CURRICULUM VITAE FORMATO EUROPEO/EUROPEAN FORMAT INFORMAZIONI PERSONALI/ PERSONAL INFORMATION Nome, Cognome/Name, Surname Indirizzo/Address Via, numero civico, c.a.p., città, nazione/ House number, street name, postcode, city, country Telefono/Telephone Fax E-mail Sito web/Website Nazionalità/Nationality Luogo e data di nascita/ Place and Date of birth TRIA, Giancarlo Fischers Allee 82 22763 Hamburg Germany MOBILE (DE): +49 [0] 17 69 90 45 28 9 MOBILE (IT): +49 [0] 34 05 94 95 88 +49 [0] 40 89902 109 giancarlo.tria@gmail.com http://www.embl-hamburg.de/biosaxs/tria.html ITALIAN Conversano (BA) – 25th August 1982 ESPERIENZA PROFESSIONALE/ WORK EXPERIENCE Se dipendente CNR indicare: In ordine di data /Dates (from – to) Nome e indirizzo del datore di lavoro / Name and address of employer Tipo o settore di attività / Type of business or sector Funzione o posto occupato / Occupation or position held Principali mansion e responsabilità / Main activities and responsibilities Page 1 - Curriculum vitae di / of TRIA, Giancarlo // March 01st, 2009 - July 31st, 2010 Molecular Biodiversity LABoratory(MBLAB) - IBM Italy S.p.A. - Via Pietro Leonida Laforgia 14 70125 Bari INDUSTRIAL RESEARCH FULL TIME RESEARCHER Research, design and development of bioinformatics tools for studies concerning molecular biodiversity. In particular, I was involved in the design and development of software for the prioritization of genes associated to Hereditary Hearing Loss disease. This project was developed in collaboration with IRCCS CSS San Giovanni Rotondo – specialized centre for Hereditary Hearing Loss condition. In details, the tool automatically evaluates the probability of candidate genes to be associated to the pathology according to: biomedical literature, GeneOntology products, sequence features, gene expression profiles and protein-protein interaction. ISTRUZIONE E FORMAZIONE / EDUCATION AND TRAINING In ordine di data /Dates (from – to) Nome e tipo d’istituto di istruzione o formazione / Name and type of organisation providing education and training Principali materie e competenze professionali apprese / Principal subjects occupational skills covered Certificato o diploma ottenuto /Title of qualification awarded Livello nella classificazione nazionale o internazionale / Level in National classification In ordine di data /Dates (from – to) Nome e tipo d’istituto di istruzione o formazione / Name and type of organisation providing education and training Principali materie e competenze professionali apprese / Principal subjects occupational skills covered Certificato o diploma ottenuto /Title of qualification awarded Livello nella classificazione nazionale o internazionale / Level in National classification In ordine di data /Dates (from – to) Nome e tipo d’istituto di istruzione o formazione / Name and type of organisation providing education and training Principali materie e competenze professionali apprese / Principal subjects occupational skills covered Certificato o diploma ottenuto /Title of qualification awarded Livello nella classificazione nazionale o internazionale / Level in National classification Page 2 - Curriculum vitae di / of TRIA, Giancarlo August 16th, 2010 - (in progress) (expected to finish by end of April 2014) European Molecular Biology Laboratory (EMBL) – Hamburg Outstation, DESY campus, Notkestrasse 85, D-22603, Hamburg, Germany Development of novel computational methods for constructing of 3D structural models of macromolecules from Small Angle X-ray Scattering (SAXS) data. Special attention is given to the joint use of SAXS with other structural, biophysical and biochemical techniques including crystallography, NMR, electron microscopy, neutron scattering and bioinformatics for the study of flexible macromolecules BIOTECHNOLOGY RESEARCH DOCTOR OF PHILOSOPHY (Ph.D.) September 01st, 2008 - February 28th, 2009 Molecular Biodiversity LABoratory(MBLAB) - IBM Italy S.p.A. - Via Pietro Leonida Laforgia 14 70125 Bari Advanced training of expert bioinformatics researchers for the studies concerning molecular biodiversity BIOINFORMATICS RESEARCH INDUSTRIAL RESEARCHER October 01st, 2006 - March 30th, 2010 UNIVERSITA’ DEGLI STUDI DI BARI - Via E. Orabona, 4 - 70125 Bari - Italy Advanced training on Knowledge Base and Data mining, Knowledge Engineering and Artificial Intelligence (with particular focus on practical application to biological data) Master of Science in Computer Science (with 110/110 and honours) Second level degree – Master of Science In ordine di data /Dates (from – to) Nome e tipo d’istituto di istruzione o formazione / Name and type of organisation providing education and training Principali materie e competenze professionali apprese / Principal subjects occupational skills covered Certificato o diploma ottenuto /Title of qualification awarded Livello nella classificazione nazionale o internazionale / Level in National classification October 01st, 2003 – October 11th, 2006 UNIVERSITA’ DEGLI STUDI DI BARI - Via E. Orabona, 4 - 70125 Bari - Italy Advanced training on Software Engineering and Technology for Software Developing (with focus on all the aspects of software engineering) Bachelor of Science in Computer Science and Technology for Software Developing (with 110/110 and honours) First level degree – Bachelor of Science ATTIVITA’ DI RICERCA / RESEARCH ACTIVITIES Attuali campi di ricerca / Research sectors Small Angle X-ray Scattering (SAXS) in solution on Macromolecules Recenti attività scientifiche/ Recent Scientific Activities. Development of dedicated software for the interpretation of SAXS data (ATSAS package) with particular focus on experimental data from flexible particles ULTERIORI INFORMAZIONI / ADDITIONAL INFORMATION Page 3 - Curriculum vitae di / of TRIA, Giancarlo Speaker in several courses and/or workshops dedicated (or related) to SAXS in solution on macromolecules: • BioSAXS 2014, February 22nd - 28th, 2014, University of Copenhagen, Denmark • X-ray Diffraction and Bio-SAXS Core Facility of CEITEC – Inaugural workshop September 12th - 13th, 2013, University Campus Bohunice, Brno, Czech Republic • Practical course in Solution X-ray scattering data analysis – Application to Structural Biology, August 5th - 14th, 2013, School of Biological Sciences, Nanyang Technological University, Singapore • SAXS and computational techniques to study intrinsically disordered proteins (IDPbyNMR project), March 11th - 16th, 2013, EMBL Hamburg, Germany • EMBO Practical Course on Solution Scattering From Biological Macromolecules October 17th - 24th, 2012, EMBL Hamburg, Germany Pubblicazioni/ Books and Articles Ilari A*, Alaleona F*, Tria G, Petrarca P, Battistoni A, Zamparelli C, Verzili D, Falconi M and Chiancone E. (2013) The Salmonella enterica ZinT structure, zinc affinity and interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc. Biochim Biophys Acta. 2013 Oct 12;1840(1):535-544. doi: 10.1016/j.bbagen.2013.10.010. Møller M, Nielsen SS, Ramachandran S, Li Y, Tria G, Streicher, W, Petoukhov, M, Cerione, R, Gillilan, R, and Vestergaard, B. (2013) Small Angle X-Ray Scattering Studies of Mitochondrial Glutaminase C Reveal Extended Flexible Regions, and Link Oligomeric State with Enzyme Activity. PLoS ONE 8(9): e74783. doi:10.1371/journal.pone.0074783 B. Sander, G. Tria, A. V. Shkumatov, E.-Y. Kim, J. G. Grossmann, I. Tessmer, D. I. Svergun and H. Schindelin (2013) Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states. Acta Cryst. (2013). D69, 2050-2060. doi:10.1107/S0907444913018714 Koch C*, Tria G*, Fielding AJ, Brodhun F, Valerius O, Feussner K, Braus GH, Svergun DI, Bennati M, Feussner I. (2013) A structural model of PpoA derived from SAXS-analysisImplications for substrate conversion. Biochim Biophys Acta. 2013 Sep;1831(9):1449-57. doi: 10.1016/j.bbalip.2013.06.003. Petoukhov, M.V., Franke, D., Shkumatov, A.V., Tria, G., Kikhney, A.G., Gajda, M., Gorba, C., Mertens, H.D.T., Konarev, P.V. and Svergun, D.I. (2012) New developments in the ATSAS program package for small-angle scattering data analysis. J. Appl. Cryst. 45, 342-350 Sachyani, D., Dvir, M., Strulovich, R., Tria, G., Pongs, O., Svergun, D. I., Attali, B., and Hirsch J. A. 2014. "Structural Basis of a Kv7.1 (KCNQ1) Potassium Channel Gating Module: Studies of the Intracellular C- terminal Domain in Complex with Calmodulin". (under review) Soykan, T., Schneeberger, D., Tria, G., Bader, N., Svergun, D. I., Tessmer, I., Poulopoulos, A., Papadopoulos, T., Varoqueaux, F., Schindelin, H. and Buechner, C. N. 2014. "A Conformational Switch in Collybistin Determines the Differentiation of Inhibitory Postsynapses". (under review) Giancarlo Tria, Dmitri I Svergun and Pau Bernadó: Use of Ensemble Methods to Describe Biomolecular Dynamics by Small Angle X-ray Scattering. In Computational Approaches to Protein Dynamics From Quantum to Coarse-Grained Methods. Edited by Taylor&Fracis (in press) (chapter in book) Page 4 - Curriculum vitae di / of TRIA, Giancarlo TRATTAMENTO DEI DATI PERSONALI, INFORMATIVA E CONSENSO Il D.Lgs. 30/6/2003, n. 196 “Codice in materia di protezione dei dati personali” regola il trattamento dei dati personali, con particolare riferimento alla riservatezza, all’identità personale e al diritto di protezione dei dati personali; l’interessato deve essere previamente informato del trattamento . La norma in considerazione intende come “trattamento” qualunque operazione o complesso di operazioni concernenti la raccolta, la registrazione, l’organizzazione, la conservazione, la consultazione, l’elaborazione, la modifica, la selezione, l’estrazione, il raffronto, l’utilizzo, l’interconnessione, il blocco, la comunicazione, la diffusione, la cancellazione e la distruzione di dati, anche se non registrati in una banca dati. In relazione a quanto riportato, autorizzo il CNR al trattamento dei dati contenuti nel presente curriculum vitae e nella documentazione della quale fa parte integrante, sollevandolo da ogni responsabilità e autorizzandolo alla pubblicazione, nel sito web del CNR, della relazione inerente alle proprie ricerche svolte durante il soggiorno finanziato dal CNR nell’ambito del Programma STM . Inoltre acconsento all’aggiornamento delle informazioni intranet che mi riguardano sia relative le pubblicazioni sia alle ricerche svolte. ( barrare la casella) Si, acconsento Hamburg, 24/02/2014 (Giancarlo Tria) Page 5 - Curriculum vitae di / of TRIA, Giancarlo
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