Gene Synthesis Market

Gene
Synthesis
Developments
Market
Latest
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Gene synthesis is chemically in vitro synthesis of double-stranded DNA molecules. It is a
technology used in biotechnology and plays an important role in the field of synthetic biology.
The technology has become a significant tool in various fields of recombinant DNA technology
including gene therapy, vaccine development, molecular engineering, and heterologous gene
expression. It can help in designing novel enzymes for cancer treatment. Also, it can be used in
diagnosis of viral genomes for vaccine development in real-time. Gene synthesis can develop
mutated, recombinant, or entirely novel DNA sequences without any template DNA strand.
Moreover, it can also synthesize, oligos and RNA containing modified bases or chimeric DNARNA backbones along with DNA sequences.
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Custom gene synthesis derives from oligonucleotide synthesis technology and is the gold
standard method for synthesis of PCR primers. Gene synthesis builds on this platform and uses
exclusive technologies to join the oligos to synthesize full gene sequence. The price for custom
gene synthesis was around US$ 0.69/base, earlier. Gene synthesis is a useful codon optimization
tool to circumvent codon bias problems during heterologous protein expression. Protein
expression can be improved considerably by designing DNA sequences with only codons
preferred by the intended expression host.
Report includes chapters which deeply display the following deliverable about industry :
• Gene Synthesis Market Research Objective and Assumption
• Gene Synthesis Market Purview - Report Description, Executive Summary, and Coherent
Opportunity Map (COM)
• Gene Synthesis Market Dynamics, Regulations, and Trends Analysis - Market Dynamics,
Regulatory Scenario, Industry Trend, Merger and Acquisitions, New system Launch/Approvals,
Value Chain Analysis, Porter’s Analysis, and PEST Analysis
• Global Gene Synthesis Market, By Regions
• Gene Synthesis Market Competition by Manufacturers including Production, Share, Revenue,
Average Price, Manufacturing Base Distribution, Sales Area and Product Type.
• Gene Synthesis Market Manufacturers Profiles/Analysis including Company Basic Information,
Manufacturing Base and Its Competitors.
• Gene Synthesis Market Manufacturing Cost Analysis including Key Raw Materials and Key
Suppliers of Raw Materials.
• Industrial Chain, Sourcing Strategy and Downstream Buyers including Upstream Raw Materials
Sourcing and Downstream Buyers
• Marketing Strategy Analysis, Distributors/Traders including Marketing Channel, Market
Positioning and Distributors/Traders List.
• Market Effect Factors Analysis including Technology Progress/Risk, Consumer Needs/Customer
Preference Change and Economic/Political Environmental Change.
• Gene Synthesis Market Forecast including Production, Consumption, Import and Export
Forecast by Type, Applications and Region.
• Research Findings and Conclusion
Market Dynamics
Increasing R&D associated with gene synthesis coupled with continuous improvement in the
technological processes such as molecular separation and protein purification technology helps
in developing reliable, fast, and cost effective solutions. In recent years, gene synthesis has
advanced with innovations in DNA as a data storage device and re-engineered genomes. Nextgeneration gene synthesis provides highly accurate constructs in greater numbers and at
comparatively lower prices than has been possible so far.
Solid-phase synthesis is highly accurate, however, is an expensive process and offers low
output. Chip-based DNA synthesis is less expensive than solid-phase method and can produce a
large amount of the target gene, however, with less accuracy. PCR-based enzyme synthesis
produces gene fragments with a variety of cell systems. It synthesizes long gene fragments with
higher accuracy. Gene synthesis methods have a profound impact in vaccine design, genetic and
metabolic engineering. However, currently available methods are inconsistent with drawbacks
such as high error rate, low yield, and lack of scalability on the size of the gene and size of
the project.
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Regional Insights
Regional segmentation of gene synthesis market by Coherent Market Insights includes North
America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America gene
synthesis market is expected to hold a dominant position over the forecast period, due to
increased demand from biopharmaceutical companies and academic institutes, coupled with
presence of large number of industry players with strong distribution channel. For instance, in
2016, Twist Bioscience, revenue increased with US$ 61 million for scale-up and commercial
operation of its silicon chip-based high throughput low-cost gene synthesis platform. Increasing
R&D expenditure by pharmaceutical and biotech companies for up gradation of technology and
production output is expected to drive growth of gene synthesis market in Europe. For instance,
according to European Commission 2016 report, EU companies have significantly raised their
investment in R&D, rising above the world's average growth rate. Asia Pacific market is
expected to exhibit the highest growth rate, owing to increasing investment by government and
private organizations to support growth of synthetic biology. Japan is a leading Asian country
in synthetic biology with more private companies participating in synthetic biology research.
Competitive Analysis
Major players operating in the gene synthesis market include Atum, ATDBio Ltd., Bioneer
Corporation, Eurofins Scientific, Eurogentec, GenScript Biotech Corporation, Genewiz, Integrated
DNA Technologies, Inc., OriGene Technologies, Inc., and Thermo Fisher Scientific, Inc.
Companies are focusing on strengthening their sales force and expanding their production
facilities in various geographies. For instance, in 2016, Eurofins Lancaster Laboratories (Eurofins
Scientific), announced strategic plans for expansion of its Ireland campus, including development
of a new building, expansion of its facility, and increase its workforce. The International Gene
Synthesis Consortium (IGSC) is a group of gene synthesis organizations and companies that
applies and designs a common method to screen sequences of synthetic gene orders. The group
also works with international and national government organizations. Currently, the IGSC
members together comprises around 80% of commercial gene synthesis capacity worldwide.
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Gene synthesis is chemically in vitro synthesis of double-stranded DNA molecules. It is a technology used in biotechnology and plays an important role in the field of synthetic biology.

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