Summary HORIZON 2020 FUNDING OPPORTUNITIES ON HEALTH Presentation of project ideas for consortia building April 10th 2014 H 15:15-16:45 Novarello – Villaggio Azzurro, Novara, Italy Catalogue of Participants 1. Presentation........................................................................................................................ 3 2. Associazione Vivere la Montagna......................................................................................... 4 3. HPV-UNIT – Regina Elena National Cancer Institute (IRE)...................................................... 6 4. Infomedica srl – Medical Education & Information ............................................................... 8 5. Istituto Nazionale per le Malattie Infettive „Lazzaro Spallanzani“ ...................................... 10 6. German Cancer Research Centre – Div. of Viral Transformation Mechanisms ..................... 12 7. Università degli studi del Piemonte Orientale – Dip. di Medicina........................................ 14 8. Università degli studi del Piemonte Orientale – Dip. di Scienze e Innovazione Tecnologica . 16 9. Università di Torino – Dip. Surgical Sciences....................................................................... 18 10. 1 Università di Torino of Torino – Dep. of Agricultural, Forest and Food Sciences ............... 20 2 1. Presentation Objective of the event: The special event is organized by Finpiemonte and Unioncamere Piemonte, during the 7th International Conference on “HPV, Polyomavirus and UV in Skin Cancer”. The event is organized in the framework of the Enterprise Europe Network (EEN), which is the EU’s largest business support network promoting competitiveness and innovation in Europe and beyond, with 600 partner organizations in more than 50 countries. One of the most important mission of EEN is to help SMEs, universities and research organization to build international partnerships and take part to international RTD projects. 2. Associazione Vivere la Montagna Country/Region: Italy – Piedmont - Cumiana (Torino) Main objective of the workshop is to present FUNDING OPPORTUNITIES in Horizon 2020 for HEALTH and to give to the participants the opportunity to present and discuss potential project ideas. Giorgio Chiaretta – President Massimo Apicella – Vice-President Chiara Reggiani – Scientific Committee Donata Vinelli – Scientific Committee Name of Researcher: Added value of the event: • Get background information about the Health call in Horizon 2020 • Meet new partners for potential collaboration on specified issues • Facilitate the setup of Horizon 2020 project consortia • Present, discuss and develop new project ideas at international level • Initiate cross-border contacts • Promote your organization and expertise in Europe and USA. Researcher Contact Details Phone +39.011.198.36.595 – 349.67.67.113 E-mail presidenza@viverelamontagna.org montagnacumiana@gmail.com Thematic focus: For additional information on Horizon 2020: Main Sectors of application: • Programme Framework • Health specific Programme and call information • Health, demographic change and wellbeing, Work Programme 2014-2015 For further information: Cristiana Tabacco - cristiana.tabacco@finpiemonte.it , tel +39 011 5717814. 3 Human Health and Mountain Psycho-social rehabilitation and environment developement International cooperation experience Not previously experienced NO Involved in international and RTD projects NO Experience in the following cooperation and RTD programmes: NO 4 Project Description “Alpinhealth® - A mountain of health” Alpinhealth® is a project that acts on several levels, which looks at the Highlands as a resource and as a tool for healthy well-being oriented in the psychological, social, occupational areas and for rehabilitation. 3. HPV-UNIT – Regina Elena National Cancer Institute (IRE) Country/Region: Alpinhealth ® suggests and develops a kind of interactive approach, both for the inner being for a person as himself, and for his relationship with the outer environment Italy Name of Researcher: Aldo Venuti Alpinhealth ® provides an innovative approach for the psycho-physical welfare oriented to the geographical area, the project can also be an exportable model to other highland areas. Researcher Contact Details HPV-UNIT IRE via Chianesi 53 00144 Rome Italy Phone +39065266250 E-mail venuti@ifo.it; venutie4@yahoo.com Type of Partner Searched Universities, local Authorities, Social-Healthcare Consortia, Banking foundations, Other potential lenders/investors Thematic focus: Main Sectors of application: Viruses and cancer Biological (immuno)Therapy, biomarkers, diagnosis Contacts for further information International cooperation experience EEN Partners Cristiana Tabacco Phone: +39 011 5717814 Not previously experienced E-mail: cristiana.tabacco@finpiemonte.it Involved in international and RTD projects Yes, but not European RTD projects (Collab. projects with Scotland, Argentina and Australia) Experience in the following cooperation and RTD programmes: None in granted European framework programmes but participating in (unfortunately) not granted Projects. Project Description Search for new viruses associated with human malignancy. Discovery of new virus-related biomarkers (and biosensor device for their detection) for early diagnosis and population screening New personalized (immuno and/or small molecules) therapy against virus/host interacting pathways 5 6 Type of Partner Searched 4. Bioinformatics for in silico research (metagenomics). Infomedica srl – Medical Education & Information Company producing/possessing large arrays of small molecules with interacting activity on different viral/cellular pathways Company producing/developing new therapeutic vaccines Country/Region: Italy Clinical Dept with large archival samples/patients Name of Researcher: Infomedica – Giorgio Mantovani Biosensor researchers for the development of new diagnostic device for biomarker detections Researcher Contact Details Contacts for further information Phone +39 011 859990 E-mail gmantovani@infomedica.com EEN Partners Cristiana Tabacco Thematic focus: Phone: +39 011 5717814 E-mail: cristiana.tabacco@finpiemonte.it Main Sectors of application: Medical Education & Information Distance learning (Self-Assessment & Self-Education Programs / CME Journals / Clinical cases & Interactive study modules / Information – broadcasting & web) International cooperation experience Not previously experienced Previous international experience with international private entities Involved in international and RTD projects In international private projects Experience in the following cooperation and RTD programmes: Distance learning for health care professionals Project Description Project 1: Compliance / Adherence Background: For millions of patients, medications for chronic diseases are often misunderstood or misused. Most patients quickly abandon therapy; many times for the wrong reasons—and with serious consequences. Objectives: Design & create an integrated system to bring together all parties (patient, physician, care giver) to improve patients’ experiences with medications, for the benefit of patients, their families and the entire healthcare system. Project 2: Share your health knowledge Background: In medical practice professionals guarantee the best care for their patients by committing to 7 8 life-long learning. Objectives: Design & implement a virtual meeting place for the promotion of medical & scientific learning for teachers and learners within the healthcare scenario and throughout all EU. The online courses will be subject to rigorous peer-review and guaranteed by institutional or academic partners taking part in the project. 5. Project 3: Mobility for health workforce (HWF) Background: According to an estimate, Europe expects a shortage of 1 million health workers by 2020. Demand, need and supply of the HWF are influenced by multiple factors like ageing population, ageing HWF, rising care use and rising costs in a context of budget constraints. Objectives: Analyse and project a platform for the HWF for exchange data/information between EU countries to support mobility of the HWF. Istituto Nazionale per le Malattie Infettive „Lazzaro Spallanzani“ Country/Region: Italy Name of Researcher: Garbuglia Anna Rosa Researcher Contact Details Phone +390655170692 E-mail argarbuglia@iol.it Type of Partner Searched Thematic focus: Project 1: Researchers, physicians, and institutions in the most important EU to map the different situations and define a possible standard procedures for managing the compliance/adherence in the EU countries. / IT experts. Main Sectors of application: Project 2: Institutions (academic or other), teacher/trainers, educationalists, physicians within the EU to create a network of experts to create, manage and share knowledge disseminated through e-learning for all health care workers. / IT experts. International cooperation experience Project 3: Institutions) in the most important EU to map the different situations to manage and share a platform for supply/demand of all the potential mobility EU / IT experts. Not previously experienced HPV in oral site Phylogenetic analysys; potential oncogenicity of HPV Involved in international and RTD projects Yes Experience in the following cooperation and RTD programmes:PREDEMICS Contacts for further information Project Description EEN Partners Cristiana Tabacco Phone: +39 011 5717814 In view of the increased life-span of HIV patients undergoing long term highly active antiretroviral therapy (HAART) as well as the possible etiologic role of the oral HPV in carcinogenesis, aging HIV/HPV-coinfected patients may be at significant risk as regards HPV-associated lesions and malignancies. Preliminary data showed that β and γ HPV prevalence was higher than those of α HPV in oropharingeal swabs samples. Several unclassified genotypes were found (HPV FA12.2; HPV ISOL FA97; HPV ISOL. FA68) and some rare genotypes, i.e. HPV120, were detected in multiple anatomical sites (oral and anal). E-mail: cristiana.tabacco@finpiemonte.it Objectives: 1) Charaterization of new HPV types, 2) tropism analysis of rare β and γ HPVs 3) potential oncogenicity of β and γ HPV in oral site in HIV subjects. 9 10 Type of Partner Searched 6. • Bioinformatic expertise in the analysis of new HPV genotypes and in performance of a metagenomic approach for detecting multiple HPV infections. • Know-how in molecular field to analyze transcriptional regulation of viral gene expression in nonmalignant and malignant cells. German Cancer Research Centre – Div. of Viral Transformation Mechanisms Country/Region: Germany Name of Researcher: Prof. Dr. Frank Rösl / Dr. Sabrina Vinzón Researcher Contact Details Phone +49 6221 42-4922 E-mail f.roesl@dkfz.de; s.vinzon@dkfz.de Contacts for further information EEN Partners Cristiana Tabacco Thematic focus: Phone: +39 011 5717814 Development of second generation vaccines against papillomavirus E-mail: cristiana.tabacco@finpiemonte.it Main Sectors of application: Pharmaceutical industry; Human medicine. International cooperation experience x Not previously experienced Involved in international and RTD projects Experience in the following cooperation and RTD programmes: Project Description Papillomaviruses are small, non-enveloped viruses which infect the stratified squamous epithelia of skin and mucosal membranes. Different types of papillomaviruses are involved in the development of a variety of human cancers. Among them, there are approximately 15 types named high-risk types because they are considered the etiological agents of most cervical cancers, and are also associated with many penile, vulvar and anal carcinomas and more than 40% of head and neck cancers. The remaining mucosal types are rarely found in malignancies and therefore called low-risk. On the other hand, the cutaneous HPV types are associated with the development of skin warts and also with the development of non-melanoma skin cancer, especially in organ transplant patients. The rodent Mastomys coucha is naturally and persistently infected with Mastomys natalensis papilloma virus (MnPV). The animals are unique in spontaneously developing not only benign skin tumours, such as papillomas and keratoacanthomas, but also squamous cell carcinomas, for which MnPV is the etiological agent. Infection occurs early in lifetime, similarly to cutaneous HPVs, and high viral loads can be detected in the skin of older animals, which trigger the onset of papilloma development. Therefore, M. coucha represents an excellent read-out model to investigate prophylactic approaches against PV-induced skin 11 12 tumors under natural conditions. In a recent study, we evaluated the efficacy of a virus-like particle (VLP)-based vaccine on either previously or newly established infections. VLPs raise a strong and long-lasting neutralizing antibody response that confers protection even under systemic long-term cyclosporine A treatment. Remarkably, the vaccine completely prevents the appearance of benign as well as malignant skin tumors. Protection involves the maintenance of a low viral load in the skin by an antibody-dependent prevention of virus spread. Our results provide first evidence that VLPs elicit an effective immune response in the skin under immunocompetent and immunosuppressed conditions in an outbred animal model, irrespective of the infection status at the time of vaccination. These findings provide the basis for the clinical development of potent vaccination strategies against cutaneous HPV infections and HPV-induced tumors, especially in patients awaiting organ transplantation. 7. Università degli studi del Piemonte Orientale – Dip. di Medicina Vaccination against genital HPV types is currently being used worldwide to prevent infection and, in turn, the development of HPV-induced lesions in the mucosa, including cervical carcinoma. The two licensed vaccines are composed of HPV VLPs, which elicit high titers of neutralizing antibodies that protect from a subsequent infection by the targeted HPV types. However, these vaccines have several limitations: (i) they target only two mucosal high-risk types, therefore potentially preventing approximately 70% of the cervical cancer cases, which leaves 30% of the cases unattended; (ii) they don´t target any cutaneous type; (iii) they are very costly, making implementation of wide-covering vaccination schedules difficult in underdeveloped countries. Country/Region: Italy Name of Researcher: Filippo Renò Phone +39-0321-660634 Given the variety of HPV types that could be involved in the development of non-melanoma skin cancer in humans, as well as the many types causing mucosal tumors, a broadly protective HPV vaccine would be ideal. The papillomavirus minor capsid protein L2, contains a major cross-neutralizing epitope that could be used to develop a second generation vaccine. E-mail Filippo.reno@med.unipmn.it Thematic focus: Skin disease The aim of our project is to investigate whether administration of such a broadly protective vaccine (i.e., an L2-vaccine) is as effective in preventing skin tumors in Mastomys coucha as its L1 counterpart. Main Sectors of application: Dermatology, inflammation, pharmacology Researcher Contact Details International cooperation experience Type of Partner Searched Academic. Not previously experienced Industrial. Involved in international and RTD projects x Experience in the following cooperation and RTD programmes: Contacts for further information EEN Partners Cristiana Tabacco Phone: +39 011 5717814 Project Description E-mail: cristiana.tabacco@finpiemonte.it Autonomic dysfunction has been associated with human inflammatory diseases including rheumatoid arthritis, diabetes and sepsis; whether this dysfunction results from the inflammatory component of these diseases, or is actually an underlying cause, is not clear. Recently, a neural circuit has been identified that 13 14 controls the inflammatory response in a reflex- involving the vagus nerve which is able to sense inflammation and to respond to it by releasing acetylcholine (Ach) which inhibits macrophage cytokine production interacting specifically with macrophage alpha7 subunits of nicotinic ACh receptors. Others Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine, and agonist stimulation of these AChRs causes functional and biochemical changes in the cells. In addition, a recently discovered endogenous allosteric α7 nAChR ligand, SLURP-1, also appears to be involved in modulating both normal T cell function and keratinocyte behaviour. Since nicotinic AChRs have been shown to regulate SLURPs production, these peptides have been suggested as prototype drugs for the treatment of wounds that fail to heal. 8. Università degli studi del Piemonte Orientale – Dip. di Scienze e Innovazione Tecnologica The aims of the project are: Country/Region: Itay/Piemonte 1) to investigate the role of the “vagal tone” in the onset of inflammatory and autoimmune disease cutaneous effects; Name of Researcher: M. Botta, L. Tei, F. Carniato Researcher Contact Details Dr. Lorenzo Tei 2) to test the ability of physical exercise, colinomimetic drugs and acetylcholine synthesis and degradation modulators to mitigate cutaneous effects 3) to design new therapeutic and pharmacological approaches to inflammatory and autoimmune disease cutaneous effects; Phone 0131 360208 E-mail lorenzo.tei@unipmn.it Thematic focus: Type of Partner Searched Theranostic nanoparticles Main Sectors of application: Personalise nanomedicine Type of Partner Searched International cooperation experience Clinical centres, university research groups, biotech and pharmaceutical companies Not previously experienced Involved in international and RTD projects Participation in EU Projects (coordinator Prof. S. Aime, University of Torino, Italy): Contacts for further information European Networks of Excellence (6th EU Framework Programme): “European Molecular Imaging Laboratories - EMIL” (2004-2009). EEN Partners Cristiana Tabacco “Diagnostic Molecular Imaging DiMI” (2005-2010). Phone: +39 011 5717814 Experience in the following cooperation and RTD programmes: E-mail: cristiana.tabacco@finpiemonte.it MEDITRANS (NMP4-CT-2006-026668), Targeted Delivery of Nanomedicine (2006-2011). Members of EU COST Action TD 1004: “Theranostics imaging and therapy: an action to develop novel nanosized systems for imaging-guided drug delivery” (2012 – 2016). EU COST Actions D38 and D18: "Metal-Based Systems for Molecular Imaging Applications" (2006-2011) and “Lanthanide Chemistry for Diagnosis and Therapy” (2001-2006). 15 16 Project Description Use of functionalised Gd-loaded mesoporous silica nanoparticles or efficient Gd-based liposomes for imaging guided drug delivery and for theranostic applications Optimization of: i) the contrast efficiency; ii) the modulation of drug loading and release; iii) the selectivity of the nanoparticle targeting to malignant tissues 9. Type of Partner Searched Università di Torino – Dip. Surgical Sciences Country/Region: ITALY/ PIEMONTE 1) Academic groups specialized in “in vitro” and “in vivo” application of theranostic agents or high field MRI contrast agents. Name of Researcher: ELISABETTA RADICE 2) Pharmaceutical companies for development of novel drug delivery systems. Researcher Contact Details Contacts for further information Phone +39 011/0915385 E-mail Elisabetta.radice@unito.it EEN Partners Cristiana Tabacco Thematic focus: Phone: +39 011 5717814 E-mail: cristiana.tabacco@finpiemonte.it Main Sectors of application: Cancer research,pre-clinical/clinical application Colorectal cancer (CRC), pelvic floor pathologies International cooperation experience Not previously experienced x Involved in international and RTD projects Experience in the following cooperation and RTD programmes: H2020 - PHC13 – innovative therapy against CRC Project Description Each project involving: Clinical and pre-clinical research (basic/traslational research, TRL 1-4) Pelvic floor pathology, cancer research (i.e. CRC, etc.) Mini-invasive sirurgy Robotic sirurgy 17 18 Nanomedicines pre-clinical/clinical application Type of Partner Searched Universities (medicine and surgery department) Researchers (clinical pre-clinical studies) Hospitals and research center/labs (public/private) Pharmaceutical/Nutreceutical manufacturer 10. Università di Torino of Torino – Dep. of Agricultural, Forest and Food Sciences Country/Region: Italy/Piedmont Name of Researcher: Valentina Scariot Researcher Contact Details Via Leonardo da Vinci 44, 10095, Grugliasco, Torino healthcare SME Contacts for further information Phone +390116708935 E-mail valentina.scariot@unito.it EEN Partners Cristiana Tabacco Phone: +39 011 5717814 E-mail: cristiana.tabacco@finpiemonte.it Thematic focus: Main Sectors of application: Ornamental and medicinal plants Biology, biotechnology, sustainable practices International cooperation experience X Not previously experienced Involved in international and RTD projects Experience in the following cooperation and RTD programmes: Project Description Plant secondary metabolites do not play a major role in growth and development. Conversely, their production and accumulation are fundamental for plant survival under extreme environmental conditions (abiotic stresses). Many of these are important bioactive compounds potentially beneficial for human health. The pharmacological involvement of so-called “medicinal plants”, which include the Lamiaceae, Labiatae, Asteraceae, Cistaceae, Punicaceae, and Oleaceae families, has long time been known. Concerning pharmacologal aspects, the metabolic syndrome incidence (dyslipidemia, insulin resistance and hypertension) 19 20 is increasing in Western countries and represents a risk factor for many cardiovascular diseases. Nowadays, the identification of dietary supplements that can reduce these possible cardiovascular complications is therefore of considerable pharmacological interest. Thus, the main purpose of this project will be to evaluate the dietary pharmacological properties of essential oils extracted from Melissa officinalis L., Salvia fruticosa L., Helichrysum italicum (Roth) Don, Artemisia princeps Pamp, Cistus populifolius Mill., Punica granatum L., and Olea europea L., in conditions of abiotic stress, with a view to health promotion and disease prevention (Horizon 2020). The study of the biosynthesis of plant compounds will be conducted through in vivo and in vitro approaches. In both cases, plants will be cultivated under drought, cold, and ozone stress. In particular, for all trials a multidisciplinary approach will be undertaken, ranging from ecophysiological characterization (for example osmotic potential, turgor loss, cell walls elasticity, leaf conductance, gas exchange, xanthophylls cycle), through the analysis of primary metabolism, the characterization of secondary metabolite classes, the quantification of phytohormones (HPLC), and the characterization of volatile compounds (GC and SPME), to proteomics studies (LC and Q-trap MS-MS). In order to better understand the molecular basis of stress response, the total transcriptome of stressed plants will be sequenced by means of Next Generation Sequencing (NGS) using the RNA-Seq technique. Plants subjected to different theses will be submitted to the extraction of essential oils through two techniques, i.e. the ultrasound-assisted and the microwave-assisted extraction. These methodologies are known to be high throughput and to yield high-quality oils through a rapid protocol, reducing solvent consumption as well (green extraction). Finally, the extracted plant compounds will be tested in vivo in animal models with fat dietary, miming a condition of human metabolic syndrome. In parallel, in vitro studies will be aimed to the analysis of potential antiflammatory effects of essential oils by usingvascular endothelial cells (Human Umbilical Vein Endothelial Cells, HUVEC), the main target tissue of the metabolic syndrome, and polymorphonuclear cell, as reference target. As a final aim, it will be of high scientific interest to integrate physiology, morphology, metabolomics and transcriptomics, in order to identify molecules that can potentially have a positive activity on human health. Type of Partner Searched We are searching for partner mainly involved in the medicinal and pharmacological aspects related to the activity of natural compounds. Contacts for further information EEN Partners Cristiana Tabacco Phone: +39 011 5717814 E-mail: cristiana.tabacco@finpiemonte.it 21
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