IPF FROM PATHOGENESIS TO CURE Rome, Italy Chairmen: V. Poletti, L. Richeldi, C. Saltini PRELIMINARY PROGRAM May 9-10, 2014 Palazzo delle Esposizioni IPF: FROM PATHOGENESIS TO CURE Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and limited to the lungs. It is characterized by progressive worsening of dyspnea and lung function and is associated with a poor prognosis. The pathogenesis of IPF is still unclear and a complex series of pathological events, many of which shared by other forms of pulmonary and systemic idiopathic fibrosing disorders, have been shown to be involved in the development of the typical Usual Interstitial Pneumonia (UIP) pulmonary lesions. Among them, increased local production of reactive oxygen species, abnormal wound healing in response to multiple microscopic injury, epithelial activation and hyperplasia, presence of cellular de-differentiation and epithelial to mesenchymal transition, imbalance in angiogenetic/ angiostatic process, unusual proliferation of mesenchymal cells with matrix deposition, disruption of coagulation pathway and increase of capillary permeability. On the research side, a growing number of studies have been aimed at the identification of the susceptibility gene(s) or the environmental exposures that could drive the pathogenic process of IPF. On the other hand, several controlled clinical trials have been carried out and new effective agents are -or will be soon- available for the treatment of IPF affected patients. In addition, considerable efforts have been made by scientific societies and associations to improve upon diagnostic and treatment standards for IPF patients and a simpler approach to the diagnosis have emerged from these efforts. Most importantly, interest in IPF basic and clinical research alike is continuously growing. The purpose of this meeting is to provide an update on recent advances in the field of the basic and clinical science of IPF. The most recent advancements in the understanding of the biological processes responsible for IPF pathogenesis will be critically reviewed and the most recent criteria for diagnosing and treating the disease, both in research and real life settings, will be discussed. Venerino Poletti, Luca Richeldi, Cesare Saltini RAZIONALE Rome, May 9-10 2014 FACULTY Carlo Agostini, Padova Carlo Albera, Torino Raffaele Antonelli Incalzi, Roma Vittorio Enrico Avvedimento, Napoli Joan Albert Barberà, Barcelona (ES) Marco Chilosi, Verona Marco Confalonieri, Trieste Elena Corradini, Modena Fausto De Michele, Napoli Wonder Puryear Drake, Nashville - TN (USA) Gianfranco Farinelli, Roma Andrew J. Ghio, Chapel Hill – NC (USA) Paolo Graziano, San Giovanni Rotondo (FG) Sergio Alfonso Harari, Milano Maurizio Luisetti, Pavia Fernando J. Martinez, Ann Arbor - MI (USA) Gennaro Mazzarella, Napoli Carlo Mereu, Pietra Ligure (SV) Augusto Orlandi, Roma Francesco Pallone, Roma Leonardo Palombi, Roma Franco Pasqua, Monte Compatri (RM) Venerino Poletti, Forlì Ermanno Puxeddu, Roma Luca Richeldi, Southampton (UK) Paola Rottoli, Siena Cesare Saltini, Roma Federica Sangiuolo, Roma David Schwartz, Aurora – CO (USA) Roberto Testi, Roma Carlo Vancheri, Catania Dominique Valeyre, Paris (FR) Maurizio Zompatori, Bologna IPF: Rome, May 9-10 FROM PATHOGENESIS TO CURE FRIDAY, May 9th 09.30-10.00 10.00-10.30 SATURDAY, May 10th Welcome Coffee Welcome Introduction G. Novelli, Rector University Rome “Tor Vergata” C. Saltini SESSION 1 IDIOPATHIC FIBROSING DISORDERS-1 Chairs: F. Pallone, F. Pasqua 10.30-11.00 11.00-11.30 11.30-12.00 12.00-12.30 IgG4 related Disease Sarcoidosis Pulmonary alveolar proteinosis Friedreich’s ataxia P. Graziano W. P. Drake M. Luisetti R. Testi SESSION 2 PATHOGENESIS OF IPF: INSIGHTS AND PROSPECTIVES Familial Interstitial Pneumonia Mucin genes Lunch Chairs: R. Antonelli Incalzi, F. Sangiuolo 12.30-13.00 13.00-13.30 13.30-14.30 P. Rottoli D. Schwartz SESSION 3 VASCULAR ABNORMALITIES IN PULMONARY FIBROSIS Vascular abnormalities in smokers and COPD J. A. Barberà Alveolar iron in IIPs: hemorrhage or inhalation? E. Puxeddu A common signaling pathway drives fibrosis in lung and skin V. E. Avvedimento Coffee Break Chairs: M. Confalonieri, G. Mazzarella 14.30-15.00 15.00-15.30 15.30-16.00 16.00-16.30 SESSION 4 IDIOPATHIC FIBROSING DISORDERS-2 Chairs: A. Orlandi, C. Mereu 16.30-17.00 17.00-17.30 17.30-18.00 2014 Asbestosis Hereditary hemochromatosis gene related diseases Lung fibrosing damage A. Ghio E. Corradini C. Saltini SESSION 5 FROM GUIDELINES TO PATIENT MANAGEMENT: INTERACTIVE SESSION Chairs: C. Agostini, G. Farinelli Introduction 09.00-09.30 Radiologically confident IPF, real life Ground Rounds - MDD presentation: the possible/inconsistent IPF 09.30-10.00 Histological patterns 10.00-10.30 The clinical picture 10.30-11.00 Coffee Break Chair: L. Palombi 11.00-11.30 LECTURE Guidelines implementation: National, European, International? M. Zompatori M. Chilosi V. Poletti D. Valeyre SESSION 6 EVIDENCE BASED TREATMENT Chairs: C. Albera, F. De Michele 11.30-12.00 12.00-12.30 12.30-13.00 13.00-13.30 From Ifigenia to Panther Pirfenidone post-marketing studies PH in IPF what to do: ERA, PDE5 inhibitors or palliation? New therapeutic perspectives 13.30 Closing remarks F. J. Martinez C. Vancheri S. A. Harari L. Richeldi IPF IPF: Rome, May 9-10 FROM PATHOGENESIS TO CURE Note REGISTRATION FORM Please read the information in the program. Return complete form and payment to: AIPO Ricerche srl - Via Antonio da Recanate, 2 - 20121 MILANO (Italy) Tel. +39 02 36590350 - Fax +39 02 67382337 - segreteria@aiporicerche.it 2014 PERSONAL DATA Family Name Profession: First Name Other (specity) Physician Specialty For Italian participants only Codice Fiscale Date of birth Place of birth ADDRESS Department Hospital/Institution/University Street Postal Code Contry City Phone Fax REGISTRATION FEE @ E-mail PAYMENT Medical Doctor Euro 350,00 + VAT Postgraduate Euro 175,00 + VAT Payment of registration fee should be in Euros: By Bank Transfer Holder: AIPO Ricerche srl Bank: Intesa San Paolo IBAN: IT12A0306909515615231271831 SWIFT BIC: BC IT IT 33127 · admission to scientific sessions · congress kit · coffee breaks and working lunch The registration fee includes: DETAILS FOR INVOICE TO Invoice be made out to: Invoice to be send to: Street Postal Code Street City Country For Italian partecipants only Postal Code City Country P. IVA With reference to the Decreto Legislativo 196/2003 pertaining the safeguard of personal information, I authorize AIPO Ricerche srl to use my information NOTICE strictly for the purpose of managing my attendance to the event in question. Date Signature PROVIDER NAZIONALE n°442 SOCIETÀ SCIENTIFICA CERTIFICATA UNI EN ISO 9001:2008 PER LA PROGETTAZIONE, GESTIONE ED EROGAZIONE DI EVENTI FORMATIVI E CONGRESSI NELL’AMBITO SANITARIO E NELL’EDUCAZIONE CONTINUA IN MEDICINA (IAF37) Certificato TÜV Italia N. 501004504 - Rev. 05 AIPO DICHIARA CHE LE ATTIVITÀ ECM SONO SVOLTE IN MANIERA AUTONOMA ASSUMENDOSI LA RESPONSABILITÀ DEI CONTENUTI FORMATIVI, DELLA QUALITÀ SCIENTIFICA E DELLA CORRETTEZZA ETICA DI DETTE ATTIVITÀ CHAIRMEN Venerino Poletti U.O. Pneumologia Ospedale G.B. Morgagni - L. Pierantoni, Forlì Luca Richeldi Professor of Respiratory Medicine University of Southampton (UK) Cesare Saltini U.O. Malattie dell’Apparato Respiratorio Policlinico Universitario “Tor Vergata” Università degli Studi di Roma “Tor Vergata” SCIENTIFIC SECRETARIAT Gabriella Pezzuto, Roma Ermanno Puxeddu, Roma Cesare Saltini, Roma CONFERENCE VENUE Palazzo delle Esposizioni Via Milano, 9 - Roma CONTINUING MEDICAL EDUCATION Continuing Medical Education (CME) accreditation will be available for only Italian medical specialist. The event has been insert in the Continuing Medical Education Planning AIPO 2014 Provider 442 ID Code: 89175 Partecipants: 60 CME: 10 Medical Doctor Disciplines: Pneumology, Geriatrics, Internal Medicine, Thoracic Surgery, Clinical Pathology, Pathological Anatomy, Radiodiagnostics. OFFICIAL LANGUAGE ENGLISH ORGANIZING SECRETARIAT Via Antonio da Recanate, 2 – 20124 MILANO Tel. +39 02 36590350 – Fax +39 02 67382337 segreteria@aiporicerche.it www.aiporicerche.it Dal 2004 al servizio della Pneumologia Italiana aiposegreteria@aiporicerche.it www.aiponet.it
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