Chronic Idiopathic Constipation (CIC) Treatment Market

Chronic Idiopathic Constipation (CIC) Treatment Market Size, Share, Outlook and Opportunity Analysis, 2018-2026
Constipation is condition wherein the stool frequency reduces up to three times per week with
difficulty in stool passing. Chronic constipation is a highly common functional gastrointestinal
disorder that adversely affects patient’s life. Chronic idiopathic constipation is defined as the
presence of chronic symptoms of constipation with no well-defined underlying cause. The
symptoms of chronic idiopathic constipation includes infrequent bowel movements, hard stools,
straining during defecation, feeling of incomplete evacuation, abdominal discomfort, and
bloating sensation. Chronic idiopathic constipation is diagnosed by laboratory tests, endoscopy,
radiological tests, magnetic resonance imaging, and physiological testing. Currently, very few
approved treatment options are available for chronic idiopathic constipation, which is expected
to be a major factor restrain growth of the chronic idiopathic constipation treatment market.
However, this gives opportunity for the market player to come up with the novel treatment to
grab the foothold in growing chronic idiopathic constipation treatment market.
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Chronic Idiopathic Constipation (CIC) Treatment Market Dynamics
Increasing clinical trials and approval of drug candidates by pharmaceutical companies to fulfil
unmet medical needs of the chronic idiopathic constipation treatment is a key factor driving the
market growth over the forecast period. For instance, March 2018, Shire plc received new drug
application from U.S. FDA for its drug candidate, SHP555 (prucalopride) for the indication of
chronic idiopathic constipation in adults. Moreover, in 2015, SHP555 (prucalopride)received
approval from European Commission for the symptomatic treatment of chronic constipation in
adults with failure of laxative treatment. Furthermore, Renexxion is conducting phase 2 clinical
trial for Naronapride (ATI-7505) for the treatment of multiple gastrointestinal disorders, which
includes chronic idiopathic constipation. In 2017, FDA approved Ironwood and Allergan’s
Linzess (linaclotide) for the treatment of chronic idiopathic constipation. However, 50% of
patients with chronic constipation dissatisfied with their current treatment, mainly because of
the lack of efficacy, which highlights a continued medical need for more effective and safer
therapeutic agents.
However, the use of alternate therapy such as home-based remedies and herbal medication such
as herbal laxative, probiotic foods etc. are expected to be major factors hindering the chronic
idiopathic constipation treatment market growth.
Chronic Idiopathic Constipation (CIC) Treatment Market - Regional Analysis
Regional segmentation of chronic idiopathic constipation treatment market by Coherent Market
Insights includes North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.
North America chronic idiopathic constipation treatment market holds dominant position owing
to high percentage of population suffering from chronic constipation. For instance, according to
European Journal of Pharmacology, 2017, in the U.S. 12%–19% of population suffers from
chronic constipation. This is expected to aid in growth of the market in the region over the
forecast period. However, Asia Pacific is expected to witness the fastest growth, owing to
increasing prevalence of constipation in the Asian countries. According to Journal of
Neurogastroenterology and Motility article 2016, in Asian countries such as China, Korea, Hong
Kong, and India, the prevalence of constipation reportedly ranges from 8.2% to 16.8%. This is
expected to support growth of the chronic idiopathic constipation treatment market size over
the forecast period.
Report includes chapters which deeply display the following deliverable about industry :
• Chronic Idiopathic Constipation (CIC) Treatment Market Research Objective and Assumption
• Chronic Idiopathic Constipation (CIC) Treatment Market Purview - Report Description,
Executive Summary, and Coherent Opportunity Map (COM)
• Chronic Idiopathic Constipation (CIC) Treatment Market Dynamics, Regulations, and Trends
Analysis - Market Dynamics, Regulatory Scenario, Industry Trend, Merger and Acquisitions, New
system Launch/Approvals, Value Chain Analysis, Porter’s Analysis, and PEST Analysis
• Global Chronic Idiopathic Constipation (CIC) Treatment Market, By Regions
• Chronic Idiopathic Constipation (CIC) Treatment Market Competition by Manufacturers
including Production, Share, Revenue, Average Price, Manufacturing Base Distribution, Sales
Area and Product Type.
• Chronic Idiopathic Constipation (CIC) Treatment Market Manufacturers Profiles/Analysis
including Company Basic Information, Manufacturing Base and Its Competitors.
• Chronic Idiopathic Constipation (CIC) Treatment Market Manufacturing Cost Analysis including
Key Raw Materials and Key Suppliers of Raw Materials.
• Industrial Chain, Sourcing Strategy and Downstream Buyers including Upstream Raw Materials
Sourcing and Downstream Buyers
• Marketing Strategy Analysis, Distributors/Traders including Marketing Channel, Market
Positioning and Distributors/Traders List.
• Market Effect Factors Analysis including Technology Progress/Risk, Consumer Needs/Customer
Preference Change and Economic/Political Environmental Change.
• Chronic Idiopathic Constipation (CIC) Treatment Market Forecast including Production,
Consumption, Import and Export Forecast by Type, Applications and Region.
• Research Findings and Conclusion
Chronic Idiopathic Constipation (CIC) Treatment Market – Competitive Analysis
Key players in chronic idiopathic constipation treatment market are Ironwood Pharmaceuticals,
Allergan, Synergy Pharmaceuticals, Inc., Shire plc, and Mallinckrodt plc. The presence of very
few market player provides wide opportunity for new entrant in chronic idiopathic constipation
market. Moreover, in February 2018, Mallinckrodt plc, global specialty pharmaceutical
company, announced acquisition of Sucampo Pharmaceuticals, Inc., a biopharmaceutical
company. The acquisition assets includes its FDA approved blockbuster drug Amitiza
(lubiprostone) for the treatment of chronic idiopathic constipation (CIC) in adults, irritable
bowel syndrome with constipation (IBS-C). The Sucampo Pharmaceuticals, Inc. also partnered
with Par Pharmaceuticals, Inc. and Dr. Reddy’s Laboratories Ltd. As a part of the agreement
both the partners were granted a non-exclusive license to market Par's generic version of
lubiprostone in the U.S. from January, 2021. Such inorganic strategies of market players are
expected to boost growth of the market significantly over the forecast period. In 2012, Ferring
Pharmaceuticals acquired the rights for development and commercialization of Elobixibat, firstin-class compound for chronic idiopathic constipation from Albireo AB, a Swedish biotechnology
company. Further, in 2013, Ferring Pharmaceuticals, initiated phase III clinical trials of
Elobixibat.
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Chronic Idiopathic Constipation (CIC) Treatment Market Taxonomy
On the basis of drug, the chronic idiopathic constipation treatment market is segmented into:
• Linaclotide
• Plecanatide
• Lubiprostone
• Others
On the basis of distribution channel, the chronic idiopathic constipation treatment market is
segmented into:
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies
On the basis of region, the chronic idiopathic constipation treatment market is segmented into:
• North America
• Europe
• Latin America
• Asia Pacific
• Middle East
• Africa
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Constipation is condition wherein the stool frequency reduces up to three times per week with difficulty in stool passing. Chronic constipation is a highly common functional gastrointestinal disorder that adversely affects patient’s life.