Turkish Journal of Medical Sciences Turk J Med Sci (2014) 44: 946-954 © TÜBİTAK doi:10.3906/sag-1310-77 http://journals.tubitak.gov.tr/medical/ Research Article Discovering missing heritability and early risk prediction for type 2 diabetes: a new perspective for genome-wide association study analysis with the Nurses’ Health Study and the Health Professionals’ Follow-Up Study 1, 2 3 Hüsamettin GÜL *, Yeşim AYDIN SON , Cengizhan AÇIKEL Department of Medical Informatics, Gülhane Military Medical Academy, Etlik, Ankara, Turkey 2 Department of Health Informatics, Informatics Institute, Middle East Technical University, Ankara, Turkey 3 Department of Biostatistics, Gülhane Military Medical Academy, Etlik, Ankara, Turkey 1 Received: 21.10.2013 Accepted: 03.01.2014 Published Online: 24.10.2014 Printed: 21.11.2014 Background/aim: Despite the rise in type 2 diabetes prevalence worldwide, we do not have a method for early risk prediction. The predictive ability of genetic models has been found to be little or negligible so far. In this study, we aimed to develop a better early risk prediction method for type 2 diabetes. Materials and methods: We used phenotypic and genotypic data from the Nurses’ Health Study and Health Professionals’ Follow-up Study cohorts and analyzed them by using binary logistic regression. Results: Phenotypic variables yielded 70.7% overall correctness and an area under the curve (AUC) of 0.77. With regard to genotype, 798 single nucleotide polymorphisms with P-values of lower than 1.0E-3 yielded 90.0% correctness and an AUC of 0.965. This is the highest score in the literature, even including the scores obtained with phenotypic variables. The additive contributions of phenotype and genotype increased the overall correctness to 92.9% and the AUC to 0.980. Conclusion: Our results showed that genotype could be used to obtain a higher score, which could enable early risk prediction. These findings present new possibilities for genome-wide association study analysis in terms of discovering missing heritability. These results should be confirmed by follow-up studies. Key words: Type 2 diabetes, genome-wide association study, single nucleotide polymorphism, Affymetrix, binary logistic regression, ROC curve 1. Introduction Type 2 diabetes is a complex disease that is characterized by insulin resistance in peripheral tissues and dysfunction in insulin secretion. Type 2 diabetes is a major public health problem, and its prevalence is increasing at an alarming rate worldwide. It has been estimated that 371 million people are already affected by type 2 diabetes, and the number is projected to reach 552 million by 2030 (1). The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors (2,3). Some risk factors, such as diet and obesity, are under personal control; however, genetic factors are not (4). Although the rise in type 2 diabetes prevalence can be mostly attributed to changes in diet and lifestyle, there is strong evidence of a genetic basis for type 2 diabetes (2). However, genetic risk factors have been found to have lower predictive values when compared to phenotype variables such as body *Correspondence: hgul23@gmail.com 946 mass index (BMI), familial diabetes history (FAMDB), high blood pressure (HBP), and cholesterol (CHOL) (5,6). Furthermore, the additive contribution of genetic studies using single nucleotide polymorphisms (SNPs) to phenotype variables was found to be almost negligible in several studies (5–12). Because numerous genetic and nongenetic risk factors interact in the causation of type 2 diabetes, the predictive ability of genetic models will likely remain modest. At present, the clinical use of genetic testing for type 2 diabetes prediction in adults is not recommended (13). Phenotypic risk factors have a higher predictive ability with area under the curve (AUC) values of 0.70–0.90, but these are in middle or later ages when the reversibility of factors is low. Therefore, a model to predict the risk score for type 2 diabetes in the early stages is needed. Additionally, as prediabetic individuals usually remain undiagnosed and GÜL et al. / Turk J Med Sci untreated, identifying new methods using the genotype for the screening and prediction of risk factors is very important. The early prediction of risk factors may help patients to make lifestyle modifications in connection with preventable risk factors, such as obesity (14). Genome-wide association studies (GWASs) have been widely used to investigate the role of the genotype in the development of diseases. Although many studies have been conducted to uncover the heritability of type 2 diabetes, only a small proportion of genetic heritability can be explained by the variants identified. GWASs have shown significant genome-wide associations with type 2 diabetes at 44 susceptibility loci so far (15). The current type 2 diabetes risk variants explain only about 5%–10% of the genetic basis of type 2 diabetes; much of the genetic basis remains unexplained (16,17). Most of these studies used logistic regression for the analysis of genetic variables. However, the maximum number of SNPs used was 42, and C-statistics results (AUC) for the genotype were lower than 0.60 (5–12). In the course of our GWAS analysis of Nurses’ Health Study (NHS) and Health Professionals’ Follow-up Study (HPFS) data, we realized that sensitivity, specificity, and C-statistics increased with the number of SNPs. As we used genotype data for the whole genome instead of a finite number of SNPs, unlike previous studies, a high number of SNPs were included in the analysis. The highest prediction risk scores and AUCs for type 2 diabetes in the literature, even when phenotype studies are included, were achieved in this study using the 798 SNPs selected with P-values of less than 1.0E-3 for the model. Our findings demonstrate the importance of genotype in the prediction of type 2 diabetes, which has been previously disregarded. 2. Materials and methods 2.1. Study population The NHS and HPFS are well-characterized cohorts of nurses and health professionals, conducted in order to identify novel genetic factors that contribute to type 2 diabetes through large-scale, GWASs and to investigate the role of environmental exposure on the development of type 2 diabetes. The NHS and HPFS cohorts are part of the Gene Environment Association Studies initiative (GENEVA, http://www.genevastudy.org). The NHS was established in 1976, and the HPFS study was started in 1986. Participants of the NHS and HPFS completed a mailed questionnaire on their medical history and lifestyle. Blood was collected in 1989–1990 for the NHS and in 1993–1995 for the HPFS. Genotyping was completed in December 2008 for the NHS and in March 2009 for the HPFS. Lifestyle factors, including smoking, menopausal status and postmenopausal hormone therapy, and body weight, have been updated by validated questionnaires every 2 years. Participants meeting the following criteria were excluded from the study: 1) those with other types of diabetes (65 NHS, 68 HPFS); 2) those belonging to races other than white (61 NHS, 100 HPFS); 3) HapMap controls (45 NHS, 29 HPFS); and 4) first-degree relatives (15 NHS, 14 HPFS). The final sample included 3248 (1769 controls and 1479 cases) for the NHS and 2391 (1277 controls and 1114 cases) for the HPFS. The current analysis includes SNPs mapped to chromosomes 1 through 23, as annotated based on the Affymetrix Genome-Wide Human SNP Array 6.0 (GeneChip 6.0). 2.2. Phenotypic variables BMI has been shown to be the most important phenotypic variable in risk prediction of type 2 diabetes. BMI data were continuous in our study, and we converted them to binary using threshold levels that were calculated separately for males and females using the Youden Index (YI = sensitivity + specificity – 1) against the status of diabetes. We found BMI threshold levels of 26.3 kg/m2 for females and 27.1 kg/m2 for males that maximized the YI. Other phenotypic data including FAMDB, CHOL, and HBP were binary. We also analyzed other phenotypic variables. While sex, polyunsaturated fat intake, trans fat intake, and magnesium intake were statistically not important, smoking, activity levels, postmenopausal hormonal status, alcohol, cereal fiber intake, heme iron intake, and glycemic load were found to be significantly related to diabetic status (data not shown). However, since these variables mostly depend on individual declaration, they are subjective. The contribution of these variables to classification and the AUC were negligible; therefore, we excluded them from the analysis for clarity. 2.3. Software Analyses were conducted using PLINK and SPSS 15.0 for Windows. Amelia software was used to fill in missing values, and R was used for graphical presentation of quantile plots and Manhattan plots (www.r-project.org). PLINK version 1.07 was used to analyze genome-wide data (http://pngu.mgh.harvard.edu/~purcell/plink). We merged NHS and HPFS data first. SNPs that met any of the following criteria were excluded from the analysis: 1) minor allele frequencies (MAF) of <0.05; 2) call rate of <95%; 3) P for Hardy–Weinberg equilibrium of <0.001; and 4) missing rates 0.1. After applying the QC filter, 642,576 SNPs remained for the analyses. 2.4. Binary logistic regression We performed binary logistic regression (BLR) using NHS and HPFS genotypic and phenotypic data via SPSS to test the associations of the genotypic and phenotypic risk scores with diabetes. We coded genotypes for common allele homozygotes, heterozygotes, and rare allele 947 GÜL et al. / Turk J Med Sci 3. Results 3.1. The clinical characteristics of the participants The clinical characteristics of the study populations are presented in Table 1. We performed a genome-wide analysis of NHS and HPFS participants. The frequency distribution of the P-value of the SNPs is given in Table 2. The P-values of 886 SNPs were less than 1.0E-03. The distribution of P-values for all SNPs (642,576) versus chromosomal distribution is shown as a Manhattan plot in Figure 1. Chromosomes, P-values, odds ratios, and MAF values of 798 SNPs are provided in the Appendix (on the journal’s website). Quantile–quantile (QQ) plots of P-values of SNPs are given against the expected P-values in Figure 2. We accepted 1.0E-3 as the threshold level to determine which SNPs would be included in the analysis (Figure 2). Initially, 886 SNPs were considered; after a quality check for missing criteria, 798 SNPs were used. 3.2. BLR analysis of phenotype The analysis results of phenotype variables of the NHS and HPFS data sets are presented in Table 2. The summary of BMI is also listed in Table 3 as a continuous variable. As noted in Section 2, BMI was converted to a binary form before BLR analysis. Type 2 diabetes patients had significantly higher BMIs than the controls. BMI was strongly associated with type 2 diabetes; the odds ratio for Table 1. Clinical characteristics of the participants. Data presented as mean ± SD. Type 2 diabetes Control subjects n (male/female) 1114/1479 1277/1769 Age (years) 57.42 ± 7.72 57.12 ± 7.66 Female 29.91 ± 5.76 25.39 ± 4.83 Male 27.89 ± 4.14 25.21 ± 2.82 BMI (kg/m2) 948 Table 2. P-value distribution of SNPs (before filtering of missing alleles, see Section 2). P-value Cumulative frequency Frequency <1.0E-11 1 1 1.0E-10 6 5 1.0E-09 6 0 1.0E-08 6 0 1.0E-07 10 4 1.0E-06 29 19 1.0E-05 132 103 1.0E-04 886 754 BMI was 3.86. Other important phenotypes were FAMDB, HBP, and CHOL. Their P-values and odds ratios are also given in Table 4. The combined effect of these 4 phenotype variables yielded an overall classification of 70.7% and an AUC of 0.77. We also compared rs10739592, which had the lowest P-value in GWAS analysis, with phenotypic variables. It should be noted that rs10739592 alone (OR: 1.34, P-value: 2.08E-14) increased the overall prediction by only 2.84%. The composite effect of phenotypic variables was less than the sum of the individual effects of each variable alone due to the effect of overlap. We were able to predict individual risk scores using the following formula with constants obtained from logistic regression analyses of familial diabetes history, high blood pressure, cholesterol, and BMI. 14 12 10 –log10 (ρ) homozygotes separately for analysis. We evaluated model discrimination by using C-statistics (areas under receiver operating characteristic curves, ROC-AUCs), which were calculated for the predicted risk of the logistic regression model. We used SNPs with P-values of less than 1.0E-3. There were 886 SNPs with P-values below this level. However, we excluded SNPs if the missing allele number was greater than 50 (patients), except for rs10739592, since it had the lowest P-value (2.08E-14). It had 99 missing alleles. To fill in the missing alleles, we used the Amelia toolbox for imputation (18). The result of the imputation was validated by comparing ‘before’ and ‘after’ P-values of SNPs and observing the relative distribution density of the original data set and the imputed data set. 8 6 4 2 0 1 2 3 4 5 6 8 10 12 Chromosome 14 17 21 Figure 1. Manhattan plot of the point-wise P-values for the 642,576 SNP loci of the NHS and HPFS data sets. GÜL et al. / Turk J Med Sci 14 12 Observed –log10 (ρ) 10 8 6 4 2 0 0 1 2 3 4 Expected –log10 (ρ) 5 6 Figure 2. Quantile-quantile plots of SNP P-values in (NHS+HPFS) GWAS analysis. The x-axis is –log10 of the expected P-values and the y-axis is –log10 of the observed P-values. Detaching point from the expected –log10 is nearly 1.0E-3. P= exp(-1,579+famdb+1,132+hbp×0,862+chol×0,556+BMI×1,351 1+exp(-1,579+famdb+1,132+hbp×0,862+chol×0,556+BMI×1,351 The C-statistics (AUC) value for the 4 phenotype variables was found to be 0.77 ± 0.003. 3.3. BLR analysis of genotype Because the number of SNPs (798) is high and is unusual for BLR, as reported in the literature, we used a different approach to evaluate the effect of genotype on prediction scores and AUC. First, we grouped SNPs according to their P-values. Three groups of SNPs with P-values of less than 1.0E-4 yielded a maximum prediction score of 67.4% and an AUC of 0.735; 680 SNPs with P-values between 1.0E04 and 1.0E-03 yielded a prediction score of 87.7% and an AUC of 0.947. When we used an incremental approach, the first 3 groups containing 118 SNPs with P-values of less than 1.0E-4 yielded prediction scores that were lower than that of the fourth group (Table 5). This showed that more SNPs should be included for higher prediction rates and explained why previous studies in the literature that used a maximum of 40 SNPs obtained lower predictive values. In addition, we tested how various threshold levels in BLR analysis affected the prediction score and AUC (Table 6). The threshold level was chosen to be 0.5 by default in BLR analysis. When the threshold level increases, negative predictive value increases, positive predictive value decreases, and AUC does not change (Table 6). We also investigated the additive contribution of phenotypes to the model built from genotyping data. The addition of 4 phenotypes (BMI, FAMDB, CHOL, and HBP) increased the prediction score from 90.0% to 92.9% and the AUC from 0.965 to 0.980 (Figure 3). In addition, we found important differences between females and males in SNPs corresponding to the transcription factor-7–like 2 (TCF7L2) gene (Table 7). We found that the TCF7L2 gene was more determinative in males than in females. Although the TCF7L2 gene is one of the most significant genetic marker associated with type 2 diabetes mellitus risk (19), there is no information in the literature about the relationship between the TCF7L2 gene and sex. This finding is important when interpreting literature on interethnic differences that do not mention sex. 4. Discussion Development of genotype-based prediction will help us in the early prediction, identification, and prevention of type 2 diabetes. We showed that genotype-based predictions for type 2 diabetes yielded as high a score as phenotype-based methods. We obtained 90.0% prediction correctness, and the AUC was 0.965 with only genotype (SNP) variables. According to our knowledge, this is the highest score reported in the literature for risk prediction of type 2 diabetes. GWAS has facilitated the understanding of the genetic basis of complex traits; it is a powerful method for the detection of genetic variations that predispose individuals Table 3. Body mass index values of males and females in the control and diabetic groups. Data presented as mean ± SD. Male n Female n Average n Control 25.21 ± 2.82 1277 25.39 ± 4.83 1769 25.31 ± 4.11 3046 Diabetes 27.89 ± 4.14a 1114 29.91 ± 5.76b 1479 29.04 ± 5.22c 2593 Average 26.45 ± 3.74 2391 27.44 ± 5.73 3248 27.03 ± 5.01 5639 Independent sample t-test, 3.72E-115. Independent sample t-test, 1.52E-68. c Independent sample t-test, 1.85E-174. a b 949 GÜL et al. / Turk J Med Sci Table 4. P-value, odds ratio, net reclassification improvement (NRI) percentage, overall prediction percentage, and AUC of phenotypic variables (n/a, not applicable). Phenotype P-value Odds ratio NRI % Overall prediction % AUC Baseline n/a n/a n/a 54 n/a Body mass index 5.21E-108 3.86 13.99 68.0 0.68a Familial diabetes history 4.32E-69 3.10 9.70 63.7 0.63b High blood pressure 3.25E-39 2.37 9.68 63.7 0.62b Cholesterol 7.76E-15 1.74 4.40 58.4 0.56 Four phenotypes (BMI+FAMDB+HBP+CHOL) 1.56E-187 n/a 16.70 70.7 0.77c rs10739592 2.08E-14 1.34 2.84 56.9 0.55 P < 0.001, significantly higher than other groups except BMI+FAMDB+HBP+CHOL. P < 0.001, significantly higher than cholesterol and rs10739592. c P < 0.001, significantly higher than others. BMI: Body mass index, FAMDB: familial diabetes history, HBP: high blood pressure, CHOL: cholesterol. a b Table 5. Additive binary logistic regression analysis of SNPs grouped according to their P-values obtained in GWAS analysis. NPV: Negative predictive value, PPV: positive predictive value, AUC: area under curve. SNP groups according to their P-values Number of SNPs (n) NPV (percentage correct for control) PPV (percentage correct for diabetes) Overall % AUC <1.0E-06 10 75.0 38.7 58.3 0.602 <1.0E-05 27 (10+17) 72.8 45.3 60.2 0.636 <1.0E-04 118 (91+27) 74.3 59.3 67.4 0.735 <1.0E-03 798 (680+118) 90.7 89.1 90.0 0.965 Table 6. Effects of cut-off value on classification correctness and AUC. ROC cutoff value SNPs (n) NPV PPV Overall % AUC 0.5 798 90.7 89.1 90.0 0.965 ± 0.002 0.6 798 94.0 83.7 89.3 0.965 ± 0.002 0.7 798 96.8 76.8 87.6 0.965 ± 0.002 0.8 798 98.4 67.5 84.2 0.965 ± 0.002 0.9 798 99.3 52.6 77.8 0.965 ± 0.002 NPV: Negative predictive value, PPV: positive predictive value, AUC: area under curve. to complex chronic diseases. GWAS has provided many useful insights into the pathophysiology of type 2 diabetes by enabling the identification of novel susceptibility loci that were not identified by classical approaches. However, for most of the identified type 2 diabetes susceptibility loci, the causal variants and molecular mechanisms for diabetes risk are unknown. Our findings do not reject the importance 950 of susceptibility loci for causal variants, but rather provide more accurate risk prediction. It is also important to remember that the effect sizes found for SNPs thus far are not a reflection of their biological or clinical significance. Although their individual predictive values may be small, SNPs as a profile might point to important biological pathways that could be targeted for therapeutic intervention. GÜL et al. / Turk J Med Sci Table 7. SNPs corresponding to the TCF7L2 gene in our GWAS analysis. The P-values of some SNPs differ between males and females. ROC Curve 1.0 Sensitivity 0.8 SNP 0.6 0.4 Phenotype Genotype 0.2 Genotype+ Phenotype 0.0 0.0 0.2 0.4 0.6 Specificity 0.8 1.0 Figure 3. ROC plot for the BLR model containing type 2 diabetes and 4 phenotype variants, body mass index, familial diabetes history, high blood pressure, and cholesterol (black line, AUC = 0.77), for the 798 SNP variants (red line, AUC = 0.965) and genotype plus phenotype (blue line, AUC = 0.980). Fortunately, the incidence of type 2 diabetes can be delayed or prevented by maintaining healthy lifestyle behaviors (14). The early identification of population subgroups that are at particularly high risk for type 2 diabetes might facilitate the targeting of prevention efforts to those who might benefit from them the most. Until these findings, genetic associations have not appeared to improve type 2 diabetes risk prediction, which has already been achieved through clinical risk predictors alone. In the time since the first GWAS data were published in 2007 by the Wellcome Trust Case Control Consortium (20), significant progress has been made and much information has been obtained from GWASs. However, GWAS-based studies to improve clinical decisions are still in their initial stages (21). Previous studies have focused mostly on causative loci rather than the entire risk prediction approach. In addition, the results of risk prediction models are not satisfactory for type 2 diabetes. Nearly 40 susceptible loci have been identified in European and Asian populations, but the heritability of type 2 diabetes remains largely unexplained (22). Only ~10% of the known type 2 diabetes heritability could be explained by the results of a European twin study (23). This evidence suggests that information on a large portion of heritability is missing. Since a statistical P-value of 5 × 10–8 is generally accepted for genome-wide significance (24), previous studies did not use SNPs that had P-values P-value General NHS (Female) HPFS (Male) rs12255372 4.37E-10 9.72E-05 5.52E-07 rs12243326 6.12E-10 1.80E-04 3.47E-07 rs4132670 6.53E-10 2.56E-04 1.94E-07 rs7901695 8.18E-10 1.53E-04 5.83E-07 rs4506565 9.48E-10 1.67E-04 5.92E-07 rs11196208 2.40E-05 3.67E-03 2.08E-03 rs10885409 2.71E-05 5.33E-03 1.50E-03 rs11196205 3.49E-05 5.59E-03 1.91E-03 rs4074720 1.30E-04 1.22E-02 3.29E-03 rs7077039 1.35E-04 1.50E-02 2.77E-03 rs10787472 1.38E-04 1.36E-02 3.09E-03 rs6585201 3.96E-04 3.57E-02 2.95E-03 rs4073288 3.88E-03 >0.05 1.40E-02 rs7901275 4.71E-03 >0.05 2.25E-03 rs11196212 7.30E-03 4.39E-02 >0.05 rs7917983 7.76E-03 >0.05 2.62E-03 rs11196181 2.67E-02 >0.05 >0.05 rs12266632 3.28E-02 4.17E-02 >0.05 rs11196203 3.39E-02 >0.05 1.64E-02 greater than this. Several limitations of the current approach for GWASs in revealing the missing heritability information have been proposed. One limitation is that the accepted importance threshold level for GWASs (P < 5 × 10–8) may produce type 2 errors (false-negative results). Therefore, many important loci could be obscured among other loci having only borderline associations. In addition, Imamura et al. suggested that the other reason for the low percentage of genetic contribution might be the omission of susceptibility variants that have an MAF value of less than 1% (22). However, our findings do not agree with these suggestions. In this study, we used SNPs that had P-values of greater than 5 × 10–8, accepted 5% as the threshold for MAF, and thereby obtained a higher risk prediction score. The most important reason for the low genetic contribution reported so far is that the use of a small number of SNPs for analysis fails to yield a sufficient composite risk score. We proposed that SNPs that have P-values of less than the detaching point of a distribution (in QQ plot), 1.0E-3 in our study, could contribute to risk prediction. Furthermore, Imamura et al. (22) suggested 951 GÜL et al. / Turk J Med Sci that genome-wide exon (exome) sequencing by nextgeneration sequencers might help explain the missing heritability. Our findings suggest that this might not be necessary in order to obtain a high risk-prediction score. However, next-generation sequencing technology may help find the exact causative loci near or encompassing the newly discovered SNPs. Because individual SNPs do not yield adequate prediction scores, combining SNPs to yield composite genotype risk scores has also been tested. In such a simulation study by Janssens et al., risk alleles were weighted according to the type 2 diabetes effect size from the original GWAS; this might not substantially improve the C-statistic for alleles with small effect sizes (odds ratio: 1.10–1.25) (25). However, we found that 680 SNPs with P-values between 1.0E-04 and 1.0E-03 yielded an overall prediction score of 87.7% and AUC of 0.947, while 118 SNPs, with P-values of less than 1.0E-04, yielded an overall prediction score of 67.4% and AUC of 0.735. This shows that a high SNP number is required for higher composite genotype risk scores. However, Janssens et al. used only 40 SNPs. The composite risk score is not equal to the sum of individual SNP scores. Due to the overlapping effect of the risk alleles, we could obtain a higher composite risk score with a higher number of SNPs. However, phenotype risk scores are higher than those of individual SNP scores, i.e. OR is 3.86 for BMI in our study. Thus, small phenotype variables could yield higher scores. The prediction of an individual’s risk of developing type 2 diabetes is the most anticipated clinical use of genetic information. Prediction values of phenotypic and genotypic characters have been investigated in the Malmö Preventive Project, the Botnia Study (8), the Framingham Offspring Study I (9), the Whitehall II study (10), and the GoDARTS Study (26). These studies examined loci ranging in number from 11 to 20 that were associated with type 2 diabetes. The results of these analyses showed no clear improvement in predictive power when adding the genetic risk score to the established risk prediction models by using phenotypic variables such as age, sex, family history, BMI, fasting glucose level, systolic blood pressure, and lipid profile. Basic demographic, clinical, and laboratory predictors have C-statistics (AUC) ranging from 0.66 in the Rotterdam Study (11) to 0.90 in the Framingham Offspring Study I (9). The C-statistic improves from 0.903 to 0.906 with the addition of a 40-SNP score to the clinical model in the Framingham Offspring Study II (7) and from 0.74 to 0.75 in the larger Malmö Preventive Project (8). In other studies, adding genetic information to phenotypebased risk models did not improve discrimination and showed a maximum increase of only 2% over phenotype in ROC curves (6,10,26). AUC values were equal to or lower than 0.60 for genetic variants alone in these studies 952 (9–11,26). Therefore, phenotype scores were found to be superior to the scores achieved thus far by using genotype alone. Genotype-based risk prediction may work better in younger individuals. In the Framingham Offspring II study, the addition of a 40-SNP score to a full clinical model achieved better net reclassification improvement (NRI) among those younger than 50 years old (7). However, the degree of prediction scores obtained from genotype is still below the widely accepted clinical prevention target. The greater contribution of genotype over the prediction value of phenotype for patients at a younger age is expected since phenotype variables are more overt only at middle age or older. The most desirable risk prediction method is one with a higher prediction value at an early age, even in childhood. Therefore, our findings provide an opportunity for risk prediction of type 2 diabetes with high accuracy at an early stage. A limitation on the use of phenotypic variables is the reduced range of ages and follow-up durations for type 2 diabetes genetic prediction. In previous studies, participants with baseline ages were generally in middle adulthood, and the follow-up period was around 10 years. However, we need a model that can estimate the risk earlier, which should be validated at a young age with a longer prediction time horizon to help achieve early prevention. As noted above, in the Framingham Offspring Study II, the 40-SNP genotype risk score significantly improved NRI in younger participants but not in older ones. Here, we show that genetic risk prediction alone using 798 SNPs could yield higher risk prediction for type 2 diabetes. Due to the low predictive value of the genetic susceptibility loci of type 2 diabetes so far, alternative GWAS strategies, such as enrichment of genetic effects for improving predictive power (i.e. selecting more severe cases, early onset of disease, and family history of type 2 diabetes), and original GWAS study designs (such as response to an antidiabetic treatment or type 2 diabetes in the presence of extreme obesity) (15,27) have been proposed. Complementary epigenomic approaches such as DNA methylation studies have also been proposed in addition to GWAS (27). However, our strategy of using more SNPs may provide greater risk prediction for type 2 diabetes; therefore, the need for a sophisticated approach to risk prediction could be reviewed. Our approach might be combined with epigenomic, environmental, or other enrichment methods for further insight into type 2 diabetes etiology. In the future, follow-up studies with a reasonable time period should be designed to evaluate the development of type 2 diabetes using the genotype-based risk prediction value from our study. We were able to calculate individual risk scores using the constants of the present GÜL et al. / Turk J Med Sci study obtained through analysis. Our findings should be validated by comparing the cumulative type 2 diabetes incidence in low- and high-risk groups in a follow-up study. In addition, interethnic differences should be reviewed from the perspective of our results, since some GWAS studies did not mention the sex of the participants (28,29). Furthermore, our prediction strategy could also be tested for treatment success of type 2 diabetes by establishing a pharmacogenetic investigation of a genomewide approach. In a previous study, it was found that a SNP, rs11212617, at a locus containing the ataxia telangiectasia mutated gene could explain 2.5% of the variance in the metformin response (30). Variance greater than this can probably be explained using the composite SNP score approach. Translation of the findings of the present study will provide a gateway into personalized preventive and therapeutic medicine. In conclusion, we found that genotype-based risk prediction could yield higher risk prediction values when a sufficient number of SNPs are used. This could enable early risk prediction for type 2 diabetes. 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Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343–1350. 15. Wheeler E, Barroso I. Genome-wide association studies and type 2 diabetes. Briefings in Functional Genomics 2011; 10: 52–60. 16. Florez JC. The genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab 2008; 93: 4633–4642. 17. Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci 2010; 1212: 59–77. 8. Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, Berglund G, Altshuler D, Nilsson P, Groop L. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008; 359: 2220–2232. 18. Blankers M, Koeter MW, Schippers GM. Missing data approaches in eHealth research: simulation study and a tutorial for nonmathematically inclined researchers. J Med Internet Res 2010; 12: e54. 9. Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PW, D’Agostino RB Sr et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008; 359: 2208– 2219. 19. Tong Y, Lin Y, Zhang Y, Yang J, Zhang Y, Liu H, Zhang B. Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis. BMC Med Genet 2009; 10: 15. 953 GÜL et al. / Turk J Med Sci 20. Wellcome Trust Case Control C. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661–678. 21. Lander ES. Initial impact of the sequencing of the human genome. Nature 2011; 470: 187–197. 22. Imamura M, Maeda S. Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]. Endocr J 2011; 58: 723– 739. 23. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010; 42: 579–589. 24. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008; 9: 356–369. 25. Janssens AC, Moonesinghe R, Yang Q, Steyerberg EW, van Duijn CM, Khoury MJ. The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med 2007; 9: 528–535. 26. Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008; 57: 3129–3135. 954 27. Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I et al. Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One 2010; 5: e14040. 28. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316: 1336–1341. 29. Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 2010; 42: 864–868. 30. GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group; Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet 2011; 43: 117–120. 0,8541 rs6696927 rs1562217 rs6656912 29 30 31 rs6697088 rs10889634 27 28 rs7537440 rs1373909 25 rs12142962 24 26 rs699253 rs12739235 22 23 rs11584807 rs783323 20 21 rs1587578 rs11579242 18 19 rs12131641 rs12118788 16 17 rs215792 rs215791 14 rs215773 13 15 rs6704040 rs215770 11 12 rs1546263 rs6701048 9 10 0,8585 rs7529705 rs10492998 7 8 1,154 0,8658 0,8682 0,8703 0,8708 0,8595 1,142 1,142 1,247 1,232 0,8535 0,8723 0,8304 0,8546 0,8518 0,82 0,8424 0,8776 0,8748 0,8676 1,165 1,294 1,237 1,139 0,8611 rs149562 rs6660946 1,225 5 rs11580525 4 0,7559 0,7922 0,8513 OR 6 rs11121467 rs2336381 2 rs4654582 1 3 rsid # 2,15E-04 2,24E-04 2,89E-04 3,05E-04 8,66E-05 5,08E-04 5,02E-04 1,53E-04 3,14E-04 2,96E-05 3,10E-04 1,28E-04 9,45E-04 2,23E-04 3,08E-05 2,90E-04 8,13E-04 6,10E-04 2,84E-04 3,04E-04 7,84E-04 7,70E-04 8,28E-04 8,99E-04 8,30E-04 7,63E-04 8,72E-04 5,35E-04 9,28E-04 2,34E-04 5,28E-04 P value 0,405 0,414 0,414 0,414 0,404 0,426 0,426 0,118 0,119 0,476 0,468 0,187 0,197 0,254 0,198 0,198 0,375 0,376 0,369 0,268 0,065 0,097 0,207 0,219 0,380 0,239 0,259 0,114 0,055 0,105 0,213 MAF 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 CHR 66856259 66846154 66842969 66838499 66817312 66813463 66804495 66730690 66728087 66713736 66713368 47993041 47987966 37401328 37398350 37384100 37378878 37378028 37368827 37358560 30417261 29676041 19646020 19645434 19592679 18606142 16667788 14119518 11931611 9620920 4630143 BP T T T G C G G A C A A T G C T A C C T A C G A T A G T C G A T A1 Appendix. Chromosomes, P-values, odds ratios, and MAF values of 798 SNPs. C C C A G A T G T G G C A A C G T T G C T C G C G A C T A T A A2 84251 84251 84251 84251 84251 84251 84251 832 832 832 114819 5351 55966 EntrezGene SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 CAPZB CAPZB CAPZB CROCCP3 PLOD1 AJAP1 Gene Symbol SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 capping protein (actin filament) muscle Z-line, beta capping protein (actin filament) muscle Z-line, beta capping protein (actin filament) muscle Z-line, beta ciliary rootlet coiled-coil, rootletin pseudogene 3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 adherens junctions associated protein 1 Gene Name GÜL et al. / Turk J Med Sci 1 2 rs7539680 rs10753046 rs6425178 rs3919967 rs10753049 60 61 62 63 64 rs12133943 rs1208517 58 59 rs1543594 rs11579824 56 57 rs2761441 rs1942216 54 55 rs1415359 rs10493988 52 53 rs2616010 rs7550118 50 51 rs3767273 rs12046389 48 49 rs3789442 rs2220760 46 47 rs2143992 rs3789439 44 45 rs1780731 rs1434431 42 43 rs10789215 rs344935 40 41 rs7542924 rs4655506 38 39 rs6588215 rs4655650 36 37 rs6681460 rs6694782 34 35 rs4655648 rs9662943 32 33 1,248 1,252 1,248 1,25 1,232 0,8426 1,236 0,8034 0,8413 0,8648 0,8785 1,141 1,139 1,141 1,148 1,147 1,149 1,138 0,8538 0,8588 1,141 1,139 1,15 0,8661 0,8755 0,8717 0,8699 0,8726 0,8694 1,135 0,8745 0,8762 0,8718 Appendix. (Continued). 3,51E-04 1,12E-05 1,28E-05 1,18E-05 8,65E-05 2,53E-04 9,76E-04 4,74E-04 5,29E-06 2,22E-04 7,95E-04 6,23E-04 8,36E-04 9,58E-04 8,33E-04 3,74E-04 3,45E-04 2,96E-04 9,66E-04 4,95E-04 8,37E-04 5,19E-04 5,85E-04 9,22E-04 4,06E-04 5,22E-04 3,60E-04 2,78E-04 4,00E-04 2,56E-04 8,31E-04 4,57E-04 5,82E-04 0,415 0,165 0,161 0,164 0,124 0,123 0,155 0,106 0,190 0,204 0,262 0,493 0,356 0,359 0,357 0,413 0,416 0,417 0,372 0,222 0,220 0,437 0,477 0,274 0,321 0,413 0,422 0,414 0,415 0,414 0,457 0,415 0,407 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 66886897 186639485 186638225 186632905 186631148 186584179 183539106 145561705 145469224 115845877 115721322 110538385 103338744 103337029 103335690 103181905 103181688 103173621 94977931 94354044 94352014 94109636 87960918 79108612 67910451 66923773 66923399 66915643 66914874 66914537 66899350 66895645 66893720 C A A C G G T G C A A G G C T C A G A C C C A C G T G G T A G A C T G C G C C C C T C C A A T C T C C G G T T G T A C A A C G A G T 84251 10625 607 388662 1301 1301 1301 1301 1301 1301 24 24 30836 84251 84251 84251 84251 84251 84251 84251 84251 SGIP1 IVNS1ABP BCL9 SLC6A17 COL11A1 COL11A1 COL11A1 COL11A1 COL11A1 COL11A1 ABCA4 ABCA4 DNTTIP2 SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 influenza virus NS1A binding protein B-cell CLL/lymphoma 9 solute carrier family 6, member 17 collagen, type XI, alpha 1 collagen, type XI, alpha 1 collagen, type XI, alpha 1 collagen, type XI, alpha 1 collagen, type XI, alpha 1 collagen, type XI, alpha 1 ATP-binding cassette, sub-family A (ABC1), member 4 ATP-binding cassette, sub-family A (ABC1), member 4 deoxynucleotidyltransferase, terminal, interacting protein 2 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 SH3-domain GRB2-like (endophilin) interacting protein 1 GÜL et al. / Turk J Med Sci rs11096680 rs3796064 rs10166174 rs17803553 rs12613835 93 94 95 96 97 rs930760 rs4666438 91 92 rs11897611 rs4666430 89 90 rs3893111 rs1550105 87 88 rs2362255 rs7520116 85 86 rs2378607 rs6429366 83 84 rs17465637 rs1053316 81 82 rs2133189 rs17163358 79 80 rs2820444 rs3002142 77 78 rs2250509 rs340835 75 76 rs1119030 rs4950949 73 74 rs4428892 rs10922227 71 72 rs4313401 rs11800563 69 70 rs1565272 rs172235 67 68 rs7516670 rs6667131 65 66 0,874 0,8743 0,8685 1,16 1,15 1,156 0,8558 0,8301 0,836 0,8791 0,8655 0,8719 0,81 0,8731 0,8567 0,8119 0,8632 0,8592 0,8579 0,8268 0,8653 1,138 0,8247 0,8767 0,8829 0,882 0,8806 0,8811 1,136 1,171 1,234 1,25 1,242 Appendix. (Continued). 1,78E-05 6,66E-04 6,86E-04 3,97E-04 5,39E-04 9,87E-04 7,02E-04 8,79E-05 2,33E-04 6,05E-04 7,11E-04 4,40E-04 7,19E-04 3,66E-04 3,87E-04 1,50E-04 4,82E-04 5,02E-04 3,42E-04 2,78E-04 8,38E-04 6,80E-04 6,34E-04 7,20E-04 8,67E-04 9,94E-04 8,96E-04 7,86E-04 8,25E-04 7,69E-04 1,22E-04 4,24E-05 1,04E-05 0,164 0,356 0,356 0,349 0,260 0,270 0,264 0,355 0,173 0,161 0,444 0,302 0,329 0,126 0,426 0,315 0,117 0,281 0,284 0,283 0,129 0,276 0,473 0,129 0,372 0,485 0,486 0,495 0,496 0,499 0,296 0,165 0,164 1 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 186642303 25682705 25678607 20702484 20701799 20675712 20674067 20669817 20641940 20638798 20613584 8692795 244271398 244130482 240833628 220986518 220906461 220890152 220887262 220881065 220854685 217808443 212230298 201405593 201077185 187787822 187787128 187719770 187698667 187650996 186726999 186649670 186649073 T A T A A A A C G C T G G G T T A A G C C A A A C A A T G A C A T C G C G G T G T A T C A C A C G G C A T T G G G T G G A C G A G A 1838 1838 64342 64342 64754 64754 400823 375056 375056 375056 375056 5629 4608 DTNB DTNB HS1BP3 HS1BP3 SMYD3 SMYD3 FAM177B MIA3 MIA3 MIA3 MIA3 PROX1 MYBPH dystrobrevin, beta dystrobrevin, beta HCLS1 binding protein 3 HCLS1 binding protein 3 SET and MYND domain containing 3 SET and MYND domain containing 3 family with sequence similarity 177, member B melanoma inhibitory activity family, member 3 melanoma inhibitory activity family, member 3 melanoma inhibitory activity family, member 3 melanoma inhibitory activity family, member 3 prospero homeobox 1 myosin binding protein H GÜL et al. / Turk J Med Sci 3 4 rs4954045 rs17786300 rs1355421 rs1355420 127 129 130 rs17575791 126 128 rs6705790 rs17010780 124 125 rs17715688 rs17715867 122 123 rs2118836 rs11123406 120 121 rs1159764 rs10221769 118 119 rs12470994 rs1159766 116 117 rs359274 rs17662176 114 115 rs4672367 rs17329726 112 113 rs1446441 rs7575107 110 111 rs17043120 rs1843032 108 109 rs6720390 rs13430296 106 107 rs2552356 rs12622811 104 105 rs17730780 rs6545274 102 103 rs3821153 rs2727880 100 101 rs7562790 rs2160367 98 99 0,7953 0,7852 1,189 0,8795 0,8652 0,8116 1,175 0,7716 0,8029 1,147 1,165 1,158 1,15 1,151 1,288 0,7373 1,175 1,23 0,8309 1,228 0,828 1,138 0,8574 0,8517 1,139 0,8602 0,8732 0,8526 0,8557 1,141 1,139 1,148 1,146 Appendix. (Continued). 3,94E-04 1,12E-04 4,95E-05 9,41E-04 9,06E-04 6,66E-04 4,87E-04 5,21E-04 2,45E-04 2,28E-04 4,66E-04 2,46E-04 5,05E-04 9,47E-04 8,91E-04 3,02E-04 1,65E-04 9,55E-04 2,03E-04 2,06E-04 1,94E-04 2,42E-04 8,27E-04 1,70E-04 8,30E-05 6,06E-04 2,44E-04 3,56E-04 3,46E-04 4,53E-04 5,83E-04 6,86E-04 3,09E-04 0,399 0,119 0,118 0,149 0,390 0,283 0,113 0,213 0,078 0,113 0,365 0,292 0,276 0,273 0,273 0,082 0,059 0,178 0,129 0,176 0,133 0,170 0,396 0,313 0,313 0,467 0,303 0,459 0,233 0,236 0,429 0,417 0,429 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 36527059 160621517 160621464 140253872 133695340 129802415 124531274 121609358 115096853 115089550 111667012 96526699 72332562 72317874 72317749 67528010 64950508 60360385 60338590 60251920 55159490 53155170 52694816 52679905 52672168 52654578 52641453 52508248 52497718 52416883 52408156 36606626 36535123 G T A C A T G T C G T C T A T A G C A T G T A G G C T G C G C G G T C G A C C T A A T C T A T C C C G G C T C G A C T C A T A T T C 51232 22925 22925 344148 129684 57628 57628 23233 23233 23233 51232 51232 CRIM1 PLA2R1 PLA2R1 NCKAP5 CNTNAP5 DPP10 DPP10 EXOC6B EXOC6B EXOC6B CRIM1 CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) phospholipase A2 receptor 1, 180kDa phospholipase A2 receptor 1, 180kDa NCK-associated protein 5 contactin associated protein-like 5 dipeptidyl-peptidase 10 (non-functional) dipeptidyl-peptidase 10 (non-functional) exocyst complex component 6B exocyst complex component 6B exocyst complex component 6B cysteine rich transmembrane BMP regulator 1 (chordin-like) cysteine rich transmembrane BMP regulator 1 (chordin-like) GÜL et al. / Turk J Med Sci rs4664323 rs13009374 rs6742799 rs6752569 rs13390172 159 160 161 162 163 rs12998587 rs7587102 157 158 rs11693602 rs10929982 155 156 rs9287795 rs6718526 153 154 rs10165319 rs4538150 151 152 rs4386280 rs4664013 149 150 rs7593730 rs4589705 147 148 rs9917155 rs4077463 145 146 rs12692590 rs12692592 143 144 rs1020731 rs1020732 141 142 rs12692588 rs7572970 139 140 rs2925757 rs13023477 137 138 rs12692585 rs10181181 135 136 rs7573469 rs3111397 133 134 rs4665146 rs16844742 131 132 1,169 1,15 0,8377 0,8469 0,8711 0,8384 0,8344 0,8021 0,8048 0,7817 0,8055 0,8508 0,8585 0,8334 0,8605 0,806 0,8053 0,807 0,8574 0,8126 0,8606 0,8552 0,8064 0,8261 0,8511 1,176 0,7906 0,809 1,163 0,8201 0,7916 0,7949 0,8047 Appendix. (Continued). 5,34E-05 1,69E-04 4,89E-04 2,39E-04 5,84E-05 3,11E-04 1,99E-05 1,19E-05 4,55E-06 2,29E-06 2,74E-07 2,66E-06 2,18E-05 1,41E-04 6,49E-06 7,99E-05 2,75E-06 2,55E-06 3,16E-06 5,20E-05 5,95E-06 9,21E-05 4,42E-05 2,45E-07 5,97E-06 2,43E-05 8,11E-04 1,71E-06 4,03E-07 4,91E-04 2,58E-05 1,27E-05 1,94E-05 0,147 0,287 0,327 0,198 0,305 0,428 0,306 0,307 0,195 0,219 0,197 0,218 0,451 0,337 0,331 0,449 0,219 0,218 0,218 0,454 0,221 0,419 0,422 0,293 0,281 0,435 0,193 0,183 0,290 0,254 0,204 0,149 0,148 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 160624329 161233847 161182219 161025706 160973345 160967931 160967528 160950541 160944523 160932904 160922421 160918034 160917573 160901051 160892410 160891041 160884382 160879700 160874480 160871805 160871627 160861443 160852485 160852301 160844902 160832428 160820133 160809415 160795657 160789087 160759609 160653973 160639530 A C C C C C T T C C T C G T G A T T A C G C G G A C T G T G C G T C T T A A T C C T T C G A C C G A C G A T G A A G T C A C A T A A 22925 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 5937 3694 PLA2R1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 RBMS1 ITGB6 phospholipase A2 receptor 1, 180kDa RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 RNA binding motif, single stranded interacting protein 1 integrin, beta 6 GÜL et al. / Turk J Med Sci 5 6 rs969494 rs970816 rs7595029 rs4663596 193 195 196 rs10933000 192 194 rs4673054 rs2203733 190 191 rs16840004 rs7585736 188 189 rs1075041 rs2663891 186 187 rs10198084 rs6435252 184 185 rs4675425 rs7583852 182 183 rs4241279 rs6739080 180 181 rs13010985 rs719736 178 179 rs1526212 rs10497643 176 177 rs2369202 rs12232884 174 175 rs10176147 rs826186 172 173 rs10190741 rs12477346 170 171 rs1402108 rs12185628 168 169 rs4368343 rs16851382 166 167 rs12473293 rs4383351 164 165 1,203 1,218 0,8605 0,8637 0,8657 0,8618 0,8649 1,17 1,298 1,267 1,22 1,229 0,8448 0,8505 0,8212 1,216 1,236 1,137 1,15 1,137 1,135 1,135 1,134 0,8776 1,138 0,8777 0,8765 1,207 0,8632 1,21 1,198 1,172 1,18 Appendix. (Continued). 6,70E-05 2,29E-04 7,62E-05 7,28E-05 1,07E-04 1,37E-04 8,41E-05 1,25E-04 7,85E-04 8,31E-04 9,40E-04 7,58E-04 4,89E-04 4,67E-05 4,74E-04 6,52E-04 8,61E-04 3,06E-04 7,00E-04 2,49E-04 6,98E-04 8,54E-04 8,70E-04 9,11E-04 7,66E-04 6,24E-04 6,60E-04 5,27E-04 4,01E-05 6,78E-04 1,55E-04 4,39E-06 1,35E-04 0,287 0,167 0,168 0,481 0,484 0,488 0,484 0,487 0,213 0,064 0,078 0,119 0,116 0,297 0,214 0,124 0,119 0,117 0,487 0,458 0,462 0,460 0,454 0,468 0,397 0,466 0,444 0,443 0,219 0,257 0,169 0,353 0,286 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 161237591 236065943 236056702 223805584 223803302 223801654 223801345 223796106 214300694 208325193 208281566 205372981 205366261 204855576 204766132 204734173 192322352 192317911 184895389 184812923 184761027 184719102 184709630 184694310 184403897 184378789 179445855 179396117 179389216 176957972 166621721 161242897 161242414 C A C G G G A A T A A A A A T A T T G A T A G T G G A T C G A C A A G T A A A G T G G G G G G G G G C A G C G C C A C G C T T G G G 79582 151195 117583 117583 285025 6323 SPAG16 CCNYL1 PARD3B PARD3B CCDC141 SCN1A sperm associated antigen 16 cyclin Y-like 1 par-3 partitioning defective 3 homolog B (C. elegans) par-3 partitioning defective 3 homolog B (C. elegans) coiled-coil domain containing 141 sodium channel, voltage-gated, type I, alpha subunit GÜL et al. / Turk J Med Sci rs831081 rs6766190 rs291475 rs524431 225 226 227 228 rs11707184 rs831080 223 rs17400084 222 224 rs4626067 rs10155027 220 221 rs1021734 rs17288993 218 219 rs6794229 rs13061634 216 rs11917010 215 217 rs9830825 rs12485914 213 214 rs4858348 rs4858352 211 rs2130505 210 212 rs11712016 rs12185978 208 209 rs359032 rs2088620 206 rs359033 205 207 rs359025 rs359024 203 204 rs6773179 rs6442929 200 rs1161171 rs7649544 199 201 rs7630509 198 202 rs4685598 197 0,8666 1,261 1,24 0,8493 0,8579 1,184 1,254 1,254 0,8091 0,8128 0,8224 0,8717 0,8528 0,8644 1,207 1,275 0,8526 0,8554 0,8432 0,8598 1,206 0,8501 0,8549 0,86 0,8434 0,8336 0,8322 1,148 1,148 1,243 1,172 1,175 Appendix. (Continued). 5,60E-04 6,23E-04 9,16E-04 1,91E-04 3,13E-04 2,12E-04 1,46E-04 1,60E-04 2,09E-04 3,12E-04 7,23E-04 7,75E-04 2,15E-04 7,17E-04 7,85E-04 3,53E-04 4,51E-05 7,59E-05 1,43E-05 3,98E-04 7,15E-04 4,58E-04 5,74E-04 9,99E-04 2,13E-04 8,15E-05 6,51E-05 6,47E-04 7,55E-04 8,03E-04 8,62E-04 7,98E-04 0,296 0,091 0,102 0,250 0,273 0,215 0,117 0,118 0,135 0,131 0,129 0,307 0,260 0,259 0,133 0,083 0,374 0,358 0,368 0,272 0,134 0,223 0,232 0,227 0,224 0,221 0,225 0,327 0,308 0,092 0,195 0,191 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 74383584 73883578 73871082 71515298 71515191 62316084 60261426 60259909 56968071 56940107 56938384 56029117 54189989 54181107 31437904 31431027 21743250 21730685 21727970 11061367 9174613 8435932 8432379 8431789 8421265 8420729 8417494 5073759 5072993 353069 349168 348693 A C A A C T T T T G T C T A C A G G G C G G C A G T C A T C G A G G T G G C C G C A C T G G T C A A A G C T T G A C T T C A A C 27086 27086 2272 2272 50650 50650 50650 26059 55799 55799 79750 79750 79750 9901 100288428 100288428 100288428 100288428 100288428 100288428 10752 10752 10752 cell adhesion molecule with homology to L1CAM (close homolog of L1) cell adhesion molecule with homology to L1CAM (close homolog of L1) cell adhesion molecule with homology to L1CAM (close homolog of L1) FOXP1 FOXP1 FHIT FHIT ARHGEF3 ARHGEF3 ARHGEF3 ERC2 CACNA2D3 CACNA2D3 ZNF385D ZNF385D ZNF385D SRGAP3 forkhead box P1 forkhead box P1 fragile histidine triad fragile histidine triad Rho guanine nucleotide exchange factor (GEF) 3 Rho guanine nucleotide exchange factor (GEF) 3 Rho guanine nucleotide exchange factor (GEF) 3 ELKS/RAB6-interacting/CAST family member 2 calcium channel, voltage-dependent, alpha 2/delta subunit 3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 zinc finger protein 385D zinc finger protein 385D zinc finger protein 385D SLIT-ROBO Rho GTPase activating protein 3 LOC100288428 uncharacterized LOC100288428 LOC100288428 uncharacterized LOC100288428 LOC100288428 uncharacterized LOC100288428 LOC100288428 uncharacterized LOC100288428 LOC100288428 uncharacterized LOC100288428 LOC100288428 uncharacterized LOC100288428 CHL1 CHL1 CHL1 GÜL et al. / Turk J Med Sci 7 8 rs10034033 rs17219704 rs13150883 rs17750311 257 258 259 260 rs7662477 rs11726723 255 rs10938681 254 256 rs7613340 rs11929598 252 rs10937330 251 253 rs1402002 rs939338 249 250 rs2131017 rs1565567 247 rs10490809 246 248 rs877439 rs1522378 244 245 rs6792168 rs12695943 242 rs7646166 241 243 rs2365012 rs11715474 239 240 rs4314124 rs6796610 237 rs1132202 236 238 rs16823934 rs17281612 234 rs9840925 233 235 rs9815149 rs9816344 231 232 rs471800 rs6551483 229 230 0,8294 0,8059 1,168 1,209 1,174 1,138 0,7794 0,8355 0,8474 1,144 1,144 1,135 0,8511 0,8595 0,842 0,8768 0,8819 1,163 1,15 1,149 1,171 0,8541 0,8683 0,8663 1,216 1,208 1,162 1,342 1,141 0,8716 0,8779 0,8741 Appendix. (Continued). 9,77E-04 3,36E-04 4,64E-04 9,18E-04 1,21E-04 8,07E-04 6,44E-04 8,69E-05 2,93E-04 7,90E-04 3,64E-04 4,01E-04 8,86E-04 4,30E-04 7,95E-04 1,64E-04 5,13E-04 8,89E-04 9,81E-04 6,29E-04 4,62E-04 6,46E-05 6,97E-05 7,97E-04 6,53E-04 5,93E-04 8,85E-04 9,09E-04 7,41E-04 5,71E-04 4,77E-04 9,58E-04 0,312 0,157 0,108 0,200 0,176 0,190 0,482 0,099 0,179 0,179 0,479 0,446 0,451 0,224 0,242 0,227 0,496 0,497 0,225 0,307 0,345 0,350 0,348 0,278 0,278 0,122 0,122 0,228 0,054 0,408 0,366 0,364 3 4 4 4 4 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 74392334 65866784 65828632 61735051 26071049 26065365 23847568 8066769 189235958 189233423 189221460 185186762 185125488 172706855 172700255 172699449 169283231 169282596 150988107 150319263 150307102 150284605 127299894 127280603 127270322 120633181 120606689 116818374 116582546 115162780 87569165 87568689 T G C A A T A A T C G G A A C G G C A C A T T A A C C A G C G C C A T G C G G G C T A A G T T A A T T T G G A G G G T G A T C T 84448 10057 10057 27333 27333 389161 6596 54946 54946 54946 55254 57514 254887 ABLIM2 ABCC5 ABCC5 GOLIM4 GOLIM4 ANKUB1 HLTF SLC41A3 SLC41A3 SLC41A3 TMEM39A ARHGAP31 ZDHHC23 actin binding LIM protein family, member 2 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 golgi integral membrane protein 4 golgi integral membrane protein 4 ankyrin repeat and ubiquitin domain containing 1 helicase-like transcription factor solute carrier family 41, member 3 solute carrier family 41, member 3 solute carrier family 41, member 3 transmembrane protein 39A Rho GTPase activating protein 31 zinc finger, DHHC-type containing 23 GÜL et al. / Turk J Med Sci rs7660373 rs13117869 rs4863069 rs6553232 rs11942138 289 290 291 292 293 rs10050099 rs1434621 287 288 rs7683671 rs11939106 285 286 rs12501200 rs7679856 283 284 rs12644625 rs13136521 281 282 rs12505043 rs17508289 279 280 rs17475948 rs12501586 277 278 rs13107501 rs17024826 275 276 rs10019264 rs17473405 273 274 rs10433975 rs1836899 271 272 rs17024571 rs1836900 269 270 rs11931752 rs11946552 267 268 rs10006978 rs7657124 265 266 rs7377225 rs4693846 263 264 rs6849315 rs7377204 261 262 1,175 1,188 1,202 1,193 1,374 1,151 0,8766 0,8803 0,8794 0,8773 0,8522 0,8591 1,204 0,7895 1,177 1,174 1,284 1,215 1,17 1,237 1,173 1,172 1,175 1,173 1,226 1,24 1,268 1,241 1,258 0,8494 0,8562 0,8534 1,173 Appendix. (Continued). 9,60E-04 2,58E-04 2,00E-04 1,64E-05 3,19E-05 9,21E-06 8,80E-04 8,45E-04 9,63E-04 8,79E-04 7,03E-04 2,20E-04 9,10E-05 9,67E-04 1,96E-04 2,15E-04 8,91E-05 3,09E-05 5,54E-04 9,34E-04 1,54E-04 7,48E-04 8,21E-04 6,58E-04 6,12E-04 1,09E-04 4,24E-05 1,64E-05 3,38E-05 3,07E-05 1,52E-04 3,10E-04 2,29E-04 0,191 0,238 0,206 0,263 0,269 0,077 0,274 0,358 0,402 0,401 0,401 0,266 0,392 0,130 0,104 0,244 0,307 0,109 0,126 0,194 0,126 0,202 0,195 0,195 0,204 0,147 0,151 0,135 0,155 0,136 0,262 0,262 0,261 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 83795901 189969188 189947109 189928060 189923244 162915033 162869105 160343857 160335911 160334667 160315988 155170600 144425014 111935962 106334482 102874385 102861035 97002780 96983626 96971822 96970645 96966176 96966126 96960072 96958725 96942220 96940053 96938876 96914610 96898971 88728693 88727547 88727430 A G G A G T G T T A G C T T A T T C C C A C A G G G A A C G A C C T C A C C C C G C G C A C C G C C G T T T G G A A A C T A A C T T 79966 56884 56884 54790 SCD5 FSTL5 FSTL5 TET2 stearoyl-CoA desaturase 5 follistatin-like 5 follistatin-like 5 tet methylcytosine dioxygenase 2 GÜL et al. / Turk J Med Sci 9 10 rs7726354 rs786699 325 rs16886496 322 rs7725377 rs16886448 321 323 rs16886364 320 324 rs1979398 rs16886034 318 319 rs6866823 rs6871286 316 317 rs4336383 rs6886001 314 rs1834967 313 315 rs2199214 rs1428256 311 312 rs6880526 rs6890310 309 310 rs4518345 rs4510545 307 308 rs2974591 rs4429812 305 306 rs2974602 rs13164886 303 304 rs10037115 rs8180522 301 302 rs4866046 rs4866047 299 300 rs396 rs2530913 297 rs10491222 296 298 rs1017924 rs10491223 294 295 1,315 0,8078 0,7451 0,7772 0,7709 0,7709 0,7589 0,8801 0,8781 0,8769 0,879 1,149 1,228 1,182 0,8431 0,8586 0,8558 0,8557 0,8576 0,8601 0,8784 0,8797 0,8805 0,8719 0,8766 0,8746 0,8759 0,7781 0,8796 0,8724 0,8729 1,164 Appendix. (Continued). 9,47E-04 8,76E-04 6,65E-04 3,94E-04 1,20E-04 5,91E-04 5,91E-04 3,06E-04 7,33E-04 5,92E-04 5,37E-04 6,63E-04 5,91E-04 2,95E-04 4,18E-04 8,33E-04 2,95E-04 2,22E-04 2,17E-04 2,68E-04 3,48E-04 6,79E-04 7,06E-04 8,66E-04 5,26E-04 8,77E-04 7,19E-04 8,30E-04 1,32E-04 8,05E-04 4,18E-04 4,47E-04 0,220 0,056 0,103 0,056 0,093 0,068 0,068 0,067 0,473 0,479 0,484 0,483 0,323 0,123 0,198 0,166 0,278 0,280 0,277 0,277 0,277 0,437 0,484 0,431 0,355 0,355 0,354 0,357 0,094 0,428 0,395 0,395 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2029187 64711237 56292353 56292240 56253286 56206570 56158101 56019613 52230084 52222513 52222328 52222194 38831091 38401890 38309217 27338180 27229330 27227465 27225107 27221661 27209030 20325791 20302871 20286581 20274979 20272670 20270828 20270802 11638455 9668339 8870497 8843528 A A A T C G G C A T A C A A T C A T C A C C T C C G C A T C A C G C G C T C A T G C G T T G G T G C A G T T G T G A A G C G G G 11174 4214 4214 3672 3672 3672 3672 133584 133584 1501 ADAMTS6 MAP3K1 MAP3K1 ITGA1 ITGA1 ITGA1 ITGA1 EGFLAM EGFLAM CTNND2 ADAM metallopeptidase with thrombospondin type 1 motif, 6 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase integrin, alpha 1 integrin, alpha 1 integrin, alpha 1 integrin, alpha 1 EGF-like, fibronectin type III and laminin G domains EGF-like, fibronectin type III and laminin G domains catenin (cadherin-associated protein), delta 2 GÜL et al. / Turk J Med Sci rs1150644 rs686269 rs9396712 rs1240833 rs9348440 354 355 356 357 358 rs255318 rs10456781 352 353 rs6887695 rs454036 350 351 rs7709212 rs6861600 348 349 rs31330 rs2160505 346 347 rs6878559 rs13165374 344 345 rs9327165 rs4895286 342 343 rs9326826 rs9327027 340 341 rs2416248 rs11745646 338 339 rs12655815 rs1350294 336 337 rs7723767 rs12517265 334 335 rs6892259 rs456236 332 333 rs9293433 rs3846620 330 331 rs4704438 rs1422406 328 329 rs12514992 rs12516836 326 327 1,223 1,145 1,157 1,155 1,168 0,8734 1,345 1,142 1,158 1,158 1,156 0,872 0,8478 1,144 1,142 1,145 1,135 1,286 1,156 1,144 1,166 1,174 1,19 1,17 1,166 0,8798 1,224 1,229 1,134 0,8771 0,861 1,15 1,154 Appendix. (Continued). 6,33E-04 3,45E-04 6,80E-04 5,37E-04 2,84E-04 2,13E-04 4,91E-04 5,60E-05 9,82E-04 3,08E-04 3,38E-04 3,08E-04 3,34E-04 3,07E-04 8,02E-04 4,69E-04 4,64E-04 9,62E-04 7,69E-04 5,05E-04 8,64E-04 8,16E-04 4,86E-04 1,58E-04 6,16E-04 9,17E-04 8,55E-04 5,65E-04 3,40E-04 9,84E-04 5,85E-04 1,83E-04 8,41E-04 0,282 0,131 0,349 0,276 0,356 0,278 0,396 0,068 0,326 0,321 0,315 0,335 0,431 0,225 0,344 0,445 0,408 0,418 0,067 0,295 0,323 0,224 0,222 0,224 0,224 0,216 0,413 0,121 0,120 0,468 0,433 0,339 0,278 5 6 6 6 6 6 6 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 75554502 20749315 16939387 16926604 16922625 16922283 16125021 172548635 172486267 158755223 158752193 158696755 157292346 132889400 125177257 120236091 120206274 120168056 116418496 110522145 110521442 110206705 110205180 110196417 110189680 110182685 110115057 110113641 103014552 84630874 76981162 76980795 75554524 G T A T G A G A C C G C A C T G A C A A G G A A T C G C C C C G A T C G C A C A G G G C T C G G A G T T G A A C G C T T A G G A A G 22987 54901 153222 23105 91137 91137 22987 SV2C CDKAL1 CREBRF FSTL4 SLC25A46 SLC25A46 SV2C synaptic vesicle glycoprotein 2C CDK5 regulatory subunit associated protein 1-like 1 CREB3 regulatory factor follistatin-like 4 solute carrier family 25, member 46 solute carrier family 25, member 46 synaptic vesicle glycoprotein 2C GÜL et al. / Turk J Med Sci 11 12 rs1341230 rs9373855 rs488282 rs10457307 388 390 391 rs4642522 387 389 rs11966310 rs11964002 385 386 rs1343232 rs17438648 383 384 rs9343877 rs6454097 381 382 rs7739908 rs16885102 379 380 rs1996679 rs9446323 377 378 rs12204627 rs9342803 375 376 rs1266825 rs3765446 373 374 rs3010529 rs761167 371 372 rs6910476 rs6458620 369 370 rs12195232 rs1361864 367 368 rs9269202 rs12202197 365 366 rs3117108 rs9268835 363 364 rs2516478 rs2523503 361 362 rs7767391 rs16894194 359 360 0,7555 1,14 1,141 0,882 0,8758 1,136 1,138 1,138 1,138 1,277 1,277 0,8226 0,7784 0,8393 0,836 0,841 0,8179 1,137 1,136 1,136 1,157 1,155 1,184 1,14 0,866 0,8605 0,8629 1,166 0,8686 1,191 1,196 1,17 1,178 Appendix. (Continued). 5,69E-04 1,56E-04 8,44E-04 7,74E-04 9,00E-04 5,66E-04 9,02E-04 7,49E-04 7,37E-04 7,49E-04 5,05E-04 5,26E-04 2,30E-04 9,65E-04 1,81E-04 6,36E-05 6,73E-04 2,42E-05 7,63E-04 7,75E-04 7,52E-04 7,94E-04 8,94E-04 9,97E-04 8,60E-04 2,60E-04 1,32E-04 3,91E-04 2,66E-04 5,92E-04 7,91E-04 3,64E-04 2,39E-04 0,198 0,071 0,363 0,363 0,482 0,407 0,418 0,418 0,418 0,415 0,077 0,076 0,157 0,067 0,216 0,241 0,172 0,204 0,428 0,466 0,471 0,262 0,261 0,164 0,371 0,360 0,363 0,289 0,303 0,305 0,152 0,168 0,276 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 20833219 116927364 106923806 106922248 82436294 82249727 82217840 82217732 82216223 82187051 79934936 79922723 75341319 72090767 71789723 71783440 71781245 71778351 52249629 52221625 52219767 48701049 48678807 48633649 48627226 39201111 39200945 32557501 32536093 32450800 31621538 31606716 28756062 C A A T C T A G A G T T T G G G C A T T T C C G G T C T A C A A A T G G G T G T A G A G A C T A C T T A C C T G A A C T C G G C G T 54901 100128327 4172 534 CDKAL1 BET3L MCM3 ATP6V1G2 CDK5 regulatory subunit associated protein 1-like 1 BET3 like (S. cerevisiae) minichromosome maintenance complex component 3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 GÜL et al. / Turk J Med Sci rs4416776 rs2618989 rs450854 rs12538286 rs10270614 420 421 422 423 424 rs10225389 rs17148752 418 419 rs17735671 rs1404198 416 417 rs7787769 rs11763192 414 415 rs964126 rs2113643 412 413 rs4722932 rs17159921 410 411 rs4722930 rs12700969 408 409 rs11769156 rs10228072 406 407 rs7456390 rs7782529 404 405 rs4722483 rs17789894 402 403 rs317801 rs6902491 400 401 rs6570562 rs6908896 398 399 rs1572045 rs9321916 396 397 rs2789010 rs1416419 394 395 rs1338980 rs1998458 392 393 0,876 0,8597 0,8777 1,147 0,8519 0,7622 0,8372 0,8066 0,7745 0,8105 0,8011 1,14 1,149 1,36 1,166 1,137 1,146 1,148 1,244 0,8132 1,186 0,8228 0,8304 1,207 0,8598 1,22 0,8389 0,8315 0,8553 1,161 1,164 1,162 1,17 Appendix. (Continued). 4,64E-04 4,83E-04 3,15E-04 8,10E-04 8,54E-04 2,66E-05 2,83E-04 4,45E-04 1,46E-04 1,03E-05 6,06E-04 1,25E-04 5,56E-04 8,69E-04 3,09E-04 1,00E-04 7,82E-04 3,77E-04 2,98E-04 8,68E-04 3,11E-04 2,31E-04 4,66E-04 5,78E-04 4,71E-04 8,16E-04 2,20E-04 4,51E-04 7,90E-04 7,19E-04 7,72E-04 6,40E-04 7,43E-04 0,232 0,459 0,285 0,392 0,299 0,439 0,078 0,171 0,130 0,126 0,110 0,126 0,482 0,284 0,051 0,352 0,425 0,427 0,428 0,091 0,132 0,217 0,131 0,143 0,142 0,240 0,151 0,181 0,139 0,216 0,239 0,239 0,239 6 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 6 6 6 6 6 6 6 6 6 118325563 101624464 101536040 101485453 95193842 82814002 75092000 62973655 54052372 53034984 53002660 52963068 52104228 47620828 31123725 29578479 29552772 29552436 29542212 28545359 27264316 14784079 6709622 3159273 166381836 159010196 156869074 143879508 143878225 137972810 118369087 118368173 118367258 A A A T C G C C A C T G G A T G A A C C A G T C G T C A A C T T G G G G C A A T A G T C C T G C A C G T T G C G G T C A G T T A G T 1523 1523 1523 3092 9586 1607 7559 94120 222553 222553 222553 CUX1 CUX1 CUX1 HIP1 CREB5 DGKB ZNF12 SYTL3 SLC35F1 SLC35F1 SLC35F1 cut-like homeobox 1 cut-like homeobox 1 cut-like homeobox 1 huntingtin interacting protein 1 cAMP responsive element binding protein 5 diacylglycerol kinase, beta 90kDa zinc finger protein 12 synaptotagmin-like 3 solute carrier family 35, member F1 solute carrier family 35, member F1 solute carrier family 35, member F1 GÜL et al. / Turk J Med Sci 13 14 rs12678728 rs4562310 rs4268118 rs4256587 454 456 457 rs10504242 453 455 rs12549902 rs4317621 451 452 rs4389890 rs7825337 449 450 rs4733453 rs4733456 447 448 rs12681837 rs6997728 445 446 rs11989798 rs2976405 443 444 rs2929301 rs2705042 441 442 rs1731847 rs1968853 439 440 rs361445 rs855733 437 438 rs2701016 rs2555048 435 436 rs12707008 rs6467643 433 434 rs1357674 rs11764046 431 432 rs7801931 rs10270960 429 430 rs4730053 rs10245031 427 428 rs7341475 rs4730052 425 426 0,8034 0,8079 0,7894 0,8559 0,7733 0,8807 0,8771 0,8801 0,8804 0,8799 0,8793 0,8641 0,8643 0,8705 0,7405 1,37 1,146 1,135 0,8764 0,8632 1,208 1,141 0,8703 0,8632 1,136 1,171 1,173 0,8641 0,8633 0,8761 1,171 1,166 1,179 Appendix. (Continued). 9,79E-04 1,06E-04 2,08E-04 3,93E-05 6,74E-04 2,66E-04 9,46E-04 6,57E-04 8,20E-04 8,23E-04 7,79E-04 7,26E-04 9,68E-04 9,95E-04 4,33E-04 3,97E-04 2,66E-04 5,16E-04 8,65E-04 5,00E-04 2,38E-04 7,34E-04 8,64E-04 9,73E-04 5,23E-04 8,86E-04 9,94E-04 8,70E-04 2,77E-04 2,49E-04 8,89E-04 6,34E-04 8,69E-04 0,169 0,132 0,125 0,127 0,218 0,079 0,410 0,405 0,431 0,442 0,443 0,443 0,250 0,249 0,358 0,055 0,053 0,363 0,457 0,467 0,333 0,127 0,348 0,279 0,274 0,404 0,188 0,191 0,328 0,329 0,346 0,213 0,213 7 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 103192051 63218545 63217632 63207496 62909278 59148749 41635738 41628416 41626394 33777560 33775901 33770287 27196000 27191888 24911831 22326597 17366632 9085514 9083722 155348283 148993580 141838625 135622266 135622254 135614381 131282522 119324606 119236456 117312875 117294094 117285697 104269619 104269557 A T G G G G A G C A A G T T A A T G C C A T C A T T G G C G C A C G C A C A A G A T G G A A G G C C A A T G C T C G C A A G C T G T 5649 90362 286 23516 28601 83992 83992 375612 375612 RELN FAM110B ANK1 SLC39A14 TRBV6-6 CTTNBP2 CTTNBP2 LHFPL3 LHFPL3 reelin family with sequence similarity 110, member B ankyrin 1, erythrocytic solute carrier family 39 (zinc transporter), member 14 T cell receptor beta variable 6-6 cortactin binding protein 2 cortactin binding protein 2 lipoma HMGIC fusion partner-like 3 lipoma HMGIC fusion partner-like 3 GÜL et al. / Turk J Med Sci rs506086 rs491798 rs2209882 rs2013557 rs6479067 486 487 488 489 490 rs10738743 rs511545 484 485 rs676484 rs17559639 482 483 rs13300741 rs10966484 480 481 rs7041951 rs4977251 478 479 rs16923521 rs12553948 476 477 rs10964493 rs10964495 474 475 rs10465048 rs4977395 472 473 rs10811330 rs10964477 470 471 rs10960363 rs1319332 468 469 rs2514756 rs11777070 466 467 rs13278423 rs2436860 464 465 rs16928602 rs10957216 462 463 rs16928545 rs7833958 460 461 rs7832144 rs10504344 458 459 0,8569 1,206 1,256 0,8682 0,8444 0,8698 1,146 0,8709 1,141 0,8278 0,8262 1,371 1,456 1,35 1,438 1,37 1,338 1,474 1,244 1,37 1,228 1,37 1,196 1,172 1,158 1,252 0,8768 0,8109 0,8151 0,8204 0,7521 0,8093 0,8034 Appendix. (Continued). 1,35E-04 3,92E-04 9,56E-04 5,06E-04 3,00E-04 1,07E-04 3,28E-04 4,94E-04 5,63E-04 7,52E-04 1,74E-04 1,41E-04 6,35E-05 6,41E-06 1,14E-04 1,07E-05 6,32E-05 2,87E-04 7,64E-06 6,32E-06 9,75E-05 1,65E-05 2,16E-04 5,55E-04 7,54E-04 8,04E-04 5,49E-04 5,08E-04 1,14E-04 9,57E-05 1,75E-04 4,81E-06 2,11E-04 0,126 0,257 0,132 0,090 0,401 0,257 0,404 0,371 0,334 0,367 0,169 0,178 0,063 0,057 0,067 0,058 0,064 0,061 0,053 0,196 0,060 0,200 0,055 0,162 0,200 0,247 0,092 0,488 0,143 0,156 0,152 0,105 0,128 8 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 8 8 8 8 8 8 8 8 8 63225135 103635386 103615815 81127236 78519989 78516428 78501010 26027974 26011612 25953989 24802191 20953339 20269793 20265354 20253186 20251635 20235283 20229840 20216358 20208695 20206063 20197095 20182495 1190703 141019541 119151124 103811225 87789535 63319367 63309109 63273320 63256978 63229338 A A T A T C C C A C G C G G G C C C G A C C G C T A A A T T A G G G T A G A G T T C A A T A C A T T T A G T T A T G G G C A C G A T 158471 158471 158471 54914 83696 2131 54714 PRUNE2 PRUNE2 PRUNE2 FOCAD TRAPPC9 EXT1 CNGB3 prune homolog 2 (Drosophila) prune homolog 2 (Drosophila) prune homolog 2 (Drosophila) focadhesin trafficking protein particle complex 9 exostosin 1 cyclic nucleotide gated channel beta 3 GÜL et al. / Turk J Med Sci 15 16 rs2393400 rs1930455 rs1930456 rs10740725 519 520 521 522 rs1930450 rs2939583 517 518 rs2658641 rs2658630 515 516 rs11593943 rs10430541 513 514 rs11013555 rs10763790 511 rs983990 510 512 rs7913401 rs1856113 508 509 rs6482289 rs12244668 506 507 rs6482285 rs4333914 504 505 rs7085999 rs7900252 502 503 rs12246098 rs11013514 500 rs7920535 499 501 rs3802577 rs956007 rs7468351 496 497 rs10760182 495 498 rs10739816 rs10739592 493 494 rs2786716 rs1415647 491 492 0,8784 0,8447 0,8507 0,846 0,8453 0,8418 0,8453 0,8287 0,8777 0,8722 0,8642 1,149 1,157 1,159 1,154 1,145 1,143 1,156 1,143 1,163 1,141 1,174 1,155 1,147 1,176 0,8656 1,14 1,137 1,34 0,8619 0,8643 0,8623 Appendix. (Continued). 6,66E-04 9,56E-04 2,03E-04 3,87E-04 2,32E-04 2,19E-04 1,74E-04 3,09E-04 1,29E-04 7,30E-04 4,44E-04 9,06E-04 9,25E-04 2,63E-04 2,23E-04 3,30E-04 7,84E-04 7,67E-04 3,31E-04 7,67E-04 1,62E-04 9,35E-04 1,12E-04 4,55E-04 8,72E-04 1,35E-04 5,18E-04 8,33E-04 6,75E-04 2,08E-14 6,53E-04 8,06E-04 0,257 0,371 0,224 0,223 0,225 0,224 0,221 0,208 0,186 0,395 0,377 0,244 0,284 0,342 0,341 0,341 0,337 0,347 0,328 0,348 0,340 0,347 0,291 0,312 0,309 0,276 0,298 0,369 0,481 0,485 0,251 0,256 9 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 9 9 9 9 9 103636342 59460061 59414551 59414530 59414510 59412336 59410701 59409250 59394437 56494253 33585087 30831361 23858933 23846388 23844775 23844221 23841366 23816469 23810664 23808719 23802398 23800758 23799607 23786957 23774744 23761418 13361864 138114710 123452782 123011433 103656291 103636455 C G A A T T T A G A T C A G T A G T A T G G A G G G C T A G C A T A G G G C G G A G C G G A C C A C G C A C G A A T T C G A T T 8829 5264 138151 153090 NRP1 PHYH NACC2 DAB2IP neuropilin 1 phytanoyl-CoA 2-hydroxylase NACC family member 2, BEN and BTB (POZ) domain containing DAB2 interacting protein GÜL et al. / Turk J Med Sci rs11196208 rs10510004 rs2483593 rs1091179 rs2420928 551 552 553 554 555 rs10885409 rs12255372 549 550 rs7077039 rs11196205 547 548 rs10787472 rs12243326 545 546 rs4132670 rs6585201 543 544 rs7901695 rs4506565 541 542 rs2804614 rs4074720 539 540 rs10787019 rs2804611 537 538 rs1421503 rs2111995 535 536 rs10883942 rs12765878 533 534 rs11191841 rs7100920 531 532 rs11553840 rs17415112 529 530 rs12571751 rs703982 527 528 rs3915932 rs810517 525 526 rs11006021 rs1759365 523 524 0,8735 0,7741 0,7592 0,8647 1,173 1,292 1,172 1,17 1,157 1,292 1,155 1,144 1,282 1,278 1,28 1,156 1,235 1,245 1,146 1,16 1,164 0,8699 0,8699 0,8741 0,8746 0,837 1,323 0,8567 0,8533 0,8533 0,8544 0,8511 0,8718 Appendix. (Continued). 4,72E-04 4,36E-04 1,03E-04 4,89E-04 1,97E-04 2,40E-05 4,37E-10 2,71E-05 3,49E-05 1,35E-04 6,12E-10 1,38E-04 3,96E-04 6,53E-10 9,48E-10 8,18E-10 1,30E-04 7,72E-04 4,64E-04 9,79E-04 9,82E-04 7,37E-04 2,30E-04 2,30E-04 3,81E-04 3,97E-04 7,52E-04 7,27E-04 6,72E-05 3,05E-05 3,08E-05 4,70E-05 3,68E-04 0,377 0,408 0,092 0,062 0,373 0,472 0,302 0,472 0,473 0,467 0,295 0,474 0,459 0,331 0,331 0,328 0,476 0,107 0,107 0,306 0,226 0,227 0,486 0,486 0,488 0,500 0,156 0,054 0,395 0,452 0,452 0,409 0,226 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 59460712 123143462 116556258 116359696 116214569 114801306 114798892 114798062 114797037 114779067 114778805 114771287 114758773 114757761 114746031 114744078 114738487 113841831 113837462 109050808 107497352 107485090 105659612 105641376 105630968 105629601 99194781 82268160 80612727 80612637 80612626 80611942 59490502 C G A G A C T C C C C C A A T C T C C T G G C C T C A C G G T C A T A G A G T G T G T T A G G A T C T T G A A T T C T G T A A C G G 3983 3983 6934 6934 6934 6934 6934 6934 6934 6934 6934 6934 6934 6934 79991 79991 51013 81619 57178 57178 57178 57178 ABLIM1 ABLIM1 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 TCF7L2 OBFC1 OBFC1 EXOSC1 TSPAN14 ZMIZ1 ZMIZ1 ZMIZ1 ZMIZ1 actin binding LIM protein 1 actin binding LIM protein 1 transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2 (T-cell specific, HMG-box) oligonucleotide/oligosaccharide-binding fold containing 1 oligonucleotide/oligosaccharide-binding fold containing 1 exosome component 1 tetraspanin 14 zinc finger, MIZ-type containing 1 zinc finger, MIZ-type containing 1 zinc finger, MIZ-type containing 1 zinc finger, MIZ-type containing 1 GÜL et al. / Turk J Med Sci 17 18 rs17833579 rs17150882 rs9666479 rs7121252 585 587 588 rs17150852 584 586 rs11232429 rs11235302 582 583 rs11237675 rs17310875 580 581 rs10793350 rs10751301 578 579 rs11228506 rs644961 576 577 rs11603383 rs17709552 574 575 rs2955949 rs7115702 572 573 rs2957523 rs2926463 570 571 rs329526 rs2926461 568 569 rs2351044 rs7117077 566 567 rs4277103 rs1881820 564 565 rs2723663 rs2303493 562 563 rs7104128 rs935951 560 561 rs7075825 rs11827296 558 559 rs1322328 rs12412485 556 557 1,206 1,202 1,267 1,258 1,263 1,21 1,347 1,207 0,8708 0,8623 0,8643 0,8824 0,8812 1,245 1,174 1,175 0,863 0,8694 0,8663 0,8703 1,137 0,8411 1,169 0,8518 0,7731 0,8762 0,8763 0,8276 1,232 1,187 0,7641 1,163 0,8817 Appendix. (Continued). 9,04E-04 2,52E-04 3,35E-04 2,10E-04 5,03E-04 3,74E-04 5,02E-04 3,79E-04 7,14E-04 2,56E-04 9,09E-05 1,17E-04 9,73E-04 8,60E-04 1,59E-04 9,99E-05 9,69E-05 3,64E-04 7,23E-04 5,25E-04 7,80E-04 7,56E-04 4,65E-04 6,83E-05 1,09E-04 7,73E-05 5,63E-04 4,90E-04 2,12E-04 9,03E-04 3,63E-04 1,83E-04 6,93E-04 0,466 0,163 0,160 0,095 0,087 0,089 0,135 0,052 0,130 0,490 0,485 0,483 0,473 0,458 0,117 0,291 0,291 0,304 0,302 0,303 0,303 0,438 0,182 0,363 0,292 0,097 0,474 0,466 0,166 0,106 0,186 0,075 0,234 10 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 10 10 123911094 87256116 87250138 87219070 87203798 87202808 87132574 80397567 79832113 78375191 78372286 78372163 78370468 68645758 61797095 61794159 61787955 34210651 34208964 34208431 34208169 29458729 19510993 15535033 13757134 8345806 6455791 6440086 5918145 4697321 3334236 133720979 131731590 C C G C C A A T C C G T T A G A T A G G C T C A G C A C T T C T T G T A T T G T A G T C C C G A G A T T A T G T G C T G A G C T C G 10579 26011 26011 26011 26011 4250 4250 25841 25841 25841 25841 89797 23647 10612 TACC2 ODZ4 ODZ4 ODZ4 ODZ4 SCGB2A2 SCGB2A2 ABTB2 ABTB2 ABTB2 ABTB2 NAV2 ARFIP2 TRIM3 transforming, acidic coiled-coil containing protein 2 odz, odd Oz/ten-m homolog 4 (Drosophila) odz, odd Oz/ten-m homolog 4 (Drosophila) odz, odd Oz/ten-m homolog 4 (Drosophila) odz, odd Oz/ten-m homolog 4 (Drosophila) secretoglobin, family 2A, member 2 secretoglobin, family 2A, member 2 ankyrin repeat and BTB (POZ) domain containing 2 ankyrin repeat and BTB (POZ) domain containing 2 ankyrin repeat and BTB (POZ) domain containing 2 ankyrin repeat and BTB (POZ) domain containing 2 neuron navigator 2 ADP-ribosylation factor interacting protein 2 tripartite motif containing 3 GÜL et al. / Turk J Med Sci rs10770836 rs10841850 rs11046122 rs10783760 rs4759173 617 618 619 620 621 rs10841848 rs11046116 615 616 rs10492118 rs6487236 613 614 rs11610942 rs10841843 611 612 rs10849045 rs7135390 609 610 rs10849040 rs17700406 607 608 rs2887474 rs10848958 605 606 rs1870199 rs10849464 603 604 rs4937342 rs433443 601 602 rs3935795 rs3935796 599 600 rs1600223 rs3935794 597 598 rs17134278 rs4559717 595 596 rs4122057 rs11020093 593 594 rs11018816 rs7937882 591 592 rs1939168 rs7101865 589 590 0,877 0,8774 1,159 1,161 1,16 1,164 1,163 1,17 1,165 1,176 0,8747 0,8718 0,862 0,864 1,147 0,8312 0,8693 0,8563 0,8733 0,8724 0,7488 0,7476 0,7216 0,7246 0,8376 1,253 1,246 0,8564 0,8374 1,225 1,225 1,174 1,17 Appendix. (Continued). 7,65E-04 8,81E-04 9,15E-04 7,69E-04 6,69E-04 6,93E-04 8,22E-04 8,61E-04 5,34E-04 9,48E-04 2,20E-04 4,42E-04 3,18E-04 1,57E-04 1,81E-04 3,01E-04 2,51E-04 2,37E-04 6,59E-05 3,73E-04 6,98E-04 2,31E-04 2,56E-04 3,45E-05 4,41E-05 4,84E-04 7,39E-04 6,85E-04 4,36E-04 6,05E-04 8,26E-05 8,87E-05 3,13E-04 0,212 0,357 0,358 0,250 0,248 0,248 0,226 0,226 0,227 0,215 0,249 0,443 0,444 0,368 0,378 0,498 0,174 0,471 0,391 0,444 0,334 0,063 0,061 0,064 0,063 0,165 0,087 0,094 0,247 0,165 0,157 0,160 0,231 11 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 11 11 11 11 11 11 11 11 11 11 11 11 11 87288340 54287453 54262230 21608288 21608123 21608008 21600886 21600821 21591183 21583225 21583158 21492898 21489968 4337744 4332859 4312167 3901365 666392 659413 656499 130876412 127903519 127896137 127896001 127895887 126798259 112656309 99106275 92267291 87619967 87579997 87579357 87577209 A A A T G A G A G T T G T A C C T C A A A G A C G T A G T A G C A G G G C A G C G A C C A C G T T C T C G G T T T A C G C C G A T G 2998 2998 2998 2998 2998 2998 2998 2998 79912 79912 57103 57103 57103 50863 2113 2113 2113 2113 53942 120114 GYS2 GYS2 GYS2 GYS2 GYS2 GYS2 GYS2 GYS2 PYROXD1 PYROXD1 C12orf5 C12orf5 C12orf5 NTM ETS1 ETS1 ETS1 ETS1 CNTN5 FAT3 glycogen synthase 2 (liver) glycogen synthase 2 (liver) glycogen synthase 2 (liver) glycogen synthase 2 (liver) glycogen synthase 2 (liver) glycogen synthase 2 (liver) glycogen synthase 2 (liver) glycogen synthase 2 (liver) pyridine nucleotide-disulphide oxidoreductase domain 1 pyridine nucleotide-disulphide oxidoreductase domain 1 chromosome 12 open reading frame 5 chromosome 12 open reading frame 5 chromosome 12 open reading frame 5 neurotrimin v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) contactin 5 FAT tumor suppressor homolog 3 (Drosophila) GÜL et al. / Turk J Med Sci 19 20 rs3825381 rs10846941 rs10773187 rs10846955 650 651 652 653 rs979589 rs3803152 648 649 rs10773182 rs2058012 646 647 rs12313339 rs11057765 644 645 rs10400410 rs11067587 642 rs4964671 641 643 rs753479 rs10860877 639 640 rs12580632 rs855287 637 638 rs12578418 rs7300815 635 636 rs12815988 rs11115663 633 rs12582634 632 634 rs1275556 rs998137 630 631 rs3851608 rs998314 628 629 rs7132617 rs10878211 626 627 rs11614506 rs3916529 624 625 rs10747758 rs4759186 622 623 1,134 1,135 1,142 0,861 0,8741 0,8686 0,879 0,8758 0,8408 0,7823 0,863 1,228 1,145 0,8429 0,8316 0,8329 1,205 1,301 0,7861 0,7634 0,7707 1,292 0,8749 0,8717 1,143 1,137 1,143 1,136 0,8284 0,8544 0,8419 0,8779 Appendix. (Continued). 9,48E-04 8,82E-04 7,97E-04 4,56E-04 6,46E-04 4,00E-04 4,55E-04 7,02E-04 6,21E-04 8,20E-04 9,90E-04 7,45E-04 9,70E-04 6,62E-04 6,74E-04 3,25E-04 6,57E-04 9,75E-04 2,15E-04 4,98E-04 9,08E-05 1,70E-04 9,45E-04 6,75E-04 6,98E-04 5,49E-04 9,35E-04 5,35E-04 9,37E-04 3,60E-04 7,92E-04 5,66E-04 0,369 0,487 0,484 0,483 0,253 0,454 0,337 0,462 0,393 0,161 0,070 0,259 0,100 0,349 0,173 0,163 0,146 0,131 0,076 0,083 0,084 0,083 0,066 0,401 0,324 0,392 0,381 0,396 0,392 0,153 0,211 0,176 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 54287594 124762711 124724088 124720392 124702816 124701148 124693655 124693362 124686312 123759382 119870876 114338107 109677882 107227824 101483695 101482692 101470239 100486792 100486144 95081078 82184765 82183441 80385922 77486027 74496341 63506634 63495765 63486189 63482244 62721863 56101942 54350346 T T G T T G T G G C A C A G A G A C C A G T T C A G G C A G C A C C A C C A C A T T G T G C G A T T A G A C C G G A A T G A T G 114795 114795 114795 114795 114795 1240 8499 23329 57522 TMEM132B TMEM132B TMEM132B TMEM132B TMEM132B CMKLR1 PPFIA2 TBC1D30 SRGAP1 transmembrane protein 132B transmembrane protein 132B transmembrane protein 132B transmembrane protein 132B transmembrane protein 132B chemokine-like receptor 1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 TBC1 domain family, member 30 SLIT-ROBO Rho GTPase activating protein 1 GÜL et al. / Turk J Med Sci rs4942796 rs9316428 rs1407827 rs1983805 rs9591246 682 683 684 685 686 rs4258502 rs9568143 680 681 rs1888810 rs2026960 678 679 rs17357143 rs549305 676 677 rs10847919 rs452876 674 675 rs10773257 rs2010484 672 673 rs10744243 rs2346669 670 671 rs10773245 rs10773247 668 669 rs11058574 rs10847114 666 667 rs11058371 rs917337 664 665 rs11058369 rs11610391 662 663 rs6489021 rs7978045 660 661 rs6489019 rs6489020 658 659 rs7954415 rs917334 656 657 rs10846980 rs7313371 654 655 0,8627 0,8704 0,8688 0,8733 0,8653 1,148 1,14 0,8286 0,8314 1,179 0,7415 0,881 1,192 1,168 0,8732 0,8677 0,8624 0,8625 0,8667 0,8648 0,866 0,8585 1,197 0,8484 1,188 1,193 0,8455 0,8582 0,8632 0,8675 0,8642 0,8751 1,143 Appendix. (Continued). 4,13E-04 3,72E-04 7,21E-04 6,17E-04 9,53E-04 4,10E-04 2,88E-04 5,87E-04 8,28E-04 9,95E-04 8,55E-04 1,37E-04 9,55E-04 5,42E-04 1,36E-04 5,11E-04 1,78E-04 9,12E-05 9,24E-05 1,55E-04 1,24E-04 1,44E-04 8,28E-05 3,66E-05 1,61E-05 7,00E-04 5,76E-04 1,63E-05 5,91E-05 1,47E-04 2,41E-04 2,46E-04 9,86E-04 0,486 0,306 0,310 0,308 0,311 0,311 0,456 0,456 0,139 0,142 0,175 0,063 0,416 0,164 0,309 0,378 0,483 0,484 0,484 0,486 0,486 0,477 0,393 0,248 0,441 0,162 0,159 0,401 0,445 0,393 0,395 0,343 0,319 12 13 13 13 13 13 13 13 13 13 13 13 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 124857508 48704899 48609971 48608987 48526552 48484019 48468631 48461701 30458544 30442238 26037876 22504391 129326198 128706939 126298378 125292483 125264114 125260860 125260779 125257058 125256831 125256569 124903032 124894762 124894658 124891017 124873743 124872053 124866956 124866835 124864111 124862134 124861036 T T C C A T A A C T T C G T C G G A C A G T T A T T T T C A G T A G C T T G C T G T G G T T C G A A G T C A C C G G A C G T G A C G 22862 22862 22862 22862 22862 22862 122046 10810 121256 FNDC3A FNDC3A FNDC3A FNDC3A FNDC3A FNDC3A TEX26 WASF3 TMEM132D fibronectin type III domain containing 3A fibronectin type III domain containing 3A fibronectin type III domain containing 3A fibronectin type III domain containing 3A fibronectin type III domain containing 3A fibronectin type III domain containing 3A testis expressed 26 WAS protein family, member 3 transmembrane protein 132D GÜL et al. / Turk J Med Sci 21 22 rs7154599 rs17764096 rs190092 rs327465 715 716 717 718 rs7144011 rs7153625 713 714 rs11159227 rs17109221 711 712 rs4243642 rs17808467 709 710 rs17119980 rs740974 707 rs1548687 706 708 rs2283381 rs10483845 704 705 rs12885258 rs2283422 702 703 rs7156200 rs12884777 700 701 rs4899384 rs10483837 698 rs1387754 697 699 rs1998193 rs28502509 695 696 rs10135562 rs6571647 693 694 rs3751488 rs424964 691 692 rs7991210 rs916048 689 690 rs1013347 rs9571208 687 688 0,8637 0,8533 0,8089 0,815 0,8089 1,165 1,164 0,8498 0,8227 0,863 0,8648 0,8615 0,8381 0,846 0,805 1,184 1,197 1,177 1,176 1,205 0,88 1,143 1,142 1,14 0,7866 1,186 1,147 1,16 1,138 1,188 1,22 0,8592 Appendix. (Continued). 2,95E-04 1,07E-04 1,40E-04 3,01E-04 4,68E-04 3,27E-04 8,36E-04 9,72E-04 8,86E-04 7,61E-04 2,33E-04 2,76E-04 2,01E-04 5,46E-05 3,15E-05 5,34E-07 1,44E-04 1,58E-04 2,35E-04 2,48E-04 1,07E-04 7,61E-04 4,85E-04 4,79E-04 5,78E-04 2,51E-04 5,23E-04 3,33E-04 9,91E-04 9,35E-04 9,62E-06 2,03E-04 0,284 0,494 0,299 0,125 0,126 0,123 0,216 0,214 0,186 0,121 0,335 0,338 0,333 0,248 0,342 0,255 0,239 0,197 0,240 0,241 0,193 0,455 0,421 0,457 0,456 0,093 0,182 0,425 0,224 0,379 0,395 0,149 13 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 13 13 48708882 80299793 79121236 79120259 79119562 79119015 79010136 78979872 76269385 76239145 72258454 72257827 72253994 72028222 71984874 71978830 71531955 71531051 71530913 71527435 71519244 70695709 62341315 38761768 38760507 33836835 32198399 30055554 22373934 21860760 99549906 63876687 T C C T C A T T A A C G A A G G C A T C G T C C T G T A A A G C G T A G G G G C T G G A T G C A T G C A A A T T G A C G G C A T 145508 9369 9369 9369 9369 9369 9369 8110 8110 8110 9628 9628 9628 9628 9628 9628 9628 9628 27133 9472 122704 5095 CEP128 NRXN3 NRXN3 NRXN3 NRXN3 NRXN3 NRXN3 DPF3 DPF3 DPF3 RGS6 RGS6 RGS6 RGS6 RGS6 RGS6 RGS6 RGS6 KCNH5 AKAP6 MRPL52 PCCA centrosomal protein 128kDa neurexin 3 neurexin 3 neurexin 3 neurexin 3 neurexin 3 neurexin 3 D4, zinc and double PHD fingers, family 3 D4, zinc and double PHD fingers, family 3 D4, zinc and double PHD fingers, family 3 regulator of G-protein signaling 6 regulator of G-protein signaling 6 regulator of G-protein signaling 6 regulator of G-protein signaling 6 regulator of G-protein signaling 6 regulator of G-protein signaling 6 regulator of G-protein signaling 6 regulator of G-protein signaling 6 potassium voltage-gated channel, subfamily H (eag-related), member 5 A kinase (PRKA) anchor protein 6 mitochondrial ribosomal protein L52 propionyl CoA carboxylase, alpha polypeptide GÜL et al. / Turk J Med Sci rs2131659 rs11247226 rs8033689 rs7180844 747 748 749 750 rs11629542 rs2290271 744 rs11636210 rs6495081 743 745 rs7177970 742 746 rs2059322 rs10518921 740 741 rs10083639 rs11072156 738 739 rs8030240 rs1436955 736 737 rs6494307 rs10083587 734 735 rs2456526 rs10519107 732 733 rs7180600 rs10518694 730 rs7170955 729 731 rs12592542 rs16962542 727 728 rs11848957 rs12907278 725 726 rs6574608 rs10444745 723 724 rs2888032 rs11625199 721 722 rs2556611 rs12050342 719 720 0,8721 0,8736 0,8731 0,8711 0,8803 1,154 1,152 1,139 1,242 1,242 1,246 0,8357 0,836 0,8659 0,8632 0,8756 0,8769 0,8559 1,215 1,225 1,201 1,194 0,7151 1,141 1,149 1,244 0,8628 0,8742 0,8741 0,8678 0,8686 0,8646 Appendix. (Continued). 1,19E-04 3,11E-04 4,08E-04 3,46E-04 2,84E-04 8,33E-04 1,99E-04 3,43E-04 6,53E-04 6,51E-04 6,24E-04 5,21E-04 1,82E-04 1,78E-04 8,85E-04 7,29E-04 5,60E-04 6,36E-04 3,93E-05 2,77E-04 1,58E-04 5,53E-04 1,32E-04 4,52E-05 5,00E-04 2,60E-04 7,53E-04 1,00E-04 3,77E-04 3,73E-04 1,77E-04 2,07E-04 0,495 0,473 0,434 0,468 0,475 0,434 0,472 0,358 0,435 0,104 0,105 0,106 0,191 0,193 0,263 0,259 0,413 0,413 0,481 0,145 0,142 0,151 0,209 0,057 0,456 0,451 0,096 0,470 0,500 0,498 0,500 0,492 14 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 14 14 14 14 14 14 80415919 98953582 98951820 98938486 98925810 89415484 87899758 83248639 71903355 68832308 68793963 68792114 68369472 68368811 60191674 60186856 60185825 60181982 59114168 50876734 50859965 50857433 44444884 34189070 31773110 31760469 94731600 87891057 80444575 80442498 80439264 80438617 A T G C T C C C G G T C A A T T T G G C A A C A A A C G A A C T G C C T G T G A T A C A T G C C C C C T C G A T G G G T C G T C 145508 55180 55180 55180 9154 55075 55075 55075 6095 3175 3175 6263 6263 79789 145508 145508 145508 145508 CEP128 LINS LINS LINS SLC28A1 UACA UACA UACA RORA ONECUT1 ONECUT1 RYR3 RYR3 CLMN CEP128 CEP128 CEP128 CEP128 centrosomal protein 128kDa lines homolog (Drosophila) lines homolog (Drosophila) lines homolog (Drosophila) solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 uveal autoantigen with coiled-coil domains and ankyrin repeats uveal autoantigen with coiled-coil domains and ankyrin repeats uveal autoantigen with coiled-coil domains and ankyrin repeats RAR-related orphan receptor A one cut homeobox 1 one cut homeobox 1 ryanodine receptor 3 ryanodine receptor 3 calmin (calponin-like, transmembrane) centrosomal protein 128kDa centrosomal protein 128kDa centrosomal protein 128kDa centrosomal protein 128kDa GÜL et al. / Turk J Med Sci 23 24 rs559655 rs3737361 rs9947011 rs6507323 780 782 783 rs2299836 779 781 rs688248 rs508816 777 778 rs555935 rs575420 775 776 rs767300 rs471999 773 774 rs10512617 rs1531797 771 772 rs8076794 rs6501238 769 770 rs4968816 rs11656969 767 768 rs228768 rs1968393 765 766 rs16964890 rs11652197 763 764 rs8062047 rs11648295 761 762 rs8063424 rs3924889 759 760 rs171125 rs216944 757 758 rs809684 rs249301 755 756 rs12597219 rs8062975 753 754 rs8055183 rs8043935 751 752 0,8509 0,8569 1,159 1,202 1,167 1,151 1,155 1,136 1,153 1,16 1,142 1,15 1,133 1,14 1,142 1,198 0,8764 1,146 1,143 0,8246 0,7752 0,8258 1,366 1,202 1,176 0,8718 1,283 1,209 1,203 1,191 1,183 1,181 1,183 Appendix. (Continued). 5,50E-04 2,93E-04 4,90E-04 3,64E-04 2,26E-04 1,90E-04 2,54E-04 2,85E-04 8,21E-04 2,39E-04 2,01E-04 9,45E-04 2,27E-04 9,67E-04 5,87E-04 4,76E-04 5,35E-04 6,27E-04 7,52E-04 9,15E-04 3,46E-04 4,36E-05 6,97E-04 2,18E-04 2,83E-04 5,47E-04 5,42E-04 3,43E-05 1,61E-04 3,94E-05 1,86E-04 3,83E-04 6,16E-04 0,187 0,244 0,249 0,295 0,173 0,287 0,393 0,342 0,421 0,387 0,329 0,328 0,488 0,487 0,460 0,461 0,150 0,398 0,320 0,333 0,150 0,106 0,134 0,052 0,172 0,208 0,356 0,110 0,165 0,227 0,200 0,195 0,183 16 18 18 18 18 18 18 18 18 18 18 18 17 17 17 17 17 17 17 17 17 17 16 16 16 16 16 16 16 16 16 16 16 919237 18680676 18674407 12821324 10055123 9840212 9839620 9838613 9838371 9835307 9834729 9830230 74333763 74205146 74181334 74172864 69822772 64200570 49919431 39547419 28478690 24567546 87432022 78457228 78426000 78424987 58798850 34618468 9377408 6322435 6311714 6310627 6306727 T G A C T A T C A T G A T C T A T G A G C C T G C T A T T A T A G C C G T C G C T C C A G C G C C C A G T A T G T A C G C A G A C A 64788 5771 11031 11031 11031 11031 11031 11031 11031 57602 9267 64446 10014 40 2588 LMF1 PTPN2 RAB31 RAB31 RAB31 RAB31 RAB31 RAB31 RAB31 USP36 CYTH1 DNAI2 HDAC5 ASIC2 GALNS lipase maturation factor 1 protein tyrosine phosphatase, non-receptor type 2 RAB31, member RAS oncogene family RAB31, member RAS oncogene family RAB31, member RAS oncogene family RAB31, member RAS oncogene family RAB31, member RAS oncogene family RAB31, member RAS oncogene family RAB31, member RAS oncogene family ubiquitin specific peptidase 36 cytohesin 1 dynein, axonemal, intermediate chain 2 histone deacetylase 5 acid-sensing (proton-gated) ion channel 2 galactosamine (N-acetyl)-6-sulfate sulfatase GÜL et al. / Turk J Med Sci rs7251215 rs10409299 rs41332947 rs2876409 rs3746476 812 813 814 815 816 rs7252689 rs1017207 810 811 rs470443 rs4805258 808 809 rs9955666 rs1421521 806 807 rs607104 rs557416 804 805 rs639407 rs619662 802 803 rs476828 rs9947403 800 801 rs7235626 rs17782313 798 799 rs6567157 rs1942880 796 797 rs1539952 rs9966951 794 795 rs11664327 rs8091524 792 793 rs7234864 rs1942867 790 791 rs2056015 rs16973756 788 789 rs9304261 rs6507457 786 787 rs3911557 rs4800138 784 785 0,8168 1,141 0,8161 1,166 1,173 1,176 1,173 1,169 1,158 1,139 1,152 1,148 1,141 1,15 1,153 1,151 1,168 1,161 1,162 1,169 1,159 1,148 1,176 1,19 1,173 1,18 1,174 0,7505 1,134 0,8393 0,8586 0,8482 0,848 Appendix. (Continued). 2,06E-04 9,10E-04 7,11E-04 4,90E-04 9,10E-04 2,09E-04 8,08E-04 6,56E-04 8,10E-04 5,80E-04 9,78E-04 5,20E-04 5,53E-04 8,97E-04 3,05E-04 3,44E-04 4,18E-04 3,76E-04 7,07E-04 1,92E-04 1,02E-04 2,35E-04 6,16E-04 1,73E-04 5,56E-05 6,36E-05 8,71E-05 1,57E-04 6,68E-04 8,99E-04 9,33E-05 8,68E-04 2,15E-04 0,246 0,109 0,367 0,127 0,208 0,259 0,183 0,202 0,211 0,267 0,348 0,336 0,347 0,355 0,398 0,352 0,349 0,258 0,253 0,338 0,339 0,340 0,335 0,266 0,267 0,348 0,285 0,281 0,055 0,492 0,250 0,225 0,245 18 20 20 19 19 19 19 19 19 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18726561 36373583 15415075 55391757 41016164 39099587 39057327 33080647 32763882 72832968 60236486 56063765 56046039 56042573 56035531 56021159 56020730 56003567 56002077 55949677 55944189 55941205 55926275 55917492 55902940 55890603 55887250 55885837 36617062 32164600 18880434 18860594 18768295 T G A C G G A T A A A A G G A G T C C T T G A G C C A T G G T T G C A G T A A G C G G G G A C G A C T T G C T G A T T G C A T C C A 671 140733 4868 4155 80206 5932 5932 BPI MACROD2 NPHS1 MBP FHOD3 RBBP8 RBBP8 bactericidal/permeability-increasing protein MACRO domain containing 2 nephrosis 1, congenital, Finnish type (nephrin) myelin basic protein formin homology 2 domain containing 3 retinoblastoma binding protein 8 retinoblastoma binding protein 8 GÜL et al. / Turk J Med Sci 25 26 rs2831054 rs1888433 rs2831854 rs2831863 844 845 846 847 rs2826244 rs1029258 842 843 rs2826242 rs1985053 840 841 rs2826239 rs9980427 838 839 rs369347 rs158046 836 837 rs1667570 rs380220 834 835 rs2823759 rs915856 832 833 rs6089568 rs2037994 830 831 rs1468056 rs6061921 828 829 rs2257 rs6098138 826 827 rs1883553 rs487096 823 rs6020178 rs676035 822 824 rs6063438 821 825 rs16985285 rs6103716 819 820 rs6103249 rs6073055 817 818 1,159 1,162 1,139 1,167 0,8229 0,8668 0,8615 0,8687 0,873 0,8685 1,22 1,253 1,25 1,254 1,24 1,245 1,226 0,8517 0,8584 1,154 1,214 1,158 1,168 1,193 1,217 1,186 1,183 1,157 0,8374 0,8728 0,8325 Appendix. (Continued). 7,24E-04 2,21E-04 3,31E-04 8,63E-04 5,52E-04 5,69E-04 3,54E-04 2,27E-04 5,09E-04 6,81E-04 5,02E-04 4,29E-04 1,44E-04 2,02E-04 1,42E-04 3,59E-04 2,57E-04 8,93E-04 2,69E-05 6,35E-05 3,96E-04 7,76E-04 3,47E-04 9,91E-04 6,38E-05 5,20E-04 2,26E-04 3,04E-04 3,05E-04 7,84E-04 7,12E-04 0,147 0,347 0,283 0,386 0,239 0,136 0,340 0,328 0,326 0,346 0,326 0,132 0,115 0,109 0,112 0,111 0,111 0,105 0,425 0,432 0,333 0,119 0,306 0,200 0,240 0,128 0,205 0,204 0,327 0,153 0,338 20 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 20 20 20 20 20 20 20 20 20 20 20 20 20 41399350 28788692 28782159 27954964 27954865 26710675 20716906 20713786 20713322 20709933 20709622 18316684 16669662 16668953 16668591 16668120 16667957 15880541 59967110 59966907 54399395 52701411 51245861 48037347 48007523 47932666 47916399 47874575 42433044 41448057 41406604 C T T T A C G G T A T C G A G A C A A C C T G C T G G T C T G T C C C G A C A C G G T A G A G G C G T G C C T C C A C A C A 140578 388815 388815 388815 388815 388815 6790 55816 128553 6615 23315 23315 23315 3172 CHODL LINC00478 LINC00478 LINC00478 LINC00478 LINC00478 AURKA DOK5 TSHZ2 SNAI1 SLC9A8 SLC9A8 SLC9A8 HNF4A chondrolectin long intergenic non-protein coding RNA 478 long intergenic non-protein coding RNA 478 long intergenic non-protein coding RNA 478 long intergenic non-protein coding RNA 478 long intergenic non-protein coding RNA 478 aurora kinase A docking protein 5 teashirt zinc finger homeobox 2 snail homolog 1 (Drosophila) solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 hepatocyte nuclear factor 4, alpha GÜL et al. / Turk J Med Sci rs1999318 rs9975371 rs11701035 rs8132538 rs2835530 rs2845812 rs8127236 rs220161 rs9981459 rs2401163 rs2587103 rs713999 rs6008226 rs11090806 rs12009434 rs5979784 rs17277503 rs5914799 rs5914807 rs5960811 rs1930978 rs11091598 rs5914852 rs4379572 rs4557841 848 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 867 868 869 870 871 872 1,193 1,184 1,186 1,187 1,197 1,191 1,192 1,189 1,182 1,169 1,181 1,29 1,189 0,8414 0,8412 0,8312 0,823 0,8149 1,143 1,204 1,237 1,229 1,246 1,215 1,148 Appendix. (Continued). 2,75E-04 6,85E-04 9,99E-04 6,06E-04 3,48E-04 4,95E-04 4,32E-04 5,27E-04 8,38E-04 5,82E-04 2,51E-04 9,95E-04 3,71E-04 1,07E-05 8,87E-04 4,02E-04 2,92E-04 9,16E-04 8,21E-04 1,09E-04 1,20E-05 2,21E-05 5,68E-06 9,45E-04 9,33E-04 0,274 0,243 0,214 0,240 0,241 0,239 0,240 0,239 0,239 0,329 0,324 0,065 0,184 0,376 0,156 0,154 0,148 0,109 0,353 0,189 0,182 0,183 0,186 0,114 0,284 23 23 23 23 23 23 23 23 23 23 23 22 22 22 22 22 21 21 21 21 21 21 21 21 21 57383907 56968844 56948766 56927696 56927132 56870079 56867944 56840879 56833086 12876296 12875922 46777160 46243314 46210776 16528454 16511078 42681878 42422362 37271007 37220194 37199189 37197902 37162840 28817851 28817820 G G C G T G G C G C A A C A T C G C T T C A A T C T A T T C A T T A A G C T G C T C G C C T G G C A 158584 550643 550643 23786 23786 64699 89766 3141 3141 3141 3141 3141 FAAH2 LOC550643 LOC550643 BCL2L13 BCL2L13 TMPRSS3 UMODL1 HLCS HLCS HLCS HLCS HLCS fatty acid amide hydrolase 2 uncharacterized LOC550643 uncharacterized LOC550643 BCL2-like 13 (apoptosis facilitator) BCL2-like 13 (apoptosis facilitator) transmembrane protease, serine 3 uromodulin-like 1 holocarboxylase synthetase (biotin-(proprionyl-CoAcarboxylase (ATP-hydrolysing)) ligase) holocarboxylase synthetase (biotin-(proprionyl-CoAcarboxylase (ATP-hydrolysing)) ligase) holocarboxylase synthetase (biotin-(proprionyl-CoAcarboxylase (ATP-hydrolysing)) ligase) holocarboxylase synthetase (biotin-(proprionyl-CoAcarboxylase (ATP-hydrolysing)) ligase) holocarboxylase synthetase (biotin-(proprionyl-CoAcarboxylase (ATP-hydrolysing)) ligase) GÜL et al. / Turk J Med Sci 27 28 rs5919623 rs12862591 rs12861185 rs5965955 883 884 885 886 rs2997052 rs5965947 881 rs2256173 880 882 rs2495622 rs2495626 878 879 rs6642958 rs4825603 876 877 rs5942729 rs5942752 874 875 rs10855622 873 0,8593 0,8554 0,8637 0,86 0,8593 1,213 1,204 1,219 1,215 1,206 1,215 1,22 1,216 0,8459 Appendix. (Continued). 4,87E-04 3,44E-04 7,72E-04 5,09E-04 5,27E-04 6,24E-04 9,46E-04 4,27E-04 5,13E-04 8,05E-04 9,84E-04 7,71E-04 9,40E-04 5,73E-04 0,406 0,403 0,406 0,411 0,408 0,178 0,174 0,174 0,176 0,177 0,154 0,155 0,155 0,267 23 23 23 23 23 23 23 23 23 23 23 23 23 23 144807588 144801952 144801782 144779048 144777233 117800548 117773617 117742946 117737020 117727895 108249271 108209528 108181279 85902249 A G G C C G C T G C G G A G T C T G T A T C T G A A G C 3597 3597 117154 IL13RA1 IL13RA1 DACH2 interleukin 13 receptor, alpha 1 interleukin 13 receptor, alpha 1 dachshund homolog 2 (Drosophila) GÜL et al. / Turk J Med Sci
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