinok na enzГЅmy zapojenГ©
v procese steroidogenГ©zy, signГЎlne drГЎhy pГґsobenia gonadotropГ­nov) testovanГЅch nanoДЌastГ­c na
vybranГ© ovariГЎlne folikulГЎrne procesy a regulГЎciu sekrГ©cie gonadotropГ­nov.
14.) ModulaДЌnГЅ vplyv rizikovГЅch faktorov spojenГЅch so ЕѕivotnГЅm ЕЎtГЅlom na mechanizmy
subcelulГЎrnej adaptГЎcie srdca voДЌi ischГ©mii myokardu (Modulatory effects of risks factors
associated with the life style on the mechanisms of subcellular adaptation of the heart against
myocard ischemia)
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v
organizГЎcii SAV:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
TГЎЕ€a RavingerovГЎ
VladimГ­r Е trbГЎk
1.1.2011 / 31.12.2013
VEGA 2/0054/11
nie
0
0,- Eur
15.) ГљДЌinok vytrvalostnГ©ho a silovГ©ho trГ©ningu na sekreДЌnГЅ profil a charakteristiky
kostrovГ©ho svalu a primГЎrnych bunkovГЅch kultГєr kostrovГ©ho svalu u obГ©znych prediabetikov
(Effect of Endurance and Strength Training on the Secretory Profile and Molecular Phenotype of
Skeletal Muscle and Cultured Primary Human Muscle Cells from Obese Prediabetic Individuals)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Barbara UkropcovГЎ
1.1.2012 / 31.12.2014
VEGA 2/0174/12
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
4.704,77,- Eur
DosiahnutГ© vГЅsledky:
98
SprГЎva o ДЌinnosti organizГЎcie SAV
CieДѕom tejto intervenДЌnej ЕЎtГєdie je komplexne zhodnotiЕҐ efekt trojmesaДЌnГ©ho trГ©ningu
na antropometrickГ© a metabolickГ© zmeny ako aj zmeny sekreДЌnej aktivity kostrovГ©ho svalu a
fenotypu primГЎrnych buniek ДѕudskГ©ho kostrovГ©ho svalu u sedavГЅch jedincov s viscerГЎlnou obezitou
a rizikom metabolickГ©ho ochorenia. Okrem toho sme v spoluprГЎci s AKH vo Viedni (dr. KrЕЎЕЎГЎk)
stanovili vplyv 3-mesaДЌnГ©ho trГ©ningu na in vivo svalovГЅ metabolizmus. VГЅsledky tejto pilotnej
ЕЎtГєdie boli publikovanГ© v NMR Biomed. PokraДЌovali sme v skГєmanГ­ myokГ­nu irisГ­nu, hormГіnu
kostrovГ©ho svalu, ktorГЅ sa zo svalu uvoДѕЕ€uje vplyvom cviДЌenia a mГЎ potenciГЎlne pozitГ­vny vplyv na
fenotyp tukovГ©ho tkaniva a na metabolizmus. Jeho regulГЎcia a funkcia je vЕЎak u ДЌloveka zatiaДѕ len
mГЎlo preskГєmanГЎ. V ДЏalЕЎГ­ch in vitro experimentoch na primГЎrnych ДѕudskГЅch myotubГЎch sme
sledovali regulaДЌnГЅ vplyv glukГіzy a voДѕnГЅch mastnГЅch kyselГ­n na regulГЎciu expresie tohto
hormГіnu. Okrem toho sme v rГЎmci projektu realizovali pilotnГ© ЕЎtГєdie, zameranГ© na efekt akГєtneho
trГ©ningu na profil mikroRNA a myokГ­nov v kostrovom svale, v tukovom tkanive, v sГ©re a v moДЌi
trГ©novanГЅch jedincov.
In-extenso publikГЎcie :
KURDIOVA T., BALAZ M., VICIAN M., MADEROVA D., VLCEK M., VALKOVIC L.,
SRBECKY M., IMRICH R., KYSELOVICOVA O., BELAN V., JELOK I., WOLFRUM C.,
KLIMES I., KRSSAK M., ZEMKOVA E., GASPERIKOVA D., UKROPEC J., UKROPCOVA
B.: Are Skeletal Muscle & Adipose Tissue Fndc5 Gene Expression and Irisin Release Affected by
Obesity, Diabetes and Exercise? In vivo & in vitro studies. In The journal of physiology (London),
2013. (IF2012 – 4.38)
PozvanГ© prednГЎЕЎky na Slovensku
UKROPCOVГЃ B.: ГљДЌinky fyzickej (in)aktivity: DialГіg svalu s telom. LekГЎrska Fakulta UK
v Bratislave. 12. FebruГЎr 2013
UKROPCOVГЃ B.: KostrovГЅ sval ako mediГЎtor benefiДЌnГ©ho ГєДЌinku pravidelnГ©ho cviДЌenia. XVIII.
Kongres Slovenskej kardiologickej spoloДЌnosti, Bratislava, 10.-12. OktГіber 2013
UKROPCOVГЃ B., MADEROVГЃ D., KURDIOVГЃ T., BALГЃЕЅ M., KLIMEЕ I., GAЕ PERГЌKOVГЃ
D., VICIAN M., ZEMKOVГЃ E., UKROPEC J.: KostrovГЅ sval v patogenГ©ze chorГґb z nedostatku
pohybu. Národný kongres telovýchovného lekárstva: „Aktuálne problémy telovýchovného
lekárstva“, 22 – 23.11.2013, Bratislava.
AktГ­vna ГєДЌasЕҐ na zahraniДЌnГЅch konferenciГЎch:
BALГЃЕЅ M., KURDIOVA T., MADEROVA D., VICIAN M., GASPERIKOVA D., ZEMKOVA
E., UKROPEC J., UKROPCOVA B.: A Novel myokine irisin: in vivo & in vitro changes with
obesity & metabolic status. Keystone Symposia – Adipose Tissue Biology. Keystone, Colorado,
USA, 27.1-1.2.2013. J3041, p. 160 (poster)
KURDIOVA T., UKROPCOVA B., BALAZ M., VICIAN M., VLCEK M., SRBECKY M.,
OLEJNIK J., IMRICH R., BELAN V., KLIMES I., SCHMITZ G., GASPERIKOVA D.,
UKROPEC J.: Physical inactivity and muscle mitochondrial function in diabetes are associated with
specific changes in plasma lipidome. 20th European Congress on Obesity, Liverpool, UK, 12-14.mГЎj
2013, In Obes Facts, vol. 6, Suppl.1, 2013, p166, ISBN 978-3-318-02450-0, (poster).
BALГЃЕЅ M., KURDIOVГЃ T., MADEROVГЃ D., VICIAN M., JELOK I., GAЕ PERГЌKOVГЃ D.,
ZEMKOVГЃ E., KRЕ Е AK M., WOLFRUM CH., UKROPEC J., UKROPCOVГЃ B..: A novel
myokine irisin: in vivo and in vitro changes with obesity and metabolic status“. 20 th. European
99
SprГЎva o ДЌinnosti organizГЎcie SAV
Congress on Obesity, ECO 2013, Liverpool, 12.-15. mГЎj 2013, abstrakt publikovanГЅ v Obesity
facts, ISSN 1662-4025, aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka).
UKROPCOVГЃ B., KURDIOVГЃ T., BALГЃЕЅ M., ZEMKOVГЃ E., JELOK I., KYSELOVIДЊOVГЃ
O., UKROPEC J., KRЕ Е AK M.: The effects of three months exercise training on physical fitness,
adiposity and muscle energy metabolism in obese individuals. 5th International Congress on
Prediabetes and the Metabolic Syndrome, April 2013, Vienna, Austria (poster).
AktГ­vna ГєДЌasЕҐ na domГЎcich konferenciГЎch:
UKROPCOVГЃ B., KURDIOVГЃ T., BALГЃЕЅ M., MADEROVГЃ D., VICIAN M., ZEMKOVГЃ E.,
UKROPEC J.: Zmeny v spektre myokГ­nov, bioaktГ­vnych sekreДЌnГЅch produktov kostrovГ©ho svalu,
vo vzЕҐahu k obezite a diabetu 2. typu. XI. SlovenskГ© obezitologickГ© dni s medzinГЎrodnou ГєДЌasЕҐou,
14.-16. november 2013, Dudince, aktГ­vna ГєДЌasЕҐ (prednГЎЕЎka).
16.) TkanivovГЅ zГЎpal, metabolickГ© a endokrinnГ© ЕЎpecifikГЎ podkoЕѕnГ©ho a viscerГЎlneho tuku a
oxidatГ­vna kapacita kostrovГ©ho svalu v molekulГЎrnej patofyziolГіgii inzulГ­novej rezistencie u
pacientov s extrГ©mnou obezitou. (Tissue inflammation, metabolic and endocrine character of
subcutaneous and visceral adipose tissue and oxidative capacity of skeletal muscle in
pathophysiology of insulin resistance in individuals with extreme obesity)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Jozef Ukropec
1.1.2011 / 31.1.2013
2/0198/11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
5.408,30,- Eur
DosiahnutГ© vГЅsledky:
V sГєlade s cieДѕmi projektu sme zГ­skali biologickГЅ materiГЎl od 42 pacientov s extrГ©mnou obezitou
(BMI >40kg.m-2), ktorГ­ podstГєpili bandГЎЕѕ ЕѕalГєdka (banding ventriculi); laparoskopickГЅ chirurgickГЅ
zГЎkrok indikovanГЅ u pacientov s vГЅraznou obezitou za ГєДЌelom znГ­Еѕenia hmotnosti. DesaЕҐ pacientov
malo normГЎlnu toleranciu glukГіzy,13 poruЕЎenГє toleranciu glukГіzy a 9 diabetes 2. typu.
PerioperaДЌnГЅ odber sa uskutoДЌnil aj u 14 ЕЎtГ­hlych pacientov rovnakГ©ho veku a pohlavia. Okrem
charakterizГЎcie tukovГ©ho tkaniva od pacientov s extrГ©mnou obezitou (BMI > 40 kg.m-2) sme
vГЅznamnГє pozornosЕҐ venovali aj patofyziolГіgii tukovГ©ho tkaniva pacientov s deficitom rastovГ©ho
hormГіnu (vzorky tkaniva sme zГ­skali v predchГЎdzajГєcej ЕЎtГєdii). TukovГ© tkanivo je u tГЅchto
pacientov tvorenГ© obrovskГЅmi tukovГЅmi bunkami, ktorГ© nie sГє schopnГ© efektГ­vne ukladaЕҐ tuky vo
forme neutrГЎlnych lipidov. Deficit rastovГ©ho hormГіnu preto predisponuje jedinca k rozvoju
dyslipidГ©mie, metabolickГЅch ochorenГ­ a zГЎpalu v postihnutom tukovom tkanive, a to aj pri niЕѕЕЎom
stupni obezity. NaЕЎa prГЎca naznaДЌila tieЕѕ prГ­tomnosЕҐ Lrh1-Shp regulaДЌnej osi pri vzniku
metabolickГЅch komplikГЎciГ­ obezity. V spoluprГЎci so zahraniДЌnГЅm partnerom sme ukГЎzali, Еѕe Lrh1
je inhibГ­torom adipogenГ©zy, kГЅm Shp pГґsobГ­ ako jej aktivГЎtor prГЎve prostrednГ­ctvom represie
aktivity Lrh1. TГЎto regulГЎcia je aspoЕ€ do istej miery modulovanГЎ konverziou estradiolu
prostrednГ­ctvom Cyp19a1 in vitro. In vivo zvieracia ЕЎtГєdia ukГЎzala, Еѕe cielenГЎ inaktivГЎcia Lrh1
100
SprГЎva o ДЌinnosti organizГЎcie SAV
vedie k indukcii adipogenГ©zy, kГЅm inaktivГЎcia Shp spГґsobГ­ nekontrolovanГє aktivГЎciu Lrh1, a tak
znГ­Еѕi adipogenГ©zu (publikГЎcia v Molecular Metabolism).
In-extenso publikГЎcie :
MROSEK N., MEISSBURGER B., MATAKI C., ROEDER E., UKROPEC J., KLIMES I.,
GASPERIKOVA D., NAWROTH PP., RUDOFSKY G., AUWERX J., SCHOONJANS K.,
WOLFRUM C. Transcriptional regulation of adipocyte formation by the liver receptor homologue
1 (Lrh1)-Small hetero-dimerization partner (Shp) network. Mol Metab. 2013 Mar 16;2(3):314-23.
doi: 10.1016/j.molmet.2013.03.003. (IF-N.A. - 2 years history)
KURDIOVA T., BALAZ M., VICIAN M., MADEROVA D., VLCEK M., VALKOVIC L.,
SRBECKY M., IMRICH R., KYSELOVICOVA O., BELAN V., JELOK I., WOLFRUM C.,
KLIMES I., KRSSAK M., ZEMKOVA E., GASPERIKOVA D., UKROPEC J., UKROPCOVA
B.: Are Skeletal Muscle & Adipose Tissue Fndc5 Gene Expression and Irisin Release Affected by
Obesity, Diabetes and Exercise? In vivo & in vitro studies. In The journal of physiology (London),
2013. (IF2012 – 4.38)
AktГ­vna ГєДЌasЕҐ na zahraniДЌnГЅch konferenciГЎch:
BALГЃЕЅ M., KURDIOVA T., MADEROVA D., VICIAN M., GASPERIKOVA D., ZEMKOVA
E., UKROPEC J., UKROPCOVA B.: A Novel myokine irisin: in vivo & in vitro changes with
obesity & metabolic status. Keystone Symposia – Adipose Tissue Biology. Keystone, Colorado,
USA, 27.1-1.2.2013. J3041, p. 160 (poster)
AktГ­vna ГєДЌasЕҐ na domГЎcich konferenciГЎch :
BALГЃЕЅ M., JANГЃKOVГЃ Z., UKROPCOVГЃ B., KURDIOVГЃ T., BALOGOVГЃ M., PENESOVГЃ P.,
VLДЊEK M., MГЃDEROVГЃ D., BELAN V., KISS A., KLIMEЕ I., IMRICH R., GAЕ PERГЌKOVГЃ D.,
UKROPEC J.: Obezita a diabetes 2. typu sa spГЎjajГє s vГЅraznГЅm poklesom produkcie zink-О±2glykoproteГ­nu v podkoЕѕnom tukovom tkanive. XXIII. DiabetologickГ© dni v Bratislave, 12.-14. jГєn 2013,
aktГ­vna ГєДЌasЕҐ (poster).
17.) Гљloha proteГ­nov 14-3-.3, AS 160 a adiponektГ­nu v tukovom tkanive pri kompenzaДЌnГЅch
mechanizmoch v priebehu vzniku obezity a inzulГ­novej rezistencie. (The role of 14-3-3 and ASP
160 proteins and adiponectin in adipose tissue compensatory mechanisms during development of
obesity and insulin resistance.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Е tefan ZГіrad
1.1.2011 / 31.12.2013
2/0089/11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
DosiahnutГ© vГЅsledky:
Dokázali sme kľúčovú úlohu aktivácie postreceptorovej inzulínovej dráhy Akt kináza-AS160–
protein 14-3-3–GLUT4 v tukovom tkanive mladych obéznych potkanov kmeňa Zucker pri
kompenzГЎcii vplyvu hyperfГЎgie, nГЎslednej hypertrofie tukovГ©ho tkaniva a hyperinzulinГ©mie na
101
SprГЎva o ДЌinnosti organizГЎcie SAV
glukózový metabolizmus. Zvýšená fosforylácia AS160 umožňuje zvýšenú väzbu proteínu 14-3-3 na
AS160, jeho znГ­ЕѕenГє GTP-ГЎzovГє aktivitu a stimulГЎciou translokГЎcie GLUT4 na plazmatickГє
membrГЎnu. V sГєlade s tГЅmto sme zistili zvГЅЕЎenГє expresiu 14-3-3 a zvГЅЕЎenГ© mnoЕѕstvo GLUT4 vo
frakcii plazmatickГЅch membrГЎn. Potrebujeme identifikovaЕҐ podiel izomГ©rov 14-3-3Гџ a/alebo gama
na inhibГ­cii GTP-ГЎzovej aktivity AS160 u obГ©znych potkanov.
NaЕЎe vГЅsledky ukazujГє, Еѕe zvyЕЎujГєcim vekom zvierat zanikГЎ schopnosЕҐ tukovГ©ho tkaniva aktivovaЕҐ
dráhu Akt kináza-AS160–proteín 14-3-3–GLUT4 a tak kompenzovať negatívne metabolické účinky
obezity.
Naviac sme zistili, Еѕe GLUT1 a oxidГЎcia proteГ­nov v tukovom tkanive nesГєvisia s tГЅmto
kompenzaДЌnГЅm mechanizmom.
GAJDOSECHOVA L., SUSKI M., KRSKOVA K., OLSZANECKI R., ZORAD S.: Metabolic
health in 12-week-old obese Zucker rats is associated with increase in 14-3-3ОІ and phosphorylation
of AS160 in epididymal adipose tissue. Obesity Facts, 6 (suppl. 1): 75, 2013, 20th European
Congress on Obesity (ECO2013)
Programy : APVV
1. VГЅvinovГ© ГєДЌinky neuropeptidov (Developmental effects of neuropeptides)
ZodpovednГЅ rieЕЎiteДѕ:JГЎn BakoЕЎ
ZodpovednГЅ rieЕЎiteДѕ v organizГЎcii SAV: JГЎn BakoЕЎ
Trvanie projektu: 1.5.2011-1.5.2014
EvidenДЌnГ© ДЌГ­slo projektu: APVV-0253-10
OrganizГЎcia je koordinГЎtorom projektu: ГЎno
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­: 1
ДЊerpanГ© financie:
38 323,- EUR (z toho UEE SAV): 30 311,- EUR
DosiahnutГ© vГЅsledky :
V roku 2013 boli realizovanГ© animГЎlne ЕЎtГєdie aj in vitro experimenty. PodГЎvali sme oxytocГ­n
a/alebo atosiban intracerebroventrikulГЎrne potkanom a nГЎsledne sme analyzovali sprГЎvanie a po
odobratГ­ tkanГ­v expresiu mikrofilamentovГЅch proteГ­nov (nestГ­n, microtubule associated protein 2MAP2) a rastovГЅch faktorov (BDNF, NGF). VГЅsledky sГє v procese vyhodnotenia. Na bunkovГЅch
lГ­niГЎch (SK-N-SH, SH- SY5Y, U87MG) sme ДЏalej pokraДЌovali v experimentoch s inkubГЎciou
v prostredí ligandov oxytocínových receptorov. Testovali sme najmä účinok rôzne dlhej inkubácie
(2h, 6h, 12h, 48h) SK-N-SH a U-87-MG buniek s oxytocГ­nom, priДЌom bolo preukГЎzanГ©, Еѕe dДєЕѕka
pГґsobenia oxytocГ­nu mГґЕѕe byЕҐ dГґleЕѕitГЎ pre regulГЎciu stability mikrotubulovГЅch proteГ­nov.
Pomocou transfekcie oxytocinovГ©ho receptora sme ГєspeЕЎne dosiahli jeho silencing, ktorГ©ho
sprievodnГЅm javom bolo aj naruЕЎenie gГ©novej expresie cytoskeletovГЅch proteГ­nov. Zmeny
v gГ©novej expresii MAP2 a nestГ­nu u neuronГЎlnych buniek naznaДЌujГє, Еѕe ligandy oxytocГ­novГЅch
receptorov mГґЕѕu maЕҐ vplyv na bunkovГЅ cyklus a diferenciГЎciu buniek. Vplyv oxytocГ­nu sme
pozorovali aj na primГЎrnych kortikohipokampГЎlnych neurГіnoch. SpoloДЌne so spolurieЕЎiteДѕskou
organizГЎciou- FyziologickГЅm Гєstavom LF UK sme vyhodnotili vzorky krvnГЅch plaziem
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autistickГЅch pacientov.
PublikГЎcie :
BAKOS J.,STRBAK V., PAULIKOVA H., KRAJNAKOVA L., LESTANOVA Z., BACOVA Z.
Oxytocin receptor ligands induce changes in cytoskeleton in neuroblastoma cells. In Journal of
Mollecular Neuroscience. 2013; vol. 50, n. 3, pp. 462-468.
HUSГЃROVГЃ V., LAKATOЕ OVГЃ S., PIVOVARДЊIOVГЃ A., BAKOЕ , J., DURDIAKOVГЃ J.,
KUBRANSKГЃ A., OSTATNГЌKOVГЃ D. Brief report: Plasma oxytocin is lower in children with
Asperger syndrome and associated with autistic trait attention to detail. Open Journal of Psychiatry,
3, 399-402,
LEЕ Е¤ANOVГЃ Z., BAДЊOVГЃ Z., HAVRГЃNEK T., BAKOЕ J. Mechanizmy zmien dДєЕѕky axГіnov a
dendritov neurГіnu. Cesk Fysiol. 62(2):47-53, 2013
LEЕ Е¤ANOVГЃ Z., BAДЊOVГЃ Z., HAVRГЃNEK T., BAKOЕ , J. Neuropeptidy vo vГЅvine mozgu:
potenciГЎl na protekciu proti zГЎpalovГЅm zmenГЎm. In Trendy vo vГЅvinovej toxikolГіgii a teratolГіgii,
s. 59-73. ISBN 978-80-971042-2-1, 2013
2.) AplikГЎcia proteomickГЅch technГ­k pre sledovanie ГєДЌinkov biologicky aktГ­vnych ligandov
reetinoidnГЅch receptorov vyuЕѕiteДѕnГЅch v terapii karcinГіmu prsnГ­ka (Application of proteomic
techniques for monitoring of biologically active retinoid receptors ligands effects explitable for
therapy of breast cancer)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
JГєlius Brtko
1.7.2012 / 31.12.2015
APVV-SK-CZ-0211-11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
1
(UACH AVДЊR Brno)
1.755,- Eur
DosiahnutГ© vГЅsledky:
IzomГ©ry ako aj derivГЎty retinovГЅch kyselГ­n sa povaЕѕujГє za dГґleЕѕitГ© terapeutickГ© ДЌinidlГЎ pre
niektorГ© typy nГЎdorovГЅch ochorenГ­, napr. akГєtnej promyelocytickej leukГ©mie ako aj niektorГЅch
dermatologickГЅch ochorenГ­. ProteomickГЎ analГЅza sa v sГєДЌasnosti povaЕѕuje za vГЅznamnГЅ nГЎstroj
umoЕѕЕ€ujГєci identifikГЎciu nГЎdorovГЅch biomarkerov ako aj pre hodnotenie ГєДЌinnosti zvolenej terapie
nГЎdorovГ©ho ochorenia. Aj v druhom roku rieЕЎenia projektu sme sledovali molekulГЎrne mechanizmy
vplyvu retinovГЅch kyselГ­n (all-trans retinoic acid a/alebo 9-cis retinoic acid) na Гєrovni nГЎdorovГЅch
buniek ľudského karcinómu prsníka matódami „in gel digestion“ a MALDI-TOF hmotnostnou
spektrometriou (MS). Vplyvom izomГ©rov retinovГЅch kyselГ­n v koncentrГЎciГЎch 1 Вµmol/l sa
identifikovali zmeny v koncentrГЎciГЎch niektorГЅch ДЏalЕЎГ­ch ЕЎpecifickГЅch biomerkerov nГЎdorovГ©ho
ochorenia prsníka „heat shock“ proteínu HSP 90-beta ako aj „heat shock cognate“ 71 kDa
proteГ­novГЎ forma 1. UvedenГЎ metГіda takto poskytuje rГЅchlu cestu k frakcionГЎcii a identifikГЎcii
dГґleЕѕitГЅch proteГ­nov.
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SprГЎva o ДЌinnosti organizГЎcie SAV
Pre efektГ­vnejЕЎiu separГЎciu proteГ­nov a za ГєДЌelom zisЕҐovania zmien v proteГ­novom profile
MCF-7 buniek ДѕudskГ©ho nГЎdoru prsnГ­ka (estrogГ©n receptor pozitГ­vnych) po aplikГЎcii jednotlivГЅch
izomГ©rov retinovГЅch kyselГ­n v koncentrГЎcii 1 Вµmol/l bola pouЕѕitГЎ dvojrozmernГЎ (2D) gГ©lovГЎ
elektrofГ©za, priДЌom prvГЅ rozmer separГЎcie proteГ­nov sa zГ­skal izoelektroforetickou fokusГЎciou
proteГ­nov a nГЎsledne sa ДЏalЕЎie delenie proteГ­nov uskutoДЌnilo pomocou SDS-polyakrylamidovej
elektroforГ©zy. Po 2D separГЎcii a vizualizГЎcii proteГ­nov na polyakrylamidovom gГ©li boli izolovanГ©
jednotlivé „spoty“ proteínov a po proteolytickom štepení proteínov produkty identifikované
pomocou MALDI-TOF hmotnostnej spektrometrie. VГЅsledky jednoznaДЌne ukГЎzali ДЏalЕЎiu
identifikГЎciu potencionГЎlnych biomarkerov, ktorГ© sa vyskytujГє v nГЎdorovГЅch bunkГЎch prsnГ­ka bez
ich spracovania izomГ©rmi kyseliny retinovej alebo na druhej strane len vo vzorkГЎch nГЎdorovГЅch
buniek, ktorГ© sa inkubovali v prГ­tomnosti izomГ©rov retinovГЅch kyselГ­n.
ZГЎverom je moЕѕnГ© konЕЎtatovaЕҐ, Еѕe uvedenГЎ proteomickГЎ metГіda je vhodnГЎ pre ЕЎtГєdium
zmien v proteГ­novom zloЕѕenГ­ nГЎdorovГЅch buniek prsnГ­ka po lieДЌbe izomГ©rmi retinovГЅch kyselГ­n ako
aj pre hДѕadanie a identifikГЎciu potencionГЎlnych, avЕЎak eЕЎte nepreskГєmanГЅch biomarkerov lieДЌby
nГЎdorovГ©ho ochorenia izomГ©rmi retinovГЅch kyselГ­n.
ДЋalЕЎГ­m, veДѕmi cennГЅm prГ­nosom tohto projektu (mobility) je prehlbovanie spoluprГЎce medzi
Гљstavom analytickej chГ©mie AV ДЊR, v. v. i., a Гљstavom experimentГЎlnej endokrinolГіgie, SAV, SR.
PublikГЎcie:
FLODROVA D., BENKOVSKA D., MACEJOVA D., BIALESOVA L., BOBALOVA L., BRTKO
J.: Effects of retinoic acid isomers on proteomic pattern in human breast cancer MCF-7 cell line.
Endocr. Regul., 47: 205-2209, 2013.
VyЕѕiadanГЎ prednГЎЕЎka:
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., BOBГЃLOVГЃ J.: Nuclear receptors and their
cognate ligands: Insight into physiology and therapy of malignant diseases. Technische Universität,
Dresden, Nemecko, 22.10.2013.
3.) ProtinГЎdorovГЅ ГєДЌinok biologicky aktГ­vnych ligandov heterodimГ©rov nukleГЎrnych
retinoidnГЅch X receptorov v tkanivovГЅch kultГєrach nГЎdorovГЅch buniek (Antitumour effect of
biologically active ligands of nuclear retinoid X receptor heterodimers in tissue carcinoma cell
lines)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
JГєlius Brtko
1.7.2012 / 31.12.2015
APVV-0160-11
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
1
38.879,-
DosiahnutГ© vГЅsledky:
Hodnotili sa cytotoxickГ© vlastnosti tributylcГ­n chloridu (TBT-Cl), tributylcГ­n bromidu (TBTBr), tributylcГ­n jodid (TBT-I), a non-halogenidu tributylcГ­nhydridu (TBT-H) v estrogГ©n receptorpozitГ­vnej Дѕudskej lГ­nii rakoviny prsnГ­ka MCF-7 a estrogГ©n receptor-negatГ­vnej MDA-MB-231
bunkovej lГ­nii, ktorГ© vykazujГє veДѕmi odliЕЎnГ© fenotypy. Ako zГЎkladnГє metГіdu sa vybrala metГіda
104
SprГЎva o ДЌinnosti organizГЎcie SAV
MTT, zaloЕѕenГЎ na sledovanГ­ schopnosti enzГЅmu mitochondriГ­, konkrГ©tne NADH-zГЎvislej
sukcinГЎtdehydrogenГЎzy, lokalizovanej na vnГєtornej membrГЎne mitochondriГ­, redukovaЕҐ rozpustnГє
tetrazГіliovГє soДѕ MTT na nerozpustnГЅ formazГЎn modrej, aЕѕ fialovej farby u viabilГЅch buniek.
SchopnosЕҐ sledovanГЅch lГЎtok inhibovaЕҐ rast nГЎdorovГЅch buniek sa nГЎsledne potvrdila aj
zobrazovacГ­m bunkovГЅm systГ©mom INCUCYTEв„ў Kinetic Imaging System, ktorГЅm sa sledovala
konfluencia bunkovГЅch kultГєr ovplyvnenГЅch testovanГЅmi lГЎtkami. Toxicity vybranГЅch
tributylcГ­novГЅch halogenidov sa vГЅznamne nelГ­ЕЎili v ER-pozitГ­vnej, slabo invazГ­vnej, luminГЎlnej
epiteliГЎlnej MCF-7 lГ­nii a v ER-negatГ­vnej, vysoko invazГ­vnej, fibroblastoidnej MDA-MB-231
bunkovej lГ­nii a bola v nasledujГєcom poradГ­: tributylcГ­n chlorid > tributylcГ­n bromid > tributylcГ­n
jodid, ДЌo znamenГЎ, Еѕe ich toxicita mГґЕѕe zГЎvisieЕҐ od typu atГіmu halogГ©nu (Cl, Br, I) a nehalogГ©nu
(hydrid) v molekule tributylcГ­nu, ktorГ©ho toxicita bola najmenЕЎia
Zistilo sa, Еѕe cytotoxicita tributylcГ­novГЅch zlГєДЌenГ­n v P-glykoproteГ­n-negatГ­vnych L1210
myЕЎГ­ch leukemickГЅch bunkГЎch bola v poradГ­: TBT-I = TBT-H > TBT-Cl = TBT-Br a v myЕЎГ­ch PglykoproteГ­n-pozitГ­vnych L1210 bunkГЎch bola v poradГ­: TBT-Br = TBT-I > TBT-Cl = TBT-H.
Nakoľko je známe, že tributylcín chlorid je väzobným ligandom nukleárnych retinoidných
X receptorov (RXR), porovnГЎvali sme vplyv TBT-Cl, TBT-Br, TBT-I, TBT-H (100 nmol/l) v
prГ­tomnosti kyseliny all-trans retinovej (10 Вµmol/l), ktorГЎ je prirodzenГЅm ligandom nukleГЎrnych
retinoidnГЅch receptorov (receptorov pre kyselinu all-trans retinovГє, RAR). Zistilo sa, Еѕe uvedenГ©
zlГєДЌeniny v porovnanГ­ s kontrolnou skupinou spГґsobujГє znГ­Еѕenie expresie vЕЎetkГЅch podtypov RAR
ako aj RXR v estrogГ©n receptor-pozitГ­vnej Дѕudskej lГ­nii rakoviny prsnГ­ka MCF-7.
PublikГЎcie:
MACEJOVГЃ D., GALBAVГќ S., PODOBA J., BIALEЕ OVГЃ L., BRTKO J.: mRNA expression
pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary
carcinoma, Oncology Reports, 30: 2371-2378, 2013.
LENKO V., BIALESOVA L., MACEJOVA D., BUJDAK P., BREZA J., BRTKO J.: The
relationship between renal cell carcinoma and nuclear retinoid/rexinoid receptors. Biomed Pap Med
Fac Univ Palacky Olomouc Czech Repub. 157: 316-324, 2013.
BIALEЕ OVГЃ L., BRTKO J., LENKO V., MACEJOVГЃ D.: Nuclear receptors - target molecules
for isoflavones in cancer chemoprevention. Gen. Physiol. Biophys., 32: 467–478, 2013.
FLODROVA D., BENKOVSKA D., MACEJOVA D., BIALESOVA L., BOBALOVA L., BRTKO
J.: Effects of retinoic acid isomers on proteomic pattern in human breast cancer MCF-7 cell line.
Endocr. Regul., 47: 205-2209, 2013.
Abstrakty:
BRTKO J., MACEJOVГЃ D., GALBAVГќ Е ., BIALEЕ OVГЃ L., PODOBA J.: Expression mRNA
pattern of retinoic acid and retinoid X nuclear receptor subtypes in thyroid carcinomas. Thyroid
Research, 6: (Suppl. 2): 4-5, 2013.
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., GALBAVГќ Е .: Expresia podtypov retinoidnГЅch a
rexinoidnГЅch jadrovГЅch receptorov a ich koregulГЎtorov v karcinГіmoch ЕЎtГ­tnej ЕѕДѕazy. Diabetologie,
Metabolizmus, Endokrinologie, VГЅЕѕiva, 16: (Suppl.), 2-3, 2013.
BRTKO J., MACEJOVГЃ D., Е ., BIALEЕ OVГЃ L., FICKOVГЃ M., HUNГЃKOVГЃ L.: Toxicity of
nuclear retinoid X receptors cognate ligands of organotin origin in breast cancer cell lines: Effects
on selected retinoid/retinoid X receptor subtypes expression. Military Medical Science Letters, 82:
(Suppl.), 3, 2013.
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SprГЎva o ДЌinnosti organizГЎcie SAV
MACEJOVГЃ D., BIALEЕ OVГЃ L., BRTKO J.: Effects of two isomers of retinoic acid and genistein
on the expression of selected nuclear receptors, their coregulators and genes involved in apoptosis
in ACHN human kidney cancer cell line. Military Medical Science Letters, 82: (Suppl.), 18, 2013.
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., FICKOVГЃ M., BOHГЃДЊOVГЃ V., SULOVГЃ Z.,
BREIER A., HUNГЃKOVГЃ L.: Selected organotin halides: Toxicity versus nuclear retinoic
acid/retinoid X receptors and their co-regulators expression in breast cancer and leukemia cell lines.
Toxicology Letters, 221S: S113, P08-47, 2013.
MACEJOVГЃ D., BIALEЕ OVГЃ L., HAVRГЃNEK T., BRTKO J., FICKOVГЃ M.: Effects of di(2ethylhexyl)-phtalate alone or in combination with 17пЃў-estradiol on expression of RXRalpha and
RXRbeta retinoid X receptor subtypes in the MCF-7 breast cancer cell line. Toxicology Letters,
221S: S105, P08-23, 2013.
HUNГЃKOVГЃ L., MACEJOVГЃ D., BIALEЕ OVГЃ L., BRTKO J.: Effects of selected organotin
halides on human breast cancer cell line growth and nuclear all-trans retinoic acid receptor (RAR)
and retinoid X receptor (RXR) subtypes expression. Abstracts from the UAE Cancer Congress,
Dubai, 43, 2013.
BRTKO J., BIALEЕ OVГЃ L., LENKO V., MACEJOVГЃ D.: The road to nuclear receptors and their
cognate ligands: Insight into physiology and therapy of malignant diseases. Abstracts from the
Genetic Toxicology and Cancer Prevention Conference, Smolenice, L5, 6, 2013.
BIALEЕ OVГЃ L., BRTKO J., ONDKOVГЃ S., GALBAVГќ Е ., MACEJOVГЃ D.: Selected nuclear
receptors expression in human breast carcinoma tissues. Abstracts from the Genetic Toxicology and
Cancer Prevention Conference, Smolenice, P6, 44, 2013.
LENKO V., OBЕ ITNГЌK M., ONDRIЕ M.: VГЅznam TRUS riadenej punkcie a aspirГЎcie v lieДЌbe
abscesu prostaty – naše skúsenosti. Klin. urol. 2013; 9(S): s. 34. ISSN 1336-7579.
4.) Zmeny v metabolizme bunky vyvolanГ© nadexpresiou transportГ©ra lieДЌiv - P-glykoproteГ­nu
v leukemickГЅch bunkГЎch . (Changes in the cell metabolism developed by overexpression of the
drug transporter – P-glycoprotein in leukemic cells.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
JГєlius Brtko
1.7.2011 / 31.12.2014
APVV-0290-10
nie
UMFG SAV
0
10.215,- Eur
106
SprГЎva o ДЌinnosti organizГЎcie SAV
DosiahnutГ© vГЅsledky:
Rozvoj najДЌastejЕЎieho fenotypu multidrug rezistencie nГЎdorovГЅch buniek sa spГЎja
s masГ­vnou upregulГЎciou expresie P-glykoproteГ­nu (P-gp). Z literatГєry je popГ­sanГЎ indukcia
expresie/aktivity P-gp v malГ­gnych bunkovГЅch lГ­niГЎch pГґsobenГ­m kyseliny all-trans retinovej
(AtRA). V našich experimentoch sme použili tri varianty L1210 buniek: S bunky – parentálne
senzitívne bunky, R bunky – rezistentné bunky, v ktorých bola nadexpresia P-gp vyvolaná
vinkristínom a T bunky – rezistentné bunky, v ktorých je nadexpresia P-gp indukovaná stabilnou
transfekciou plazmidom pHaMDRwt kГіdujГєcim ДѕudskГЅ P-gp.
Expresia RARalfa bola signifikantne vyЕЎЕЎia v T bunkГЎch ako v S bunkГЎch (p<0,05).
Verapamil samotnГЅ signifikantne znГ­Еѕil expresiu RARalfa vo vЕЎetkГЅch bunkovГЅch lГ­niГЎch
v porovnanГ­ s prГ­sluЕЎnГЅmi kontrolnГЅmi skupinami (p<0,05). Podanie (AtRA) S a R bunkГЎm viedlo
k signifikantnГ©mu zvГЅЕЎeniu RARalfa mRNA (p<0,05). VER v kombinГЎcii s AtRA taktieЕѕ potlaДЌil
expresiu RARalpha v S, R a T bunkГЎch (p<0,05), avЕЎak hladiny mRNA tohto receptora boli stГЎle
signifikantne vyЕЎЕЎie v porovnanГ­ s bunkami, ktorГЅm bol podanГЅ len VER samotnГЅ (p<0,05).
PodobnГ© vГЅsledky sme pozorovali aj pri podГЎvanГ­ kyseliny 9-cis retinovej (9cRA).
RARbeta bol prГ­tomnГЅ v pribliЕѕne rovnakГЅch hladinГЎch v S a R bunkГЎch, transfekcia
ДѕudskГ©ho P-gp vЕЎak bola spojenГЎ s vГЅraznou redukciou expresie tohto receptora v T bunkГЎch
(p<0,01). пЂ VER samotnГЅ inhiboval expresiu v S bunkГЎch. ZatiaДѕ ДЌo AtRA ДЌi uЕѕ samotnГЎ alebo
v kombinГЎcii s VER nemala vplyv na expresiu RARbeta, 9cRA indukovala jeho expresiu vo
vЕЎetkГЅch lГ­niГЎch (p<0,05). KombinГЎcia 9cRA a VER signifikantne znГ­Еѕila expresiu tohto izoformu
RAR v R a T bunkГЎch (p<0,05) v porovnanГ­ s 9cRA skupinou.
Expresia RARgama bola signifikantne vyЕЎЕЎia v P-gp-pozitГ­vnych bunkГЎch (R a T)
(p<0,001). VER samotnГЅ signifikantne znГ­Еѕil tento transkript v R a T bunkГЎch (p<0,001). AtRA
alebo 9cRA signifikantne zvГЅЕЎila expresiu RARgama vo vЕЎetkГЅch lГ­niГЎch пЂ (p<0,001).
Abstrakty:
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., FICKOVГЃ M., BOHГЃДЊOVГЃ V., SULOVГЃ Z.,
BREIER A., HUNГЃKOVГЃ L.: Selected organotin halides: Toxicity versus nuclear retinoic
acid/retinoid X receptors and their co-regulators expression in breast cancer and leukemia cell lines.
Toxicology Letters, 221S: S113, P08-47, 2013.
5.) Objasnenie ГєДЌinku vybranГЅch endokrinnГЅch disruptorov zvyЕЎujГєcich riziko vГЅvoja
nГЎdorov prsnГ­ka, prostaty a ovariГЎlnych disfunkciГ­. (The effect of selected endocrine disruptors
on the development of mammary gland , prostatic cancer and ovarian disfunctions)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
MГЎria FickovГЎ
1.5.2011 / 31.10.2014
APVV-0147-10
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
58.089,- Eur
DosiahnutГ© vГЅsledky :
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SprГЎva o ДЌinnosti organizГЎcie SAV
Zistenie optimГЎlnych podmienok pre inkubГЎciu LNCaP buniek (ДѕudskГ© nГЎdorovГ© bunky prostaty,
semiadherentnГ©) umoЕѕnilo realizГЎciu identickГЅch pokusov ako v predchГЎdzajГєcich rokoch na MCF7
bunkГЎch. PodДѕa plГЎnu bola analyzovanГЎ proliferaДЌnГЎ aktivita vybratГЅch fenolov: bisfenolu A (BPA)
a nonylfenolu (NP); zo skupiny ftalГЎtov: dietylhexylftalГЎt (DEHP) a ich kombinГЎcie
s testosterГіnom (T).
BPA stimuluje rast LNCaP buniek ДЌasovo zГЎvislГЅm spГґsobom a dГЎvkovГЎ zГЎvislosЕҐ sa menГ­ od ДЌasu
pГґsobenia (efekt hormГ©zy, t.j. niЕѕЕЎie dГЎvky indukujГє vyЕЎЕЎiu odpoveДЏ). ProliferaДЌnГЅ ГєДЌinok BPA (aj
BPA+T) je mierny (~ 110-120 %), prejavГ­ aЕѕ po dlhodobom pГґsobenГ­ (72h a 120h) nedosahuje
parametre stimulГЎcie samotnГЅm T.
ProliferaДЌnГ© ГєДЌinky DEHP a NP samotnГЅch, alebo v kombinГЎcii s T sГє mierne a prejavia sa aЕѕ po
dlhodobom pГґsobenГ­ (120h).
HodnotenГ­m ГєДЌinku vybratГЅch endokrinnГЅch disruptorov fenolovГ©ho a ftalГЎtovГ©ho typu na expresiu
gГ©nov, ktorГЅch produkty (proteГ­ny) sГє sГєДЌasЕҐou proliferaДЌnГЅch procesov, sme zistili rГЅchly nГЎstup
inhibiДЌnГ©ho ГєДЌinku BPA (aj v kombinГЎcii s T) na expresiu gГ©nu pre RXRalfa receptor kyseliny
retinovej (uЕѕ po 24h). ZnГ­Еѕenie mnoЕѕstva mRNA pre RXRalfa gГ©n mГґЕѕe nГЎsledne zniЕѕovaЕҐ
translГЎciu, vyvolaЕҐ pokles prГ­sluЕЎnГЅch retinoidnГЅch X receptorov, ktorГ© sprostredkujГє
antiproliferaДЌnГ© ГєДЌinky kyseliny retinovej. BPA a tieЕѕ DEHP nemenili expresiu gГ©nov pre RXRbeta
a pre RXRgama receptory.
Na molekulГЎrnej Гєrovni sme v LNCaP bunkГЎch ДЏalej analyzovali expresiu gГ©nov kГіdujГєcich
proteГ­ny apoptГіzy a bunkovГ©ho cyklu. ГљДЌinkom BPA, DEHP a ich kombinГЎcii s T analГЅzy
nepotvrdili zmeny na Гєrovni mRNA pre proapoptickГ© proteГ­ny (p53, p21, Bax, kaspГЎza 3)
a antiapoptickГЅ Bcl2 proteГ­n. NajvГЅznamnejЕЎГ­m vГЅsledkom je zistenie, Еѕe BPA v kombinГЎcii s T
vГЅrazne zvyЕЎuje expresiu gГ©nov pre proteГ­ny bunkovГ©ho cyklu (cyklГ­n A2 a cyklГ­n B1), ДЌo
charakterizuje prvotnГ© molekulГЎrne zmeny podmieЕ€ujГєce proliferaДЌnГЅ mechanizmus BPA.
ZnamenГЎ to, Еѕe BPA v naЕЎom experimentГЎlnom modeli stimuluje rast nГЎdorovГЅch buniek na Гєrovni
bunkovГ©ho cyklu a nie mechanizmom inhibГ­cie apoptГіzy.
ДЋalЕЎГ­m veДѕmi vГЅznamnГЅm vГЅsledkom je zistenie, Еѕe kГЅm samotnГЅ BPA nemГЎ ГєДЌinok, v kombinГЎcii
s T vГЅznamne zvyЕЎuje expresiu gГ©nu pre PSA (indikГЎtor rakoviny prostaty). K procesu
proliferaДЌnГЅch ГєДЌinkov BPA mГґЕѕe prispievaЕҐ aj znГ­Еѕenie aktivity antioxidaДЌnГ©ho enzГЅmu SOD, ДЌo
spГґsobГ­ akumulГЎciu voДѕnГЅch kyslГ­kovГЅch radikГЎlov, t.j. prГ­tomnosЕҐ oxidaДЌnГ©ho stresu, ktorГ©
podmieЕ€ujГєci karcinogenГ©zu.
ProliferaДЌnГ© ГєДЌinky BPA v LNCaP bunkГЎch tak budГє vГЅsledkom aktivГЎcie viacerГЅch mechanizmov
a drГЎh. V naЕЎich experimentГЎlnych podmienkach mГґЕѕeme vylГєДЌiЕҐ ovplyvnenie apoptГіzy (bez
zmeny expresie gГ©nov); zistil sa pokles aktivity SOD (s nГЎslednГЅm zvГЅЕЎenГ­m karcinogГ©nnych
reaktГ­vnych foriem kyslГ­ka) a nepriamo zvГЅЕЎenie proliferГЎcie (zvГЅЕЎenГЎ expresia gГ©nov pre proteГ­ny
bunkovГ©ho cyklu: A2, B1). PozoruhodnГЅm je zistenie, Еѕe BPA stimuluje expresiu gГ©nu pre PSA
(indikГЎtor rakoviny prostaty).
6. IdentifikГЎcia novГЅch aspektov monogГ©novГЅch endokrinopatiГ­ metГіdou sekvenovania novej
generГЎcie (Identification of new genetic aspects of monogenic endocrinopathies by next generation
sequencing).
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ
v organizГЎcii SAV
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
Daniela GaЕЎperГ­kovГЎ
1.10.2013 – 31.5.2017
APVV-0187-12
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie
1
108
SprГЎva o ДЌinnosti organizГЎcie SAV
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
11.557,- €
DosiahnutГ© vГЅsledky:
Projekt odЕЎtartoval 1.10.2013. V rГЎmci realizГЎcie projektu s 1. detskou klinikou LF UK v Bratislave
sa v roku 2013 identifikoval jeden proband so zriedkavГЅm syndrГіmom MEHMO. U tohto pacienta
sa realizovalo vyЕЎetrenie exГіmu metГіdou sekvenovania Novej generГЎcie (na pracovisku v JuЕѕnej
KГіrey). VyЕЎetrenie identifikovalo viacero kandidГЎtnych gГ©nov, priДЌom v sГєДЌasnosti sa overuje ich
moЕѕnГЅ dopad na fenotyp pacienta. ZГЎroveЕ€ sa zaДЌal vГЅber rodГ­n s cukrovkou typu MODY,
vhodnГЅch na identifikГЎciu novГЅch gГ©nov.
7.
MolekulГЎrno-genetickГЅ vГЅskum s farmakogenetickГЅmi konsekvenciami u detГ­ s
hyperinzulinemickГЅmi hypoglykГ©miami (Molecular-genetic research with pharmacogenetic
consequences in children with hyperinsulinemic hypoglycemia).
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ
v organizГЎcii SAV
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Daniela GaЕЎperГ­kovГЎ
1.10.2013 – 31.5.2017
APVV-0107-12
nie
LekГЎrska fakulta UK
1
17.833,- €
DosiahnutГ© vГЅsledky:
V rГЎmci realizГЎcie projektu s 1. detskou klinikou LF UK v Bratislave sa v roku 2013 zaДЌalo
vyhДѕadГЎvanie jedincov s izolovanГЅmi ako aj syndrГіmovГЅmi formami kongenitГЎlneho
hyperinzulinizmu. Za 3 mesiace rieЕЎenia sa na DNA analГЅzu odoslala vzorka od 3 probandov s
perzistujГєcimi hypoglykГ©miami u ktorГЅch sa spolu s 5 pacientami z DNA banka vykonala DNA
analГЅza gГ©nov KCNJ11, ABCC8 a GCK. U jednГ©ho probanda sa naЕЎli dve rГґzne mutГЎcie v gГ©ne
KCNJ11 spГґsobujГєce zГЎvaЕѕnГє, diazoxid rezistentnГє, formu hyperinzulinizmu. Na zГЎklade vГЅsledku
DNA analГЅzy sa upravila lieДЌba u pacienta (zmena z diazoxidu na oktreotid), pod ktorou sa
glykГ©mie postupne normalizovali.
Abstrakty :
STANГЌK J., ROSOДЅANKOVГЃ M., HUДЊKOVГЃ M., VALENTГЌNOVГЃ L., MAЕ INDOVГЃ I.,
MIKULAJOVГЃ S., STANГЌKOVГЃ D., KYЕ KOVГЃ S., SLOVAK CONGENITAL
HYPERINSILINISM STUDY GROUP, TICHГЃ ДЅ., GAЕ PERГЌKOVГЃ D., KLIMEЕ I.:
Pharmacogenetics in channelopathies causing congenital hyperinsulinism. 19th Middle European
Worshop of Paediatric Endocrinology. Endocr Regul. 2013 October;47(3):228.
8.) Interakcia psychickГЅch, kardiovaskulГЎrnych, neuroendokrinnГЅch a metabolickГЅch
faktorov: od novГЅch animГЎlnych modelov po klinickГ© aplikГЎcie. (Interaction of mental,
cardiovascular, neuroendocrine and metabolic factors: from animal models toclinical applications)
ZodpovednГЅ rieЕЎiteДѕ:
Daniela JeЕѕovГЎ
109
SprГЎva o ДЌinnosti organizГЎcie SAV
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
1.5.2011 / 31.12.2014
APVV-0028-10
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
91.899,- Eur
DosiahnutГ©
vГЅsledky:
S cieДѕom umoЕѕniЕҐ ЕЎirЕЎie vyuЕѕitie hodnotenia sekrГ©cie aldosterГіnu za klinickГЅch podmienok sme
validovali metodiku na jeho meranie v slinГЎch. JednoznaДЌne sme dokГЎzali prГ­tomnosЕҐ pohlavnГЅch
rozdielov v koncentrГЎciГЎch salivГЎrneho aldosterГіnu s najvyЕЎЕЎГ­mi hodnotami u Еѕien v luteГЎlnej fГЎze.
Po podanГ­ nГ­zkej dГЎvky ACTH sa koncentrГЎcie salivГЎrneho aldosterГіnu signifikantne zvyЕЎovali a
dobre korelovali s koncentrГЎciami plazmatickГ©ho aldosterГіnu (Hlavacova a spol. 2013). Metodiku
sme uЕѕ zaДЌali vyuЕѕГ­vaЕҐ na overenie experimentГЎlnych nГЎlezov zГ­skanГЅch v tomto projekte, a to novГ©
poznatky o Гєlohe aldosterГіnu v animГЎlnych modeloch depresie, priamo u pacientov s depresiou
(Izakova a Jezova 2013).
Napriek tomu, Еѕe poznГЎme sГєvis medzi stresom a viacerГЅmi civilizaДЌnГЅmi ochoreniami, stГЎle
nevieme meraЕҐ stresovГє zГЎЕҐaЕѕ ani predchГЎdzaЕҐ negatГ­vnym dГґsledkom (Prokopova a Jezova 2013).
DokГЎzali sme, Еѕe kardiovaskulГЎrna odpoveДЏ poДЌas stresu je niЕѕЕЎia, ak sa sГєДЌasne pociЕҐuje vyЕЎЕЎia
ГєzkosЕҐ. Vzostup systolickГ©ho krvnГ©ho tlaku poДЌas izometrickГ©ho cviДЌenia u zdravГЅch ДѕudГ­ bol vyЕЎЕЎГ­
v experimentГЎlnej situГЎcii, v ktorej sa zabrГЎnilo anxiogГ©nnemu pГґsobeniu pouЕѕitГЅch stresovГЅch
podnetov (Jezova a spol. 2013).
UkГЎzali sme, Еѕe pacienti so zatiaДѕ nelieДЌenou hypertenziou I. stupЕ€a bez prГ­tomnosti inГЅch
rizikovГЅch faktorov preukazujГє znГЎmky inzulГ­novej rezistencie a ДЏalЕЎie prГ­znaky
kardiometabolickГ©ho syndrГіmu. Tieto nГЎlezy, ktorГ© je nutnГ© eЕЎte rozЕЎГ­riЕҐ, sГє motivГЎciou pre
hДѕadanie spГґsobov skorej terapeutickej intervencie s cieДѕom spomaliЕҐ rozvoj kardiometabolickГЅch
porГєch (Penesova a spol. 2013).
PopГ­sali sme zmeny expresie gГ©nov pre enzГЅmy metabolizujГєce aldosterГіn, ako aj pre
glukokortikoidnГ© a mineralokortikoidnГ© receptory u potkanov v obdobГ­ krГЎtko po narodenГ­.
VГЅsledky dovoДѕujГє predpokladaЕҐ vyЕЎЕЎiu ГєДЌinnosЕҐ aldosterГіnu na kardiovaskulГЎrne, metabolickГ© aj
psychickГ© funkcie v ranom postnatГЎlnom obdobГ­ v porovnanГ­ so stavom v dospelosti (Varga a spol.
2013).
PublikГЎcie:
VARGA J., FERENCZI S., KOVГЃCS KJ., GARAFOVA A., JEZOVA D., ZELENA D.
Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main
Adrenocortical Stress Hormone during the Perinatal Period in Rats? In PLoS One, 2013, vol. 8, no.
9, p. e72313. (IF=3,730)
JEZOVA D., HLAVACOVA N., MAKATSORI A., DUNCKO R., LODER I., HINGHOFERSZALKAY H. Increased anxiety induced by listening to unpleasant music during stress exposure is
110
SprГЎva o ДЌinnosti organizГЎcie SAV
associated with reduced blood pressure and ACTH responses in healthy men. In
Neuroendocrinology, 2013, vol. 98, no. 2, p. 144-150. (IF=3,537)
KRIZOVA L., KOLLAR B., JEZOVA D., TURCANI P. Genetic aspects of vitamin D receptor and
metabolism in relation to the risk of multiple sclerosis. In General Physiology and Biophysics,
2013, vol. 32, no. 4, p. 459-466. (IF=0,852)
KRГЌЕЅOVГЃ L., KOLLГЃR B., ДЊARNICKГЃ Z., Е IARNIK P., JEЕЅOVГЃ D., TURДЊГЃNI P.: GenetickГ©
a environmentГЎlne faktory zapojenГ© do patogenГ©zy sklerГіzy multiplex. In ДЊeskГЎ a slovenskГЎ
neurologie a neurochirurgie, 2013, vol. 76/109, no. 4, p. 430-437. (IF=0,372)
HLAVACOVA N., KERLIK J., RADIKOVA Z., IZAKOVA L., JEZOVA D. Measurement of
salivary aldosterone: validation by low-dose ACTH test and gender differences. In Endocrine
Regulations. 2013, vol. 47, no. 4, p. 201-204.
PENESOVГЃ A., RADIKOVГЃ Z., ДЊIЕЅMГЃROVГЃ E., VLДЊEK M., IMRICH R.: Insulin sensitivity
in young patients with hypertension devoid of conventional risk factors. In Journal fЕ±r Hypertonie.
2013, vol. 1, p. 15-19.
IZAKOVA L., JEZOVA D. Aldosterón – nový biologický marker alebo ďalšia možnosť v liečbe
depresie? In Psychiatrie, 2013, vol. 17, no. 1, p. 13-18.
PROKOPOVÁ B., JEŽOVÁ D. Stres a možnosti jeho farmakologického ovplyvnenia – vieme
meraЕҐ stresovГє zГЎЕҐaЕѕ? In Psychiatrie pro praxi, 2013, vol.14, no. 4, p. 150-154.
Abstrakty
GAJDOSECHOVA L., KRSKOVA K., OLSZANECKI R., ZORAD S.: An integrative insight into
powerfull IRAP/AT4/OTASE in obesity: A glucose homeostasis, adipose tissue RAS and oxytocin
system. IRAP 2013, 2013, p. 22.
GAJDOЕ ECHOVГЃ L., KRЕ KOVГЃ K., ZORAD S.: Гљloha tukovГ©ho tkaniva pri rozvoji
inzulГ­novej rezistencie. Kniha abstraktov XXIII. DiabetologickГ© dni Bratislava, 2013, p. 54.
GAJDOSECHOVA L., SUSKI M., KRSKOVA K., OLSZANECKI R., ZORAD S.: Metabolic
health in 12-week-old obese Zucker rats is associated with increase in 14-3-3ОІ and phosphorylation
of AS160 in epididymal adipose tissue. In Obesity Facts, 2013, vol. 6, suppl. 1, p. 75.
HLAVACOVA N., WAWRUCH M., TISONOVA J., JEZOVA D.: Neuroendocrine activation
during stress in women depends on trait anxiety. Abstracts of the 11th World Congress of
Biological Psychiatry, Abstract CD-ROM, 2013.
HLAVГЃДЊOVГЃ N., MAKATSORI A., HINGHOFER-SZALKAY H., JEЕЅOVГЃ D.: HormonГЎlna a
kardiovaskulГЎrna odpoveДЏ na kombinovanГЅ stresovГЅ podnet pri zvГЅЕЎenej Гєzkosti vyvolanej
poДЌГєvanГ­m hudby. In Psychiatrie, 2013, vol. 17, suppl. 1, p. 38.
JEZOVA D., HLAVACOVA N.: Hyperaldosteronism in an animal model - changes in depressionlike behavior and gene expression relevant to major depressive disorder. Abstracts of the 11th
World Congress of Biological Psychiatry, Abstract CD-ROM, 2013.
JEŽOVÁ D., HLAVÁČOVÁ N.: Ovplyvnenie hormónu aldosterónu – nový smer vo vývoji
anxiolytГ­k. In Psychiatrie, 2013, vol. 17, suppl 1, p. 25.
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JEЕЅOVГЃ D., HLAVГЃДЊOVГЃ N.: Aldosterone - A Bridge Between Cardiovascular and Mood
Disorders? Abstracts of The International Academy of Cardiology, 18th World Congress on Heart
Disease Annual Scientific Sessions 2013, The Journal of Heart Disease, 2013, vol.10, no. 1, p. 21,
KRSKOVA K., PENESOVA A., VLCEK M., IMRICH R., GAJDOSECHOVA L., OKSA A.,
POGLITSCH M., ZORAD S.: Replacement of ACEi by AT1 receptor blocker candesartan changes
pattern of serum angiotensin peptides without effect on glucose metabolism and subcutaneous
adipose tissue. IRAP 2013, 2013, p. 24.
KRЕ KOVГЃ K., GAJDOЕ ECHOVГЃ L., OLSZANECKI R., POGLITSCH M., ZORAD S.:
FunkДЌnГЅ lokГЎlny renГ­n-angiotenzГ­novГЅ systГ©m v tukovom tkanive - fakt alebo hypotГ©za? Kniha
abstraktov XXIII. DiabetologickГ© dni Bratislava, 2013, p. 64.
KRSKOVA K., ZORAD S., GAJDOSECHOVA L., IMRICH R., PENESOVA A., VLCEK M.,
CHOVANOVA L., OKSA A.: Renin-angiotensin system blockade with AT1 receptor blocker
versus ACE inhibitors - impact on glucose metabolism in hypertensive patients. In Obesity Facts,
2013, vol. 6, suppl. 1, p. 70.
KRSKOVA K., ZORAD S., GAJDOSECHOVA L., PENESOVA A., VLCEK M., IMRICH R.,
CHOVANOVA L., OKSA A.: Selected metabolic effects of ace inhibitor replacement by at1
receptor blocker candesartan in hypertensive patients. 5th International Congress on Prediabetes and
the Metabolic Syndrome, 2013, vol. 5, suppl. 1, p. 97.
PENESOVГЃ A., KRЕ KOVГЃ K., ZORAD Е ., HOLГљBKOVГЃ A., GARAFOVГЃ A., VLДЊEK M.,
IMRICH R., JEŽOVÁ D: Metabolické abnormality u mladých pacientov s hypertenziou – pilotná
ЕЎtГєdia. Kniha abstraktov XXIII. DiabetologickГ© dni Bratislava, 2013, p. 86.
PENESOVГЃ A., KRЕ KOVГЃ K., ZORAD Е ., HOLГљBKOVГЃ A., GARAFOVГЃ A., VLДЊEK M.,
IMRICH R., JEЕЅOVГЃ D: Metabolic abnormalities in young subjects with hypertension in
comparison to obese and lean healthy individuals – a pilote study. In Journal of Diabetes, 2013, vol.
5, suppl. 1, p. 169.
PROKOPOVГЃ B., KRГЌЕЅOVГЃ L., VLДЊEK M., PENESOVГЃ A., HLAVГЃДЊOVГЃ N., KOLLГЃR B.,
TURДЊГЃNI P., JEЕЅOVГЃ D: VybranГ© psychologickГ© charakteristiky u pacientov so sklerГіzou
multiplex. In Psychiatrie, 2013, vol. 17, suppl. 1, p. 61.
9. KognitГ­vne, osobnostnГ© a psychofyziologickГ© faktory zvlГЎdania stresu v kontexte vzЕҐahu
anxiety a alergie a moЕѕnosti ich optimalizГЎcie (Cognitive, personal and psychophysiological
factors of the stress in the context of the relationship between anxiety and allergies and their
optimalisation)
ZodpovednГЅ rieЕЎiteДѕ: Igor Brezina
ZodpovednГЅ rieЕЎiteДѕ v organizГЎcii SAV: Daniela JeЕѕovГЎ, NataЕЎa HlavГЎДЌovГЎ
Trvanie projektu: 1.10.2013 / 30.9.2017
EvidenДЌnГ© ДЌГ­slo projektu: APVV-0496-12
OrganizГЎcia je koordinГЎtorom projektu: nie
KoordinГЎtor: FilozofickГЎ fakulta UK
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­: 2
Čerpané financie: 4463,00 €
DosiahnutГ© vГЅsledky:
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SprГЎva o ДЌinnosti organizГЎcie SAV
V iniciГЎlnej fГЎze rieЕЎenia projektu prebiehala logistickГЎ prГ­prava vГЅskumu, dizajnu experimentov
a tieЕѕ zaraДЏovanie probandov do experimentГЎlnych a kontrolnГЅch skupГ­n. V iniciГЎlnej fГЎze rieЕЎenia
projektu sa v LaboratГіriu farmakologickej neuroendokrinolГіgie ГљEE SAV validovali metodiky na
stanovenie koncentrГЎciГ­ enzГЅmu alfa-amylГЎzy a steroidnГЅch hormГіnov kortizolu, aldosterГіnu
a testosterГіnu zo slГ­n.
10.) SkrГ­ning dediДЌnГЅch porГєch sluchu na Slovensku metГіdami DNA analГЅzy. (Screening of
hereditary hearing disorders in Slovakia by DNA analysis.)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Iwar KlimeЕЎ
1.5.2011 / 31.10.2014
APVV-0148-10
nie
LF UK
1
66.400,- Eur
DosiahnutГ© vГЅsledky :
NГЎbor pacientov so SNHL v roku 2013 pokraДЌoval na klinickГЅch pracoviskГЎch v Bratislave
(novodiagnostikovanГ­ pacienti vyЕЎetrovanГ­ na I. ORL klinike LFUK a Detskej ORL klinike
DFNsP). Celkovo boli ku dЕ€u 31.12.2013 zГ­skanГ© vzorky od 692 sluchovo postihnutГЅch pacientov a
ich pokrvnГЅch prГ­buznГЅch, ДЌo predstavuje medziroДЌnГЅ nГЎrast o 125 novГЅch vzoriek. LaboratГіrne
spracovanie zГ­skanГ©ho biologickГ©ho materiГЎlu pokraДЌovalo na pГґde laboratГіria DIABGENE Гљstavu
experimentГЎlnej endokrinolГіgie SAV IzolovanГЎ DNA bola uloЕѕenГЎ do DNA banky pacientov
s obojstrannou senzorineurГЎlnou poruchou sluchu, zaloЕѕenej v prvom roku rieЕЎenia projektu.
Do konca roku 2013 boli metГіdou sekvenovania gГ©nu GJB2 zanalyzovanГ© vzorky pribliЕѕne od 620
pacientov. MLPA analýza prioritne zameraná na identifikácia „hot-spot“ delécie v géne GJB6 bola
vykonanГЎ u 210 neprГ­buznГЅch jedincov. UvedenГЅm prГ­stupom bolo moЕѕnГ© identifikovaЕҐ presnГє
prГ­ДЌinu poruchy sluchu u 32,8 % neprГ­buznГЅch pacientov. V tejto skupine pacientov sa podarilo
identifikovaЕҐ 15 mutГЎciГ­ v gГ©ne GJB2 a jednu delГ©ciu v gГ©ne GJB6 (delD13S180). U pacientov
s tyroidГЎlnou symptomatolГіgiou bol metГіdou priameho obojsmernГ©ho sekvenovania analyzovanГЅ
gГ©n SLC26A4. Vzorky DNA pacientov s progredujГєcou poruchou sluchu, cukrovkou alebo
matrilineГЎrnym typom dediДЌnosti boli podrobenГ© RFLP analГЅze mitochondriГЎlnej mutГЎcie A3243G
(spolu asi 140 pacientov). MutГЎcie gГ©nu MARVELD2 (novГЅ gГ©n zavedenГЅ v roku 2013) boli, po
vylГєДЌenГ­ GJB2 etiolГіgie, vyЕЎetrovanГ© u pribliЕѕne 70 neprГ­buznГЅch pacientov rГіmskeho etnika,
113
SprГЎva o ДЌinnosti organizГЎcie SAV
keДЏЕѕe vГЅskyt tejto mutГЎcie bol doteraz vo svete zaznamenanГЅ len v pakistanskej a rГіmskej
populГЎcii.
PUBLIKГЃCIE:
VARGA L., MAЕ INDOVГЃ I., HUДЊKOVГЃ M., KABГЃTOVГЃ Z., GAЕ PERГЌKOVГЃ D., KLIMEЕ I., PROFANT M.
Prevalence of DFNB1 mutations among cochlear implant users in Slovakia and its clinical
implications. Eur Arch Otorhinolaryngol. 2013, DOI 10.1007/s00405-013-2559-0
ABSTRAKTY
MAЕ INDOVГЃ I., VARGA L., HUДЊKOVГЃ M., BALOGOVГЃ M., Е UCHOVГЃ ДЅ., PROFANT M., KLIMEЕ I.,
GASPERIKOVA D. 2013. Nation-wide genetic screening for patients with bilateral nonsyndromic
sensorineural hearing loss (SNHL) in Slovakia. European Journal of Human Genetics, 21 (supp. 2): p.124125
VARGA L., MAЕ INDOVГЃ I., KABГЃTOVГЃ Z., HUДЊKOVA M., KLIMEЕ I., GAЕ PERГЌKOVГЃ D., PROFANT M.
Screening for hereditary causes of SNHL in Slovak deaf population and its practical consequences.
IFOS 20th World Congress, June 1-5 2013, Seoul, Korea, Book of abstracts (on CD), FA-00237.
VARGA L., MAЕ INDOVГЃ I., KABГЃTOVГЃ Z., GAЕ PERГЌKOVГЃ D., KLIMEЕ I., PROFANT M. 2013.
Prevalence of mutations in the DFNB1 locus among cochlear implant users in Slovakia and their
impact on postoperative hearing outcomes in prelingually deaf children. 9th Molecular Biology of
Hearing and Deafness Conference, 22-25 June, 2013, Stanford, USA. Book of abstracts, p.176
MAЕ INDOVГЃ I., VARGA, L., HUДЊKOVГЃ, M., PROFANT M., KLIMEЕ I., GAЕ PERГЌKOVГЃ D. 2013.
Mutation in MARVELD2 gene detected in Slovak roma patients with nonsyndromic hearing loss.
9th Molecular Biology of Hearing and Deafness Conference, 22-25 June, 2013, Stanford, USA.
Book of abstracts, p.106
VARGA L., KABГЃTOVГЃ Z., MAЕ INDOVГЃ I., GAЕ PERГЌKOVГЃ D., KLIMEЕ I., PROFANT M. 2013 Hearing
outcomes after cochlear implantation in three etiology groups of prelingually deaf children. 29th
Politzer Society Meeting, 14-17 November, Antalya, Turkey, The International Journal of
Advanced Otology, 9 (3, suppl. 1): p. 131-132.
MAЕ INDOVГЃ I., VARGA L., HUДЊKOVГЃ M., BALOGOVГЃ M., Е UCHOVГЃ ДЅ., PROFANT M., KLIMEЕ I.,
GAЕ PERГЌKOVГЃ D. CeloslovenskГЅ genetickГЅ skrГ­ning pacientov s bilaterГЎlnou nesyndrГіmovou
senzorineurГЎlnou poruchou sluchu. XXIV. IzakoviДЌov MemoriГЎl, 26. - 27. 9. 2013, Donovaly,
Hotel Residence, Program a zbornГ­k abstraktov, p. 52-53.
Е KOPKOVГЃ M., MAЕ INDOVГЃ I., STANГЌK J., VARGA L. , VALENTГЌNOVГЃ L., HUДЊKOVГЃ M. ,
NECHOJDOMOVГЃ D., ЕЅIGRAI M. , MANДЊГЌKOVГЃ T., PROFANT M., KLIMEЕ I. , GAЕ PERГЌKOVГЃ D. DNA
diagnostika syndrГіmu MIDD a MELAS na Slovensku. XXIV. IzakoviДЌov MemoriГЎl, 26. - 27. 9.
2013, Donovaly, Hotel Residence, Program a zbornГ­k abstraktov, p. 58-59.
11.) Je stres jednГЅm z podstatnГЅch faktorov neurodegeneraДЌnГ©ho procesu pri Alzheimerovej
chorobe? (Is stress a crucial factor in the process of neurodegeneration accompanying
Alzheimer's disease?)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
Richard KvetЕ€anskГЅ
1.5.2011 / 31.10.2014
APVV-0088-10
ГЎno
114
SprГЎva o ДЌinnosti organizГЎcie SAV
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Гљstav experimentГЎlnej endokrinolГіgie SAV
1
73.390,- Eur
DosiahnutГ© vГЅsledky:
V treЕҐom roku (2013) rieЕЎenia tohto APVV projektu sme sa zamerali na ЕЎtГєdium ГєДЌinkov
jednorГЎzovГ©ho a opakovanГ©ho stresu u potkanov a myЕЎГ­ s vyradenГЅm noradrenalinovГЅm systГ©mom
v mozgu, predovЕЎetkГЅm v locus coeruleus (LC). Je znГЎme, Еѕe noradrenalГ­n pГґsobГ­ protektГ­vne na
zГЎpalovГ© procesy, ktorГ© sa podieДѕajГє na vzniku a vГЅvoji neurodegeneratГ­vnych zmien, typickГЅch aj
pre demenciu Alzheimerovho typu (DAT).
Pre realizГЎciu tohto cieДѕa sme v naЕЎich experimentoch previedli elektrokoagulaДЌnГє lГ©ziu oblasti
locus coeruleus (LC) s cieДѕom eliminovaЕҐ noradrenalГ­novГє inervГЎciu mozgovej kГґry a hipocampu,
ktorГ© hrajГє kДѕГєДЌovГє Гєlohu pri DAT. Druhou pouЕѕitou technikou na eliminГЎciu, resp. redukciu
noradrenalГ­nu v tГЅchto oblastiach bolo stereotaktickГ© podГЎvanie toxГ­nu DSP-4 do oblasti LC
u potkanov, resp. i. p. podГЎvanie toxГ­nu u myЕЎГ­. Realizovali sme makro-experiment, v ktorom sme
mali 16 skupín myší – WT, CRH-KO, sham-operované, ledované, akútne stresované a opakovane
stresovanГ© (14 dnГ­). U potkanov WT a transgГ©nnych (TG) sme aplikovali ako stresor LPS (vyvolГЎva
zГЎpal). Tieto experimenty poskytli niekoДѕko stoviek vzoriek mozgov, v ktorГЅch sa postupne
analyzuje koncentrГЎcia noradrenalГ­nu, adrenalГ­nu a dopamГ­nu, expresia a proteГ­ny enzГЅmov
syntetizujГєcich katecholamГ­ny, tau-proteГ­ny, prozГЎpalovГ© a protizГЎpalovГ© cytokГ­ny, atДЏ. VГЅsledky
budГє k dispozГ­cii aЕѕ vo ЕЎtvrtom roku rieЕЎenia projektu.
ZaujГ­malo nГЎs tieЕѕ, do akej miery sГє tieto procesy ovplyvniteДѕnГ© endogГ©nnymi hladinami
glukokortikoidov, prГ­padne hladinou kortikoliberГ­nu (CRH) v centrГЎlnom nervovom systГ©me.
S tГЅmto cieДѕom sme sledovali ГєДЌinky imobilizaДЌnГ©ho stresu na expresiu a hyper-fosforylГЎciu tau
proteГ­nu a na hladiny katecholamГ­nov v rГґznych oblastiach a jadrГЎch mozgu u normГЎlnych WT
myЕЎГ­, ako aj u CRH deficientnych myЕЎГ­. UvedenГ© parametere sme merali v 15 mozgovГЅch
oblastiach, ktorГ© sa podieДѕajГє na regulГЎcii neuroendokrinnГЅch procesov a mГґЕѕu ЕЎpecificky
regulovaЕҐ vznik a priebeh DAT. ZaujГ­malo nГЎs do akej miery je DAT determinovanГЅ
neprГ­tomnosЕҐou CRH, predovЕЎetkГЅm v stresovГЅch situГЎciГЎch.
Zistili sme Еѕe imobilizaДЌnГЅ stres indukuje expresiu DAT - ЕЎpecifickГЅch epitopov na molekule tau
proteГ­nu (naprГ­klad AT8, PHF1 a pT181). TГЎto expresia je prechodnГЅm javom a po urДЌitom ДЌase sa
hladina DAT- špecifických epitopov dostáva späť na úroveň kontrolných hodnôt aj napriek tomu,
Еѕe stresovГЅ podnet naДЏalej pretrvГЎva. V niektorГЅch mozgovГЅch oblastiach nasleduje druhГЎ vlna
hyperfosforylГЎcie - asi 120 minГєt od zaДЌiatku stresu. AkГєtna indukcia hyperfosforylГЎcie je
generalizovanГЅ jav a je prГ­tomnГЎ nielen v oblastiach klasicky asociovanГЅch s DAT, ale aj v inГЅch
oblastiach mozgu, ktorГ© neboli z tohoto hДѕadiska doteraz v literatГєre opГ­sanГ©.
MagnitГєda tau-hyperfosforylГЎcie, ako odozvy na imobilizaДЌnГЅ stres, je niЕѕЕЎia u CRH
deficientnГЅch zvierat v porovnanГ­ s WT stresovanГЅmi kontrolami. OpakovanГ© vystavenie zvierat
imobilizaДЌnГ©mu stresu vyvolГЎva vГЅraznГ© znГ­Еѕenie hladГ­n fosforylovanej formy tau proteГ­nu a to vo
väčšine sledovaných oblastí mozgu.
DosiahnutГ© vГЅsledky poukazujГє na vГЅznamnГє Гєlohu CRH a glukokortikoidnГ©ho systГ©mu
v patogenГ©ze Alzheimerovej choroby a naznaДЌujГє vГЅznamnГ© prepojenie mechanizmov stresu a
demencie Alzheimerovho typu. Stresom-indukovanГЎ hyperfosforylГЎcia tau proteГ­nu mГґЕѕe
reprezentovať patologickú situáciu „upstream of tau protein misfolding“, ktorá vedie k progresu,
prГ­padne aj k vzniku neurodegenerГЎcie.
PublikГЎcie:
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SprГЎva o ДЌinnosti organizГЎcie SAV
VARGOVIДЊ P., UKROPEC J., LAUKOVГЃ M., KURDIOVГЃ T., BALГЃЕЅ M., - MANZ
B.,UKROPCOVÁ B., KVETŇANSKÝ R.:
Repeated
immobilization stress induces catecholamine production in rat mesenteric adipocytes.
Stress : The international journal on the biologie of stress, 2013, 16 (3): pp. 340-352.
(2.476
– IF 2011). DOI:10.3109/10253890.736046.
Typ: ADCA
TILLINGER A., NOSTRAMO R., KVETŇANSKÝ R., SEROVA L., SABBAN E. L.: Stressinduced changes in gene expression of urocortin 2 and other CRH peptids in rat adrenal medulla:
involvement of glucocorticoids.
Journal of
Neurochemistry, 2013, 125: pp. 185-192. DOI: 10.1111/jnc.12152.
(3,973 – IF2013)
Typ: ADCA
NOSTRAMO R., TILLINGER A., SEROVA L., KVETŇANSKÝ R., SABBAN E. L.:
Bradykinin B2 reeptor in the adrenal medulla of male rats and mice: Glucocorticoid-dependent
increase with immobilization stress.
Endocrinology,
2013, 154 (10): pp. 3729-3738. (4,717 – IF2013)
Typ: ADCA
BENEŠJ., TOMANKOVA H., NOVAKOVA M., ROHAN Z., KVETŇANSKÝ R.,
MYSLIVEДЊEK J.: Corticotropin-releasing hormone affects short immobilization stress-induced
changes in lung cytosol and membrane glucocorticoid binding sites.
Cellular and
Molecular Neurobiology, 2013, 33: pp. 503-511.
(2.293 IF2012). DOI 10.1007/s10571-013-9916-9.
Typ: ADCA
NOVÁK P., ŽILKA N., FILIPČÍK P., KVETŇANSKÝ R., NOVÁK M.: Stres ako modulátor
neurodegeneraДЌnej kaskГЎdy indukovanej proteГ­nom tau, VydavateДѕstvo AHO3, aprГ­l 2013, str. 6480, ISBN 978-80-971357-0-6 Typ: nekarentovanГЅ ДЌlГЎnok v zbornГ­ku
Abstrakty z konferenciГ­ :
FILIPČÍK P., NOVÁK P., MRAVEC B., ONDIČOVÁ K., KVETŇANSKY R., -NOVÁK M.:
From emotional stress to cognitive deficit: through tau protein modifications?
In: The Jerusalem International Conference on Neuroplasticity and Cognitive Modifiability,
Abstract and Program Book p. 41, Jerusalem, June 2013.
KVETŇANSKÝ R.: „Stress-induced regulation of molecular genetic mechanisms in neuroendocrine-immune systems“.
Pozvaná prednáška na Európskom kongrese pre neurovedy „FENS Featured Regional Meeting“
v Prahe, 11.-15. September 2013.
KVETŇANSKÝ R.: „Does chronic or repeated stress produce pathological changes in the
organism: Effect of catecholaminergic systems“.
PozvanГЎ prednГЎЕЎka na 7th International Symposium on Experimental and Clinical Neurobiology,
23.-27. jГєna 2013 v KoЕЎiciach.
VARGOVIČ P., UKROPEC J., KVETŇANSKÝ R.: Opakovaný stres zvyšuje produkciu
endogГ©nnych katecholamГ­nov v adipocytoch mezenterickГ©ho tukovГ©ho tkaniva potkana.
PrednesenГ© na VII. RoДЌnГ­ku Drobnicovho memoriГЎlu, BojnГЎ, 16.-18. Sept. 2013, str. 54-55.
116
SprГЎva o ДЌinnosti organizГЎcie SAV
12. NeurobiolГіgia nГЎdorov: ЕЎtГєdium Гєlohy nervovГ©ho systГ©mu v etiopatogenГ©ze nГЎdorovГ©ho
rastu
a
tvorby
metastГЎz
(Neurobiology of cancer: the study of the nervous system role in etiopathogenesis of tumor growth
and development of metastasis)
Boris Mravec
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ
rieЕЎiteДѕ
v organizГЎcii SAV
1.5.2011 - 31.10.2014
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu: APVV-0007-10
OrganizГЎcia
jenie
koordinГЎtorom projektu:
LekГЎrska fakulta UK
KoordinГЎtor:
PoДЌet
spolurieЕЎiteДѕskГЅch2 (okrem UEE SAV sГє to eЕЎte LF UK a UEO SAV)
inЕЎtitГєciГ­:
14.761,-€
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky :
V rГЎmci rieЕЎenia grantu APVV sme pokraДЌovali vo vГЅskume neuro-nГЎdorovГЅch interakciГ­, priДЌom
sme nadviazali na predchГЎdzajГєce etapy projektu. U jednotlivГЅch typov nГЎdorov sme detegovali
pozitivitu na rГґzne neuronГЎlne markery, priДЌom denzita signГЎlu sa medzi jednotlivГЅmi markermi a
nГЎdormi lГ­ЕЎila. ZatiaДѕ ДЌo u intraperitoneГЎlnych fibrosarkГіmov sme preukГЎzali pozitivitu na NF,
ChrA a NSE, v prГ­pade subkutГЎnnych fibrosarkГіmov bola zistenГЎ len pozitivita na NF. U melanГіmu
a feochromocytГіmu sme zistili pozitivitu na NF, ChrA, ako aj S100 proteГ­n. NaЕЎe vГЅsledky
naznaДЌujГє, Еѕe inervГЎcia nГЎdorovГ©ho tkaniva vykazuje ЕЎpecifickosЕҐ v zГЎvislosti od typu nГЎdoru.
SkГєmali sme aj Гєlohu hypotalamickГ©ho zГЎpalu v procesoch spojenГЅch s nГЎdorovou kachexiou.
UskutoДЌnili sme experiment, v ktorom sme prostrednГ­ctvom implantovanГЅch osmotickГЅch
minipГєmp a intracerebrГЎlnych kanГЅl dlhodobo aplikovali do hypotalamu lГЎtku, ktorГЎ inhibuje zГЎpal.
Zistili sme, Еѕe tГЎto lГЎtka PS-1145 dihydrochlorid vГЅznamne inhibuje lipopolysacharidom
indukovanГЅ zГЎpal v hypotalame, konkrГ©tne v nucleus paraventricularis. V nasledujГєcom
experimente sme po intraperitoneГЎlnej aplikГЎcii Yoshida AH-130 ascitickГЅch buniek podkoЕѕne
implantovali osmotickГ© minipumpy napojenГ© na intracerebrГЎlnu kanylu. Zistili sme, Еѕe aj keДЏ
aplikГЎcia lГЎtky PS-1145 dohydrochlorid mierne znГ­Еѕila zГЎpal v hypotalame, preЕѕГ­vanie zvierat
nebolo ovplyvnenГ©.
PublikГЎcie:
LACKOVICOVA L., GAYKEMA RP., BANOVSKA L., KISS A., GOEHLER LE., MRAVEC B.
The time-course of hindbrain neuronal activity varies according to location during either
intraperitoneal or subcutaneous tumor growth in rats: single Fos and dual Fos/dopamine ОІhydroxylase immunohistochemistry. J Neuroimmunol 2013; 260: 37-46. IF=3,033
BANOVSKA L., LACKOVICOVA L., MRAVEC B. NГЎdorovГЎ kachexia z neurobiologickГ©ho
hДѕadiska: vplyv hypotalamickГ©ho zГЎpalu. Monitor mediciny 2013; 1-2: 9-13.
MRAVEC B. NervovГЅ systГ©m: patofyziolГіgia. SAP, Bratislava 2013; 132 s.
13. BezpeДЌnosЕҐ terapeuticky a komerДЌne pouЕѕГ­vanГЅch nanoДЌastГ­c: vplyv na reprodukДЌnГЅ
a imunitnГЅ systГ©m, oxidaДЌnГЅ status a prevencia moЕѕnГ©ho rizika (Biosafety of therapeutically
and commercially used nanoparticles: focus on reproductive and immune system, oxidative status
and prevention of potential risk).
117
SprГЎva o ДЌinnosti organizГЎcie SAV
SoЕ€a ScsukovГЎ
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v organizГЎcii SAV: SoЕ€a ScsukovГЎ
1.7.2012-31.12.2015
Trvanie projektu:
APVV-0404-11
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je koordinГЎtorom projektu: ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
KoordinГЎtor:
3
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­:
51 000,- eur
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky :
RГЅchly rozvoj nanotechnolГіgiГ­ prispieva k rozsiahlemu pouЕѕitiu nanomateriГЎlov v priemysle,
produktoch dennej potreby, ako aj v biomedicГ­ne. PredpokladГЎ sa, Еѕe nanoДЌastice vДЏaka svojim
„nano“ rozmerom môžu ovplyvňovať normálne fyziologické funkcie a predstavovať neznáme
riziko pre ДѕudskГ© zdravie. PolymГ©rna nanoДЌastica poly(ethylene glycol)-block-poly(lactic acid)
(PEG-b-PLA) bola vyvinutГЎ na prenos vo vode Дѕahko rozpustnГЅch lieДЌiv CNS, mГЎ schopnosЕҐ
prechГЎdzaЕҐ BB bariГ©rou a uvoДѕniЕҐ lieДЌivo priamo v mozgu. V druhom roku rieЕЎenia projektu sme
sledovali moЕѕnГЅ in vivo ГєДЌinok PEG-b-PLA (20 alebo 40 mg/kg b.w.) na funkcie imunitnГ©ho
systГ©mu (krv, slezina-subpopulaДЌnГЎ analГЅza pomocou prietokovej cytometrie, mitogГ©nna odpoveДЏ
a protilГЎtkovГЎ odpoveДЏ proti baranГ­n erytrocytom, SRBC) a oxidaДЌnГЅ status (krv, peДЌeЕ€lipoperoxidy, proteГ­novГ© karbonyly, antioxidaДЌnГЅ status) u prepubertГЎlnych a dospelГЅch samГ­c
potkanov kmeЕ€a Wistar. VГЅsledky vyЕЎetrenia sledovanГЅch parametrov imunitnГ©ho systГ©mu a hladГ­n
markerov oxidaДЌnГ©ho poЕЎkodenia lipidov, proteГ­nov, aktivity antioxidaДЌnГЅch enzГЅmov sa postupne
vyhodnocujГє. V in vitro podmienkach sme sledovali koncentraДЌnГЅ a ДЌasovГЅ priebeh pГґsobenia
testovanГЅch kovovГЅch nanoДЌastГ­c (striebro, oxid titaniДЌitГЅ) na bazГЎlnu a gonadotropГ­nmi (FSH, LH)
stimulovanГє produkciu steroidnГЅch hormГіnov (progesterГіn, estradiol) granulГіznymi bunkami.
Zistili sme, Еѕe so zvyЕЎujГєcou sa koncentrГЎciou testovanГ© nanoДЌastice inhibovali sledovanГ© procesy.
NaЕЎe vГЅsledky naznaДЌujГє, Еѕe testovanГ© nanoДЌastice mГґЕѕu naruЕЎiЕҐ funkcie nielen endokrinnГ©ho, ale
aj imunitnГ©ho systГ©mu a oxidaДЌnГЅ status.
14.) ProgresГ­vne polymГ©rne technolГіgie v biomedicГ­ne: PolymГ©rne mikrokapsule pre
imunitnГє ochranu transplantovanГЅch pankreatickГЅch ostrovДЌekov v lieДЌbe cukrovky.
(Advanced polymer technologies in biomedicine: Polymer microcapsules for immunoprotection of
transplanted pancreatic islets in diabetes treatment)
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v
organizГЎcii SAV:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Igor LacГ­k
VladimГ­r Е trbГЎk
1.5.2011 / 31.10.2014
APVV-0468-10
nie
0
14.770,- Eur
DosiahnutГ© vГЅsledky:
Projekt je sГєДЌasЕҐou ЕЎirokej medzinГЎrodnej spoluprГЎce zodpovednГ©ho rieЕЎiteДѕa Ing. LacГ­ka.. Bol
vykonanГЅ pokus, izolovali sme pankreatickГ© ostrovДЌeky, ktorГ© boli potom enkapsulovanГ©. Po
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SprГЎva o ДЌinnosti organizГЎcie SAV
vyhodnotenГ­ vГЅsledkov koordinujГєce pracovisko pokraДЌovalo v optimalizГЎcii zloЕѕenia kapsГєl.
PublikГЎcie:
ŠTRBÁK V. Cell volume –role in obesity and its maintenance. Minireview. Invited review. In
Serbian Journal of Experimental and Clinical Research. 2013, vol. 14, no 2, p. 45-48. ISSN 18208665.
Е TRBГЃK V. Cell volume conferences. In Bulletin of Siberian Medicine. 2013, vol. 12, no 4, p. 812. ISSN 1682-0363.
PozvanГ© prednГЎЕЎky:
Е TRBГЃK V., BAДЊOVГЃ Z. Cell swelling, novel regulatory signal affecting various functions.
Abstract book p.19. “New frontiers in physiological research from scientific truth via friendship to
the art “20.-22. 6.2013, Kovačica, Srbsko, ISBN 978-86-904799-6-2
ŠTRBÁK V., BAČOVÁ Z., RAVINGEROVÁ T. Cell swelling-induced hormone secretion –
pathophysiological implications. The 10th International Congress Cell volume regulation – novel
therapeutic targets & pharamcological approaches. Bulletin of Siberian Medicine. 2013, vol. 12, no
4, p. 64. ISSN 1682-0363.
Programy: Е trukturГЎlne fondy EГљ VГЅskum a vГЅvoj
1.) KCMM - Vybudovanie KompetenДЌnГ©ho centra pre vГЅskum a vГЅvoj v oblasti molekulГЎrnej
medicГ­ny (Building a Competency Centre for research and development in the field of molecular
medicine)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Iwar KlimeЕЎ
1.10.2011 / 31.1.2015
26240220071
nie
PriF UK
0
2.216,72 €
DosiahnutГ© vГЅsledky :
V roku 2013 sme zaviedli DNA diagnostiku jednej z najДЌastejЕЎГ­ch zriedkavГЅch monogГ©novГЅch
dediДЌnГЅch porГєch metabolizmu, a to DNA diagnostiku glykogenГіz (poruchy uskladnenia
glykogГ©nu). Vypracovali sme metodickГЅ postup pre DNA analГЅzu gГ©nov zodpovednГЅch za prvГЅ a
druhГЅ podtyp tohto dediДЌnГ©ho metabolickГ©ho ochorenia. KonkrГ©tne pre glykogenГіzu typu 1a, za
ktorГє sГє zodpovednГ© mutГЎcie gГ©nu pre glukГіza-6-fosfatГЎzu (G6PC) a glykogenГіzu typu 2, za ktorГ©
sГє zodpovednГ© mutГЎcie gГ©nu pre alfa glukozidГЎzu (GAA) (Pompeho choroba). U pacientky
119
SprГЎva o ДЌinnosti organizГЎcie SAV
s klinickГЅm podozrenГ­m na Pompeho chorobu (kardiomyopatia, hypotonus, hepatopatia) sme zistili
v gГ©ne GAA v exГіne 8 mutГЎciu c.1203 G>A a v intrГіne 8 c.1326+2 T>C.
2.) Transfer poznatkov genetickГ©ho endokrinologickГ©ho vГЅskumu do klinickej praxe
TRANSENDOGEN (Transfer of genetic knowledge of endocrine research into clinical praxis)
ZodpovednГЅ rieЕЎiteДѕ:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
Iwar KlimeЕЎ
1.11.2010 / 31.8.2013
26240220051
ГЎno
Гљstav experimentГЎlnej endokrinolГіgie SAV
0
282.248,65 €
DosiahnutГ© vГЅsledky :
V roku 2013 sa pracovalo najmä na aktivitách 1.3. Nákup spotrebného materiálu a 1.4.
Transfer poznatkov, vГЅskum a odbornГ© analГЅzy.
V rГЎmci aktivity 1.3. sa zrealizoval nГЎkup spotrebnГ©ho materiГЎlu, ktorГ©ho verejnГ© obstarГЎvanie bolo
ГєspeЕЎne zrealizovanГ© v roku 2012.
V rГЎmci aktivity 1.4. sa v spoluprГЎci s klinickГЅmi diabetolГіgmi a endokrinolГіgmi z celГ©ho
Slovenksa pokraДЌovalo vo vyhДѕadГЎvanГ­ pacientov s klinickГЅm podozrenГ­m na monogГ©novГЅ diabetes
a kongenitГЎlny hyperinzulinizmus s vyuЕѕitГ­m aj vzoriek pacienti z existujГєcej DNA. banky. V
oblasti monogГ©novej obezity pokraДЌovala spoluprГЎca s I. Detskou Klinikou Detskej fakultnej
nemocnice s poliklinikou v Bratislave a s Chirurgickou klinikou SZU a UNB Univerzitnej
Nemocnice Bratislava - pracovisko Nemocnica akad. L DГ©rera KramГЎre. NaДЏalej sa rozvГ­jala
spoluprГЎca s LekГЎrskou fakultou Ostravskej Univerzity v Ostrave, ktorГЎ disponuje DNA bankou
pacientov s extrГ©mnou obezitou, priДЌom do nГЎЕЎho LaboratГіria sГє priebeЕѕne zasielanГ© vzorky s DNA
od pacientov s podozrenГ­m na monogГ©novГЅ typ obezity. V oblasti familГЎrnych hypercholesterolГ©miГ­
pokraДЌovala spoluprГЎca s NГЎrodnГЅm referenДЌnГЅm centrom pre familiГЎrne hyperlipoproteinГ©mie, kde
nГЎrodnou koordinГЎtorkou je doc. MUDr. KatarГ­na RaЕЎlovГЎ , CSc. a ktorГЅ je sГєДЌasЕҐou
medzinГЎrodnej prevencie vДЌasnГ©ho Гєmrtia na srdcovГЅ infarkt - (Make Early Diagnosis - Prevent
Early Deaths in Medical Pedigrees - Urob Včasnú diagnostiku – Urob Prevenciu Včasného Úmrtia
v Rodinách) (projekt MED – PED).
PublikГЎcie :
STANIK J., DUSATKOVA P., CINEK O., VALENTINOVA L., HUCKOVA M., SKOPKOVA
M., DUSATKOVA L., STANIKOVA D., PURA M., KLIMES I., LEBL J., GASPERIKOVA D.,
PRUHOVA S.: De novo mutations of GCK, HNF1A and HNF4A may be more frequent in MODY
than previously assumed. DIABETOLOGIA, 2013 Dec 10.
ABSTRAKTY
BALГЃЕЅIOVГЃ D., STANГЌKOVГЃ D., HUДЊKOVГЃ M., STANГЌK J., VOHNOUT B.,
GAЕ PERГЌKOVГЃ D., RAЕ LOVГЃ K., KLIMEЕ I.: DNA diagnostika familiГЎrnej
hypercholesterolГ©mie na Slovensku. Abstrakt z IL. DiabetologickГЅch dnГ­, LuhaДЌovice, ДЊeskГЎ
republika, 18.-20. aprГ­la 2013
120
SprГЎva o ДЌinnosti organizГЎcie SAV
STANÍKOVÁ D., BUŽGA M., BALOGOVÁ M., STANÍK J., HUČKOVÁ M., HOLÉCZY P.,
MACHATKA E., FOLTYS A., TICHГЃ ДЅ., VIRGOVГЃ D., LOBOTKOVГЃ D., ZAVACKГЃ I.,
KLIMEЕ I., GAЕ PERГЌKOVГЃ D.: MonogГ©novГЎ obezita podmienenГЎ mutГЎciou v MC4R u obГ©znych
detГ­ vs. dospelГЅch pacientov po bariatrickom vГЅkone. Abstrakt z XXIII. DiabetologickГЅch dnГ­
s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna 2013
BALГЃЕЅIOVГЃ D., VOHNOUT B., STANГЌKOVГЃ D., .HUДЊKOVГЃ M., BALOGOVГЃ M., STANГЌK
J., KLIMEЕ I., RAЕ LOVГЃ K., GAЕ PERГЌKOVГЃ D.: DNA analГЅza monogГ©novГЅch familiГЎrnych
hypercholesterolГ©miГ­ u SlovenskГЅch pacientov. KlinickГЎ diagnostika pacientov s MODY. Abstrakt
z XXIII. DiabetologickГЅch dnГ­ s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna 2013
BALГЃЕЅIOVГЃ D., VOHNOUT B., STANГЌKOVГЃ D., HUДЊKOVГЃ M., BALOGOVГЃ M., STANГЌK
J., KLIMEЕ I., RAЕ LOVГЃ K., GAЕ PERГЌKOVГЃ D.: MutaДЌnГЎ analГЅza gГ©nov LDLR, ApoB-100
a PCSK9 u slovenskГЅch pacientov s familiГЎrnou hypercholesterolГ©miou. Abstrakt z odbornej
konferencie XXIV. IzakoviДЌov memoriГЎl s medzinГЎrodnou ГєДЌasЕҐou, Donovaly, 26.-27. September
2013
BALГЃЕЅIOVГЃ D., STANГЌKOVГЃ D., HUДЊKOVГЃ M., STANГЌK J., VOHNOUT B., RAЕ LOVГЃ K.,
KLIMEЕ I., GAЕ PERГЌKOVГЃ D.: DNA analГЅza gГ©nov zodpovednГЅch za familiГЎrnu
hypercholesterolГ©miu (LDLR, ApoB-100 a PCSK9) u SlovenskГЅch pacientov. Abstrakt zo
Е tudentskej vedeckej konferencii Prif UK v Bratislave, 24. AprГ­l 2013
GAЕ PERГЌKOVГЃ D., STANГЌK J., HUДЊKOVГЃ M., VALENTГЌNOVГЃ L., MAЕ INDOVГЃ I.,
STANГЌKOVГЃ D., MICHГЃLEK J.: Genetic heterogeneity of patients with Familial Young-Onset
Diabetes: data from the Slovak nation-wide survey in years 2003-2012. Abstrakt z odbornej
konferencie European Journal of Human Genetics, ParГ­Еѕ, FrancГєzsko, 8.- 11.june 2013
STANГЌK J., GAЕ PERГЌKOVГЃ D., HUДЊKOVГЃ M., VALENTГЌNOVГЃ L., STANГЌKOVГЃ D.,
MAЕ INDOVГЃ I., BALOGOVГЃ M., SLOVENSKГЃ SKUPINA PRE Е TГљDIUM
MONOGÉNOVÉHO DIABETU, KLIMEŠI.: Klinická diagnostika pacientov s MODY. Abstrakt
z XXIII. DiabetologickГЅch dnГ­ s medzinГЎrodnou ГєДЌasЕҐou, Bratislava, 12.-14. jГєna J. STANIK J.,
GASPERIKOVA D., HUCKOVA M., VALENTINOVA L.,, STANIKOVA D., MICHALEK J.,
BARAK L., SLOVAK MODY COLLABORATIVE STUDY GROUP, KLIMES I: Clinical
homogeneity and genetic heterogeneity of patients with familial young-onset diabetes: the Slovak
national data. Poster v rГЎmci odbornГ©ho podujatia IDF world diabetes congres Melbourne 2013, 2.6. December 2013
GASPERIKOVA D., STANIK J., , VALENTINOVA L., HUCKOVA M., BALOGOVA M.,
SLOVAK MODY COLLABORATIVE STUDY GROUP, KLIMES I.: Spectrum of glucokinase
(GCK) gene mutations and prevalence of monogenic diabetes type GCK-MODY in Slovakia.
Poster v rГЎmci odbornГ©ho podujatia IDF world diabetes congres Melbourne 2013, 2.-6. December
2013
3. UniverzitnГЅ vedeckГЅ park pre biomedicГ­nu Bratislava (University Biomedical Research Park
Bratislava)
JaromГ­r Pastorek
na Daniela GaЕЎperГ­kovГЎ
Richard Imrich,
Daniela JeЕѕovГЎ
Iwar KlimeЕЎ
1.7.2013 – 1.6.2015
Trvanie projektu centra:
EvidenДЌnГ© ДЌГ­slo projektu : 26240220087
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ
UEE
121
SprГЎva o ДЌinnosti organizГЎcie SAV
OrganizГЎcia
je nie
koordinГЎtorom projektu:
SlovenskГЎ akadГ©mia vied
KoordinГЎtor:
PoДЌet
spolurieЕЎiteДѕskГЅch 9
inЕЎtitГєciГ­:
0 €
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky:
V roku 2013 v rГЎmci projektu pre ГљEE SAV boli dodanГ© a uvedenГ© do prevГЎdzky nasledovnГ©
prГ­stroje:
1. systГ©m na masГ­vne paralelnГ© sekvenovanie nukleovГЅch kyselГ­n vrГЎtane automatizovanej prГ­pravy
templГЎtu pre masГ­vne paralelnГ© sekvenovanie. V rГЎmci uvГЎdzania do prevГЎdzky absolvovali 2
vedeckГ© pracovnГ­ДЌky dve intenzГ­vne ЕЎkolenia (Ion PGM and System Workflow Training, Ion DNA
Library Prep and Essentials) v Darmstadt, Nemecko.
2. 2. klinickГЎ jednotka, skladajГєca sa z ergospirometrickГ©ho zariadenia, systГ©mov na zГЎznam 24hodinovГ©ho EKG a tlaku krvi, systГ©mu na zГЎznam EEG, ruДЌnГ©ho dopplera pre vyЕЎetrenie ciev.
Popri uvedenГ­ do prevГЎdzky prebehlo zaЕЎkolenie osГґb na prГЎcu s uvedenГЅmi prГ­strojmi a nГЎsledne
boli vykonanГ© niekoДѕkГ© testovacie merania. Zariadenia umoЕѕЕ€ujГє komplexnГ© monitorovanie
kardiovaskulГЎrnych, respiraДЌnГЅch a nervovГЅch funkcii u ДѕudГ­, pri vykonГЎvanГ­ vedeckГЅch ЕЎtГєdiГ­.
Programy: CentrГЎ excelentnosti SAV
1.) Centrum excelentnosti na ЕЎtГєdium metabolickГЅch aspektov vГЅvoja diagnostiky a lieДЌby
nГЎdorovГЅch ochorenГ­. (Centre of Excellence for the study of metabolic aspects of development,
diagnostics and treatment of malignancies)
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v
organizГЎcii SAV:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
OДѕga KriЕѕanovГЎ
JГєlius Brtko
4.8.2011 / 31.12.2014
nie
UMFG SAV
2.000,- Eur
NakoДѕko APVV-SK-CZ 0211-11 poskytoval financie len na mobilitu, ДЌasЕҐ uvedenej problematiky
sa rieЕЎila z prostriedkov projektu CEMAN.
ProteomickГЎ analГЅza sa v sГєДЌasnosti povaЕѕuje za vГЅznamnГЅ nГЎstroj umoЕѕЕ€ujГєci
identifikГЎciu nГЎdorovГЅch biomarkerov ako aj pre hodnotenie ГєДЌinnosti zvolenej terapie nГЎdorovГ©ho
ochorenia. Aj v druhom roku rieЕЎenia projektu sme sledovali molekulГЎrne mechanizmy vplyvu
retinovГЅch kyselГ­n (all-trans retinoic acid a/alebo 9-cis retinoic acid) na Гєrovni nГЎdorovГЅch buniek
ľudského karcinómu prsníka matódami „in gel digestion“ a MALDI-TOF hmotnostnou
spektrometriou (MS). Vplyvom izomГ©rov retinovГЅch kyselГ­n v koncentrГЎciГЎch 1 Вµmol/l sa
122
SprГЎva o ДЌinnosti organizГЎcie SAV
identifikovali zmeny v koncentrГЎciach niektorГЅch ДЏalЕЎГ­ch ЕЎpecifickГЅch biomerkerov nГЎdorovГ©ho
ochorenia prsníka „heat shock“ proteínu HSP 90-beta ako aj „heat shock cognate“ 71 kDa
proteГ­novГЎ forma 1. UvedenГЎ metГіda takto poskytuje rГЅchlu cestu k frakcionГЎcii a identifikГЎcii
dГґleЕѕitГЅch proteГ­nov.
Pre efektГ­vnejЕЎiu separГЎciu proteГ­nov a za ГєДЌelom zisЕҐovania zmien v proteГ­novom profile
MCF-7 buniek ДѕudskГ©ho nГЎdoru prsnГ­ka (estrogГ©n receptor pozitГ­vnych) po aplikГЎcii jednotlivГЅch
izomГ©rov retinovГЅch kyselГ­n v koncentrГЎcii 1 Вµmol/l bola pouЕѕitГЎ dvojrozmernГЎ (2D) gГ©lovГЎ
elektrofГ©za, priДЌom prvГЅ rozmer separГЎcie proteГ­nov sa zГ­skal izoelektroforetickou fokusГЎciou
proteГ­nov a nГЎsledne sa ДЏalЕЎie delenie proteГ­nov uskutoДЌnilo pomocou SDS-polyakrylamidovej
elektroforГ©zy. Po 2D separГЎcii a vizualizГЎcii proteГ­nov na polyakrylamidovom gГ©li boli izolovanГ©
jednotlivé „spoty“ proteínov a po proteolytickom štepení proteínov produkty identifikované
pomocou MALDI-TOF hmotnostnej spektrometrie. VГЅsledky jednoznaДЌne ukГЎzali ДЏalЕЎiu
identifikГЎciu potencionГЎlnych biomarkerov, ktorГ© sa vyskytujГє v nГЎdorovГЅch bunkГЎch prsnГ­ka bez
ich spracovania izomГ©rmi kyseliny retinovej alebo na druhej strane len vo vzorkГЎch nГЎdorovГЅch
buniek, ktorГ© sa inkubovali v prГ­tomnosti izomГ©rov retinovГЅch kyselГ­n.
PublikГЎcie
MACEJOVГЃ D., GALBAVГќ S., PODOBA J., BIALEЕ OVГЃ L., BRTKO J.: mRNA expression
pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary
carcinoma. Oncol. Rep., Oncology Reports, 30: 2371-2378, 2013.
LENKO V., BIALESOVA L., MACEJOVA D., BUJDAK P., BREZA J., BRTKO J.: The
relationship between renal cell carcinoma and nuclear retinoid/rexinoid receptors. Biomed Pap Med
Fac Univ Palacky Olomouc Czech Repub. 157: 316-324, 2013.
BIALEЕ OVГЃ L., BRTKO J., LENKO V., MACEJOVГЃ D.: Nuclear receptors - target molecules
for isoflavones in cancer chemoprevention. Gen. Physiol. Biophys., 32: 467–478, 2013.
FLODROVA D., BENKOVSKA D., MACEJOVA D., BIALESOVA L., BOBALOVA L., BRTKO
J.: Effects of retinoic acid isomers on proteomic pattern in human breast cancer MCF-7 cell line.
Endocr. Regul., 47: 205-2209, 2013.
Abstrakty
BRTKO J.,MACEJOVГЃ D., GALBAVГќ Е ., BIALEЕ OVГЃ L., PODOBA J.: Expression mRNA
pattern of retinoic acid and retinoid X nuclear receptor subtypes in thyroid carcinomas. Thyroid
Research, 6: (Suppl. 2): 4-5, 2013.
BRTKO J., MACEJOVГЃ D., Е ., BIALEЕ OVГЃ L., FICKOVГЃ M., HUNГЃKOVГЃ L.: Toxicity of
nuclear retinoid X receptors cognate ligands of organotin origin in breast cancer cell lines: Effects
on selected retinoid/retinoid X receptor subtypes expression. Military Medical Science Letters, 82:
(Suppl.), 3, 2013.
BIALEЕ OVГЃ L., BRTKO J., MACEJOVГЃ D.: The effect of isoflavone genistein on the expression
of selected nuclear receptors and their coregulators. Military Medical Science Letters, 82: (Suppl.),
2-3, 2013.
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MACEJOVГЃ D., BIALEЕ OVГЃ L., BRTKO J.: Effects of two isomers of retinoic acid and genistein
on the expression of selected nuclear receptors, their coregulators and genes involved in apoptosis
in ACHN human kidney cancer cell line. Military Medical Science Letters, 82: (Suppl.), 18, 2013.
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., FICKOVГЃ M., BOHГЃДЊOVГЃ V., SULOVГЃ Z.,
BREIER A., HUNГЃKOVГЃ L.: Selected organotin halides: Toxicity versus nuclear retinoic
acid/retinoid X receptors and their co-regulators expression in breast cancer and leukemia cell lines.
Toxicology Letters, 221S: S113, P08-47, 2013.
MACEJOVГЃ D., BIALEЕ OVГЃ L., HAVRГЃNEK T., BRTKO J., FICKOVГЃ M.: Effects of di(2ethylhexyl)-phtalate alone or in combination with 17ОІ-estradiol on expression of RXRalpha and
RXRbeta retinoid X receptor subtypes in the MCF-7 breast cancer cell line. Toxicology Letters,
221S: S105, P08-23, 2013.
FICKOVГЃ M., HAVRГЃNEK T., BRTKO J., MACEJOVГЃ D.: Reduced expression of genes for
nuclear receptors RXRalpha and RXRbeta by bisphenol A in human mammary cancer cells
(MCF7). Toxicology Letters, 221S: S112-S113, P08-46, 2013.
HUNГЃKOVГЃ L., MACEJOVГЃ D., BIALEЕ OVГЃ L., BRTKO J.: Effects of selected organotin
halides on human breast cancer cell line growth and nuclear all-trans retinoic acid receptor (RAR)
and retinoid X receptor (RXR) subtypes expression. Abstracts from the UAE Cancer Congress,
Dubai, 43, 2013.
BRTKO J., MACEJOVГЃ D., BIALEЕ OVГЃ L., GALBAVГќ Е .: Expresia podtypov retinoidnГЅch a
rexinoidnГЅch jadrovГЅch receptorov a ich koregulГЎtorov v karcinГіmoch ЕЎtГ­tnej ЕѕДѕazy. Diabetologie,
Metabolizmus, Endokrinologie, VГЅЕѕiva, 16: (Suppl.), 2-3, 2013.
BRTKO J., BIALEЕ OVГЃ L., LENKO V., MACEJOVГЃ D.: The road to nuclear receptors and their
cognate ligands: Insight into physiology and therapy of malignant diseases. Abstracts from the
Genetic Toxicology and Cancer Prevention Conference, Smolenice, L5, 6, 2013.
MACEJOVГЃ D., BIALEЕ OVГЃ L., HAVRГЃNEK T., BRTKO J., FICKOVГЃ M.: Di(2-ethylhexyl)phtalate: Effects on expression of RXRalpha and RXRbeta retinoid X receptor subtypes in the
MCF-7 breast cancer cell line. Abstracts from the Genetic Toxicology and Cancer Prevention
Conference, Smolenice, P1, 39, 2013.
BIALEЕ OVГЃ L., BRTKO J., ONDKOVГЃ S., GALBAVГќ Е ., MACEJOVГЃ D.: Selected nuclear
receptors expression in human breast carcinoma tissues. Abstracts from the Genetic Toxicology and
Cancer Prevention Conference, Smolenice, P6, 44, 2013.
2. Centrum excelentnosti na ЕЎtГєdium metabolickГЅch aspektov vГЅvoja diagnostiky a
lieДЌby nГЎdorovГЅch ochorenГ­ CEMAN. (Centre of Excellence for the study of metabolic
aspects of development, diagnostics and treatment of malignancies CEMAN)
124
SprГЎva o ДЌinnosti organizГЎcie SAV
ZodpovednГЅ rieЕЎiteДѕ:
OДѕga kriЕѕanovГЎ
Trvanie projektu centra: 4.8.2011 - 31.12.2014
EvidenДЌnГ© ДЌГ­slo projektu : CEMAN
OrganizГЎcia
je nie
koordinГЎtorom projektu:
ГљMFG SAV
KoordinГЎtor:
PoДЌet
spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
SAV 3000 €
ДЊerpanГ© financie:
DosiahnutГ© vГЅsledky:
ZnГЎmy, hoci mГЎlo preskГєmanГЅ je dopad nadmernГЅch a opakovanГЅch stresovГЅch vplyvov na rozvoj
nГЎdorovГЅch ochorenГ­. ZГ­skali sme vГЅsledky, ktorГ© upozorЕ€ujГє na to, Еѕe jednotlivГ© stresovГ© hormГіny
sa vyluДЌujГє rГґzne a mГґЕѕu pГґsobiЕҐ inak v zГЎvislosti od veku. PrГ­kladom sГє glukokortikoidy, ktorГ© sГє
spomedzi nadobliДЌkovГЅch steroidov najintenzГ­vnejЕЎie vyluДЌovanГ© hormГіny poДЌas stresu
v dospelosti. Naproti tomu v obdobГ­ krГЎtko po narodenГ­ sa poДЌas stresu vyluДЌujГє glukokortikoidy
len vo veДѕmi obmedzenej miere, ДЌo predstavuje fyziologickГє ochranu vyvГ­jajГєceho sa organizmu
pred nadmernГЅmi ГєДЌinkami glukokortikoidov. My sme ukГЎzali, Еѕe v ranom postnatГЎlnom obdobГ­
preberГЎ Гєlohu hlavnГ©ho hormГіnu vyluДЌovanГ©ho poДЌas stresu aldosterГіn (Varga a spol. 2013).
PopГ­sali sme dynamiku vyluДЌovania hormГіnu oxytocГ­nu poДЌas stresu. UkГЎzali sme, Еѕe pri
opakovanГЅch ДЌi chronickГЅch podnetoch v porovnanГ­ s akГєtnymi stresovГЅmi situГЎciami mГґЕѕu pri
intenzГ­vnych podnetoch zvГЅЕЎenГ© koncentrГЎcie pretrvГЎvaЕҐ alebo sa normalizovaЕҐ v prГ­pade
krГЎtkodobГЅch alebo miernych stresovГЅch podnetov (Danevova a spol 2013).
NedГЎvne vГЅskumy ukazujГє, Еѕe medzi spГґsoby, ktorГ© aspoЕ€ ДЌiastoДЌne zabrГЎnia negatГ­vnym vplyvom
na ДѕudskГє psychiku je poДЌГєvanie hudby. SГє ЕЎtГєdie, ktorГ© popisujГє pozitГ­vne ГєДЌinky poДЌГєvania
hudby u pacientov ДЌakajГєcich na neprГ­jemnГ© lekГЎrske zГЎsahy. Sledovali sme vplyv poДЌГєvania
hudby u zdravГЅch dobrovoДѕnГ­kov poДЌas fyzickГ©ho a mentГЎlneho stresu. DokГЎzali sme, Еѕe pri
poДЌГєvanГ­ prГ­jemnej huby stresovГЎ situГЎcia nevyvolala zvГЅЕЎenie Гєzkosti. Pri vystavenГ­ stresorom a
sГєДЌasnom poДЌГєvanГ­ rovnakej hudby hranej odzadu nГЎrast Гєzkosti nastal. ZГ­skanГ© vГЅsledky dovoДѕujГє
predpokladaЕҐ, Еѕe poДЌГєvanie hudby mГґЕѕe aj pozitГ­vne, aj negatГ­vne ovplyvniЕҐ percepciu stresu a
mieru Гєzkosti (Jezova a spol. 2013), ДЌo treba braЕҐ do Гєvahy pri klinickГЅch aplikГЎciГЎch.
PublikГЎcie
HLAVACOVA N., KERLIK J., RADIKOVA Z., IZAKOVA L., JEZOVA D. Measurement of
salivary aldosterone: validation by low-dose ACTH test and gender differences. In Endocrine
Regulations. 2013, vol. 47, no. 4, p. 201-204.
DANEVOVA V., KVETNANSKY R., JEZOVA D. Kinetics of oxytocin response to repeated
restraint stress and/or chronic cold exposure. In Hormone and Metabolic Research, 2013, vol. 45,
no. 12, p. 845-848. (IF=2,145)
JEZOVA D., HLAVACOVA N., MAKATSORI A., DUNCKO R., LODER I., HINGHOFERSZALKAY H. Increased anxiety induced by listening to unpleasant music during stress exposure is
associated with reduced blood pressure and ACTH responses in healthy men. In
Neuroendocrinology, 2013, vol. 98, no. 2, p. 144-150. (IF=3,537)
125
SprГЎva o ДЌinnosti organizГЎcie SAV
VARGA J., FERENCZI S., KOVГЃCS KJ., GARAFOVA A., JEZOVA D., ZELENA D.
Comparison of
Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main
Adrenocortical Stress Hormone during the Perinatal Period in Rats? In PLoS One, 2013, vol. 8, no.
9, p. e72313. (IF=3,730)
Abstrakty:
HLAVACOVA N., WAWRUCH M., TISONOVA J., JEZOVA D. Neuroendocrine activation
during stress in women depends on trait anxiety. Abstracts of the 11th World Congress of
Biological Psychiatry, Abstract CD-ROM, 2013.
JEZOVA D., HLAVACOVA N.: Hyperaldosteronism in an animal model - changes in depressionlike behavior and gene expression relevant to major depressive disorder. Abstracts of the 11th
World Congress of Biological Psychiatry, Abstract CD-ROM, 2013.
HLAVГЃДЊOVГЃ N., MAKATSORI A., HINGHOFER-SZALKAY H., JEЕЅOVГЃ D. HormonГЎlna a
kardiovaskulГЎrna odpoveДЏ na kombinovanГЅ stresovГЅ podnet pri zvГЅЕЎenej Гєzkosti vyvolanej
poДЌГєvanГ­m hudby. In Psychiatrie, 2013, vol. 17, suppl. 1, p. 38.
POKUSA M., GAJDOЕ ECHOVГЃ L., KRЕ KOVГЃ K., CSГЃNOVГЃ A., ZORAD Е ., FRANKLIN
M., JEЕЅOVГЃ D. VybranГ© metabolickГ© parametre v tukovom tkanive v animГЎlnom modeli depresie.
In Psychiatrie, 2013, vol. 17, suppl. 1, p. 51.
3. Centrum excelentnosti pre vГЅskum mozgu BRAINCENTRUM (Centre of excellence
for research on the brain BRAINCENTRUM)
VedГєci centra: Prof. MVDr. Michal NovГЎk, DrSc.
NeuroimunologickГЅ Гєstav SAV, DГєbravskГЎ cesta 9, 845 10 Bratislava
ZodpovednГЅ rieЕЎiteДѕ:
RNDr. Alexander Kiss, DrSc.
Trvanie projektu centra:
4.8.2011 - 31.12.2014
OrganizГЎcia
je nie, koordinuje NeuroimunologickГЅ Гєstav SAV
koordinГЎtorom projektu:
Prof. MVDr. Michal NovГЎk, DrSc., NiU SAV
KoordinГЎtor:
PoДЌet
spolurieЕЎiteДѕskГЅch 6
inЕЎtitГєciГ­:
5000 €
ДЊerpanГ© financie:
4.) Centrum excelentnosti pre vГЅskum mozgu BRAINCENTRUM (Centre of excellence for
research on the brain BRAINCENTRUM)
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v
organizГЎcii SAV:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
Michal NovГЎk
Richard KvetЕ€anskГЅ
4.8.2011 / 31.12.2014
nie
Prof. MVDr. Michal NovГЎk, DrSc., NiU SAV
126
SprГЎva o ДЌinnosti organizГЎcie SAV
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
6
2.500,- Eur
VГЅsledky:
Гљvodom treba konЕЎtatovaЕҐ, Еѕe aktivГЎcia sympatoadrenГЎlneho systГ©mu (SAS) a hypotalamohypofГЅzo-adrenokortikГЎlneho systГ©mu (HPA) poДЌas stresu vedie k zvГЅЕЎeniu hladГ­n katecholamГ­nov
(CA) a glukokortikoidov v plazme potkanov. Stres je jednГЅm z faktorov, ktorГ© potencujГє vznik a
vГЅvoj
Alzheimerovej
choroby.
V rГЎmci ДЌinnosti Centra sme sa zamerali na rieЕЎenie otГЎzky, ДЌi stresom-indukovanГ© zmeny
v aktivГЎcii SAS a HPA mГґЕѕu byЕҐ ovplyvnenГ© Alzheimerovou chorobou, t.j. vznikom
neurofibrilГЎrnej patolГіgie v mozgu transgГ©nnych potkanov (TG). U WT a SHR-TG potkanov sme
z jugulГЎrnej vГ©ny pomocou implantovanej kanyly opakovane odoberali krv v rГґznych intervaloch
imobilizaДЌnГ©ho stresu. Merali sme hladiny adrenalГ­nu, noradrenalГ­nu a kortikosterГіnu v plazme.
Hladiny tГЅchto indikГЎtorov aktivity SAS a HPA sa vГЅrazne zvyЕЎovali pod vplyvom imobilizaДЌnГ©ho
stresu. Vzostupy vЕЎak boli rovnakГ© u WT aj SHR-TG potkanov, ДЌo naznaДЌovalo, Еѕe vznik
Alzheimerovskej patolГіgie v mozgu neovplyvЕ€uje stresom indukovanГє aktivГЎciu perifГ©rnych
systГ©mov SAS a HPA.
VzhДѕadom na skutoДЌnosЕҐ, Еѕe na pracovisku mГЎme k dispozГ­cii aj transgГ©nne potkany
vyselektovanГ© z normotenznГ©ho kmeЕ€a Wistar-Kyoto, pokГєsili sme sa zmeraЕҐ ich perifГ©rnu
sympatikovГє odpoveДЏ po vystavenГ­ akГєtnemu a opakovanГ©mu imobilizaДЌnГ©mu stresu. ZГ­skali sme
neoДЌakГЎvanГ© vГЅsledky dokumentujГєce, Еѕe hladina katecholamГ­nov v plazme transgГ©nnych-WKY
potkanov je po vystavenГ­ opakovanГ©mu IMO stresu vГЅznamne niЕѕЕЎia ako u WT-WKY potkanov.
Tento vГЅsledok ukazuje, Еѕe aj odpoveДЏ perifГ©rneho sympatikovГ©ho systГ©mu na stres je rozdielne
regulovanГЎ u transgГ©nnych potkanov s DAT. TГЎto odpoveДЏ je vЕЎak zГЎvislГЎ na pouЕѕitom kmeni
potkanov. Mechanizmus tohto rozdielu nevieme zatiaДѕ vysvetliЕҐ a bude predmetom ДЏalЕЎГ­ch ЕЎtГєdiГ­.
SГєhrnne teda naЕЎe vГЅsledky ukГЎzali, Еѕe u TG potkanov s Alzheimerovskou patolГіgiou
v oblastiach mozgu, ktorГ© sГє zapojenГ© do regulГЎcie perifГ©rneho sympatoadrenГЎlneho systГ©mu
a HPA osi, mГґЕѕe dГґjsЕҐ k redukcii hladГ­n katecholamГ­nov v plazme po vystavenГ­ stresu v porovnanГ­
s WT potkanmi. Tento nГЎlez mГґЕѕe maЕҐ veДѕkГЅ vГЅznam pre kliniku Alzheimerovej choroby a bude
ho potrebnГ© ДЏalej ЕЎtudovaЕҐ a vysvetliЕҐ.
RelevantnГ© publikГЎcie:
VARGOVIДЊ P., UKROPEC J., LAUKOVГЃ M., KURDIOVГЃ T., BALГЃЕЅ M., MANZ B.,
UKROPCOVÁ B., KVETŇANSKÝ R.:
Repeated
immobilization stress induces catecholamine production in rat mesenteric adipocytes.
Stress : The international journal on the biologie of stress, 2013, 16 (3): pp. 340-352.
(2.476
– IF 2011). DOI:10.3109/10253890.736046.
Typ: ADCA
BENEŠJ., TOMANKOVA H., NOVAKOVA M., ROHAN Z., KVETŇANSKÝ R.,
MYSLIVEДЊEK J.: Corticotropin-releasing hormone affects short immobilization stress-induced
changes in lung cytosol and membrane glucocorticoid binding sites.
Cellular and
Molecular Neurobiology, 2013, 33: pp. 503-511.
(2.293 IF2012). DOI 10.1007/s10571-013-9916-9.
Typ: ADCA
127
SprГЎva o ДЌinnosti organizГЎcie SAV
NOVÁK P., ŽILKA N., FILIPČÍK, P., KVETŇANSKÝ R., NOVÁK M.: Stres ako modulátor
neurodegeneraДЌnej kaskГЎdy indukovanej proteГ­nom tau, VydavateДѕstvo AHO3, aprГ­l 2013, str. 6480, ISBN 978-80-971357-0-6 Typ: nekarentovanГЅ ДЌlГЎnok v zbornГ­ku
Abstrakty z konferenciГ­:
FILIPČÍK P., NOVÁK P., MRAVEC B. ONDIČOVÁ K., KVETŇANSKY R., NOVÁK, M.:
From emotional stress to cognitive deficit: through tau protein modifications?
In: The Jerusalem International Conference on Neuroplasticity and Cognitive Modifiability,
Abstract and Program Book p. 41, Jerusalem, June 2013.
5.) CE SAV Centrum excelentnosti pre vГЅskum regulaДЌnej Гєlohy oxidu dusnatГ©ho v
chorobГЎch z civilizГЎcie. (Centre of excellence for examination of regulatory role of nitric oxide in
civilization diseases.)
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v
organizГЎcii SAV:
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
OrganizГЎcia je
koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch
inЕЎtitГєciГ­:
ДЊerpanГ© financie:
OДѕga PechГЎЕ€ovГЎ
Е tefan ZГіrad
1.6.2011 / 31.12.2015
NOREG
nie
UNPF SAV
5
2.000,- Eur
DosiahnutГ© vГЅsledky:
Porovnali sme hladiny oxtocГ­nu v plazme obГ©znych Zucker potkanov a ich chudГЅch kontrol. TieЕѕ
sme sledovali aktivitu oxytocinГЎzy v peДЌeni, obliДЌke, svale a tukovom tkanive. Zistili sme, Еѕe
obezita je spojenГЎ so znГ­ЕѕenГЅmi hladinami oxytocГ­nu v plazme a naЕЎe vГЅsledky ukazujГє, Еѕe je to
zaprГ­ДЌinenГ© zvГЅЕЎenou degradГЎciou oxytocГ­nu v peДЌeni a tukovom tkanive. Z literatГєry je znГЎme, Еѕe
oxytocГ­n mГЎ kardioprotektГ­vny ГєДЌinok (stimuluje produkciu NO v srdci) a tieЕѕ Еѕe myЕЎi
s nadprodukciou eNOS sГє rezistentnГ© voДЌi obezite navodenej vysokotukovou diГ©tou, preto sa v
ДЏalЕЎГ­ch analГЅzach zameriame na vzЕҐah medzi inzulГ­novou rezistenciou a NO systГ©mom v tukovom
tkanive kontrolnГЅch a obГ©znych Zucker potkanov po podГЎvanГ­ oxytocГ­nu.
GAJDOSECHOVA L., KRSKOVA K., SEGARRA AB., SPOLCOVA A., SUSKI M.,
OLSZANECKI R., ZORAD S. : Hypooxytocinaemia in obese Zucker rats relates to
oxytocin degradation in liver and adipose tissue. JEndocrinol 2014, Jan 3 (Epub ahead of
print)
Programy : InГ©
1. SignГЎlna drГЎha oxidu dusnatГ©ho a sГ­rovodГ­ka, jej poruchy a podiel na vzniku hypertenzie
a aterosklerГіzy. (Signal pathway of nitric oxide and hydrogen sulfide, its disturbances and
participation in development of hypertension and atherosclerosis.)
128
SprГЎva o ДЌinnosti organizГЎcie SAV
ZodpovednГЅ rieЕЎiteДѕ:
ZodpovednГЅ rieЕЎiteДѕ v ГљEE SAV
Trvanie projektu:
EvidenДЌnГ© ДЌГ­slo projektu:
FrantiЕЎek Kristek
Е tefan Zorad
19. 7. 2011 / 31.12.2015
MZ 2012/51-SAV-1
OrganizГЎcia je koordinГЎtorom projektu:
KoordinГЎtor:
PoДЌet spolurieЕЎiteДѕskГЅch inЕЎtitГєciГ­:
PridelenГ©/ДЌerpanГ© financie:
DosiahnutГ© vГЅsledky:
nie
UNPF SAV
3
4 000/0 €
PredbeЕѕne sa vykonala izolГЎcia RNA zo vzoriek kГґry obliДЌiek z obГ©znych a kontrolnГЅch potkanov
kmeЕ€a Zucker. AnalГЅza mRNA sa vykonГЎ do 31.3.2014 dokedy je potrebnГ© vyДЌerpaЕҐ pridelenГ©
finanДЌnГ© prostriedky.
129
SprГЎva o ДЌinnosti organizГЎcie SAV
PrГ­loha C
PublikaДЌnГЎ ДЌinnosЕҐ organizГЎcie (zoradenГЎ podДѕa kategГіriГ­)
AAA VedeckГ© monografie vydanГ© v zahraniДЌnГЅch vydavateДѕstvГЎch
AAA01
KRAHULEC, Boris - FÁBRYOVÁ, Ľubomíra - HOLÉCZY, Pavol - KLIMEŠ, Iwar
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UNIVERSITY, 1996, vol. 40, no. 2, p. 95-111.
CitГЎcie:
1. [1.1] Gueguinou, N., Bojados, M., Jamon, M., Derradji, H., Baatout, S.,
Tschirhart, E., Frippiat, J.-P., Legrand-Frossi, C. Stress response and humoral
immune system alterations related to chronic hypergravity in mice.
Psychoneuroendocrinology, 37(1): 137-147, 2012, WOS
NANKOVÁ, B. B. - KVETŇANSKÝ, Richard - HIREMAGALUR, B. - SABBAN,
B. - RUSNГЃK, Martin - SABBAN, E. L. Immobilization stress elevates gene
expression for catecholamine biosynthetic enzymes and some neuropeptides in rat
sympathetic ganglia: Effects of adrenocorticotropin and glucocorticoids.
CitГЎcie:
1. [1.1] Alterman, A., Mathison, R., Coronel, C.E., Stroppa, M.M., Finkelberg,
A.B., Gallara, R.V. Functional and proteomic analysis of submandibular saliva in
rats exposed to chronic stress by immobilization or constant light. Archives of
Oral Biology, 57(6): 663-669, 2012, WOS
2. [1.1] Eshkevari, L., Egan, R., Phillips, D., Tilan, J., Carney, E., Azzam, N.,
Amri, H., Mulroney, S.E. Acupuncture at ST36 prevents chronic stress-induced
increases in neuropeptide Y in rat. Experimental Biology and Medicine, 237(1):
18-23, 2012, WOS
3. [1.1] Leick, E.A., Reis, F.G., Honorio-Neves, F.A., Almeida-Reis, R., Prado,
C.M., Martins, M.A., Tiberio, F.L.C. Effects of Repeated Stress on Distal Airway
Inflammation, Remodeling and Mechanics in an Animal Model of Chronic Airway
Inflammation. Neuroimmunomodulation, 19(1): 1-9, 2012, WOS
4. [1.1] Lim, H., Jang, S., Lee, Y., Moon, S., Kim, J., Oh, S. Enhancement of
Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated
Injections of Corticosterone. Biomolecules & Therapeutics, 20(4): 418-424,
2012, WOS
PACÁK, Karel - PALKOVITS, M. - KVETŇANSKÝ, Richard - KOPIN, I.J. GOLDSTEIN, D. S. Stress-induced norepinephrine release in the paraventricular
nucleus of rats with brain brainstem hemisections - a microdialysis study. In
Neuroendocrinology, 1993, vol. 58, no. 2, p. 196-201. ISSN 0172-780X.
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09
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CitГЎcie:
1. [1.1] Spirovski, D., Li, Q., Pilowsky, P. M.Brainstem galanin-synthesizing
neurons are differentially activated by chemoreceptor stimuli and represent a
subpopulation of respiratory neurons. journal of comparative neurology, 520 (1):
154-173, 2012, WOS
ROMAN, O.V - SERES, J. - HERICHOVГЃ, Iveta - ZEMAN, Martin JURДЊOVIДЊOVГЃ, Jana. Daily profiles of plasma prolactin (PRL), growth hormone
(GH), insulin-like growth factor-1 (IGF-1), luteinizing hormone (LH), testosterone,
and melatonin, and of pituitary PRL mRNA and GH mRNA in male Long Evans rats
in acute phase of adjuvant arthritis. In CHRONOBIOLOGY INTERNATIONAL,
2003, vol. 20, no. 5, p. 823-836.
CitГЎcie:
1. [1.1] Li, Y., Komuro, Y., Fahrion, J.K., Hu T, Ohno N, Fenner KB, Wooton J,
Raoult E, Galas L, Vaudry D, Komuro H. Light stimuli control neuronal
migration by altering of insulin-like growth factor 1 (IGF-1) signaling.
Proceedings of the National Academy of Sciences of the United States of America,
109(7): 2630-2635, 2012, WOS
ROVENSKГќ, Jozef - BAKOЕ OVГЃ, Jindra - KOЕ KA, JГЎn - KSINANTOVГЃ, L. JEЕЅOVГЃ, Daniela - VIGAЕ , Milan. Somatotropic, lactotropic and adrenocortical
responses to insulin-induced hypoglycemia in patients with rheumatoid arthritis. In
Annals of the New York Academy of Sciences, 2002, p. 263-270. (1.593 - IF2001).
ISSN 0077-8923.
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1. [1.2] Türsen Ü. Pathophysiology of the behçet's disease. In Pathology Research
International. 2012; 2012: 493015. SCOPUS, SCOPUS
Е EBЕђKOVГЃ, Elena - KLIMEЕ , Iwar - GAЕ PERГЌKOVГЃ, Daniela - BOHOV, Pavol
- LANGER, Pavel - LAVAU, M. - CLANDININ, M. T. Regulation of gene
expression for lipogenic enzymes in the liver and adipose tissue of hereditary
hypertriglyceridemic, insulin-resistant rats: Effect of dietary sucrose and marine fish
oil. In BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID
METABOLISM, 1996, vol 1303, no. 1, p. 56-62.
CitГЎcie:
1. [1.1] HUANG, HSIU-CHEN; LIN, JEN-KUN.: Pu-erh tea, green tea, and black
tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through
activating AMPK in rats fed a high-fructose diet. FOOD & FUNCTION 3 (2), pp.
170-177, 2012, WOS
SHOELSON, S. - FICKOVГЃ, MГЎria - HANEDA, M. Identification of a mutant
human insulin predicted to contain a serine-for-phenylalanine substitution. In
Proceedings of the National Academy of Sciences of the United States of America,
1983, vol. 80, no. 24, p. 7390-7394. ISSN 0027-8424.
CitГЎcie:
1. [1.1] Malik, A., Al-Senaidy, A., Skrzypczak-Jankun, E., Jankun, J.: A study of
the anti-diabetic agents of camel milk. INTERNATIONAL JOURNAL OF
MOLECULAR MEDICINE 30 (3), pp. 585-592, 2012, WOS
UDELSMAN, R. Li. DG. - STAGG, C. A. - GORDON, C. B. - KVETŇANSKÝ,
Richard. Adrenergic regulation of adrenal and aortic heat-shock protein. In
SURGERY, 1994, vol. 116, no. 2, p. 177-182.
CitГЎcie:
1. [1.1] Ghasemi, A., Faraji, F., Valaee, F., Sedaghat, K., Arabian, M., Zahediasl,
S. Diminished response of isolated aorta following chronic physical and
psychological stresses and its reversibility in rats. International Journal of
Endocrinology and Metabolism, 10(1): 423-428, 2012, WOS
269
SprГЎva o ДЌinnosti organizГЎcie SAV
PrГ­loha D
Гљdaje o pedagogickej ДЌinnosti organizГЎcie
SemestrГЎlne prednГЎЕЎky:
Mgr. Zuzana BaДЌovГЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty): LekГЎrska fakulta, SlovenskГЎ zdravotnГ­cka univerzita,
Bratislava
NГЎzov katedry/Гєstavu: Гљstav normГЎlnej a patologickej fyziolГіgie
Typ ДЌinnosti: semestrГЎlne prednГЎЕЎky
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: PatologickГЎ fyziolГіgia
AkademickГЅ rok: 2013/2014
Semester: zimnГЅ
HodГ­n/semester : 3
Mgr. Zuzana BaДЌovГЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty):Fakulta verejnГ©ho zdravotnГ­ctva, SlovenskГЎ zdravotnГ­cka
univerzita, Bratislava
NГЎzov katedry/Гєstavu: Гљstav normГЎlnej a patologickej fyziolГіgie
Typ ДЌinnosti: semestrГЎlne prednГЎЕЎky
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: PatologickГЎ fyziolГіgia
AkademickГЅ rok:2012/2013
Semester: letnГЅ
HodГ­n/semester: 28
Mgr. Zuzana BaДЌovГЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty): Fakulta verejnГ©ho zdravotnГ­ctva, SlovenskГЎ zdravotnГ­cka
univerzita, Bratislava
NГЎzov katedry/Гєstavu: Гљstav normГЎlnej a patologickej fyziolГіgie
Typ ДЌinnosti: semestrГЎlne prednГЎЕЎky
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: PatologickГЎ fyziolГіgia
AkademickГЅ rok: 2013/2014
Semester: zimnГЅ
HodГ­n/semester: 19
RNDr. Robert FarkaЕЎ, CSc.
NГЎzov semestr. predmetu: Е peciГЎlna vГЅvojovГЎ genetika
PoДЌet hodГ­n za semester: 4
NГЎzov katedry a vysokej ЕЎkoly: PrГ­rodovedeckГЎ fakulta UK, Katedra genetiky
doc. MUDr. Boris Mravec, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 25
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav patologickej fyziolГіgie
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
NГЎzov semestr. predmetu: FarmakolГіgia
PoДЌet hodГ­n za zimnГЅ semester: 12
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav farmakolГіgie a klinickej farmakolГіgie
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
270
SprГЎva o ДЌinnosti organizГЎcie SAV
NГЎzov semestr. predmetu: FarmakolГіgia
PoДЌet hodГ­n za letnГЅ semester: 3
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav farmakolГіgie a klinickej farmakolГіgie
prof. PharmDr. Daniela JeЕѕovГЎ, DrSc.
NГЎzov semestr. predmetu: Novinky v lieДЌbe endokrinnГЅch ochorenГ­
PoДЌet hodГ­n za semester: 2
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, LekГЎrska fakulta
MVDr. KatarГ­na OndiДЌovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 6
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav patologickej fyziolГіgie
MUDr. Adela PenesovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 3 (zimnГЅ sem.)
NГЎzov katedry a vysokej ЕЎkoly: SlovenskГЎ zdravotnГ­cka univerzita v Bratislave, LekГЎrska fakulta,
Гљstav patologickej fyziolГіgie
PharmDr. Zdenko PirnГ­k, PhD.
NГЎzov semestr. predmetu: FarmakolГіgia (ZS, LS)
PoДЌet hodГ­n za semester: 6 (ZS), 2 (LS)
NГЎzov katedry a vysokej ЕЎkoly: Univerzita veterinГЎrskeho lekГЎrstva a farmГЎcie v KoЕЎiciach, Гљstav
humГЎnnej a klinickej farmakolГіgie
PharmDr. Zdenko PirnГ­k, PhD.
NГЎzov semestr. predmetu: KlinickГЎ farmakolГіgia (LS)
PoДЌet hodГ­n za semester: 14 (LS)
NГЎzov katedry a vysokej ЕЎkoly: Univerzita veterinГЎrskeho lekГЎrstva a farmГЎcie v KoЕЎiciach,
Гљstav humГЎnnej a klinickej farmakolГіgie
Prof.MUDr.Fedor Е imko,CSc.
Prednasky na LFUK v slovneskom a anglickom jazyku
Skusanie studentov
PostgraduГЎlne prednasky pre kardiologov, internistov a vseobecnych lekarov.
MUDr. VladimГ­r Е trbГЎk,DrSc.,
PГґsobil ako prednosta Гљstavu normГЎlnej a patologickej fyziolГіgie na LekГЎrskej fakulte Slovenskej
zdravotnГ­ckej university v Bratislave.
NГЎzov semestrГЎlneho predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n prednГЎЕЎok za roДЌnГ­k za zimnГЅ semester: 40
NГЎzov katedry a vysokej ЕЎkoly: Гљstav patologickej fyziolГіgie, LekГЎrska fakulta a Fakulta
vЕЎeobecnГ©ho zdravotnГ­ctva Slovenske zdravotnГ­ckej university v Bratislave
MUDr. VladimГ­r Е trbГЎk, DrSc.,:
NГЎzov semestrГЎlneho predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n prednГЎЕЎok za roДЌnГ­k za letnГЅ semester: 40
NГЎzov katedry a vysokej ЕЎkoly: Гљstav patologickej fyziolГіgie, LekГЎrska fakulta a Fakulta
vЕЎeobecnГ©ho zdravotnГ­ctva Slovenske zdravotnГ­ckej univerzity v Bratislave
MUDr. VladimГ­r Е trbГЎk, DrSc.,:
271
SprГЎva o ДЌinnosti organizГЎcie SAV
NГЎzov semestrГЎlneho predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n prednГЎЕЎok za roДЌnГ­k za zimnГЅ semester: 6
NГЎzov katedry a vysokej ЕЎkoly: Гљstav patologickej anatГіmie, LekГЎrska fakulta UK v Bratislave
MUDr. Barbara UkropcovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za letnГЅ semester: 60
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav Patologickej FyziolГіgie
Mgr. Jozef Ukropec, PhD.
Seminar pre doktorandov: „Pathophysiology of obesity and insulin resistance: How could endocrine
communication of skeletal muscle and adipose tissue contribute to pandemia of obesity?“
PoДЌet hodГ­n za semester: 2
NГЎzov katedry a vysokej ЕЎkoly: Katerdra ЕѕivoДЌГ­ЕЎnej fyziolГіgie a etolГіgie, PrГ­rodovedeckГЎ fakulta
UK.
MUDr. Miroslav VlДЌek, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 6 (letnГЅ sem.)
NГЎzov katedry a vysokej ЕЎkoly: SlovenskГЎ zdravotnГ­cka univerzita v Bratislave, LekГЎrska fakulta,
Гљstav patologickej fyziolГіgie
MUDr. Miroslav VlДЌek, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 6 (zimnГЅ sem.)
NГЎzov katedry a vysokej ЕЎkoly: SlovenskГЎ zdravotnГ­cka univerzita v Bratislave, LekГЎrska fakulta,
Гљstav patologickej fyziolГіgie
SemestrГЎlne cviДЌenia:
Mgr. Zuzana BaДЌovГЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty): LekГЎrska fakulta, SlovenskГЎ zdravotnГ­cka univerzita,
Bratislava
NГЎzov katedry/Гєstavu: Гљstav normГЎlnej a patologickej fyziolГіgie
Typ ДЌinnosti: semestrГЎlne cviДЌenia
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: PatologickГЎ fyziolГіgia
AkademickГЅ rok: 2012/2013
Semester: letnГЅ
HodГ­n/semester: 24
Mgr. Zuzana BaДЌovГЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty): LekГЎrska fakulta, SlovenskГЎ zdravotnГ­cka univerzita,
Bratislava
NГЎzov katedry/Гєstavu: Гљstav normГЎlnej a patologickej fyziolГіgie
Typ ДЌinnosti: semestrГЎlne cviДЌenia
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: PatologickГЎ fyziolГіgia
AkademickГЅ rok: 2013/2014
Semester : zimnГЅ
HodГ­n/semester : 24
RNDr. JГЎn BakoЕЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty): LekГЎrska fakulta, UK, Bratislava
272
SprГЎva o ДЌinnosti organizГЎcie SAV
NГЎzov katedry/Гєstavu: FyziologickГЅ Гєstav
Typ ДЌinnosti: semestrГЎlne cviДЌenia
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: LekГЎrska fyziolГіgia
AkademickГЅ rok: 2012/2013
Semester: letnГЅ
HodГ­n/semester : 96
RNDr. JГЎn BakoЕЎ, PhD.
NГЎzov vysokej ЕЎkoly (prГ­padne i fakulty): LekГЎrska fakulta, UK, Bratislava
NГЎzov katedry/Гєstavu: FyziologickГЅ Гєstav
Typ ДЌinnosti: semestrГЎlne cviДЌenia
NГЎzov predmetu/cviДЌenia/prednГЎЕЎky: LekГЎrska fyziolГіgia
AkademickГЅ rok: 2013/2014
Semester: zimnГЅ
HodГ­n/semester :96
MUDr. Adela PenesovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 12 (zimnГЅ sem.)
NГЎzov katedry a vysokej ЕЎkoly: SlovenskГЎ zdravotnГ­cka univerzita v Bratislave, LekГЎrska fakulta,
Гљstav patologickej fyziolГіgie
PharmDr. Zdenko PirnГ­k, PhD.
NГЎzov semestr. predmetu: FarmakolГіgia (ZS, LS)
PoДЌet hodГ­n za semester: 70 (ZS), 64 (LS)
NГЎzov katedry a vysokej ЕЎkoly: Univerzita veterinГЎrskeho lekГЎrstva a farmГЎcie v KoЕЎiciach, Гљstav
humГЎnnej a klinickej farmakolГіgie
PharmDr. Zdenko PirnГ­k, PhD.
NГЎzov semestr. predmetu: KlinickГЎ farmakolГіgia (LS)
PoДЌet hodГ­n za semester: 117 (LS)
NГЎzov katedry a vysokej ЕЎkoly: Univerzita veterinГЎrskeho lekГЎrstva a farmГЎcie v KoЕЎiciach, Гљstav
humГЎnnej a klinickej farmakolГіgie
MUDr. VladimГ­r Е trbГЎk, DrSc.,:
NГЎzov semestrГЎlneho predmetu: PatologickГЎ fyziolГіgia
PoДЌeth hodГ­n cviДЌenГ­ za letnГЅ semester: 24
NГЎzov katedry a vysokej ЕЎkoly: Гљstav patologickej fyziolГіgie, LekГЎrska fakulta a Fakulta
vЕЎeobecnГ©ho zdravotnГ­ctva Slovenskej zdravotnГ­ckej univerzity v Bratislave
MUDr. Barbara UkropcovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za letnГЅ semester: 19
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav Patologickej FyziolГіgie
MUDr. Barbara UkropcovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za zimnГЅ semester: 19
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav Patologickej FyziolГіgie
273
SprГЎva o ДЌinnosti organizГЎcie SAV
MUDr. Barbara UkropcovГЎ PhD.
NГЎzov semestr.: Choroby z inaktivity
PoДЌet hodГ­n za zimnГЅ semester: 30
NГЎzov katedry a vysokej ЕЎkoly: Fakulta Telesnej VГЅchovy a Е portu UK, katedra KinantropolГіgie
MUDr. Miroslav VlДЌek, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 36 (zimnГЅ sem.)
NГЎzov katedry a vysokej ЕЎkoly: SlovenskГЎ zdravotnГ­cka univerzita v Bratislave, LekГЎrska fakulta,
Гљstav patologickej fyziolГіgie
SeminГЎre:
MVDr. KatarГ­na OndiДЌovГЎ, PhD.
NГЎzov semestr. predmetu: PatologickГЎ fyziolГіgia
PoДЌet hodГ­n za semester: 32
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav patologickej fyziolГіgie
Mgr.Lucia MikovГЎ (rod. BГЎnovskГЎ)
NГЎzov semestr. predmetu: PatofyziolГіgia
PoДЌet hodГ­n za semester: 9
NГЎzov katedry a vysokej ЕЎkoly: LekГЎrska fakulta UK, Гљstav patologickej fyziolГіgie
TerГ©nne cviДЌenia:
IndividuГЎlne prednГЎЕЎky:
274
SprГЎva o ДЌinnosti organizГЎcie SAV
PrГ­loha E
MedzinГЎrodnГЎ mobilita organizГЎcie
(A) Vyslanie vedeckГЅch pracovnГ­kov do zahraniДЌia na zГЎklade dohГґd:
Krajina
Druh dohody
MAD, KD, VTS
MedziГєstavnГЎ
Meno
pracovnГ­ka
Meno
pracovnГ­ka
PoДЌet dnГ­
OstatnГ©
PoДЌet dnГ­
ArgentГ­na
ДЊesko
AlЕѕbeta
MlynarДЌГ­kovГЎ
SoЕ€a
ScsukovГЎ
Zdenko
PirnГ­k
MaДЏarsko Barbora
ProkopovГЎ
AgneЕЎa CsГЎnovГЎ
19
8
9
21
21
Robert
FarkaЕЎ
Lucia
BialeЕЎovГЎ
Lucia
BialeЕЎovГЎ
Daniela JeЕѕovГЎ
Lucia
FiaДЌanovГЎ
Michal Pokusa
5
Meno
pracovnГ­ka
PoДЌet dnГ­
Daniela JeЕѕovГЎ
11
NataЕЎa
HlavГЎДЌovГЎ
JГєlius
Brtko
11
18
31
6
1
11
11
Richard Imrich
Nemecko
1
3
JГєlius
Brtko
Fedor
Е imko
TГ­mea
KurdiovГЎ
Jozef Ukropec
RakГєsko
5
4
5
Patrik
Krumpolec
JГєlius
Brtko
Е tefan
Zorad
Miroslav BalГЎЕѕ
Е panielsko
Е vajДЌiarsko
1
3
4
184
Jozef
Ukropec
Barbara
UkropcovГЎ
Taiwan
Veronika
DanevovГЎ
Michal
Pokusa
4
4
16
16
Lucia
ChovanovГЎ
VeДѕkГЎ
BritГЎnia
PoДЌet
275
6
SprГЎva o ДЌinnosti organizГЎcie SAV
vyslanГ­
spolu
(B) Prijatie vedeckГЅch pracovnГ­kov zo zahraniДЌia na zГЎklade dohГґd:
Krajina
Druh dohody
MAD, KD, VTS
MedziГєstavnГЎ
OstatnГ©
Meno
PoДЌet dnГ­
Meno
PoДЌet dnГ­
Meno
pracovnГ­ka
pracovnГ­la
pracovnГ­ka
ArgentГ­na
BeГЎta
FuchsovГЎ
30
ДЊesko
MaДЏarsko
Eva NagyovГЎ
Diana
BalГЎzsi
92
17
Ana BelГ©n
Segarra
Е panielsko
Taiwan
PoДЌet prijatГ­
spolu
Tang-Long
Shen
Han-Yi E
Chou
Han-Jen Lin
Shi Torng
Ding
Tsaikun Li
PoДЌet dnГ­
21
3
3
3
3
3
8
154
(C) ГљДЌasЕҐ pracovnГ­kov pracoviska na konferenciГЎch v zahraniДЌГ­ (nezahrnutГЅch v "A"):
Krajina
Belgicko
ДЊesko
NГЎzov konferencie
WCCD
ДЊNPS
Meno pracovnГ­ka
FD
ДЊesko
MLPA
SpoluprГЎca MOTOL
DD
276
PoДЌet dnГ­
Jana JurДЌoviДЌovГЎ
5
Daniela JeЕѕovГЎ
Barbora ProkopovГЎ
Michal Pokusa
NataЕЎa HlavГЎДЌovГЎ
Veronika DanevovГЎ
VladimГ­r Е trbГЎk
JГЎn BakoЕЎ
Zuzana BaДЌovГЎ
Zuzana LeЕЎЕҐanovГЎ
TomГЎЕЎ HavrГЎnek
Jana JurДЌoviДЌovГЎ
Zuzana MajerДЌГ­kovГЎ
ДЅubica LackoviДЌovГЎ
Lucia ValentГ­novГЎ
Miroslava HuДЌkovГЎ
Ivica MaЕЎindovГЎ
Iwar KlimeЕЎ
Daniela GaЕЎperГ­kovГЎ
5
6
6
3
6
4
4
4
4
4
4
4
4
1
1
1
1
1
Juraj StanГ­k
Iwar KlimeЕЎ
1
3
SprГЎva o ДЌinnosti organizГЎcie SAV
RT PCR
Tox Con
IARS
FENS
DГЎnsko
FrancГєzsko
ICAC
ED
ECE
ISCHCB
ESHG
Holandsko
Japonsko
MODY
WCBP
Kanada
MaДЏarsko
WCHD
MVS
MB
EFSD
Ion Torrent
Nemecko
PoДѕsko
RakГєsko
CPTA
KPMS
BSS
Ion Tour
Rusko
MC SAfe
ICCVR
Srbsko
FPRST
Е panielsko
EULAR
AMEASD
277
Lucia ValentГ­novГЎ
Dominika BalГЎЕѕiovГЎ
Juraj StanГ­k
Daniela GaЕЎperГ­kovГЎ
Zuzana LeЕЎЕҐanovГЎ
MГЎria FickovГЎ
JГєlius Brtko
Lucia BialЕЎeovГЎ
SoЕ€a ScsukovГЎ
AlЕѕbeta MlynarДЌГ­kovГЎ
Dominika BalГЎЕѕiovГЎ
Boris Mravec
Richard KvetЕ€anskГЅ
3
3
1
3
3
3
3
3
3
3
6
5
5
KatarГ­na LejavovГЎ
Lucia ChovanovГЎ
JГєlius Brtko
TomГЎЕЎ HavrГЎnek
Richard KvetЕ€anskГЅ
Ivica MaЕЎindovГЎ
Lucia ValentГ­novГЎ
Daniela GaЕЎperГ­kovГЎ
Miroslava HuДЌkovГЎ
Juraj StanГ­k
NataЕЎa HlavГЎДЌovГЎ
Daniela JeЕѕovГЎ
Daniela JeЕѕovГЎ
5
4
4
6
5
7
4
4
4
2
9
9
5
Alexander Kiss
Richard KvetЕ€anskГЅ
Barbara UkropcovГЎ
Martina Е kopkovГЎ
Miroslava HuДЌkovГЎ
JГєlius Brtko
Barbara UkropcovГЎ
Е tefan Zorad
KatarГ­na KrЕЎkovГЎ
Miroslav VlДЌek
Lucia BialeЕЎovГЎ
Daniela GaЕЎperГ­kovГЎ
Miroslava HuДЌkovГЎ
Martina Е kopkovГЎ
AlЕѕbeta MlynarДЌГ­kovГЎ
VladimГ­r Е trbГЎk
3
1
2
6
6
4
2
3
3
2
5
1
1
1
5
6
VladimГ­r Е trbГЎk
JГЎn BakoЕЎ
Zuzana BaДЌovГЎ
VladimГ­r Е trbГЎk
AlЕѕbeta MlynarДЌГ­kovГЎ
Lucia ChovanovГЎ
TГ­mea KurdiovГЎ
3
4
4
4
4
5
5
SprГЎva o ДЌinnosti organizГЎcie SAV
Е vajДЌiarsko
IFHN
EUROTOX
Е vГ©dsko
EASD-SGGD
Taliansko
ICI
METS
IRAP
VeДѕkГЎ BritГЎnia
WKNH
ECO
USA
ADGC
KSR
KSD
MBHD
Barbara UkropcovГЎ
Barbara UkropcovГЎ
5
3
Jozef Ukropec
Dana MacejovГЎ
JГєlius Brtko
MГЎria FickovГЎ
AlЕѕbeta MlynarДЌГ­kovГЎ
Iwar KlimeЕЎ
Daniela GaЕЎperГ­kovГЎ
Juraj StanГ­k
Lucia ChovanovГЎ
Miroslav VlДЌek
3
4
4
4
4
3
3
3
5
5
SoЕ€a ScsukovГЎ
Е tefan Zorad
KatarГ­na KrЕЎkovГЎ
Lucia GajdoЕЎechovГЎ
JГЎn BakoЕЎ
Zuzana LeЕЎЕҐanovГЎ
Е tefan ZorГЎd
KatarГ­na KrЕЎkovГЎ
Lucia GajdoЕЎechovГЎ
4
4
4
4
7
7
6
6
6
Jozef Ukropec
Barbara UkropcovГЎ
6
6
Miroslav BalГЎЕѕ
Timea KurdiovГЎ
Robert FarkaЕЎ
MГЎria FickovГЎ
Barbara UkropcovГЎ
Jozef Ukropec
LukГЎЕЎ Varga
Ivica MaЕЎindovГЎ
6
6
8
7
7
7
6
6
Spolu
Vysvetlivky: MAD - medziakademickГ© dohody, KD - kultГєrne dohody, VTS - vedecko-technickГЎ
spoluprГЎca v rГЎmci vlГЎdnych dohГґd
Skratky pouЕѕitГ© v tabuДѕke C:
ДЊNPS
FD
MLPA
DD
RT PCR Tox Con IARS
FENS
ICAC
ED
WCCD Diseases
MODY ADGC
-
55. ДЊesko-slovenskГЎ psychofarmakologickГЎ konferencia
89. FyziologickГ© dni
Analysis troubleshooting workshop
49. DiabetologickГ© dni
kurz Real time PCR
18th Interdisciplinary Czech-Slovak Toxicology Conference
International Atherosclerosis Research School
FENS Featured Regional Meeting 2013International Conference Analytical Cytometry VII
XXXVI. EndokrinologickГ© dni
World Congress on Controversies, Debates and Consensus on Bone Muscles and Joint
Expert meeting on genetic testing for MODY
54 Annual Drosophila Research Conference
278
SprГЎva o ДЌinnosti organizГЎcie SAV
KSR
- 2nd Congress on Steroid Research
KSD
- Keystone Symposia Diabetes- Insights info Mechanism of Disease and its Treatment
MBHD
- 9th molecular Biology of Hearing Deafness Conference
IFHN
Institute of Food Nurition and Health
Eurotox
- Eurotox 2013
CPTA
- 4th Congress of the polish Thyroid Association
ECE
- 15th ECE Copenhagen Denmark 2013
MVS
MedzinГЎrodnГЅ vedeckГЅ seminГЎr pri prГ­l. 80.nar. prof.MUDr.M.Palkovitsa Dr.Sc.
MB
40Years of the microdissection of the Brain
KPMS
5th International Congress on Prediabetes and Metabolic Syndrome
BSS
Bregenz Sommer School on Endocrinology 2013
ION TOUR Ion Torrent TechnolГіgiГ­ 2013
MC SAFE Mutagenesis and Carciogenesis program SafeSciMET
WKNH
10th World Congress on Neurohypophysical hormones
ECO
20th European Congress on Obesity
EFSD
SympГіzium EFSD/lilly Symposium
Ion Torrent Ion DNA Library Prep Essentials a Ion PGM
EASD-SGGD - Fourth Metting of the EASD Study Group on Genetics of Diabetes
ISCHCB
- 17th International Symposium on Chromaffin Cell Biology
ESHG
- European Journal of Human Genetics
EULAR
- The Annual European Congress of Rheumatology EULAR 2013
AMEASD
49th Annual Meeting of the European Association otf the Study of Diabetes
WCBP
- 1th World Congress of Biological Psychiatry
WCHD
- 18th World Congress on Hearth Disease
ICCVR
- 10th International Congress Cell Volume Regulation
ICI
- 15th International Congress of Immunology
METS
- 41th Meeting of the European Teratology society
IRAP
- Conferencia IRAP 2013
FPRST
Frontiers in Physiological research from scientific truth via Friendship to the art
279

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