CURRICULUM VITAE Name: Ikramy Abdel Raheem Khalil Ibraheem Date of Birth: 7/12/1974 Place of birth: Tahta, Sohag, Egypt Marital Status: Married Military Service: Status: Completed Starting Date: December, 1997 Completion Date: February, 1999 Institute: Heliopolis Military Hospital – Heliopolis – Cairo – Egypt Office Mailing Address: Pharmaceutics Department – Faculty of Pharmacy – Assiut University – Assiut – Egypt Home Mailing Address: Al Marwa Tower, F11, Apartment Number 6 – Algomhuriya Street – Assiut – Egypt Tel: Home: (+20) 88-9201288 Mobile: (+20) 11-7545120 Email: ikramy@yahoo.com Current Appointment: Lecturer of Pharmaceutics - Pharmaceutics Department – Faculty of Pharmacy – Assiut University – Assiut – Egypt Language Ability: English (Excellent) – Japanese (Good) Academic Degrees: 1. Master in Pharmaceutical Sciences Date Obtained: 25/3/2003 Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery Institute: Hokkaido University – Sapporo – Hokkaido – Japan Title: Octaarginine and Stearylated Octaarginine for Gene Delivery 2. Doctor of Philosophy in Pharmaceutical Sciences Date Obtained: 24/3/2006 Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery Institute: Hokkaido University – Sapporo – Hokkaido – Japan 1 Title: Improved Cellular Uptake and Controlled Intracellular Trafficking of Liposomes by Modification with Octaarginine Peptide for Drug and Gene Delivery Higher Education: 1. Bachelor of Pharmaceutical Sciences Institute: Faculty of Pharmacy – Assiut University - Assiut – Egypt Starting Date: September, 1992 Completion Date: June, 1997 Grade: Excellent with Degree of Honor 2. Master of Pharmaceutical Sciences Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery Institute: Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido - Japan Starting Date: April, 2001 Completion Date: March, 2003 3. Doctor of Philosophy in Pharmaceutical Sciences Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery Institute: Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido - Japan Starting Date: April, 2003 Completion Date: March, 2006 Previous Employment: 1. From September, 1997 To December, 1997 Position: Demonstrator – Teaching Assistant Institute: Pharmaceutics Department - Faculty of Pharmacy – Assiut University – Assiut – Egypt 2. From January, 1998 To February, 1999 Position: Pharmacist Institute: Heliopolis Military Hospital – Heliopolis – Cairo – Egypt 3. From March, 1999 To October, 2000 Position: Demonstrator – Teaching Assistant Institute: Pharmaceutics Department - Faculty of Pharmacy – Assiut University – Assiut – Egypt 4. From October, 2000 To March, 2001 Position: Research Student Institute: Laboratory of Molecular Design of Pharmaceutics - Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido – Japan 2 5. From April, 2003 To March, 2006 Position: Research and Teaching Assistant Institute: Laboratory of Molecular Design of Pharmaceutics - Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido – Japan 6. From June, 2006 Till Present Position: Lecturer of Pharmaceutics Institute: Pharmaceutics Department – Faculty of Pharmacy – Assiut University – Assiut – Egypt Postgraduate Study: 1. From April, 1999 To September, 1999 Pre-master courses at Faculty of Pharmacy – Assiut University – Assiut –Egypt Courses included: Instrumental analysis, physical chemistry, laboratory safety, and statistical analysis 2. From October, 2000 To January, 2001 Pre-master courses at Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido - Japan Courses included: Molecular biology and advanced pharmaceutics Scholarships Awarded: 1. A scholarship from the Egyptian Government to obtain Doctoral Degree from Japan (October 2000 to March 2006) 2. A post-doctor research fellow from the Japan Society for the Promotion of Science (JSPS) (September 2007 to September 2009) Major Publications: 1. Ayman El-Sayed, Tomoya Masuda, Ikramy A. Khalil, Hidetaka Akita, and Hideyoshi Harashima. Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape. Journal of Controlled Release, 138, 160-167 (September, 2009). 2. Tomoko Higashi, Ikramy A. Khalil, Kaustabh K. Maiti, Woo Sirl Lee, Hidetaka Akita, Hideyoshi Harashima, and Sung-Kee Chung. Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery. Journal of Controlled Release, 136, 140-147 (June 2009). 3. Hidetaka Akita, Asako Kudo, Arisa Minoura, Masaya Yamaguti, Ikramy A. Khalil, Rumiko Moriguchi, Tomoya Masuda, Radostin Danev, Kuniaki Nagayama, Kentaro Kogure, and Hideyoshi Harashima. Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process. Biomaterials, 30, 2940-2949 (May 2009). 4. El-Sayed A, Khalil I.A., Kogure K, Futaki S, and Harashima H. Octaarginine- and octalysinemodified nanoparticles have different modes of endosomal escape. J Biol Chem. 283:2345061. (August 2008) 5. Khalil I.A., Kogure K, Futaki S, Hama S, Akita H, Ueno M, Kishida H, Kudoh M, Mishina Y, 3 Kataoka K, Yamada M, and Harashima H. Octaarginine-modified multifunctional envelopetype nanoparticles for gene delivery. Gene Ther. 14:682-9 (April 2007) 6. Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, and Hideyoshi Harashima. Octaargininemodified liposomes: Enhanced cellular uptake and controlled intracellular trafficking. International Journal of Pharmaceutics, 354, 39-48 (April 2008). 7. Tianzhi Yang, Alamdar Hussain, Shuhua Bai, Ikramy A. Khalil, Hideyoshi Harashima, and Fakhrul Ahsan. Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. Journal of Controlled Release, 115, 289-297 (October 2006) 8. Akitada Iwasa, Hidetaka Akita, Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, and Hideyoshi Harashima. Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1758, 713-720 (June 2006) 9. Khalil, I.A., Kogure, K., Akita, H. & Harashima, H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 58, 32-45 (March, 2006). 10. Khalil, I.A., Kogure, K., Futaki, S. & Harashima, H. High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol Chem 281, 3544-3551 (March, 2006). 11. Akita, H., Khalil, I.A., Kogure, K. & Harashima, H. Pharmacokinetic considerations in nonviral gene delivery. In: Non-viral gene delivery: Gene Design and Delivery, SpringerVerlag, Tokyo 2005. Pages 135-154. 12. Mudhakir, D., Akita, H., Khalil, I.A., Futaki, S. & Harashima, H. Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice. Drug Metab Pharmacokinet 20, 275-81 (2005). 13. Khalil, I.A., Futaki, S., Niwa, M., Baba, Y., Kaji, N., Kamiya, H. & Harashima, H. Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation. Gene Ther 11, 636-44 (April, 2004). 14. Akita, H., Ito, R., Khalil, I.A., Futaki, S. & Harashima, H. Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. Mol Ther 9, 443-51 (April, 2004). Scientific Awards: 1. Best poster for young researchers – 2nd place – From the 9TH Liposome Research Days (LRD) 2004 – Taiwan – May, 2004. 2. Nagai Konishi Student Award – From Nagai Foundation – Tokyo – Japan – September, 2005 4
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